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Asian Pacific Journal of Cancer... Oct 2023The objective of this study was to determine the survival rate and the effects of different treatments on patients with inflammatory breast cancer (IBC). The study... (Meta-Analysis)
Meta-Analysis
The objective of this study was to determine the survival rate and the effects of different treatments on patients with inflammatory breast cancer (IBC). The study employed a systematic approach that included a search strategy across four databases: Embase, Web of Sciences, PubMed, and Scopus. The results obtained were screened initially by titles and abstracts, followed by full-texts in EndNote 8 software. The next stage involved data extraction and qualitative evaluation, where the Metan command was used to estimate the pooled survival rate. A total of 28 studies with a sample size of 63,796 were finally analyzed. The overall 3- and 5-year survival rates (OS) for IBC patients were found to be 52% (95% CI; 46-58%, I2: 99.42%) and 61% (95% CI; 53-69%, I2: 93.63%), respectively. The 5-year OS rates in patients with non-metastatic and metastatic IBC were 59% (95% CI; 54-63%, I2: 98.31%) and 30% (95% CI; 26-35%, I2: 50.84%), respectively. The 5-year OS rate in non-metastatic patients who underwent BCS surgery was 60% (CI 95%; 26-94%, I2: 95.13%). The overall 5- and 3-year OS rates for patients with IBC were lower than those for all types of breast cancer, and the rates were even lower in patients with metastasis. Therefore, it is recommended that healthcare workers and women at risk should be vigilant of early symptoms of IBC to prevent metastasis by seeking medical attention on time.
Topics: Humans; Female; Inflammatory Breast Neoplasms; Survival Rate
PubMed: 37898836
DOI: 10.31557/APJCP.2023.24.10.3335 -
Cancer Control : Journal of the Moffitt... 2020Colorectal cancer (CRC) is the second most common cause of cancer-related deaths worldwide. Survival rates are among the most important factors in quality control and... (Meta-Analysis)
Meta-Analysis
Colorectal cancer (CRC) is the second most common cause of cancer-related deaths worldwide. Survival rates are among the most important factors in quality control and assessment of treatment protocols. This study was aimed to assess the survival rate of colorectal cancer in Eastern Mediterranean Region Countries. In the present study we comprehensively searched 6 international databases including PubMed/Medline, ProQuest, Scopus, Embase, Web of Knowledge and Google Scholar for published articles until November 2018. The Newcastle-Ottawa Quality Assessment Form for Cohort Studies was applied to evaluate the quality of included studies. The heterogeneity of papers was assessed with the Cochran Test and I-Square statistics. Meta-regression test was performed based on publication year, sample size and Human Development Index (HDI) of each study. Among the total of 1023 titles found in the systematic search, 43 studies were eligible to be included in the present meta-analysis. According to the results, the 1-year, 3-year and 5-year survival rate of patients with Colorectal Cancer was 88.07% (95% CI, 83.22-92.92), 70.67% (95% CI, 66.40-74.93) and, 57.26% (95% CI, 50.43-64.10); respectively. Furthermore, Meta-regressions did not show significant correlations between survival rate and year, sample size or Human Development Index. Survival rates, especially the 5-year survival rate in the EMRO were less than European countries and the USA. Documented and comprehensive evidence-based findings of the present meta-analysis can be used to enhance policies and outcomes of different medical areas including prophylaxis, treatment and health related objectives in colorectal cancer.
Topics: Cohort Studies; Colorectal Neoplasms; Early Detection of Cancer; Humans; Mediterranean Region; Prognosis; Survival Rate
PubMed: 33074714
DOI: 10.1177/1073274820964146 -
Annals of Palliative Medicine Aug 2021The most common metastatic site of hepatocellular carcinoma (HCC) is lung metastasis. When the patient has lung metastasis, the development of the disease will become... (Meta-Analysis)
Meta-Analysis
BACKGROUND
The most common metastatic site of hepatocellular carcinoma (HCC) is lung metastasis. When the patient has lung metastasis, the development of the disease will become very rapid. In severe cases, it will cause rapid death of the patient. Therefore, the treatment of HCC after lung metastasis has become a hot research topic. This study was designed to investigate the curative effect and prognostic factors of hepatectomy in patients with HCC with lung metastasis (LM) (HCC + LM patients) using meta-analysis.
