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International Journal of Molecular... Feb 2023High-density lipoproteins comprise roughly 25-30% of the circulating proteins involved in the transport of lipids in circulation. These particles differ in size and... (Review)
Review
High-density lipoproteins comprise roughly 25-30% of the circulating proteins involved in the transport of lipids in circulation. These particles differ in size and lipid composition. Recent evidence suggests that the quality of HDL particles (which depends on shape, size and the composition of proteins and lipids determining HDL functionality) may be more important than their quantity. The functionality of HDL is mirrored by its cholesterol efflux activity, as well as its antioxidant (including the protection of LDL against oxidation), anti-inflammatory and antithrombotic properties. The results of many studies and meta-analyses imply the beneficial impact of aerobic exercise on HDL-C levels. Physical activity was found to be usually associated with an increase in HDL cholesterol and a decrease in LDL cholesterol and triglycerides. Exercise, apart from inducing quantitative alterations in serum lipids, exerts a beneficial impact on HDL particle maturation, composition and functionality. The Physical Activity Guidelines Advisory Committee Report underlined the importance of establishing a program recommending exercises that enable attainment of maximal advantage at the lowest level of risk. The aim of this manuscript is to review the impact of different types of aerobic exercise (various intensities and durations) on the level and quality of HDL.
Topics: Lipids; Exercise; Lipoproteins, HDL; Triglycerides; Cholesterol, HDL
PubMed: 36902082
DOI: 10.3390/ijms24054653 -
International Journal For Vitamin and... Oct 2023Several pre-workout supplements contain niacin, although the exercise performance effects of niacin are poorly understood. The purpose of the present study was to...
Several pre-workout supplements contain niacin, although the exercise performance effects of niacin are poorly understood. The purpose of the present study was to examine the performance effects of niacin versus caffeine as a pre-workout supplement. Twenty-five untrained males were recruited to complete three identical ramped aerobic cycling exercise trials. Participants were administered caffeine (CA) at 5 mg/kg body weight, 1000 mg niacin (NI), or a methylcelluloce placebo (PL) supplement prior to each trial. NI treatment induced significantly higher respiratory exchange ratio (RER) during exercise compared to the CA treatment, but not the PL treatment (PL=0.87±0.08, NI=0.91±0.08, CA=0.87±0.08; p=0.02). Similarly, exercise time to exhaustion (in minutes) was significantly different between the NI treatment and the CA treatment, but not the PL treatment (PL=27.45±4.47, NI=26.30±4.91, CA=28.76±4.86; p<0.01). Habitual caffeine use (p=0.16), habitual aerobic exercise (p=0.60), and habitual resistance exercise (p=0.10) did not significantly affect RER. Similarly, habitual caffeine use (p=0.72), habitual aerobic exercise (p=0.08), and habitual resistance exercise (p=0.39) did not significantly affect total work performed. The elevated RER and decreased time to exhaustion in the NI treatment suggests limited lipid availability during exercise and impaired exercise performance.
Topics: Humans; Male; Caffeine; Dietary Supplements; Exercise; Niacin
PubMed: 34696617
DOI: 10.1024/0300-9831/a000736 -
Physiology & Behavior Oct 2023This study aimed to investigate the impact and mechanism of gut microbiota on the enhancement of cognitive function in methamphetamine (MA)-dependent individuals during... (Randomized Controlled Trial)
Randomized Controlled Trial
OBJECTIVE
This study aimed to investigate the impact and mechanism of gut microbiota on the enhancement of cognitive function in methamphetamine (MA)-dependent individuals during aerobic exercise training.
METHODS
A total of sixty-four MA-dependent individuals were randomly assigned to either an aerobic exercise training group (DK, n = 32) or a conventional rehabilitation group (CK, n = 32). After an eight-week intervention, the participants' working memory and inhibition ability were assessed using the Stroop paradigm and Go/NoGo paradigm, respectively. Gut microbiota composition was analyzed using high-throughput sequencing.
