-
IDCases 2022We describe a rare case of pneumonia in a pediatric patient. Our patient was admitted twice for recurrent pericarditis in the setting of persistent fevers, initially...
We describe a rare case of pneumonia in a pediatric patient. Our patient was admitted twice for recurrent pericarditis in the setting of persistent fevers, initially thought to be secondary to Coxsackie B virus. She was treated with colchicine and ibuprofen, as well as a short course of oral steroids. Patient was admitted a third time for acute respiratory failure and was found to have a large right empyema and pleural effusion requiring chest tube placement. After extensive multi-specialty workup, was isolated from chest tube culture. Patient's intravenous (IV) antibiotics were subsequently narrowed to ampicillin, and she was discharged.
PubMed: 35815110
DOI: 10.1016/j.idcr.2022.e01561 -
A "Boil" Being the Clue to Think beyond Typical Bacterial Pathogens in Community-Acquired Pneumonia.Case Reports in Pediatrics 2022Empyema necessitans is an exceptionally rare complication of bacterial pneumonia in the pediatric population. It occurs when the infection extends from the lung...
Empyema necessitans is an exceptionally rare complication of bacterial pneumonia in the pediatric population. It occurs when the infection extends from the lung parenchyma to the chest wall by forming a fistula, which leads to infection of the surrounding soft tissue. In this case, a 13-year-old boy is found to have empyema necessitans caused by , with a preceding clue to the diagnosis being that he was treated for a superficial chest wall abscess several weeks prior to developing significant respiratory symptoms. Providers should be aware of this entity as it requires obtaining cultures to identify the appropriate pathogen and avoid treatment failure as it has implications for antibiotic choice and length of therapy.
PubMed: 35391757
DOI: 10.1155/2022/8984170 -
La Revue de Medecine Interne Mar 2021Dermatological manifestations of actinomycosis are classical, most often related to Actinomyces israelii. In most of the cases, they occur near to the primary focus, and... (Review)
Review
INTRODUCTION
Dermatological manifestations of actinomycosis are classical, most often related to Actinomyces israelii. In most of the cases, they occur near to the primary focus, and in the cervicofacial area. Systemic dissemination with cutaneous distant metastasis is rare, most often related to A. israelii, too. We report an original case of upper limb actinomycosis associated with an oral localisation and due to an unusual bacteria.
CASE REPORT
A 49-year-old man was referred to the Department of dermatology for a skin lesion of the left hand and wrist. Biopsies revealed actinomycosis related to A. meyeri. Dental primary focus was identified and treated. Although the patient was lost sight of, dental eradication and prolonged antibiotics therapy allowed cutaneous improvement.
DISCUSSION
We report an atypical case of cutaneous actinomycosis due to an Actinomyces meyeri dental infection occurring in an immunocompetent, smoking adult, with poor oral hygiene. The literature review revealed only 4 well-documented cases of cutaneous A. meyeri infections distant to dental primary focus. All of patients were males, immunocompetent, with a history of poor oral hygiene. The prognosis is favourable with adequate treatment (antibiotic therapy and surgical treatment to eradicate dental infectious entry points).
Topics: Actinomyces; Actinomycetaceae; Actinomycosis; Adult; Humans; Male; Middle Aged; Skin Diseases, Bacterial
PubMed: 33303221
DOI: 10.1016/j.revmed.2020.11.011 -
Journal of Human Genetics Mar 2021Ancient DNA studies provide genomic information about the origins, population structures, and physical characteristics of ancient humans that cannot be solely examined... (Comparative Study)
Comparative Study
Ancient DNA studies provide genomic information about the origins, population structures, and physical characteristics of ancient humans that cannot be solely examined by archeological studies. The DNAs extracted from ancient human bones, teeth, or tissues are often contaminated with coexisting bacterial and viral genomes that contain DNA from ancient microbes infecting those of ancient humans. Information on ancient viral genomes is useful in making inferences about the viral evolution. Here, we have utilized metagenomic sequencing data from the dental pulp of five Jomon individuals, who lived on the Japanese archipelago more than 3000 years ago; this is to detect ancient viral genomes. We conducted de novo assembly of the non-human reads where we have obtained 277,387 contigs that were longer than 1000 bp. These contigs were subjected to homology searches against a collection of modern viral genome sequences. We were able to detect eleven putative ancient viral genomes. Among them, we reconstructed the complete sequence of the Siphovirus contig89 (CT89) viral genome. The Jomon CT89-like sequence was determined to contain 59 open reading frames, among which five genes known to encode phage proteins were under strong purifying selection. The host of CT89 was predicted to be Schaalia meyeri, a bacterium residing in the human oral cavity. Finally, the CT89 phylogenetic tree showed two clusters, from both of which the Jomon sequence was separated. Our results suggest that metagenomic information from the dental pulp of the Jomon people is essential in retrieving ancient viral genomes used to examine their evolution.
Topics: Actinomycetaceae; Asian People; Clustered Regularly Interspaced Short Palindromic Repeats; Contig Mapping; DNA, Viral; Dental Pulp; Ethnicity; Female; Fossils; Genome, Viral; History, Ancient; Humans; Japan; Likelihood Functions; Male; Metagenome; Molecular Sequence Annotation; Mouth; Open Reading Frames; Phylogeny; Sequence Alignment; Sequence Homology, Nucleic Acid; Siphoviridae; Whole Genome Sequencing
PubMed: 32994538
DOI: 10.1038/s10038-020-00841-6