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Pediatrics in Review Nov 2020
Topics: Alopecia; Hair; Humans
PubMed: 33139410
DOI: 10.1542/pir.2019-0009 -
Journal of the American Academy of... May 2023
Topics: Humans; Adolescent; Alopecia Areata; Retrospective Studies; Alopecia; Pyrazoles
PubMed: 36623557
DOI: 10.1016/j.jaad.2022.12.033 -
Dermatologic Therapy Jul 2020Αndrogenetic alopecia (AGA) is the most common hair disorder, affecting approximately 50% of men and women. A topical lotion that contains two patented formulas... (Randomized Controlled Trial)
Randomized Controlled Trial
Αndrogenetic alopecia (AGA) is the most common hair disorder, affecting approximately 50% of men and women. A topical lotion that contains two patented formulas (Redensyl and Sepicontrol A5), has been introduced as an alternative approach to standard therapies for AGA. Forty-four patients with AGA were randomized either to apply the active lotion or the vehicle, twice daily for 24 weeks. Subjects were evaluated at 0, 12, and 24 weeks by clinical examination, photographic documentation, quality of life evaluation (DLQI), and trichogram (anagen-to-telogen ratio). Forty-one patients, 18 males and 23 females, completed the study. Among patients receiving active treatment (n = 26), 7.7% had great improvement, 73.1% had moderate improvement, and 19.2% remained stable. The median self-assessment score increased from 4 at baseline to 6 at 24 weeks (P < .001), while the DLQI improved from 4 to 3, respectively (P < .001). The median anagen-to-telogen ratio increased from 2.25 to 4.00 to 6.02 at weeks 0, 12, and 24, respectively. No significant adverse events were reported. This new topical active blend is effective in the treatment of AGA, with high degree of patients' satisfaction, improvement of quality of life, and an excellent safety profile. Thus, it may represent a useful alternative therapeutic approach for AGA.
Topics: Administration, Topical; Alopecia; Female; Hair; Humans; Male; Quality of Life; Treatment Outcome
PubMed: 32473084
DOI: 10.1111/dth.13734 -
Journal of Cosmetic Dermatology Nov 2022There have been various treatment modalities available for alopecia in the form of topical and systemic with a variable response. The compliance of the patients is... (Review)
Review
BACKGROUND
There have been various treatment modalities available for alopecia in the form of topical and systemic with a variable response. The compliance of the patients is important in reaping results in alopecia. Minoxidil has come a long-way finding its use from topical formulations to systemic at lower dose in different alopecia.
OBJECTIVE
The objective of this article is to discuss various conditions in alopecia where oral minoxidil has found its role.
METHODS
A comprehensive literature search was performed relating to oral minoxidil role in various alopecia. Various clinical trials, case series, and case reports were searched on PubMed and Google Scholar. The references of available studies were also reviewed to collect the additional resources. Available data from various studies and case reports were collected and consolidated to provide a concise overview of oral minoxidil indications in various alopecia.
RESULTS
Oral minoxidil has been used in various non-scarring and scarring alopecia at a lower dosage with less side effects and with promising results. Androgenetic alopecia and female pattern hair loss were the two conditions where it has been used more commonly than other alopecia, providing a ray of hope along with overcoming the issues related to topical formulations and compliance.
Topics: Humans; Female; Minoxidil; Treatment Outcome; Alopecia; Administration, Topical
PubMed: 36065675
DOI: 10.1111/jocd.15324 -
Journal of the American Academy of... Feb 2022
Topics: Alopecia; Alopecia Areata; Humans
PubMed: 34800602
DOI: 10.1016/j.jaad.2021.11.013 -
Dermatologic Clinics Jul 2021This article focuses on the assessment and treatment of patients with primary cicatricial alopecia and provides new information regarding the genetics and... (Review)
Review
This article focuses on the assessment and treatment of patients with primary cicatricial alopecia and provides new information regarding the genetics and pathophysiology of this group of diseases.
