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Dermatology (Basel, Switzerland) 2022Optical coherence tomography (OCT) has been shown to provide non-invasive diagnosis of common skin neoplasms, especially basal cell carcinoma. OCT produces a... (Comparative Study)
Comparative Study
BACKGROUND
Optical coherence tomography (OCT) has been shown to provide non-invasive diagnosis of common skin neoplasms, especially basal cell carcinoma. OCT produces a cross-sectional view of the tissue, similar to a traditionally sectioned histopathological view, but the resolution of conventional OCT is low and thus limits clinical application.
OBJECTIVES
This study aimed to investigate the application ability of a full-field (FF)OCT system which was newly developed to scan the skin at the cellular level.
METHODS
Patients with skin tumours or inflammatory lesions warranting biopsy were consecutively enrolled. All lesions underwent clinical, dermoscopic, and OCT assessment, followed by routine biopsy. The adjacent normal skin was scanned for comparison. OCT images were interpreted (blinded to the biopsy results) and then compared with the histopathological diagnosis.
RESULTS
A total of 111 patients with 115 lesions completed the protocol, including 80 skin tumours, 28 inflammatory diseases, and 7 other diseases. Of the OCT images, 43.5% were of good quality and show expected features. Identifiable features of actinic keratosis, Bowen's disease, basal cell carcinoma, extramammary Paget's disease, seborrheic keratosis, large cell acanthoma, bullous pemphigoid, interface dermatitis, lichenoid tissue reaction, and psoriasis were demonstrated. Lesions are located deeply, and so some features were out of the field of view, accounting for 40.0% (46/115).
CONCLUSIONS
This study expanded the ability of FFOCT for the clinical diagnosis of various skin conditions. This new optical technique can clearly visualise skin lesions located in the epidermis and upper dermis. It provided an effective way to perform digital skin biopsy in superficial skin diseases.
Topics: Adult; Carcinoma, Basal Cell; Dermatitis; Dermis; Diagnosis, Differential; Epidermis; Female; Humans; Male; Middle Aged; Pilot Projects; Reproducibility of Results; Skin; Skin Neoplasms; Tomography, Optical Coherence
PubMed: 33946063
DOI: 10.1159/000514686 -
Clinical and Experimental Dermatology Jan 2021
Topics: Acanthoma; Humans; Pemphigus; Skin Neoplasms
PubMed: 33099286
DOI: 10.1111/ced.14492 -
Italian Journal of Dermatology and... Aug 2022
Topics: Acanthoma; Humans; Hyperplasia; Papilloma; Sebaceous Gland Diseases; Skin Neoplasms
PubMed: 34044515
DOI: 10.23736/S2784-8671.21.07032-8 -
European Journal of Dermatology : EJD Aug 2021
PubMed: 34405809
DOI: 10.1684/ejd.2021.4088 -
Dermatology Online Journal Feb 2021Epidermolytic acanthomas (EA) are rare benign tumors of unclear etiology that present as flat, sometimes slightly keratotic, pale or whitish papules that are usually...
Epidermolytic acanthomas (EA) are rare benign tumors of unclear etiology that present as flat, sometimes slightly keratotic, pale or whitish papules that are usually asymptomatic. Not uncommonly, their clinical appearance in the anogenital area might lead to misdiagnosis as other lesions that commonly develop at this site, such as condylomata acuminata. Though mainly asymptomatic, there are also reports of EA presenting with persistent genital pruritus. We describe the first reported case of pruritic scrotal EA successfully treated with topical pimecrolimus.
Topics: Acanthoma; Dermatologic Agents; Dosage Forms; Humans; Male; Middle Aged; Pruritus; Scrotum; Skin Neoplasms; Tacrolimus; Treatment Outcome
PubMed: 33818985
DOI: No ID Found -
Postepy Dermatologii I Alergologii Jun 2020
PubMed: 32792892
DOI: 10.5114/ada.2020.96270 -
Acta Dermato-venereologica Oct 2020
Topics: Acanthoma; Ankle; Dermoscopy; Erythema; Humans; Skin Neoplasms
PubMed: 32985678
DOI: 10.2340/00015555-3651 -
Dermatology Practical & Conceptual Oct 2023
Non-invasive Imaging Techniques for the Diagnosis of Clear Cell Acanthomas: Dermoscopy, Reflectance Confocal Microscopy and Line-Field Confocal Optical Coherence Tomography.
PubMed: 37992357
DOI: 10.5826/dpc.1304a231 -
Anais Brasileiros de Dermatologia 2020
Topics: Acanthoma; Biopsy; Dermoscopy; Female; Humans; Middle Aged; Skin Neoplasms; Thorax
PubMed: 32265053
DOI: 10.1016/j.abd.2019.06.015 -
Annals of Dermatology Jun 2021Clear cell acanthoma (CCA) is an uncommon, benign epithelial tumor presenting as a well-defined, slow-growing solitary nodule. The diagnosis of CCA is usually based on...
Clear cell acanthoma (CCA) is an uncommon, benign epithelial tumor presenting as a well-defined, slow-growing solitary nodule. The diagnosis of CCA is usually based on clinical and histopathological evaluation of the tumor. However, when such type of benign tumor occurs on an exposed area, a biopsy is not always the best diagnostic option since it may leave scar. The recent advent of dermoscopy has offered an accurate and non-invasive method to diagnose CCA without resorting to skin biopsy. A 40-year-old male presented with a shiny, erythematous-to-brown, flattened nodule on the left cheek. Dermoscopic examination revealed a 'string of pearls' vascular pattern, a characteristic dermoscopic feature of CCA. Under the clinical and dermoscopic impression of CCA, a 595 nm pulsed dye laser (PDL) therapy targeting the vascular tissue in the superficial dermis of the lesion was chosen for a minimally invasive treatment. After repeated sessions of PDL, an optimal cosmetic outcome was achieved and no recurrence was recorded during the follow-up period. Herein, we report a case of presumed CCA which was successfully diagnosed and treated by utilizing non-invasive modalities.
PubMed: 34079188
DOI: 10.5021/ad.2021.33.3.275