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Sensors (Basel, Switzerland) Dec 2020Cell adhesive force, exerting on the local matrix or neighboring cells, plays a critical role in regulating many cell functions and physiological processes. In the past... (Review)
Review
Cell adhesive force, exerting on the local matrix or neighboring cells, plays a critical role in regulating many cell functions and physiological processes. In the past four decades, significant efforts have been dedicated to cell adhesive force detection, visualization and quantification. A recent important methodological advancement in cell adhesive force visualization is to adopt force-to-fluorescence conversion instead of force-to-substrate strain conversion, thus greatly improving the sensitivity and resolution of force imaging. This review summarizes the recent development of force imaging techniques (collectively termed as cell adhesive force microscopy or CAFM here), with a particular focus on the improvement of CAFM's spatial resolution and the biomaterial choices for constructing the tension sensors used in force visualization. This review also highlights the importance of DNA-based tension sensors in cell adhesive force imaging and the recent breakthrough in the development of super-resolution CAFM.
Topics: Adhesives; DNA; Mechanical Phenomena; Mechanotransduction, Cellular; Microscopy, Atomic Force
PubMed: 33322701
DOI: 10.3390/s20247128 -
Carbohydrate Polymers Mar 2024Recently, polymer-based tissue adhesives (TAs) have gained the attention of scientists and industries as alternatives to sutures for sealing and closing wounds or... (Review)
Review
Recently, polymer-based tissue adhesives (TAs) have gained the attention of scientists and industries as alternatives to sutures for sealing and closing wounds or incisions because of their ease of use, low cost, minimal tissue damage, and short application time. However, poor mechanical properties and weak adhesion strength limit the application of TAs, although numerous studies have attempted to develop new TAs with enhanced performance. Therefore, next-generation TAs with improved multifunctional properties are required. In this review, we address the requirements of polymeric TAs, adhesive characteristics, adhesion strength assessment methods, adhesion mechanisms, applications, advantages and disadvantages, and commercial products of polysaccharide (PS)-based TAs, including chitosan (CS), alginate (AL), dextran (DE), and hyaluronic acid (HA). Additionally, future perspectives are discussed.
Topics: Tissue Adhesives; Polysaccharides; Polymers; Chitosan; Alginates; Adhesives
PubMed: 38171653
DOI: 10.1016/j.carbpol.2023.121634 -
ACS Nano Sep 2023Early stage oxidative stress, inflammatory response, and infection after tendon surgery are highly associated with the subsequent peritendinous adhesion formation, which...
Early stage oxidative stress, inflammatory response, and infection after tendon surgery are highly associated with the subsequent peritendinous adhesion formation, which may diminish the quality and function of the repaired tendon. Although various anti-inflammatory and/or antibacterial grafts have been proposed to turn the scale, most of them suffer from the uncertainty of drug-induced adverse effects, low mechanical strength, and tissue adhesiveness. Here, inspired by the tendon anatomy and pathophysiology of adhesion development, an adhesive and robust dual-layer Janus patch is developed, whose inner layer facing the operated tendon is a multifunctional electrospun hydrogel patch (MEHP), encircled further by a poly-l-lactic acid (PLLA) fibrous outer layer facing the surrounding tissue. Specifically, MEHP is prepared by gelatin methacryloyl (GelMA) and zinc oxide (ZnO) nanoparticles, which are co-electrospun first and then treated by tannic acid (TA). The inner MEHP exhibits superior mechanical performance, adhesion strength, and outstanding antioxidation, anti-inflammation, and antibacterial properties, and it can adhere to the injury site offering a favorable microenvironment for tendon regeneration. Meanwhile, the outer PLLA acts as a physical barrier that prevents extrinsic cells and tissues from invading the defect site, reducing peritendinous adhesion formation. This work presents a proof-of-concept of a drug-free graft with anisotropic adhesive and biological functions to concert the healing phases of injured tendon by alleviating incipient inflammation and oxidative damage but supporting tissue regeneration and reducing tendon adhesion in the later phase of repair and remodeling. It is envisioned that this Janus patch could offer a promising strategy for safe and efficient tendon therapy.
Topics: Adhesives; Biomimetics; Anti-Inflammatory Agents; Anti-Bacterial Agents
PubMed: 37622841
DOI: 10.1021/acsnano.3c03556 -
Journal of Materials Chemistry. B Jan 2021With the rapid development of hydrogels, hydrogel adhesion has attracted increasing attention in the last decade, but strong adhesion remains a challenge due to the... (Review)
Review
With the rapid development of hydrogels, hydrogel adhesion has attracted increasing attention in the last decade, but strong adhesion remains a challenge due to the large amount of water in hydrogels. The factors that affect hydrogel adhesion mainly include chemistries of bonds, topologies of connection, and mechanisms of energy dissipation. Strategies such as surface modification, surface initiation, bulk modification, bridging polymers, topological adhesion, and the use of nanocomposites have been developed to achieve strong hydrogel adhesion. In nanocomposite hydrogels, nanoparticles interlink with polymer chains to form strong bonds, which lower adhesion energy and offer energy dissipation, thus enhancing the adhesion. This review emphatically outlines nanocomposite adhesive hydrogels from design to application and provides useful understanding for the design and further development of nanocomposite adhesive hydrogels.
