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Journal of Cosmetic Dermatology Aug 2022According to epidemiological data, a large percentage (80-90%) of adolescents suffer from acne vulgaris and approximately 30% of them need treatment. Possible outcomes... (Review)
Review
BACKGROUND
According to epidemiological data, a large percentage (80-90%) of adolescents suffer from acne vulgaris and approximately 30% of them need treatment. Possible outcomes of the inflammatory acne lesions are acne scars which, although they can be treated in several ways, may have a negative psychological impact on social life and relationships. There are three levels of acne: mild, moderate, and severe. The main types of acne scars are atrophic and hypertrophic scars. The pathogenesis of acne scarring is still not fully understood, but several hypotheses have been proposed.
AIM
The aim of this review is phytoconstituents-loaded nanomedicines for the management of acne.
MATERIALS AND METHODS
An online literature assessment was steered for the acne, phytochemical composition, and nanomedicines, types of acne, types of nanotechnology. Appropriate information were taken from different electronic scientific databases such as Web of Science, Elsevier, Science Direct, Springer, PubMed, Google Scholar, etc., Additional data was summarized from textbooks, local prints, and scripts.
RESULTS
Nanotechnology-based nanomedicines provide a great coincidence for the enhancement in the efficacy and safety of pharmaco-therapeutic agents for acne.
DISCUSSION
In this review, we discuss the phytoconstituent that are natural compounds present in plants extensively used for the anti-acne activity. Phytochemicals target cytokine signaling pathways and thus exhibit their anti-acne activity. We further outline the advantages of loading phytoconstituents as a drug in nanocarriers such as emulsion, niosomes, SLN, and nanocrystal for better and improved topical treatment.
CONCLUSION
This review is mainly focused on the usage of herbal nanomedicines in acne, nano delivery carriers used in the delivery of phytoconstituents with an improved therapeutic profile and reduced toxicity. In recent years, phytoconstituents showing their anti-acne potential, and phytoconstituents-loaded nanomedicines have high treatment potential in the management of acne.
Topics: Acne Vulgaris; Adolescent; Atrophy; Cicatrix; Cicatrix, Hypertrophic; Emulsions; Humans; Nanomedicine
PubMed: 35435308
DOI: 10.1111/jocd.14999 -
Journal of the American Academy of... Sep 2022
Topics: Acne Vulgaris; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Inflammatory Bowel Diseases; Mendelian Randomization Analysis; Polymorphism, Single Nucleotide; Risk Factors
PubMed: 35513181
DOI: 10.1016/j.jaad.2022.04.050 -
Journal of Cosmetic Dermatology Apr 2023Scarring is a common but difficult to manage consequence of acne vulgaris. The intricate balance between the degradation of collagen and its inhibition is disturbed... (Review)
Review
INTRODUCTION
Scarring is a common but difficult to manage consequence of acne vulgaris. The intricate balance between the degradation of collagen and its inhibition is disturbed during the formation of acne scars. We mostly rely on invasive, non-topical modalities for the treatment of acne scars which may not be indicated in all patients. There is also a need for maintainence therapies after these procedures.
REVIEW
The topical agents can be utilized as individual therapy, in combination with other modalities or delivered through assisted technology like iontophoresis. Retinoids have long been tried to prevent and treat acne scars. Tacrolimus and glycolic acid are among the newer sole agents that have been explored. Ablative lasers like Er:YAG, CO2 and Microneedling are being used in combination with topical agents like silicone gel, plasma gel, lyophilized growth factors, platelet rich plasma, insulin, and mesenchymal stem cells. These procedures not only increase the permeability of the topical agents but also concomitantly improve acne scars. Iontophoresis has proven beneficial in increasing the delivery of topical estriol and tretinoin.
CONCLUSION
There is lack of evidence to support the widespread use of these topical agents, and therefore, there is need for further well designed studies.
Topics: Humans; Cicatrix; Acne Vulgaris; Tretinoin; Administration, Topical; Combined Modality Therapy; Treatment Outcome
PubMed: 36606377
DOI: 10.1111/jocd.15584 -
Journal of Drugs in Dermatology : JDD Jun 2023Acne vulgaris is the most common skin condition in the US, affecting up to 50 million Americans. The American Academy of Dermatology (AAD) guidelines on acne treatment...
Acne vulgaris is the most common skin condition in the US, affecting up to 50 million Americans. The American Academy of Dermatology (AAD) guidelines on acne treatment were developed to provide recommendations for the diagnosis, grading, and treatment of acne in adolescents and adults to support clinicians in their therapeutic decision-making process. The most recent acne guidelines were published in 2016, and the approach to care and the therapeutic landscape of acne have evolved since that time. The Acne Management Consensus Roundtable was convened in 2022 to discuss unmet needs in the management of acne. The main focus of the meeting was the role of androgens in acne pathology; the evaluation of clascoterone, the first topical anti-androgen that specifically addresses sebum production in acne; and the identification of the place of clascoterone in therapy. Clascoterone was approved by the US Food and Drug Administration for the treatment of acne in patients 12 years and older in 2020. This report aims to highlight important limitations of the 2016 AAD treatment guidelines and to familiarize practitioners with clascoterone and its indication, efficacy and safety profile, and potential use across diverse patient populations. With its new mechanism of action, clascoterone may be able to fulfill important unmet needs in acne treatment. Baldwin H, Farberg AS, Frey C, et al. Unmet needs in the management of acne vulgaris: a consensus statement. J Drugs Dermatol. 2023;22(6):582-587. doi:10.36849/JDD.7587.