Topics: Alopecia; Cicatrix; Humans
PubMed: 34053592
DOI: 10.1016/j.det.2021.05.001 -
Facial Plastic Surgery Clinics of North... May 2020Androgenetic alopecia (AGA) is the most common hair loss disorder in men and women. The characteristic and reproducible balding pattern in AGA negatively affects... (Review)
Review
Androgenetic alopecia (AGA) is the most common hair loss disorder in men and women. The characteristic and reproducible balding pattern in AGA negatively affects self-image and the external perceptions of the balding patient. The phenotypical changes are driven by dihydrotestosterone (DHT) and its precursor testosterone. DHT induces follicle miniaturization and hair cycle changes until resulting hairs no longer extrude through the skin surface. AGA is inherited in a polygenetic pattern and is susceptible to epigenetic and environmental factors. Currently, minoxidil, finasteride, and photolaser therapy are the only Food and Drug Administration-approved medical treatments for AGA.
Topics: Alopecia; Dihydrotestosterone; Dutasteride; Finasteride; Hair Preparations; Humans; Low-Level Light Therapy; Minoxidil
PubMed: 32312501
DOI: 10.1016/j.fsc.2020.01.004 -
Journal of the American Academy of... Aug 2021
Topics: Alopecia; Fibrosis; Humans; Scalp
PubMed: 34033818
DOI: 10.1016/j.jaad.2021.05.015 -
Facial Plastic Surgery Clinics of North... May 2020Hair loss can be a debilitating condition, especially for individuals who already have chronic underlying medical conditions that complicate the treatment of hair loss.... (Review)
Review
Hair loss can be a debilitating condition, especially for individuals who already have chronic underlying medical conditions that complicate the treatment of hair loss. This article addresses the challenges posed by scarring alopecia in hair-loss treatment and the evidence-based practices that exist for hair transplantation in scarring alopecia.
Topics: Alopecia; Hair Follicle; Humans; Inflammation; Platelet-Rich Plasma; Skin Transplantation
PubMed: 32312504
DOI: 10.1016/j.fsc.2020.01.001 -
Alternative Therapies in Health and... Jul 2020Androgenic alopecia is a common and unpleasant problem that directly influences the self-confidence and individual life quality. There are various treatment choices that... (Review)
Review
BACKGROUNDS
Androgenic alopecia is a common and unpleasant problem that directly influences the self-confidence and individual life quality. There are various treatment choices that currently are used by people suffering from androgenic alopecia. Drug therapies (e. g. minoxidil, finasteride, dutasteride, prostaglandin analogues, ketoconazole, Cyproterone acetate and spironolactone), Laser-light treatment, surgical treatment, cell mediated treatment and alternative treatments (vitamin, mineral and herbal components) are common therapeutic methods suggested for management of androgenic alopecia. Herbal medicines are now commonly used all over the world and this has increased global demand. Quality, safety and efficacy of these drugs have become a serious concern.
OBJECTIVES
The aim of this review is evaluating the herbal or fungal medicines were used in androgenic alopecia and introducing the phytochemicals, biological effects, responsible constituents and the mechanism of this action.
RESULTS
The 23 medicinal fungi or plants with their possible mechanisms and active phytoconstituents, which were used in androgenic alopecia are described.
METHODS/DESIGN
In this review, most of the natural sources that used in the treatment of androgenic alopecia were collected from electronic databases including Web of Science, PubMed, Scopus and Google Scholar were searched for these plants. Data were gathered from 1970 to 2016.
CONCLUSION
The summarized findings in this article could be inspiration to product new formulations for treatment of androgenic alopecia with more effective properties and fewer side effect.
Topics: Alopecia; Finasteride; Herbal Medicine; Humans; Minoxidil; Phytotherapy; Plants, Medicinal; Scalp
PubMed: 31221945
DOI: No ID Found