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Evolutionary Human Sciences 2022
PubMed: 37588910
DOI: 10.1017/ehs.2021.51 -
NEJM Evidence Apr 2022Deja vu is the sensation of having a recurrent experience. Within a year after an initial urinary tract infection (UTI), up to 30% of women will experience a recurrence...
Deja vu is the sensation of having a recurrent experience. Within a year after an initial urinary tract infection (UTI), up to 30% of women will experience a recurrence of UTI symptoms. A smaller group of women (1%) may experience frequent recurrence with six or more episodes in a year. Recurrent UTI, or "deja vUTI," is a challenging problem that still lacks a cohesive pathophysiological mechanism, and it is currently addressed with a wide range of clinical practices often based on experience rather than on high-quality evidence.
PubMed: 38319216
DOI: 10.1056/EVIDe2100072 -
Epileptic Disorders : International... Jun 2022Déjà-vu is a mental phenomenon commonly experienced during temporal lobe seizures and can be evoked by electrical stimulation of the temporal lobe. We analyzed... (Review)
Review
OBJECTIVE
Déjà-vu is a mental phenomenon commonly experienced during temporal lobe seizures and can be evoked by electrical stimulation of the temporal lobe. We analyzed reproducible déjà-vu experiences evoked by stimulating the insula in two patients with pharmacoresistant temporal lobe epilepsy.
METHODS
We reviewed video-electroencephalography (EEG) recordings from extraoperative electrical cortical stimulation sessions. In addition, we performed the directed transfer function (DTF) effective connectivity measure of monopolar signals in Patient 1. To highlight elective changes due to each stimulation, we subtracted pre-stimulation DTF matrices from early poststimulation matrices. This analysis was performed for both non-inducing-déjàvu stimulation (control matrix) and déjà-vu-inducing stimulation (active matrix). Finally, the control matrix was subtracted from the active matrix.
RESULTS
Comparison of effective connectivity during control stimulation versus déjà-vu-inducing stimulation revealed a reversal of connectivity levels in three main regions: the contralateral inferior insula (the ipsilateral insula could not be analyzed), bilateral mesiotemporal regions and the ipsilateral superior frontal gyrus. The drivers of evoked déjà-vu were the mesiotemporal regions (mainly ipsilateral) and the ipsilateral superior frontal gyrus.
SIGNIFICANCE
Although our findings are possibly anecdotal, the insula may (in rare instances) remotely generate unexpected déjà-vu. If confirmed by further studies, this might change the assessment strategy for possible causes of anterior temporal lobectomy failure.
Topics: Humans; Deja Vu; Temporal Lobe; Epilepsy, Temporal Lobe; Electroencephalography; Electric Stimulation
PubMed: 37401785
DOI: 10.1684/epd.2022.1433 -
Memory (Hove, England) Aug 2021Déjà vu occurs when a novel event is experienced with an erroneous sense of familiarity. Memory researchers theorise that this arises due to an error in the processes...
Déjà vu occurs when a novel event is experienced with an erroneous sense of familiarity. Memory researchers theorise that this arises due to an error in the processes underlying the recognition memory system. Research has indicated that there may be a link between high levels of anxiety and increased frequency and intensity of déjà vu, however, there has been a comparatively little characterisation of déjà vu as experienced by individuals with clinical anxiety. We used an online questionnaire to collect data from individuals self-reporting a clinical diagnosis of anxiety, as well as from age-matched controls. The Anxiety Group reported a significantly higher frequency of déjà vu episodes over the previous month than controls. They also reported experiencing déjà vu more frequently and with higher intensity during periods of high anxiety. In addition, the Anxiety Group reported finding déjà vu episodes significantly more distressing than the Control Group. The findings indicate that there are differences in déjà vu experienced by people reporting high levels of anxiety compared to healthy controls without an anxiety diagnosis. We discuss structural and neural mechanisms thought to underpin déjà vu in relation to these results.
Topics: Anxiety; Anxiety Disorders; Deja Vu; Humans; Recognition, Psychology; Surveys and Questionnaires
PubMed: 30384798
DOI: 10.1080/09658211.2018.1538418 -
Frontiers in Psychology 2022Previous research has contrasted fleeting erroneous experiences of familiarity with equally convincing, and often more stubborn erroneous experiences of remembering....
Previous research has contrasted fleeting erroneous experiences of familiarity with equally convincing, and often more stubborn erroneous experiences of remembering. While a subset of the former category may present as nonpathological "déjà vu," the latter, termed "déjà vécu" can categorize a delusion-like confabulatory phenomenon first described in elderly dementia patients. Leading explanations for this experience include the dual process view, in which erroneous familiarity and erroneous recollection are elicited by inappropriate activation of the parahippocampal cortex and the hippocampus, respectively, and the more popular encoding-as-retrieval explanation in which normal memory encoding processes are falsely flagged and interpreted as memory retrieval. This paper presents a novel understanding of this recollective confabulation that builds on the encoding-as-retrieval hypothesis but more adequately accounts for the co-occurrence of persistent déjà vécu with both perceptual novelty and memory impairment, the latter of which occurs not only in progressive dementia but also in transient epileptic amnesia (TEA) and psychosis. It makes use of the growing interdisciplinary understanding of the fluidity of time and posits that the functioning of memory and the perception of novelty, long known to influence the subjective experience of time, may have a more fundamental effect on the flow of time.
