-
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing... Jan 2023Pulmonary fibrosis is end-stage of variety of heterogeneous interstitial lung disease, characterizedby excessive proliferation of fibroblasts and extracellular matrix... (Review)
Review
Pulmonary fibrosis is end-stage of variety of heterogeneous interstitial lung disease, characterizedby excessive proliferation of fibroblasts and extracellular matrix deposition and destruction of lung parenchyma. Thyroid and lung are derived from the same endodermal cells, thyroid hormone affect the occurrence、development and prognosis of the chronic obstructive pulmonary disease, lung cancer and other lung diseases, This article reviews the role and mechanism of thyroid hormone in pulmonary fibrosis in order to provide new idea for the study of the role and mechanism of thyroid hormone in silicosis.
Topics: Humans; Pulmonary Fibrosis; Lung; Silicosis; Lung Diseases, Interstitial; Fibroblasts; Thyroid Hormones; Fibrosis
PubMed: 36725299
DOI: 10.3760/cma.j.cn121094-20210727-00377 -
Frontiers in Psychology 2022We present a theory of sequential information processing in persuasion (SIP). It extends assumptions of the heuristic-systematic model, in particular the idea that...
We present a theory of sequential information processing in persuasion (SIP). It extends assumptions of the heuristic-systematic model, in particular the idea that information encountered early in a persuasion situation may affect the processing of subsequent information. SIP also builds on the abstraction from content-related dichotomies in accord with the parametric unimodel of social judgment. SIP features one constitutional axiom and three main postulates: (A) Persuasion is the sequential processing of information that is relevant to judgment formation. (1) Inferences drawn from initial information may bias the processing of subsequent information if they are either activated rules or valence expectations that are relevant to the subsequent information. (2) Inferences drawn from initial information are resistant to change. Thus, the interpretation of subsequent information is assimilated to inferences drawn from the initial information. Or, if assimilation is impossible, contrast effects occur. (3) The overall effect of a persuasion attempt corresponds to the recipient's judgment at the moment the processing of information is terminated. We illustrate how our predictions for assimilation and contrast effects may be tested by presenting results from an experiment ( = 216) in which we presented exactly the same arguments but varied the processing sequence. We discuss theoretical and applied implications of sequence effects for persuasion phenomena, as well as challenges for further research developing and testing the theory.
PubMed: 36148101
DOI: 10.3389/fpsyg.2022.902230 -
Journal of Experimental Psychology.... Jun 2022Why do people gesture when they speak? According to one influential proposal, the Lexical Retrieval Hypothesis (LRH), gestures serve a cognitive function in speakers'...
Why do people gesture when they speak? According to one influential proposal, the Lexical Retrieval Hypothesis (LRH), gestures serve a cognitive function in speakers' minds by helping them find the right spatial words. Do gestures also help speakers find the right words when they talk about abstract concepts that are spatialized metaphorically? If so, then preventing people from gesturing should increase the rate of disfluencies during speech about both literal and metaphorical space. Here, we sought to conceptually replicate the finding that preventing speakers from gesturing increases disfluencies in speech with literal spatial content (e.g., the rocket went up), which has been interpreted as evidence for the LRH, and to extend this pattern to speech with metaphorical spatial content (e.g., my grades went up). Across three measures of speech disfluency (disfluency rate, speech rate, and rate of nonjuncture filled pauses), we found no difference in disfluency between speakers who were allowed to gesture freely and speakers who were not allowed to gesture, for any category of speech (literal spatial content, metaphorical spatial content, and no spatial content). This large dataset (7,969 phrases containing 2,075 disfluencies) provided no support for the idea that gestures help speakers find the right words, even for speech with literal spatial content. Upon reexamining studies cited as evidence for the LRH and related proposals over the past 5 decades, we conclude that there is, in fact, no reliable evidence that preventing gestures impairs speaking. Together, these findings challenge long-held beliefs about why people gesture when they speak. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Topics: Gestures; Humans; Metaphor; Speech
PubMed: 34855443
DOI: 10.1037/xge0001135 -
Therapeutic Advances in Ophthalmology 2024New developments in artificial intelligence, particularly with promising results in early detection and management of keratoconus, have favorably altered the natural... (Review)
Review
BACKGROUND
New developments in artificial intelligence, particularly with promising results in early detection and management of keratoconus, have favorably altered the natural history of the disease over the last few decades. Features of artificial intelligence in different machine such as anterior segment optical coherence tomography, and femtosecond laser technique have improved safety, precision, effectiveness, and predictability of treatment modalities of keratoconus (from contact lenses to keratoplasty techniques). These options ingrained in artificial intelligence are already underway and allow ophthalmologist to approach disease in the most non-invasive way.