RESULTS
1) Eight weeks of aerobic exercise training significantly improved the working memory and inhibition ability of MA-dependent individuals (P < 0.05). 2) Following the intervention, the DK group exhibited significantly higher levels of Lactobacillus, Lactococcus lactis, Prevotellaceae, and Ruminococcaceae compared to the CK group. Conversely, the DK group demonstrated significantly lower levels of Desulfovibrio and Akkermansia compared to the CK group. Furthermore, the DK group showed significantly increased metabolic pathways associated with d-Glutaralate and d-Galactate Degradation, as well as the Alanine, aspartate, and glutamate metabolism pathway, compared to the control group. 3) Cognitive function related to MA addiction positively correlated with Bifidobacterium, Dialister, and Adlercreutzia, while negatively correlated with Enterobacteria, Bacillus cereus, Catabacter, and Akkermansia.
CONCLUSION
Aerobic exercise training enhances working memory and inhibition ability in MA-dependent individuals, thereby mitigating the detrimental effects of MA addiction on cognitive function. Additionally, analysis of gut microbiota suggests that the modulation of gut microbiota and associated metabolic pathways play a role in regulating the improvement of cognitive function in MA-dependent individuals through exercise.
Topics: Humans; Cognition; Exercise; Exercise Therapy; Gastrointestinal Microbiome; Methamphetamine
PubMed: 37474085
DOI: 10.1016/j.physbeh.2023.114302 -
Supportive Care in Cancer : Official... Nov 2022Tumour blood vessels are structurally and functionally abnormal, resulting in areas of hypoxia and heterogeneous blood supply. Aerobic exercise may modulate tumour blood... (Meta-Analysis)
Meta-Analysis Review
PURPOSE
Tumour blood vessels are structurally and functionally abnormal, resulting in areas of hypoxia and heterogeneous blood supply. Aerobic exercise may modulate tumour blood flow and normalise the tumour microenvironment to improve chemotherapy delivery. This systematic review and meta-analysis aimed to evaluate the effect of the aerobic exercise mode on tumour hypoxia, vascularisation and blood flow.
METHODS
Four online databases were searched. Preclinical and clinical randomised controlled trials examining the effects of aerobic exercise training on hypoxia, vascularisation or blood flow in solid tumours were included. The risk of bias was assessed and a meta-analysis performed.
RESULTS
Seventeen preclinical studies and one clinical study met criteria. Eleven studies assessed hypoxia, 15 studies assessed vascularisation and seven evaluated blood flow. There was large variability in measurement methods, tumour types and exercise program designs. The overall risk of bias was unclear in clinical and preclinical studies, owing to poor reporting. There was no significant effect of aerobic exercise on hypoxia (SMD = -0.17; 95% CI = -0.62, 0.28; I = 60%), vascularisation (SMD = 0.07; 95% CI = -0.40, 0.55; I = 71%) or blood flow (SMD = 0.01; 95% CI = -0.59, 0.61; I = 63%).
CONCLUSION
There is heterogeneity in methodology, resulting in evidence that is inconsistent and inconclusive for the effects of aerobic exercise on hypoxia, vascularisation and blood flow. Most evidence of aerobic exercise effects on tumour blood flow is in animal models, with very limited evidence in humans.
Topics: Humans; Exercise; Neoplasms; Hypoxia; Exercise Therapy; Tumor Microenvironment
PubMed: 35650456
DOI: 10.1007/s00520-022-07132-0 -
American Journal of Physiology.... Oct 2020Regular aerobic exercise has numerous benefits on human physiology, arguably by serving as a hormetic stressor resulting in positive adaptations over time. It has long... (Review)
Review
Regular aerobic exercise has numerous benefits on human physiology, arguably by serving as a hormetic stressor resulting in positive adaptations over time. It has long been known that aerobic exercise at a variety of intensities and durations induces intestinal permeability, which is a feature of many pathologies of the gastrointestinal tract and metabolic diseases. Given the health benefits of exercise, it seems unlikely that intestinal permeability induced by exercise outweighs the positive adaptations. In fact, a growing body of evidence suggests adoption of exercise regimens lasting weeks to months improves indicators of intestinal permeability. In this brief review, we summarize factors contributing to acute exercise-induced intestinal permeability and what is known about chronic exercise and the gut barrier. Additionally, we outline known and theoretical adaptations of the gut to chronic exercise that may explain emerging reports that exercise improves markers of gut integrity.
