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Journal of Infection and Chemotherapy :... Dec 2019Dermacoccus spp. have rarely been reported as human pathogens. We describe a case of a 4-year-old boy with congenital heart disease who was diagnosed with a brain...
Dermacoccus spp. have rarely been reported as human pathogens. We describe a case of a 4-year-old boy with congenital heart disease who was diagnosed with a brain abscess. The abscess was drained and the sample grew Streptococcus intermedius, Aggregatibacter aphrophilus and Dermacoccus sp.. Dermacoccus grew after 5 days of incubation and the patient was treated with meropenem.
Topics: Actinobacteria; Aggregatibacter aphrophilus; Anti-Bacterial Agents; Brain Abscess; Child, Preschool; Coinfection; Drainage; Heart Defects, Congenital; Humans; Male; Meropenem; Pasteurellaceae Infections; Streptococcal Infections; Streptococcus intermedius; Treatment Outcome
PubMed: 31253474
DOI: 10.1016/j.jiac.2019.05.033 -
IScience May 2024Microbial ecosystems experience spatial and nutrient restrictions leading to the coevolution of cooperation and competition among cohabiting species. To increase their...
Microbial ecosystems experience spatial and nutrient restrictions leading to the coevolution of cooperation and competition among cohabiting species. To increase their fitness for survival, bacteria exploit machinery to antagonizing rival species upon close contact. As such, the bacterial type VI secretion system (T6SS) nanomachinery, typically expressed by pathobionts, can transport proteins directly into eukaryotic or prokaryotic cells, consequently killing cohabiting competitors. Here, we demonstrate for the first time that oral symbiont possesses a T6SS and can eliminate its close relative oral pathobiont using its T6SS. These findings bring nearer the anti-bacterial prospects of symbionts against cohabiting pathobionts while introducing the presence of an active T6SS in the oral cavity.
PubMed: 38650989
DOI: 10.1016/j.isci.2024.109650