METHODS
RevMan 5.3 software was used to screen literature based on randomized controlled studies on the curative effect and prognostic factors of hepatectomy for HCC + LM published between January 2000 to January 2020 in the PubMed, Web of Science, Spring, and Science Direct databases.
RESULTS
A total of 13 articles were included, comprising 754 patients in the H group and 1,201 patients in the NH group. Meta-analysis results showed that the maximum diameter of liver tumors in the H group was much larger than that in the NH group (MD =-0.62; 95% CI: -1.20 to -0.04; Z=2.09; P=0.04). The survival rate 1, 3, and 5 years after treatment in group H was higher than that in the NH group [Mantel-Haenszel (MH) =2.91, 2.80, and 4.96; 95% CI: 2.25-3.76, 2.22-3.52, and 3.74-6.59; Z=8.20, 8.73, and 11.09, respectively; P<0.00001], and the mean survival time in group H was much longer than that in the NH group (MD =17.30; 95% CI: 11.78-22.83; Z=6.14; and P<0.00001).
DISCUSSION
The MDLT is a prognostic indicator for hepatectomy, and hepatectomy can effectively prolong the survival time of HCC + LM patients.
Topics: Carcinoma, Hepatocellular; Hepatectomy; Humans; Liver Neoplasms; Lung Neoplasms; Prognosis; Survival Rate; Treatment Outcome
PubMed: 34488390
DOI: 10.21037/apm-21-1784 -
Annals of Global Health Dec 2019Breast cancer (BC) is one of the main problems of public health around the world. As a consequence, survival rates are one of the most salient indicators for assessing... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Breast cancer (BC) is one of the main problems of public health around the world. As a consequence, survival rates are one of the most salient indicators for assessing the quality of cancer control and treatment programs.
OBJECTIVES
The aim of this study is to evaluate the survival rate of breast cancer in the Eastern Mediterranean region at different periods of time.
METHODS
Medline/PubMed, ProQuest, Scopus, Embase, Web of Knowledge and Google Scholar databases until February 1, 2018. All observational studies (cross-sectional, case-control, and cohort) referring to the survival of breast cancer were included in the study. The heterogeneity and its value were examined by Cochran test and I statistics, respectively. Analysis of subgroups performed was based on geographical area and Human Development Index (HDI), using Stata 12 software.
FINDINGS
A total of 58 papers were analyzed. Based on a random effect model, the survival rates of breast cancer in different periods-1, 2, 3, 4, 5 and 10 years-were estimated at 93.9, 85, 79.8, 72.6, 69.2, 62.1 and 55.5 percent, respectively. The highest 10-year survival rate was in Iran (59.2%), and the lowest was observed in Bahrain (45%).
CONCLUSIONS
Evidence suggests that about half of the patients in this area would die before 10 years survival, which is different from more developed countries. Also, high survival rates are associated with high human development index, which can help health policy-makers to better predict the outcomes of patients.
Topics: Africa, Eastern; Africa, Northern; Breast Neoplasms; Developed Countries; Developing Countries; Female; Humans; Middle East; Survival Rate
PubMed: 31857944
DOI: 10.5334/aogh.2521 -
European Journal of Medical Research Oct 2023Severe trauma can result in cardiorespiratory failure, and when conventional treatment is ineffective, extracorporeal membrane oxygenation (ECMO) can serve as an... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Severe trauma can result in cardiorespiratory failure, and when conventional treatment is ineffective, extracorporeal membrane oxygenation (ECMO) can serve as an adjunctive therapy. However, the indications for ECMO in trauma cases are uncertain and clinical outcomes are variable. This study sought to describe the prognosis of adult trauma patients requiring ECMO, aiming to inform clinical decision-making and future research.