OBJECTIVES
This study comprehensively describes all of the treatment modalities of keratoconus considering machine learning strategies.
DESIGN
A multidimensional comprehensive systematic narrative review.
DATA SOURCES AND METHODS
A comprehensive search was done in the five main electronic databases (PubMed, Scopus, Web of Science, Embase, and Cochrane), without language and time or type of study restrictions. Afterward, eligible articles were selected by screening the titles and abstracts based on main mesh keywords. For potentially eligible articles, the full text was also reviewed.
RESULTS
Artificial intelligence demonstrates promise in keratoconus diagnosis and clinical management, spanning early detection (especially in subclinical cases), preoperative screening, postoperative ectasia prediction after keratorefractive surgery, and guiding surgical decisions. The majority of studies employed a solitary machine learning algorithm, whereas minor studies assessed multiple algorithms that evaluated the association of various keratoconus staging and management strategies. Last but not least, AI has proven effective in guiding the implantation of intracorneal ring segments in keratoconus corneas and predicting surgical outcomes.
CONCLUSION
The efficient and widespread clinical translation of machine learning models in keratoconus management is a crucial goal of potential future approaches to better visual performance in keratoconus patients.
TRIAL REGISTRATION
The article has been registered through PROSPERO, an international database of prospectively registered systematic reviews, with the ID: CRD42022319338.
PubMed: 38516169
DOI: 10.1177/25158414241232258 -
Sheng Wu Gong Cheng Xue Bao = Chinese... May 2023In recent years, the petroleum-based plastic pollution problem has been causing global attention. The idea of "degradation and up-cycling of plastics" was proposed for... (Review)
Review
In recent years, the petroleum-based plastic pollution problem has been causing global attention. The idea of "degradation and up-cycling of plastics" was proposed for solving the environmental pollution caused by non-degradable plastics. Following this idea, plastics would be firstly degraded and then reconstructed. Polyhydroxyalkanoates (PHA) can be produced from the degraded plastic monomers as a choice to recycle among various plastics. PHA, a family of biopolyesters synthesized by many microbes, have attracted great interest in industrial, agricultural and medical sectors due to its biodegradability, biocompatibility, thermoplasticity and carbon neutrality. Moreover, the regulations on PHA monomer compositions, processing technology, and modification methods may further improve the material properties, making PHA a promising alternative to traditional plastics. Furthermore, the application of the "next-generation industrial biotechnology (NGIB)" utilizing extremophiles for PHA production is expected to enhance the PHA market competitiveness, promoting this environmentally friendly bio-based material to partially replace petroleum-based products, and achieve sustainable development with carbon-neutrality. This review summarizes the basic material properties, plastic upcycling PHA biosynthesis, processing and modification methods of PHA, and biosynthesis of novel PHA.
Topics: Polyhydroxyalkanoates; Plastics; Biotechnology; Petroleum; Carbon
PubMed: 37212231
DOI: 10.13345/j.cjb.230033 -
Zhonghua Wai Ke Za Zhi [Chinese Journal... Feb 2024As a major development in breast surgery, mastoscopy has been proven safe and been involved in almost all breast surgery operative procedures. Its extensive development...
As a major development in breast surgery, mastoscopy has been proven safe and been involved in almost all breast surgery operative procedures. Its extensive development has cultivated a group of positively young and middle-aged academic backbones, at the same time nurtured high-level breast subject leaders, providing innovative ideas and useful reference for the high-quality development of breast specialty. However, due to the relatively weak breast specialty, uneven technical treatment ideas, insufficient promotion of endoscopic technology, unique learning curve, and inhomogeneous technical aspects, the development of mastoscopy technology is uneven and the level of homogenization is low. It should be started from four aspects, including strategic focus, treatment idea, endoscopic technical training, and mastoscopic operation. Multiple measures should be taken to comprehensively improve the homogenization of mastoscopic level.
