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Nursing Open Jul 2022To explore and gain an understanding of patients' perceptions and experiences of their body and bodily function in connection with open surgery of abdominal aortic...
AIMS
To explore and gain an understanding of patients' perceptions and experiences of their body and bodily function in connection with open surgery of abdominal aortic aneurysm.
BACKGROUND
After the operation of an abdominal aortic aneurysm (AAA) it may be difficult for the patients to understand what the procedure means.
DESIGN
The design was descriptive and based on an analysis of 13 audio-taped consultations with patients undergoing open surgery for AAA at a Swedish university hospital. The patients' age varied from 57-79 and the mean age was 71 (70.5 female).
METHODS
A hermeneutic approach was used whereby patients were interviewed and draw a picture of their thoughts and experiences of the surgery and what had been done in their bodies. Once patients had finished their drawings, the interviewer asked what thoughts and experiences they had of the AAA.
RESULTS
Patients described experiences as a process of "going from broken to whole again."
Topics: Aged; Aortic Aneurysm, Abdominal; Body Image; Endovascular Procedures; Female; Humans
PubMed: 35482535
DOI: 10.1002/nop2.1225 -
Open Surgical Repair of Abdominal Aortic Aneurysms Maintains a Pivotal Role in the Endovascular Era.Seminars in Interventional Radiology Oct 2020Since the advent of endovascular aortic repair (EVAR) nearly three decades ago, there has been a paradigm shift in the treatment of the abdominal aortic aneurysm (AAA)... (Review)
Review
Since the advent of endovascular aortic repair (EVAR) nearly three decades ago, there has been a paradigm shift in the treatment of the abdominal aortic aneurysm (AAA) to favor EVAR due to its reduced operative mortality, less invasive nature, and faster recovery times. However, more recently there has been an accumulation of data from large meta-analyses and randomized clinical trials revealing that EVAR has no survival benefit after approximately 2 years and is associated with substantially higher rates of reintervention and aneurysm rupture in the long term. These findings call into question the durability of EVAR compared with open aortic repair and emphasize the need for surgeons to remain competent with open aortic surgery in the modern era. This article will provide comprehensive review of a large body of literature comparing endovascular repair to open aortic surgery for the management of AAAs, and it will offer an overview of the open surgical repair technique for AAAs.
PubMed: 33041480
DOI: 10.1055/s-0040-1715881 -
Nigerian Journal of Clinical Practice Aug 2019Wilson's disease (WD) presents with different phenotypes. Neurologic and liver involvement in WD are well documented. Few reports demonstrated cardiac and vascular...
AIM
Wilson's disease (WD) presents with different phenotypes. Neurologic and liver involvement in WD are well documented. Few reports demonstrated cardiac and vascular involvement. Several studies showed an association between serum copper levels and atherosclerosis. Although WD is the prototype disease of copper metabolism, atherosclerosis has not been studied yet. The aim of this study is to assess aortic stiffness in WD.
MATERIALS AND METHODS
Aortic pulse wave velocity (PWV), augmentation pressure (AP), augmentation index (AIx), central aortic systolic, diastolic, mean, and pulse pressures were measured using SphygmoCor (AtCor Medical) device in 32 patients with WD and 24 healthy controls.
RESULTS
Patients with WD and healthy controls were similar in terms of age sex, body mass index (BMI), and liver and kiney functions. However, patients with WD were anemic and thrombocytopenic. Echocardiographic parameters including left ventricular, atrial dimensions, and systolic and diastolic functions were similar between two groups. Patients with WD and healthy controls were compared. Baseline characteristics including age, sex, and BMI did not differ between groups. Central aortic systolic, diastolic, mean, and pulse pressures were similar between the groups. AP, AIx, and PWV did not differ between groups as well.
CONCLUSION
Aortic stiffness in WD was similar in healthy controls.