METHODS
A comprehensive search was conducted on Pubmed, Embase, Cochrane, and Scopus databases until March 13, 2023, encompassing relevant studies involving over 5 trauma patients (aged ≥ 16 years) requiring ECMO support. The primary outcome measure was survival until discharge, with secondary measures including length of stay in the ICU and hospital, ECMO duration, and complications during ECMO. Random-effects meta-analyses were conducted to analyze these outcomes. The study quality was assessed using the Joanna Briggs Institute checklist, while the certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.
RESULTS
The meta-analysis comprised 36 observational studies encompassing 1822 patients. The pooled survival rate was 65.9% (95% CI 61.3-70.5%). Specifically, studies focusing on traumatic brain injury (TBI) (16 studies, 383 patients) reported a survival rate of 66.1% (95% CI 55.4-76.2%), while studies non-TBI (15 studies, 262 patients) reported a survival rate of 68.1% (95% CI 56.9-78.5%). No significant difference was observed between these two survival comparisons (p = 0.623). Notably, studies utilizing venoarterial extracorporeal membrane oxygenation (VA ECMO) (15 studies, 39.0%, 95% CI 23.3-55.6%) demonstrated significantly lower survival rates than those using venovenous extracorporeal membrane oxygenation (VV ECMO) (23 studies, 72.3%, 95% CI 63.2-80.7%, p < 0.001). The graded assessment of evidence provided a high degree of certainty regarding the pooled survival.
CONCLUSIONS
ECMO is now considered beneficial for severely traumatized patients, improving prognosis and serving as a valuable tool in managing trauma-related severe cardiorespiratory failure, haemorrhagic shock, and cardiac arrest.
Topics: Humans; Adult; Extracorporeal Membrane Oxygenation; Prognosis; Brain Injuries, Traumatic; Respiratory Insufficiency; Survival Rate; Retrospective Studies
PubMed: 37814326
DOI: 10.1186/s40001-023-01390-2 -
Journal of Clinical Periodontology Feb 2023The aim was to systematically evaluate the effect of low insertion torque values on the survival rate of immediately loaded dental implants. (Meta-Analysis)
Meta-Analysis Review
AIM
The aim was to systematically evaluate the effect of low insertion torque values on the survival rate of immediately loaded dental implants.
MATERIALS AND METHODS
The protocol was registered with PROSPERO (ID CRD42020189499). An electronic search was performed in PubMed, Embase, Web of Science, and Cochrane Central Register of Controlled Trials until June 2022 in English and Spanish. Studies analysing the failure or survival rate of immediately loaded dental implants according to different insertion torque values were included.
RESULTS
Five-hundred seventy-three articles were assessed for eligibility, of which seven articles, four randomized clinical trials (RCTs), one controlled clinical trial, and two prospective case series studies were included in the qualitative analysis. The RCTs were classified as having low risk of bias and the non-RCTs as having moderate and serious risk of bias. The mean survival rate for implants with low insertion toque (≤35 Ncm) was 96% (p > .001, 95% confidence interval [CI]: 0.91-0.98) and that for implants with medium or high insertion torque (>35 Ncm) was 92% (p > .001, 95% CI: 0.86-0.96) (incidence rate ratio [IRR] = 1.05, 95% CI: 0.79-1.39, p = .175, I = 0.0%). Splinted implants with insertion torque >20 Ncm and single implants with insertion torque >35 Ncm had a higher survival rate than implants with lower insertion torque values (IRR = 1.05, 95% CI: 0.78-1.43, p = .956, I = 0.0%, and RR = 0.92, 95% CI: 0.48-1.75, p = .799, I = 0.0%, respectively). Different insertion torque values achieved equivalent outcomes. The mean follow-up was 24 months.
CONCLUSIONS
Low insertion torque values have no significant effect on survival rates of immediate loading implants at a mean follow-up of 24 months.
