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Cornea Jul 2022The purpose of this study was to describe a case of conjunctival melanoacanthoma, an exceedingly rare condition that has yet to be fully described in the literature.
PURPOSE
The purpose of this study was to describe a case of conjunctival melanoacanthoma, an exceedingly rare condition that has yet to be fully described in the literature.
METHODS
Melanoacanthomas are most commonly seen on the skin or oral mucosa and are believed to result from local irritation or trauma. A 34-year-old Hispanic man presented with a painless, solitary, pigmented conjunctival lesion, in addition to bilateral pterygia suggesting chronic solar damage. The lesion was excised and sent for analysis.
RESULTS
Histopathologic analysis of tissue samples demonstrated melanocyte proliferation and epithelial dysplasia, yielding a final pathologic diagnosis of conjunctival melanoacanthoma with dysplastic and acantholytic-type features. The patient is being closely followed and has not had recurrence of the lesion.
CONCLUSIONS
Only 1 prior case of conjunctival melanoacanthoma has been documented. As such, there is no standard of care regarding appropriate management.
Topics: Acanthoma; Adult; Conjunctiva; Humans; Male; Mouth Mucosa; Pterygium; Skin Neoplasms
PubMed: 34723861
DOI: 10.1097/ICO.0000000000002850 -
Dermatopathology (Basel, Switzerland) Aug 2020Degos and Civatte first described clear cell acanthoma (CCA) in 1962 and later in a review article found that, in most instances, the lesion was a solitary red-brown... (Review)
Review
Degos and Civatte first described clear cell acanthoma (CCA) in 1962 and later in a review article found that, in most instances, the lesion was a solitary red-brown dome-shaped papule that involved the distal lower extremity. The first morphologic variant of CCA was reported as a "giant form of the acanthoma of Degos" which measured 45 × 40 mm, about twice the size of the largest CCA documented earlier. Since then, many variants of CCA have been described, including polypoid, pigmented and atypical. Herein, we describe a new variant of CCA and add another example of the polypoid variant to the literature. The new variant exhibits cellular features of trichilemmoma but architecturally differs from it. We also attempt to broaden the list of CCA variants summarized by Tempark and Shwayder by adding ours and a few more examples of CCA. The new variants of CCA include verrucous, linear, subungual and trichilemmal.
PubMed: 32854184
DOI: 10.3390/dermatopathology7020005 -
World Journal of Clinical Cases Sep 2020Epidermolytic acanthoma (EA) is a rare benign skin lesion, usually found in the genital area of men and women, with epidermolytic hyperkeratosis as its distinguishing...
BACKGROUND
Epidermolytic acanthoma (EA) is a rare benign skin lesion, usually found in the genital area of men and women, with epidermolytic hyperkeratosis as its distinguishing histologic characteristic. It is commonly misdiagnosed as condyloma accuminatum, verruca, and seborrheic keratosis. Since this lesion is benign, treatment is not necessary. However, it is often misdiagnosed, and patients are likely to undergo incorrect counseling and unnecessary treatment, causing undue burden to the patient. This study seeks to increase awareness of this rare condition to prevent future misdiagnoses.
CASE SUMMARY
A 55-year-old man living with human immunodeficiency virus presented for anal cancer screening. His physical examination revealed a flesh colored papule at the anal margin. The initial differential diagnosis included molluscum contagiosum, anal condyloma, and basal cell carcinoma. The lesion was excised to obtain a definitive diagnosis and was discovered to be EA.
CONCLUSION
EA is often misdiagnosed due to its similarity to other dermatologic conditions. Careful examination and pathologic evaluation should be obtained to ensure proper diagnosis.
PubMed: 33024766
DOI: 10.12998/wjcc.v8.i18.4094 -
The American Journal of Dermatopathology Jun 2022Pilomatrical differentiation can be observed in a variety of benign and malignant tumors, with the most common prototype being pilomatricoma. Pilomatricoma often...
Pilomatrical differentiation can be observed in a variety of benign and malignant tumors, with the most common prototype being pilomatricoma. Pilomatricoma often presents in the deep dermis or subcutis, and the sole involvement of epidermis is extremely rare. In our current case series, specimens from 5 patients were included with an average age of 68 years. All lesions presented as solitary verrucous or keratotic papules on the extremities, with 1 lesion having a prominent horn. All lesions have a variable mixture of basaloid matrical cells and shadow cells, and all lesions express β-catenin (strong nuclear and cytoplasmic), lymphoid enhancer-binding factor 1 within the matrical component, and pleckstrin homology-like domain family A member 1. The histomorphology and immunoprofile of all lesions are of pilomatrical differentiation, confined to the level of the epidermis. Based on these findings and analogous to the terminology used for other benign intraepidermal proliferations (hidroacanthoma simplex and epidermolytic acanthoma), we propose the term "pilomatrical acanthoma" for these rare lesions.
Topics: Acanthoma; Aged; Hair Diseases; Humans; Pilomatrixoma; Skin Neoplasms; Sweat Gland Neoplasms
PubMed: 35120037
DOI: 10.1097/DAD.0000000000002147 -
Journal of Cutaneous Pathology Dec 2022
Topics: Humans; Porokeratosis
PubMed: 35075675
DOI: 10.1111/cup.14195 -
JAAD Case Reports May 2021
PubMed: 33912638
DOI: 10.1016/j.jdcr.2021.03.018 -
Clinical and Experimental Dermatology Jan 2021
Topics: Acanthoma; Humans; Pemphigus; Skin Neoplasms
PubMed: 32986865
DOI: 10.1111/ced.14462 -
The Australasian Journal of Dermatology Nov 2022Since large cell acanthoma (LCA) has many overlapping clinical and histopathological features with other epidermal pigmented tumours, an additional method to...
Since large cell acanthoma (LCA) has many overlapping clinical and histopathological features with other epidermal pigmented tumours, an additional method to differentiate it would be of great clinical significance. A retrospective study was performed on 33 lesions (26 patients) to identify distinct dermoscopic findings of LCA and to describe dermoscopic-histopathological correlations. The results revealed that dermoscopy significantly aids in the distinction of LCA from other epidermal tumours included in the differential diagnosis. Yellow opaque homogeneous background, brown dots, and moth-eaten border are common findings, and prominent skin markings and short white streaks are additional distinguishing features. Several important findings that are common in other diseases are rare in LCA.
Topics: Humans; Acanthoma; Dermoscopy; Skin Neoplasms; Retrospective Studies; Skin; Diagnosis, Differential
PubMed: 36005944
DOI: 10.1111/ajd.13912 -
Indian Journal of Dermatology,... 2023
Topics: Humans; Acanthoma; Skin Neoplasms; Acantholysis
PubMed: 37317765
DOI: 10.25259/IJDVL_970_2022 -
Actas Dermo-sifiliograficas Dec 2022
Topics: Humans; Acanthoma; Skin Neoplasms; Sebaceous Glands
PubMed: 36543467
DOI: 10.1016/j.ad.2021.08.010