Topics: Adult; Anemia; Arterial Pressure; Blood Pressure; Body Mass Index; Case-Control Studies; Copper; Echocardiography; Female; Hepatolenticular Degeneration; Humans; Male; Middle Aged; Pulse Wave Analysis; Thrombocytopenia; Turkey; Vascular Stiffness
PubMed: 31417056
DOI: 10.4103/njcp.njcp_578_18 -
Turk Gogus Kalp Damar Cerrahisi Dergisi Apr 2022The aim of this study was to analyze the effect of additional lower body perfusion, compared to antegrade selective cerebral perfusion, on early postoperative outcomes...
BACKGROUND
The aim of this study was to analyze the effect of additional lower body perfusion, compared to antegrade selective cerebral perfusion, on early postoperative outcomes after aortic arch repair in neonates with biventricular morphology.
METHODS
Between January 2017 and April 2020, a total of 46 neonates (34 males, 12 females; median age: 10 days; range, 7 to 14 days) with biventricular morphology underwent an aortic arch reconstruction were retrospectively analyzed. The effects of antegrade selective cerebral perfusion and additional lower body perfusion techniques on vital organ preservation and mortality were evaluated in these patients who underwent arch reconstruction.
RESULTS
In the univariate analysis of the whole cohort, postoperative creatinine level was lower in the additional lower body perfusion group, while there was no significant difference between the other parameters. In the multivariate analysis, intraoperative highest lactate level (odds ratio: 1.7; 95% confidence interval: 1.07-2.68; p=0.02) and postoperative 4th t o 6 th h lactate levels (odds ratio: 2.34; 95% confidence interval: 1.08-5.09; p=0.03) were independent predictors of early mortality. Mortality rate was higher in the antegrade selective cerebral perfusion group (22% vs. 7%), although it did not reach statistical significance. In the receiver operating characteristic curve analysis, the cut-off value for intraoperative lactate was 6.2 mmol/L (sensitivity: 85.7%, specificity: 71.1%) and the cut-off value for the lactate level at the postoperative 4th to 6th h was 4.9 mmol/L (sensitivity: 85.7%, specificity: 73.7%). Above these lactate levels were found to be associated with mortality.
CONCLUSION
Additional lower body perfusion may have a role in vital organ protection in aortic arch repair of neonates, compared to antegrade selective cerebral perfusion.
PubMed: 36168563
DOI: 10.5606/tgkdc.dergisi.2022.22805 -
European Journal of Vascular and... Jul 2023The effect of body mass index (BMI) on post-operative outcomes after abdominal aortic aneurysm (AAA) repair remains poorly defined. The association between BMI and death...
OBJECTIVE
The effect of body mass index (BMI) on post-operative outcomes after abdominal aortic aneurysm (AAA) repair remains poorly defined. The association between BMI and death following elective endovascular aneurysm repair (EVAR) and open aneurysm repair (OAR) of AAA in a large national quality registry is investigated.
METHODS
All elective AAA repairs within the Society for Vascular Surgery Vascular Quality Initiative (VQI; 2010 to September 2021) were reviewed (EVAR, n = 53 426; OAR, n = 9 479). All analyses were conducted separately for EVAR and OAR patients. The primary end points were 30 day mortality and five year survival rates. Study cohorts were divided into World Health Organisation BMI categories (C1 < 18.5, C2 18.5 ≤ BMI < 25, C3 25 ≤ BMI < 30, C4, 30 ≤ BMI < 35, C5 35 ≤ BMI < 40, C6 ≥ 40). BMI was examined as both a categorical and continuous variable. Logistic and Cox proportional hazards regression were used for risk adjustment.