Topics: Dental Implantation, Endosseous; Dental Implants; Immediate Dental Implant Loading; Survival Rate; Torque; Dental Prosthesis, Implant-Supported; Dental Restoration Failure
PubMed: 36217696
DOI: 10.1111/jcpe.13733 -
Journal of Indian Prosthodontic Society 2022The aim of this systematic review is to evaluate the survival rate of dental implant placed using different maxillary sinus floor elevation techniques. (Meta-Analysis)
Meta-Analysis
AIM
The aim of this systematic review is to evaluate the survival rate of dental implant placed using different maxillary sinus floor elevation techniques.
SETTING AND DESIGN
PRISMA guidelines were used for this systematic review and meta-analysis.
MATERIALS AND METHODS
Relevant articles were searched from Medline, PubMed, Google Scholar, ScienceDirect, and Cochrane trials. Articles published in English language were selected. Hand search was further conducted. For risk of bias, two tools were used, i.e., Cochrane tool for randomized controlled trials (RCTs) and new castle Ottawa quality assessment tool for non-RCTs.
STATISTICAL ANALYSIS
For statistical meta-analysis RevMan 5.4 software was used.
RESULTS
Seventeen studies were finalized. All studies were included in the meta-analysis to check the implant survival rate. There is no statistical difference between direct and indirect techniques, and forest plot was derived for direct approach (P = 0.688, 95% confidence interval [CI] 0.9691) and for indirect approach (P = 0.686 and 95% CI 0.970).
CONCLUSION
There is no statistically significant difference in the survival rate of implant placed using direct or indirect sinus lift approach procedures. Hence, the technique is selected as per the indications given for each direct and indirect procedure.
Topics: Maxillary Sinus; Sinus Floor Augmentation; Dental Implants; Dental Implantation, Endosseous; Dental Restoration Failure; Survival Rate
PubMed: 36511050
DOI: 10.4103/jips.jips_283_22 -
BMC Pediatrics Aug 2022This study is a systematic review and meta-analysis on published studies about the Global Survival Rate of Graft and Patients in the Kidney Transplantation of children. (Meta-Analysis)
Meta-Analysis
BACKGROUND
This study is a systematic review and meta-analysis on published studies about the Global Survival Rate of Graft and Patients in the Kidney Transplantation of children.
METHODS
Studies that investigated the survival rate of kidney transplants published until the 30th of December 2020 were selected using a systematic search strategy in the following databases: Medline, Embase, Scopus, ProQuest, ISI Web of Science, and Cochrane. The extracted data were entered into the Excel software and STATA 16.0. The search identified 6007 study references. From the total, we excluded 1348 duplicates, 3688 reference titles and abstracts that were deemed irrelevant, and 846 references that were not original articles (i.e., letter, commentary, review) or did not meet the inclusion criteria. As such, 89 studies involving 12,330 participants were included in this meta-analysis.
RESULTS
In this study 1, 3, 5, 7 and 10-year survival rates of graft were estimated to be 92, 83, 74.40, 67.10, and 63.50%, respectively. Also, 1, 3, 5, 7 and 10-year survival rates of patients were estimated to be 99.60, 97.30, 95.20, 74.60, and 97.90%, respectively.
CONCLUSIONS
The findings suggest differences in graft and patient survival among children with kidney transplants. Although differences in ethnic origin, incompatibility with deceased donor kidneys, and types of kidney disease are unavoidable, interventions to improve preventive and living-donor transplantation are particularly needed in minority groups. In addition, more research is needed to establish and address the contribution of medical and sociocultural barriers to preferential treatment of these groups.
Topics: Child; Humans; Kidney Diseases; Kidney Transplantation; Living Donors; Minority Groups; Survival Rate
PubMed: 36002803
DOI: 10.1186/s12887-022-03545-2 -
International Journal of Surgery... Aug 2023Around 5-20% of patients who undergo surgery for advanced gastric cancer (AGC), which invades into the muscularis propria or beyond, have peritoneal carcinomatosis. The... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Around 5-20% of patients who undergo surgery for advanced gastric cancer (AGC), which invades into the muscularis propria or beyond, have peritoneal carcinomatosis. The peritoneal recurrence rate is 10-54%, which is associated with a poor prognosis. The role of hyperthermic intraperitoneal chemotherapy (HIPEC) in AGC with and without peritoneal carcinomatosis is not clearly defined.