Topics: Cardiovascular System; Exercise; Gastrointestinal Absorption; Gastrointestinal Microbiome; Hormesis; Humans; Immunity; Intestinal Mucosa; Intestines; Permeability; Splanchnic Circulation; Thermotolerance
PubMed: 32845171
DOI: 10.1152/ajpgi.00232.2020 -
Aerobic Exercise Changes Low-Frequency Functional and Effective Connectivity in Cognitive Load Task.Annual International Conference of the... Jul 2023As is well known, cognitive performances are highly influenced by cognitive load, so it is meaningful to find some ways to effectively reduce the cognitive load. In...
As is well known, cognitive performances are highly influenced by cognitive load, so it is meaningful to find some ways to effectively reduce the cognitive load. In particular, aerobic exercise is a promising way. However, the neural evidence is still lacking in understanding how aerobic exercise minimizes cognitive load. To solve the problem, this study adopted the N-back task in both the before (BE) and after (AE) aerobic exercise periods, behavioral and EEG data were recorded from 21 participants. Functional connectivity was constructed by the weighted phase lag index (WPLI), and effective connectivity was constructed by the partially directed coherent (PDC). Consequently, by comparing the connection strength and pattern of BE and AE, it is found that in low-frequency (0~8 Hz), aerobic exercise could enhance the connection strength of WPLI networks under high cognitive load, and increase the importance of the forehead region in the communication of PDC networks under low cognitive load. These results could advance our understanding of the underlying mechanisms of how aerobic exercise modulates cognitive load.
Topics: Humans; Exercise; Exercise Therapy; Frontal Lobe; Cognition
PubMed: 38082696
DOI: 10.1109/EMBC40787.2023.10340660 -
Journal of Healthcare Engineering 2022In order to solve the relationship between youth aerobic exercise and obesity reduction, an improved ant colony algorithm-oriented aerobic exercise method was proposed....
In order to solve the relationship between youth aerobic exercise and obesity reduction, an improved ant colony algorithm-oriented aerobic exercise method was proposed. Firstly, the changes in body shape, weight, BMI, body fat, body circumference, and other indicators of obese adolescents before and after aerobic exercise were used as the initial pheromone distribution matrix, and the random evolution factor and evolutionary drift threshold were introduced to establish the target function of reducing obesity caused by aerobic exercise in adolescents. The constraint conditions of the relationship between aerobic exercise and adolescent obesity reduction were explained, and the particle algorithm was introduced to establish the optimal model of aerobic exercise for adolescent obesity reduction. The experimental results show that with the increasing number of experiments, the advantages of this method are more obvious. From the overall level, the average modeling error of this method is about 0.053%, while the average error of the traditional method is about 0.186%, which shows that this method can control the error within a reasonable range, and it is proved that the improved ant colony algorithm can have a good correlation with the method of aerobic exercise.
Topics: Adipose Tissue; Adolescent; Exercise; Humans; Pediatric Obesity
PubMed: 35356623
DOI: 10.1155/2022/9957916 -
The effect of mind-body and aerobic exercise on negative symptoms in schizophrenia: A meta-analysis.Psychiatry Research Sep 2019This meta-analysis aims to evaluate the effects of different types of physical exercise (PE) on negative symptoms in schizophrenia patients. Mind-body exercise (MBE),... (Meta-Analysis)
Meta-Analysis Review
OBJECTIVE
This meta-analysis aims to evaluate the effects of different types of physical exercise (PE) on negative symptoms in schizophrenia patients. Mind-body exercise (MBE), aerobic exercise (AE) and resistance training (RT) will be investigated.
METHOD
The Cochrane Library, Medline, Embase and PsycINFO were searched from their inception until April 26, 2018. Randomized controlled trials comparing PE with any control group in patients with schizophrenia were included when negative symptoms had been assessed. This meta-analysis was conducted according to the PRISMA guidelines. The methodological quality of the included studies was assessed with the Cochrane Risk of Bias assessment tool. Moderator, sensitivity, and meta regression analyses were conducted to explore causes of heterogeneity and impact of study quality.