Topics: Adult; Adolescent; Humans; Acne Vulgaris; Propionates; Cortodoxone; Sebum; Treatment Outcome
PubMed: 37276154
DOI: 10.36849/JDD.7587 -
Cutis Jul 2020Acne vulgaris is one of the most common dermatologic diseases, ranging from comedonal or inflammatory papules to large, painful, disfiguring cysts. Numerous treatment... (Review)
Review
Acne vulgaris is one of the most common dermatologic diseases, ranging from comedonal or inflammatory papules to large, painful, disfiguring cysts. Numerous treatment approaches are available, each with their own risks and benefits that must be weighed when selecting the best option for an individual patient. Active-duty military servicemembers face additional levels of complexity when pursuing acne therapy. Untreated acne may interfere with their assigned duties, while various therapies also may limit their medical readiness and fitness for duty. We present a review of various acne treatment modalities with a focus on the military population. Additionally, we present a case in which the pulsed dye laser (PDL) was successfully used to treat inflammatory acne in an active-duty servicemember to highlight the use of PDL as an available and effective treatment option for acne in this population.
Topics: Acne Vulgaris; Dermatologic Agents; Humans; Lasers, Dye; Military Personnel; Treatment Outcome
PubMed: 32915930
DOI: 10.12788/cutis.0057 -
Journal of Cutaneous Medicine and... 2022
Topics: Acne Vulgaris; Humans; Isotretinoin
PubMed: 34498501
DOI: 10.1177/12034754211045379 -
Obstetrics and Gynecology May 2022
Topics: Acne Vulgaris; Contraceptives, Oral, Hormonal; Female; Humans; Intrauterine Devices; Intrauterine Devices, Medicated
PubMed: 35576353
DOI: 10.1097/AOG.0000000000004765 -
The British Journal of Dermatology Oct 2023Acne can create a significant burden for people of all ages. However, the psychological consequences might often be overlooked. This review comments on recent evidence... (Review)
Review
Acne can create a significant burden for people of all ages. However, the psychological consequences might often be overlooked. This review comments on recent evidence in the field of psychodermatology, to highlight the importance of considering a person's mental health in the treatment of acne. A range of presenting issues are discussed, and cases of underserved patients needing additional considerations are highlighted. This article considers how the psychological sequelae can contribute to the pathogenesis of acne, and discusses how psychotherapeutic approaches can be of benefit to people experiencing appearance-related distress. Importantly, attention is paid to the need for clinicians to assess a patient's wellbeing alongside their physical symptoms. In doing this, early intervention can be facilitated if psychological comorbidities are present, with referral to appropriate specialist services, where available. To improve treatment outcomes, the skin and the mind must be addressed together in a multidisciplinary approach to dermatology care.
Topics: Humans; Acne Vulgaris; Mental Health; Referral and Consultation
PubMed: 37903071
DOI: 10.1093/bjd/ljad251 -
Journal of Cosmetic Dermatology Apr 2021Acne is a chronic inflammatory skin condition seen commonly in adolescence and young adulthood. Despite being a frequent and nonthreatening life condition, acne has a... (Review)
Review
INTRODUCTION
Acne is a chronic inflammatory skin condition seen commonly in adolescence and young adulthood. Despite being a frequent and nonthreatening life condition, acne has a significant psychological impact and comorbidity.
AIMS
This review will describe prevalence, common clinical features, different clinical presentations, differential diagnoses, and treatment recommendation. Special focus has been put on psychological aspects.
METHODS
We conducted a literature search on PubMed from January 2001 to June 2020 with the search terms of Acne vulgaris, psychological, adolescents, anxiety, suicide, mood disorders. Reference lists of identified articles were examined for further relevant studies. The search was limited to English language articles. No specified quality criteria were used for study inclusion.
RESULTS
The clinical manifestations of acne are very important in the differential diagnosis and its psychological implications.
CONCLUSION
Through this article, we conclude that despite being a frequent and nonthreatening life condition, acne has a significant psychological impact which requires effective treatment to improve the patient's skin and self-esteem.
Topics: Acne Vulgaris; Adolescent; Adult; Anxiety; Comorbidity; Humans; Self Concept; Suicide; Young Adult
PubMed: 33031607
DOI: 10.1111/jocd.13765 -
Boletin Medico Del Hospital Infantil de... 2021Neonatal acne (NA) is a transitory dermatosis that occurs between the second and fourth weeks of life in 20% of children. This condition is more frequent in males, with...
Neonatal acne (NA) is a transitory dermatosis that occurs between the second and fourth weeks of life in 20% of children. This condition is more frequent in males, with a male-female ratio of 4.5:1. Present primary skin lesions are open and closed comedones which can evolve into papules, erythematous pustules and, in rare cases, nodules and cysts. NA topography includes the forehead, cheeks, chin, and eyelids, but occasionally it spreads to the scalp, neck, and trunk. NA occurs due to an elevated production of placental and neonatal androgens (of adrenal origin in both sexes and of testicular origin in males) which cause enlargement of the sebaceous glands and increases the production of sebum. Most cases are mild and transient, but if NA is severe and long-lasting, clinical and paraclinical examination will be necessary to find congenital adrenal hyperplasia or a virilizing tumor of adrenal or gonadal origin. The diagnosis of NA is clinical; its main differential -diagnoses are neonatal cephalic pustulosis, other neonatal vesiculopustular dermatoses, infectious diseases, and acneiform reactions. The resolution of NA is spontaneous. In most cases, the use of a mild dermal cleanser and water will be sufficient. For comedogenic lesions (open and closed comedones), topical retinoids or 20% azelaic acid may be used, as well as some topical antibiotics for inflammatory lesions.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Child; Diagnosis, Differential; Female; Humans; Infant, Newborn; Male; Placenta; Pregnancy; Skin Diseases
PubMed: 34571513
DOI: 10.24875/BMHIM.20000327