Topics: Adhesives; Nanogels; Particle Size; Surface Properties
PubMed: 33290489
DOI: 10.1039/d0tb02000a -
Journal of the American Chemical Society Mar 2022Herein, a synthetic polymer proteomimetic is described that reconstitutes the key structural elements and function of mussel adhesive protein. The proteomimetic was...
Herein, a synthetic polymer proteomimetic is described that reconstitutes the key structural elements and function of mussel adhesive protein. The proteomimetic was prepared via graft-through ring-opening metathesis polymerization of a norbornenyl-peptide monomer. The peptide was derived from the natural underwater glue produced by marine mussels that is composed of a highly repetitive 10 amino acid tandem repeat sequence. The hypothesis was that recapitulation of the repeating unit in this manner would provide a facile route to a nature-inspired adhesive. To this end, the material, in which the arrangement of peptide units was as side chains on a brush polymer rather than in a linear fashion as in the natural protein, was examined and compared to the native protein. Mechanical measurements of adhesion forces between solid surfaces revealed improved adhesion properties over the natural protein, making this strategy attractive for diverse applications. One such application is demonstrated, using the polymers as a surface adhesive for the immobilization of live cells.
Topics: Adhesives; Animals; Bivalvia; Peptides; Polymerization; Polymers
PubMed: 35238544
DOI: 10.1021/jacs.1c10936 -
Small (Weinheim An Der Bergstrasse,... Oct 2021Wet adhesion is greatly demanded in fields of wearable devices, wound dressings, and smart robotics. However, reusable, noninvasive and convenient adhesive pads in the...
Wet adhesion is greatly demanded in fields of wearable devices, wound dressings, and smart robotics. However, reusable, noninvasive and convenient adhesive pads in the liquid environment have remained a challenge. Here, a novel concept of underwater adhesion inspired by the diving beetle, which utilizes the air bubbles as an adhesive to realize nondestructive and repeatable adhesion working across a wide range of scales is shown. The mechanism of underwater bubble adhesion is revealed by the capillarity of air-bubble bridge, of which the property depends on the dynamic bubble contact angles and the gap distance. The design principle of the air bubble-based underwater adhesion is proposed and validated to tune the interfacial acting force by theoretical and experimental results. Finally, a strong, reusable surface adhesive based on air bubble bridges is demonstrated from macro- to microscales in applications of particle manipulation and particle self-assembly. This unique view of underwater bubble adhesion provides new ideas for broader applications.
Topics: Adhesives; Air; Animals; Coleoptera; Physical Phenomena; Surface Tension
PubMed: 34554641
DOI: 10.1002/smll.202103423 -
Advanced Healthcare Materials Nov 2023The application of most hydrogel bio-adhesives is greatly limited due to their high swelling, low underwater adhesion, and single function. Herein, a spatial multi-level...
The application of most hydrogel bio-adhesives is greatly limited due to their high swelling, low underwater adhesion, and single function. Herein, a spatial multi-level physical-chemical and bio-inspired in-situ bonding strategy is proposed, to develop a multifunctional hydrogel bio-glue using polyglutamic acid (PGA), tyramine hydrochloride (TYR), and tannic acid (TA) as precursors and 4-(4,6-dimethoxytriazine-2-yl) -4-methylmorpholine hydrochloride(DMTMM) as condensation agent, which is used for tissue adhesion, hemostasis and repair. By introducing TYR and TA into the PGA chain, it is demonstrated that not only can the strong adhesion of bio-glue to the surface of various fresh tissues and wet materials be realized through the synergistic effect of spatial multi-level physical and chemical bonding, but also this glue can be endowed with the functions of anti-oxidation and hemostasis. The excellent performance of such bio-glue in the repair of the wound, liver, and cartilage is achieved, showing a great potential in clinical application for such bio-glue. This study will open up a brand-new avenue for the development of multifunctional hydrogel biological adhesive.