RESULTS
Among EVAR patients, BMI distribution was C1, 1 216 (2%); C2, 14 687 (28%); C3, 20 516 (38%); C4, 11 352 (21%); C5, 3 947 (7%); C6, 1 708 (3%). Class 1, 2, and 6 BMI patients experienced an increased 30 day mortality rate (C1 2.6%; C2 1.3%; C6 1.4% vs. C3 - 5 0.7%; p < .001) and C1 and C2 had correspondingly inferior long term survival (five years: C1 69 ± 3%; C2 79 ± 1% vs. C3 - 6 86 - 88 ± 2%; log rank p < .001). These survival disparities persisted after risk adjustment for multiple confounders. In the OAR cohort, BMI distribution was C1, 280 (3%); C2, 2 862 (30%); C3, 3 587 (38%); C4, 1 940 (21%); C5, 581 (6%); C6, 229 (2%). Crude 30 day mortality rates were increased for both the lowest and highest BMI patients (C1 12%, C6 7% vs. C2 - 5 3 - 4%; p < .001); these differences also persisted in long term survival (five years: C1 71 ± 6%, C6 82 ± 6% vs. C2 - 6 85 - 88 ± 3%; log rank p < .001). In risk adjusted analysis, both low and high BMI OAR patients had an increased 30 day and long term mortality rate.
CONCLUSION
Within the VQI, both the extreme low (< 18.5) and high (≥ 40) BMI groups experienced an increased 30 day mortality rate after both elective EVAR and OAR. By comparison, while the lowest BMI cohort was significantly associated with decreased long term survival after both procedures, the highest BMI group only experienced reduced long term survival after OAR. Based upon this large real world registry analysis of elective AAA repairs, differential metabolic signatures exist within extreme BMI categories, which may inform peri-operative risk stratification and clinical decision making.
Topics: Humans; Endovascular Procedures; Body Mass Index; Aortic Aneurysm, Abdominal; Risk Factors; Treatment Outcome; Blood Vessel Prosthesis Implantation; Retrospective Studies
PubMed: 36738822
DOI: 10.1016/j.ejvs.2023.01.047 -
World Journal of Cardiology Apr 2024Pacemaker post-transcatheter aortic valve replacement is related to multifactorial risk. Nwaedozie brought to the body of evidence electrocardiogram and clinical...
Pacemaker post-transcatheter aortic valve replacement is related to multifactorial risk. Nwaedozie brought to the body of evidence electrocardiogram and clinical findings. However, procedural characteristics have at least as much impact on the final need for a permanent pacemaker and potentially on the pacing rate. In this regard, long-term follow-up and understanding of the impact of long-term stimulation is of utmost importance.
PubMed: 38690219
DOI: 10.4330/wjc.v16.i4.168 -
Heart, Lung & Circulation Jan 2021Aortic dilatation and bicuspid aortic valve (BAV) are frequent in Turner syndrome (TS). Due to short stature, aortic size index (ASI)-ascending aortic diameter (AD)/body...
BACKGROUND
Aortic dilatation and bicuspid aortic valve (BAV) are frequent in Turner syndrome (TS). Due to short stature, aortic size index (ASI)-ascending aortic diameter (AD)/body surface area (BSA)-is used to identify aortic dilatation in TS patients. We sought to: 1) describe echocardiographic findings in the largest cohort of Australian women with TS; 2) assess if ASI progresses differently with age in TS BAV compared to non-syndromic BAV; and 3) determine whether adjustment of AD for body composition may be superior to BSA indexation.
METHODS
Transthoracic echocardiography (TTE) data were retrospectively collected on 125 women with TS. Body composition was quantified by dual energy X-ray absorptiometry (DXA) in 60 women within 6 months of baseline TTE. Age-matched females with non-syndromic BAV (n=170) were used as controls for TS patients with BAV.