METHODS
The authors conducted a meta-analysis, in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, of the clinical trials and high-quality nonrandomized studies evaluating the role of HIPEC in AGC over the last 10 years. The studies were searched in PubMed, EMBASE, MEDLINE, and Cochrane databases between January 2011 to December 2021. Clinical data including overall survival, recurrence free survival, overall recurrence rate, peritoneal recurrence rate, and complications analyzed using RevMan 5.4.
RESULTS
Six randomized controlled trials and 10 nonrandomized studies, comprising a total of 1700 patients were included. HIPEC was associated with significantly improved OS at 3 [odd ratio (OR) 1.89, 95% CI: 1.17-3.05] and 5 years (OR 1.87, 95% CI: 1.29-2.71). HIPEC was associated with reduced overall recurrence (OR 0.49, 95% CI: 0.31-0.80) and peritoneal recurrence (OR 0.22, 95% CI: 0.11-0.47). HIPEC was not associated with increased complications. The occurrence of postoperative renal dysfunction was significantly higher in the HIPEC group (OR 3.94, 95% CI: 1.85-8.38).
CONCLUSION
The role of HIPEC in AGC has evolved over the past decade. HIPEC may improve survival rates and reduce recurrence rates in patients with AGC, without significant increase in complications and with a favorable impact on 3 and 5-year survival.
Topics: Humans; Stomach Neoplasms; Hyperthermic Intraperitoneal Chemotherapy; Peritoneal Neoplasms; Hyperthermia, Induced; Survival Rate; Combined Modality Therapy; Antineoplastic Combined Chemotherapy Protocols; Cytoreduction Surgical Procedures; Randomized Controlled Trials as Topic
PubMed: 37158149
DOI: 10.1097/JS9.0000000000000457 -
European Journal of Obstetrics,... Jul 2022Determine the impact of indication for selective reduction (SR) on co-twin survival in monochorionic gestations undergoing radiofrequency ablation (RFA) or bipolar cord... (Meta-Analysis)
Meta-Analysis Review
Co-twin survival after selective fetal reduction in complicated multiple gestations: A systematic review and meta-analysis of survival rate according to indication for intervention.
OBJECTIVE
Determine the impact of indication for selective reduction (SR) on co-twin survival in monochorionic gestations undergoing radiofrequency ablation (RFA) or bipolar cord coagulation (BCC).
METHODS
PubMed and Web of Science were systematically searched from inception of databases to April 2021. Frequency of indications was compared between post-intervention co-twin survival and demise groups undergoing SR. Random-effect model was used to pool mean differences or odds ratios (OR) and corresponding 95% confidence intervals (CIs). Heterogeneity was assessed using the I value.
RESULTS
Of 1060 studies assessed for eligibility, nine studies met criteria. A total of 666 pregnancies underwent RFA (n = 483 co-twin survival) and 235 pregnancies underwent BCC (n = 188 co-twin survival). Twin twin transfusion syndrome (TTTS), as an indication for RFA, was associated with decreased co-twin survival (OR 0.61, 95% CI 0.41, 0.90, P 0.01, I 0.0%). Other indications for RFA were not associated with significant difference in co-twin survival. With BCC, none of the indications were found to significantly influence the co-twin survival following intervention.
CONCLUSION
RFA was found to have lower co-twin survival when performed for TTTS. No other indications was associated with differences in co-twin survival. BCC was not associated with any differences in co-twin survival based on indication.
Topics: Female; Fetofetal Transfusion; Humans; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy Reduction, Multifetal; Pregnancy, Twin; Retrospective Studies; Survival Rate; Twins, Monozygotic
PubMed: 35661541
DOI: 10.1016/j.ejogrb.2022.05.028