Topics: Humans; Adhesives; Tissue Adhesives; Hydrogels; Hemostasis; Tissue Adhesions; Tannins
PubMed: 37548628
DOI: 10.1002/adhm.202301560 -
Chemical Society Reviews Nov 2021Water and adhesives have a conflicting relationship as demonstrated by the failure of most man-made adhesives in underwater environments. However, living creatures... (Review)
Review
Water and adhesives have a conflicting relationship as demonstrated by the failure of most man-made adhesives in underwater environments. However, living creatures routinely adhere to substrates underwater. For example, sandcastle worms create protective reefs underwater by secreting a cocktail of protein glue that binds mineral particles together, and mussels attach themselves to rocks near tide-swept sea shores using byssal threads formed from their extracellular secretions. Over the past few decades, the physicochemical examination of biological underwater adhesives has begun to decipher the mysteries behind underwater adhesion. These naturally occurring adhesives have inspired the creation of several synthetic materials that can stick underwater - a task that was once thought to be "impossible". This review provides a comprehensive overview of the progress in the science of underwater adhesion over the past few decades. In this review, we introduce the basic thermodynamics processes and kinetic parameters involved in adhesion. Second, we describe the challenges brought by water when adhering underwater. Third, we explore the adhesive mechanisms showcased by mussels and sandcastle worms to overcome the challenges brought by water. We then present a detailed review of synthetic underwater adhesives that have been reported to date. Finally, we discuss some potential applications of underwater adhesives and the current challenges in the field by using a tandem analysis of the reported chemical structures and their adhesive strength. This review is aimed to inspire and facilitate the design of novel synthetic underwater adhesives, that will, in turn expand our understanding of the physical and chemical parameters that influence underwater adhesion.
Topics: Adhesives; Animals; Bivalvia; Humans; Proteins; Water
PubMed: 34751690
DOI: 10.1039/d1cs00316j -
Journal of the American Chemical Society Sep 2022Adhesives are applied extensively in daily life and industries, and people have developed numerous commercial polymeric adhesives. However, in most cases, these...
Adhesives are applied extensively in daily life and industries, and people have developed numerous commercial polymeric adhesives. However, in most cases, these adhesives work on dry surfaces in air and form permanent bonds with the substrates, limiting the applications of adhesives. Inspired by the innate adhesive functions of some animals, such as geckos, spiders, mussels, and clingfish, scientists have developed various adhesive compositions and structures to meet various conditions. Here, we show a versatile subnanometer nanowire (SNW) adhesive with high strength and great reversibility, which could be prepared at a large scale through a facile room-temperature reaction. The SNW adhesive contacts the substrates at multiple sites due to the ultrahigh flexibility, and meanwhile, the multilevel interactions among the SNWs endow them with strong cohesion, so they exhibit good adhesive performance. This adhesive is applicable to various substrates, such as metals, polymers, and glass, and not only possesses good stability at room temperature in air but also is suitable for underwater environments and ultralow temperatures. Moreover, this adhesive could be easily recycled and removed from the substrates without any residue and damage. The SNW adhesive not only inspires the design of hierarchical adhesive structures with new contact modes but also has potential for practical applications.
Topics: Adhesives; Animals; Bivalvia; Humans; Nanowires; Polymers; Spiders
PubMed: 36043241
DOI: 10.1021/jacs.2c03511 -
ACS Applied Materials & Interfaces Oct 2021Underwater adhesion is a great challenge for the development of adhesives as the attractive interfacial intermolecular interactions are usually weakened by the surface...
Underwater adhesion is a great challenge for the development of adhesives as the attractive interfacial intermolecular interactions are usually weakened by the surface hydration layer. The coacervation process of sessile organisms like marine mussels and sandcastle worms has inspired substantial research interest in the fabrication of long-lasting underwater adhesives, but they generally suffer from time-consuming curing triggered by surrounding environmental changes and cannot reserve the adhesiveness once damaged. Herein, an instant and repeatable underwater adhesive was developed based on the coacervation of tannic acid (TA) and poly(ethylene glycol)--poly(propylene glycol)--poly(ethylene glycol) (PEG-PPG-PEG, F68), which was driven by hydrogen-bonding interaction, and the hydrophobic cores of F68 micelles offered an additional cross-linking to enhance the mechanical properties. The TA-F68 coacervates could be facilely painted on different substrates, exhibiting robust and instant underwater adhesion (with adhesion strength up to 1.1 MPa on porcine skin) and excellent repeatability (at least 1000 cycles), superior to the previously reported coacervates. Due to the biological activities of TA, the underwater adhesive displayed innate anticancer and antibacterial properties against different types of cancer cells and bacteria, showing great potential for diverse biomedical applications, such as injectable drug carriers, tissue glues, and wound dressings.
Topics: Adhesiveness; Adhesives; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Escherichia coli; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Microbial Sensitivity Tests; Poloxamer; Skin; Staphylococcus aureus; Swine; Tannins; Water
PubMed: 34601867
DOI: 10.1021/acsami.1c13744