Topics: Middle Aged; Humans; Female; Breast; Endoscopy; Mastectomy; Learning Curve; Breast Neoplasms
PubMed: 38310373
DOI: 10.3760/cma.j.cn112139-20230928-00148 -
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi =... Aug 2023Single-cell transcriptome sequencing (scRNA-seq) can resolve the expression characteristics of cells in tissues with single-cell precision, enabling researchers to... (Review)
Review
Single-cell transcriptome sequencing (scRNA-seq) can resolve the expression characteristics of cells in tissues with single-cell precision, enabling researchers to quantify cellular heterogeneity within populations with higher resolution, revealing potentially heterogeneous cell populations and the dynamics of complex tissues. However, the presence of a large number of technical zeros in scRNA-seq data will have an impact on downstream analysis of cell clustering, differential genes, cell annotation, and pseudotime, hindering the discovery of meaningful biological signals. The main idea to solve this problem is to make use of the potential correlation between cells and genes, and to impute the technical zeros through the observed data. Based on this, this paper reviewed the basic methods of imputing technical zeros in the scRNA-seq data and discussed the advantages and disadvantages of the existing methods. Finally, recommendations and perspectives on the use and development of the method were provided.
Topics: Cluster Analysis; Transcriptome
PubMed: 37666769
DOI: 10.7507/1001-5515.202301009 -
Der Nervenarzt Nov 2022The reform of the guardianship law has been decided! The reform will come into force on 1 January 2023. The content of the guardianship law will not be completely... (Review)
Review
The reform of the guardianship law has been decided! The reform will come into force on 1 January 2023. The content of the guardianship law will not be completely restructured. The tense relationship between the protection of the person against decisions not made on his or her own responsibility and the self-determination of the person will be consistently further considered and strengthened in favor of the self-determination of the person concerned. Supportive decision making, the consideration of a person's wishes, the abandonment of the term (and concept of) "well-being" as a measure for guardianship are some examples; however, the new law also sets boundaries in adhering to a person's wishes. Namely, if they are associated with the risk of significant harm to the person or his or her property. The article first presents the main objectives of the reform. Based on this, the focal points are the deletion of the word "well-being", the regulation of the proxy power of attorney and measures for greater consideration and better implementation of the principle of the necessity, which is central to the guardianship law. Critical comments are made on the newly introduced spousal representation law and its significance for the psychiatric practice. As a result, it can be stated that there will be hardly any significant changes in healthcare and even less so in the area of coercive measures. It remains to be seen whether the legislator's welcome concern to avoid guardianship through improved information and counselling on social rights will be achieved in practice. The same certainly applies to the strengthening of supported decision making, the idea of which is also to be welcomed but is still looking for a gold standard for practice.
Topics: Humans; Male; Female; Advance Directives
PubMed: 36102927
DOI: 10.1007/s00115-022-01355-6 -
Zeitschrift Fur Rheumatologie Feb 2023International guidelines recommend involving various professions and disciplines at an early stage in the event of chronic back pain. In connection with this, terms such... (Review)
Review
International guidelines recommend involving various professions and disciplines at an early stage in the event of chronic back pain. In connection with this, terms such as multiprofessional or interprofessional interventions are often mentioned without a uniform idea of what they mean. This article is intended to provide an overview of multiprofessional interventions for patients with chronic back pain and the integration into a meaningful interdisciplinary and interprofessional multimodal treatment concept. This is illustrated in a biopsychosocial pillar model, which should be pursued for each patient individually.
Topics: Humans; Back Pain; Combined Modality Therapy; Chronic Pain
PubMed: 36053333
DOI: 10.1007/s00393-022-01258-6 -
Philosophical Transactions of the Royal... Oct 2023, if we are to do so in a way that is sensible, begins at the root. All too often, we jump to discussing specific postulated causes but do not first consider what we... (Review)
Review
, if we are to do so in a way that is sensible, begins at the root. All too often, we jump to discussing specific postulated causes but do not first consider what we mean by, for example, of obesity or how we discern whether something is a cause. In this paper, we address what we mean by a cause, discuss what might and might not constitute a reasonable causal model in the abstract, speculate about what the causal structure of obesity might be like overall and the types of things we should be looking for, and finally, delve into methods for evaluating postulated causes and estimating causal effects. We offer the view that different meanings of the concept of causal factors in obesity research are regularly being conflated, leading to confusion, unclear thinking and sometimes nonsense. We emphasize the idea of different kinds of studies for evaluating various aspects of causal effects and discuss experimental methods, assumptions and evaluations. We use analogies from other areas of research to express the plausibility that only inelegant solutions will be truly informative. Finally, we offer comments on some specific postulated causal factors. This article is part of a discussion meeting issue 'Causes of obesity: theories, conjectures and evidence (Part II)'.
Topics: Humans; Research Design; Causality; Obesity
PubMed: 37661742
DOI: 10.1098/rstb.2022.0227