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Future Microbiology Jan 2020
Topics: Bacteria; Drug Resistance, Microbial; Humans; Microbiological Techniques; Molecular Typing; Phylogeny; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; beta-Lactamases
PubMed: 32043365
DOI: 10.2217/fmb-2019-0264 -
Bio Systems Oct 2020Antibiotic resistance is a global public health problem which has the attention of many stakeholders including clinicians, the pharmaceutical industry, researchers and... (Review)
Review
Antibiotic resistance is a global public health problem which has the attention of many stakeholders including clinicians, the pharmaceutical industry, researchers and policy makers. Despite the existence of many studies, control of resistance transmission has become a rather daunting task as the mechanisms underlying resistance evolution and development are not fully known. Here, we discuss the mechanisms underlying antibiotic resistance development, explore some treatment strategies used in the fight against antibiotic resistance and consider recent findings on collateral susceptibilities amongst antibiotic classes. Mathematical models have proved valuable for unravelling complex mechanisms in biology and such models have been used in the quest of understanding the development and spread of antibiotic resistance. While assessing the importance of such mathematical models, previous systematic reviews were interested in investigating whether these models follow good modelling practice. We focus on theoretical approaches used for resistance modelling considering both within and between host models as well as some pharmacodynamic and pharmakokinetic approaches and further examine the interaction between drugs and host immune response during treatment with antibiotics. Finally, we provide an outlook for future research aimed at modelling approaches for combating antibiotic resistance.
Topics: Anti-Bacterial Agents; Drug Resistance, Microbial; Host Microbial Interactions; Humans; Models, Biological; Models, Theoretical; Surveys and Questionnaires
PubMed: 32525023
DOI: 10.1016/j.biosystems.2020.104182 -
Advances in Experimental Medicine and... 2024The rapid evolution of antibiotic resistance in Clostridioides difficile and the consequent effects on prevention and treatment of C. difficile infections (CDIs) are a...
The rapid evolution of antibiotic resistance in Clostridioides difficile and the consequent effects on prevention and treatment of C. difficile infections (CDIs) are a matter of concern for public health. Antibiotic resistance plays an important role in driving C. difficile epidemiology. Emergence of new types is often associated with the emergence of new resistances, and most of the epidemic C. difficile clinical isolates is currently resistant to multiple antibiotics. In particular, it is to worth to note the recent identification of strains with reduced susceptibility to the first-line antibiotics for CDI treatment and/or for relapsing infections. Antibiotic resistance in C. difficile has a multifactorial nature. Acquisition of genetic elements and alterations of the antibiotic target sites, as well as other factors, such as variations in the metabolic pathways or biofilm production, contribute to the survival of this pathogen in the presence of antibiotics. Different transfer mechanisms facilitate the spread of mobile elements among C. difficile strains and between C. difficile and other species. Furthermore, data indicate that both genetic elements and alterations in the antibiotic targets can be maintained in C. difficile regardless of the burden imposed on fitness, and therefore resistances may persist in C. difficile population in absence of antibiotic selective pressure.
Topics: Clostridioides; Clostridioides difficile; Drug Resistance, Microbial; Anti-Bacterial Agents; Biofilms
PubMed: 38175476
DOI: 10.1007/978-3-031-42108-2_9 -
Sheng Wu Gong Cheng Xue Bao = Chinese... Dec 2020The discovery of antibiotics is a big revolution in human history, and its clinical application has saved countless lives. However, with the widespread and abuse of... (Review)
Review
The discovery of antibiotics is a big revolution in human history, and its clinical application has saved countless lives. However, with the widespread and abuse of antibiotics, many pathogens have developed resistance, and even "Super Bacteria" resistance to multiple drugs have evolved. In the arms race between humans and pathogens, humans are about to face a situation where no medicine is available. Research on microbial antibiotic resistance genes, resistance mechanisms, and the spread of resistance has attracted the attention of many scientific researchers, and various antibiotic resistance gene databases and analysis tools have emerged. In this review, we collect the current databases that focus on antibiotics resistance genes, and discuss these databases in terms of database types, data characteristics, antibiotics resistance gene prediction models and the types of analyzable sequences. In addition, a few gene databases of anti-metal ions and anti-biocides are also involved. It is believed that this summary will provide a reference for how to select and use antibiotic resistance gene databases.