RESULTS
Mean age of TS women was 28±16 years, and mean height and BSA were 141.6±21.7 cm and 1.4±0.4 m, respectively. Mean AD was 2.5±0.8 cm, and ASI 2.0±0.6 cm/m. Aortic dilatation (ASI >2.0 cm/m) was present in 42 (34%) patients. Turner syndrome women with BAV (n=34; 27%) had a larger ASI than those with tri-leaflet AV (2.2±0.4 cm/m vs. 1.7±0.3 cm/m, p<0.001). In the pooled BAV cohort, TS patients had a higher baseline ASI (2.2±0.4 cm/m vs. 2.1±0.3 cm/m, p=0.02) and greater increase in ASI with age (0.21 mm/m/year vs. 0.10 mm/m/year, p=0.01) compared to non-syndromic BAV patients. DXA fat-free mass (r=0.33, p=0.01) and lean mass (r=0.32, p=0.02) correlated with AD, as did BSA (r=0.62, p<0.001).
CONCLUSION
Turner syndrome women with BAV have a greater degree of baseline aortic dilatation and a twofold faster increase in aortic dimension with age when compared to matched women with non-syndromic BAV. Several DXA-derived body composition parameters correlate with aortic size in TS, however BSA appears to be the most robust method of indexation.
Topics: Adolescent; Adult; Aged; Aorta; Aortic Aneurysm, Thoracic; Bicuspid Aortic Valve Disease; Body Composition; Echocardiography; Female; Humans; Male; Middle Aged; Retrospective Studies; Turner Syndrome; Young Adult
PubMed: 33132052
DOI: 10.1016/j.hlc.2020.10.005 -
Journal of Cachexia, Sarcopenia and... Aug 2021Patients with Marfan syndrome are at risk for aortic enlargement and are routinely monitored by computed tomography (CT) imaging. The purpose of this study is to analyse...
BACKGROUND
Patients with Marfan syndrome are at risk for aortic enlargement and are routinely monitored by computed tomography (CT) imaging. The purpose of this study is to analyse body composition using artificial intelligence (AI)-based tissue segmentation in patients with Marfan syndrome in order to identify possible predictors of progressive aortic enlargement.
METHODS
In this study, the body composition of 25 patients aged ≤50 years with Marfan syndrome and no prior aortic repair was analysed at the third lumbar vertebra (L3) level from a retrospective dataset using an AI-based software tool (Visage Imaging). All patients underwent electrocardiography-triggered CT of the aorta twice within 2 years for suspected progression of aortic disease, suspected dissection, and/or pre-operative evaluation. Progression of aortic enlargement was defined as an increase in diameter at the aortic sinus or the ascending aorta of at least 2 mm. Patients meeting this definition were assigned to the 'progressive aortic enlargement' group (proAE group) and patients with stable diameters to the 'stable aortic enlargement' group (staAE group). Statistical analysis was performed using the Mann-Whitney U test. Two possible body composition predictors of aortic enlargement-skeletal muscle density (SMD) and psoas muscle index (PMI)-were analysed further using multivariant logistic regression analysis. Aortic enlargement was defined as the dependent variant, whereas PMI, SMD, age, sex, body mass index (BMI), beta blocker medication, and time interval between CT scans were defined as independent variants.
RESULTS
There were 13 patients in the proAE group and 12 patients in the staAE group. AI-based automated analysis of body composition at L3 revealed a significantly increased SMD measured in Hounsfield units (HUs) in patients with aortic enlargement (proAE group: 50.0 ± 8.6 HU vs. staAE group: 39.0 ± 15.0 HU; P = 0.03). PMI also trended towards higher values in the proAE group (proAE group: 6.8 ± 2.3 vs. staAE group: 5.6 ± 1.3; P = 0.19). Multivariate logistic regression revealed significant prediction of aortic enlargement for SMD (P = 0.05) and PMI (P = 0.04).
CONCLUSIONS
Artificial intelligence-based analysis of body composition at L3 in Marfan patients is feasible and easily available from CT angiography. Analysis of body composition at L3 revealed significantly higher SMD in patients with progressive aortic enlargement. PMI and SMD significantly predicted aortic enlargement in these patients. Using body composition as a predictor of progressive aortic enlargement may contribute information for risk stratification regarding follow-up intervals and the need for aortic repair.