RESULTS
We included 22 studies (N = 1249). The overall methodological quality was poor. The meta-analysis (random effects model) showed a medium significant effect in favor of any PE intervention (Hedges' g = 0.434, 95% CI = 0.196-0.671) versus any control condition. MBE and AE respectively showed a medium significant effect (Hedges' g = 0.461) and a small significant effect (Hedges' g = 0.341) versus any control condition. The effect of RT could not be examined. The overall heterogeneity was high (I = 76%) and could not be reduced with moderator or sensitivity analyses.
CONCLUSION
This meta-analysis demonstrated that PE could be a promising intervention in the treatment of negative symptoms. However, the quality of the included studies was low and heterogeneity was high, which makes it impossible to make a clear recommendation. Therefore, results should be interpreted with care.
Topics: Exercise; Exercise Therapy; Humans; Mind-Body Relations, Metaphysical; Quality of Life; Randomized Controlled Trials as Topic; Resistance Training; Schizophrenia; Schizophrenic Psychology; Treatment Outcome
PubMed: 30879703
DOI: 10.1016/j.psychres.2019.03.012 -
Frontiers in Endocrinology 2023
Topics: Humans; Exercise; Resistance Training; Endocrinology
PubMed: 38179305
DOI: 10.3389/fendo.2023.1344032 -
Journal of Strength and Conditioning... Sep 2021Silva, JCG, Domingos-Gomes, JR, Freitas, EDS, Neto, GR, Aniceto, RR, Bemben, MG, Lima-dos-Santos, A, and Cirilo-Sousa, MS. Physiological and perceptual responses to... (Randomized Controlled Trial)
Randomized Controlled Trial
Silva, JCG, Domingos-Gomes, JR, Freitas, EDS, Neto, GR, Aniceto, RR, Bemben, MG, Lima-dos-Santos, A, and Cirilo-Sousa, MS. Physiological and perceptual responses to aerobic exercise with and without blood flow restriction. J Strength Cond Res 35(9): 2479-2485, 2021-Although previous studies have demonstrated the potential benefits of aerobic exercise (AE) with blood flow restriction (BFR), these findings have been limited by the approaches used to determine the occlusive pressure. In addition, the physiological and perceptual responses of AE with BFR compared to high-intensity interval exercise (HIIE) remain unclear. Thus, we investigated the physiological and perceptual responses to AE with and without BFR, and HIIE. Twenty-two men were randomly assigned to 4 experimental conditions: AE (40% of maximal oxygen consumption [V˙o2peak]), AE with 50% of BFR (AE-BFR: 40% VV˙o2peak), HIIE (80% V˙o2peak), and a no exercise control condition (CON: 50% of BFR). Each exercise bout lasted 18 minutes, during which oxygen consumption (V˙o2), heart rate (HR), and ratings of perceived exertion (RPE) were measured at rest and at every 3 minutes during exercise. Ratings of discomfort before and after each trial. The HIIE condition induced the greatest increases in V˙o2 and HR (p < 0.05), whereas AE-BFR was significantly (p < 0.05) greater than AE and CON. HIIE and AE-BFR also elicited the greatest (p < 0.05), but similar (p > 0.05), increases in RPE during exercise, although AE-BFR was significantly greater than HIIE immediately after exercise (p < 0.05). AE-BFR and HIIE also induced similar levels of discomfort after exercise (p > 0.05). In conclusion, HIIE induced the greatest increases in V˙o2 and HR, although the perceptual responses were essentially the same compared with AE-BFR. However, albeit inferior to HIIE, V˙o2 was greater during AE-BFR compared with AE, indicating that this training method may be used to replace HIIE and still significantly elevate V˙o2.
Topics: Exercise; Heart Rate; Hemodynamics; High-Intensity Interval Training; Humans; Male; Oxygen Consumption
PubMed: 31136546
DOI: 10.1519/JSC.0000000000003178