Topics: Anti-Bacterial Agents; Bacterial Infections; Drug Resistance, Bacterial; Drug Resistance, Microbial; Humans; Metals
PubMed: 33398956
DOI: 10.13345/j.cjb.200375 -
Nature Reviews. Microbiology Oct 2023Antibiotic resistance is currently one of the most important public health problems. The golden age of antibiotic discovery ended decades ago, and new approaches are... (Review)
Review
Antibiotic resistance is currently one of the most important public health problems. The golden age of antibiotic discovery ended decades ago, and new approaches are urgently needed. Therefore, preserving the efficacy of the antibiotics currently in use and developing compounds and strategies that specifically target antibiotic-resistant pathogens is critical. The identification of robust trends of antibiotic resistance evolution and of its associated trade-offs, such as collateral sensitivity or fitness costs, is invaluable for the design of rational evolution-based, ecology-based treatment approaches. In this Review, we discuss these evolutionary trade-offs and how such knowledge can aid in informing combination or alternating antibiotic therapies against bacterial infections. In addition, we discuss how targeting bacterial metabolism can enhance drug activity and impair antibiotic resistance evolution. Finally, we explore how an improved understanding of the original physiological function of antibiotic resistance determinants, which have evolved to reach clinical resistance after a process of historical contingency, may help to tackle antibiotic resistance.
Topics: Humans; Drug Resistance, Microbial; Bacterial Infections; Bacteria; Anti-Bacterial Agents; Biology; Drug Resistance, Bacterial
PubMed: 37208461
DOI: 10.1038/s41579-023-00902-5 -
Comptes Rendus Biologies Mar 2024
Topics: One Health; Drug Resistance, Microbial; Anti-Bacterial Agents
PubMed: 37655922
DOI: 10.5802/crbiol.122 -
Frontiers in Cellular and Infection... 2022
Topics: Communicable Diseases; Drug Resistance, Microbial; Humans; Probiotics
PubMed: 35846742
DOI: 10.3389/fcimb.2022.938282 -
Pest Management Science Sep 2021The challenges of resistance to antibiotics and resistance to herbicides have much in common. Antibiotic resistance became a risk in the 1950s, but a concerted global...
The challenges of resistance to antibiotics and resistance to herbicides have much in common. Antibiotic resistance became a risk in the 1950s, but a concerted global effort to manage it did not begin until after 2000. Widespread herbicide use began during the 1950s and was soon followed by an unabated rise in resistance. Here, we examine what lessons for combatting herbicide resistance could be learnt from the global, coordinated efforts of all stakeholders to avert the antibiotic resistance crisis. © 2021 Society of Chemical Industry.
Topics: Drug Resistance, Microbial; Herbicide Resistance; Herbicides; Plant Weeds; Weed Control
PubMed: 33682995
DOI: 10.1002/ps.6357 -
Sheng Wu Gong Cheng Xue Bao = Chinese... Jul 2022Recently, drug resistance resulted from the extensive abuse and over-use of antibiotics has posed a great threat to human health. Scholars have conducted numerous... (Review)
Review
Recently, drug resistance resulted from the extensive abuse and over-use of antibiotics has posed a great threat to human health. Scholars have conducted numerous studies on the impacts of antibiotic resistant bacteria and antibiotic resistance genes (ARGs) in different types of environments. Aerosol is not only a potential reservoir for ARGs, but also an important route for transmission of ARGs in the environment. However, a systematic summary of its sources, transmission, human exposure, and health risks is lacking. This review focused on four types of typical sites for aerosol research: human functional living places, farms, urban wastewater treatment plants, and hospitals. The sources, transmission routes, human exposure, and health risks of ARGs in the aerosol of these four typical sites were reviewed. This article also provides a reference for prevention and control of ARGs in aerosols.
Topics: Aerosols; Anti-Bacterial Agents; Drug Resistance, Microbial; Genes, Bacterial; Humans; Wastewater
PubMed: 35871614
DOI: 10.13345/j.cjb.210829 -
Progress in Molecular Biology and... 2021CRISPR-Cas system, antibiotic resistance and virulence are different modes of survival for the bacteria. CRISPR-Cas is an adaptive immune system that can degrade foreign...
CRISPR-Cas system, antibiotic resistance and virulence are different modes of survival for the bacteria. CRISPR-Cas is an adaptive immune system that can degrade foreign DNA, antibiotic resistance helps bacteria to evade drugs that can threaten their existence and virulence determinants are offensive tools that can facilitate the establishment of infection by pathogens. This chapter focuses on these three aspects, providing insights about the CRISPR system and resistance mechanisms in brief, followed by understanding the synergistic or antagonistic relationship of resistance and virulence determinants in connection to the CRISPR system. We have addressed the discussion of this evolving topic through specific examples and studies. Different approaches for successful detection of this unique defense system in bacteria and various applications of the CRISPR-Cas systems to show how it can be harnessed to tackle the increasing problem of antibiotic resistance have been put forth. World Health Organization has declared antibiotic resistance as a serious global problem of the 21st century. As antibiotic-resistant bacteria increase their footprint across the globe, newer tools such as the CRISPR-Cas system hold immense promise to tackle this problem.
Topics: Anti-Bacterial Agents; Bacteria; CRISPR-Cas Systems; Drug Resistance, Microbial; Humans; Virulence
PubMed: 33685595
DOI: 10.1016/bs.pmbts.2020.12.005