Topics: Aorta; Artificial Intelligence; Body Composition; Humans; Marfan Syndrome; Psoas Muscles; Retrospective Studies
PubMed: 34137512
DOI: 10.1002/jcsm.12731 -
Experimental Cell Research Nov 2023Vascular calcification (VC) is a common pathological process of cardiovascular disease that occurs in patients with type 2 diabetes mellitus (T2DM). However, the...
Vascular calcification (VC) is a common pathological process of cardiovascular disease that occurs in patients with type 2 diabetes mellitus (T2DM). However, the molecular basis of VC progression remains unknown. A GEO dataset (GSE146638) was analyzed to show that microbodies and IL-1β may play important roles in the pathophysiology of VC. The release of matrix vesicle bodies (MVBs) and IL-1β and the colocalization of IL-1β with MVBs or autophagosomes were studied by immunofluorescence in an in vivo diabetes mouse model with aortic calcification and an in vitro high glucose cell calcification model. MVB numbers, IL-1β levels and autophagy were increased in calcified mouse aortas and calcified vascular smooth muscle cells (VSMCs). IL-1β colocalized with MVBs and autophagosomes. The MVBs from calcified VSMCs induced the calcification of normal recipient VSMCs, and this effect was alleviated by silencing IL-1β. The autophagy inducer rapamycin reduced IL-1β expression and calcification in VSMCs, while these processes were induced by the autophagy inhibitor chloroquine. In conclusion, our results suggested that MVBs could carry IL-1β out of cells and induce VC in normal VSMCs, and these processes could be counteracted by autophagy. These results suggested that MVB-mediated IL-1β release may be an effective target for treating vascular calcification.
PubMed: 37774764
DOI: 10.1016/j.yexcr.2023.113803 -
Mathematical Biosciences and... Jul 2022Abdominal aortic aneurysms are serious and difficult to detect, conditions can be deadly if they rupture. In this study, the heat transfer and flow physics of Abdominal...
Abdominal aortic aneurysms are serious and difficult to detect, conditions can be deadly if they rupture. In this study, the heat transfer and flow physics of Abdominal Aortic Aneurysm (AAA) were discussed and associated with cardiac cycle to illustrate the cardiac thermal pulse (CTP) of AAA. A CTP and infrared thermography (IRT) evaluation-based on AAA and abdomen skin surface detection method was proposed, respectively. Infrared thermography (IRT) is a promising imaging technique that may detect AAA quicker and cheaper than other imaging techniques (as biomarker). From CFD rigid-wall and FSI Analysis, the transient bioheat transfer effect resulted in a distinct thermal signature (circular thermal elevation) on the temperature profile of midriff skin surface, at both regular body temperature and supine position, under normal clinical temperature. However, it is important to note that thermography is not a perfect technology, and it does have some limitations, such as lack of clinical trials. There is still work to be done to improve this imaging technique and make it a more viable and accurate method for detecting abdominal aortic aneurysms. However, thermography is currently one of the most convenient technologies in this field, and it has the potential to detect abdominal aortic aneurysms earlier than other techniques. CTP, on the other hand, was used to examine the thermal physics of AAA. In CFD rigid-wall Analysis, AAA had a CTP that only responded to systolic phase at regular body temperature. In contrast, a healthy abdominal aorta displayed a CTP that responded to the full cardiac cycle, including diastolic phase at all simulated cases. Besides, the findings from FSI Analysis suggest the influence of numerical simulation techniques on the prediction of thermal physics behaviours of AAA and abdominal skin surface. Lastly, this study correlated the relationship between natural convective heat transfer coefficient with AAA and provided reference for potential clinical diagnostic using IRT in clinical implications.
Topics: Humans; Aortic Aneurysm, Abdominal
PubMed: 36031992
DOI: 10.3934/mbe.2022479