PubMed: 35967717
DOI: 10.3389/fpsyg.2022.794683 -
Neurology(R) Neuroimmunology &... Nov 2022To assess seizure characteristics in antibody (ab)-associated autoimmune encephalitis (ab + AE) with the 3 most prevalent abs against N-methyl-d-aspartate receptor...
BACKGROUND AND OBJECTIVES
To assess seizure characteristics in antibody (ab)-associated autoimmune encephalitis (ab + AE) with the 3 most prevalent abs against N-methyl-d-aspartate receptor (NMDAR), leucine-rich glioma-inactivated protein 1 (LGI1), and glutamic acid decarboxylase (GAD).
METHODS
Multicenter nationwide prospective cohort study of the German Network for Research in Autoimmune Encephalitis.
RESULTS
Three hundred twenty patients with ab + AE were eligible for analysis: 190 NMDAR+, 89 LGI1+, and 41 GAD+. Seizures were present in 113 (60%) NMDAR+, 69 (78%) LGI1+, and 26 (65%) GAD+ patients and as leading symptoms for diagnosis in 53 (28%) NMDAR+, 47 (53%) LGI+, and 20 (49%) GAD+ patients. Bilateral tonic-clonic seizures occurred with almost equal frequency in NMDAR+ (38/51, 75%) and GAD+ (14/20, 70%) patients, while being less common in LGI1+ patients (27/59, 46%). Focal seizures occurred less frequently in NMDAR+ (67/113; 59%) than in LGI1+ (54/69, 78%) or in GAD+ patients (23/26; 88%). An aura with déjà-vu phenomenon was nearly specific in GAD+ patients (16/20, 80%). Faciobrachial dystonic seizures (FBDS) were uniquely observed in LGI1+ patients (17/59, 29%). Status epilepticus was reported in one-third of NMDAR+ patients, but only rarely in the 2 other groups. The occurrence of seizures was associated with higher disease severity only in NMDAR+ patients.
DISCUSSION
Seizures are a frequent and diagnostically relevant symptom of ab + AE. Whereas NMDAR+ patients had few localizing semiological features, semiology in LGI1+ and GAD+ patients pointed toward a predominant temporal seizure onset. FBDS are pathognomonic for LGI1 + AE. Status epilepticus seems to be more frequent in NMDAR + AE.
Topics: Humans; Glutamate Decarboxylase; Receptors, N-Methyl-D-Aspartate; Prospective Studies; Leucine; Intracellular Signaling Peptides and Proteins; Seizures; Encephalitis; Autoantibodies; Status Epilepticus
PubMed: 36266054
DOI: 10.1212/NXI.0000000000200034 -
Current Problems in Cardiology Sep 2023Recent studies have suggested a link between déjà vu and cardiovascular diseases (CVDs). While the mechanism for this association is not fully understood, 1 theory... (Review)
Review
Recent studies have suggested a link between déjà vu and cardiovascular diseases (CVDs). While the mechanism for this association is not fully understood, 1 theory suggests that déjà vu may be a result of a disruption in the temporal lobe, which is also responsible for regulating blood pressure and heart rate. Another theory suggests that there may be a shared genetic factor between the 2 conditions, with certain individuals being predisposed to experiencing both. The Apolipoprotein E (APOE) gene, in particular, has been associated with memory processing, Alzheimer's disease, and an increased risk of CVD. The protein encoded by this gene is involved in the metabolism of lipoproteins, including cholesterol and triglycerides, and is also involved in the development of atherosclerosis, which is a key risk factor for CVD. Several hypotheses have been proposed to explain how the APOE4 isoform contributes to CVD, including impairing the clearance of lipoproteins, promoting inflammation, and causing endothelial dysfunction. Psychological factors such as stress may also contribute to the development of CVD, and déjà vu may be associated with emotional arousal and stress. Further research is needed to fully understand the link between déjà vu and CVDs and to explore potential treatment options for individuals who experience both conditions.
Topics: Humans; Deja Vu; Cardiovascular Diseases; Temporal Lobe
PubMed: 37172880
DOI: 10.1016/j.cpcardiol.2023.101793 -
The Veterinary Record
Topics: Animals; Dogs; Dangerous Behavior
PubMed: 37594840
DOI: 10.1002/vetr.3395 -
Epileptic Disorders : International... Jun 2022Déjà-vu is a mental phenomenon commonly experienced during temporal lobe seizures and can be evoked by electrical stimulation of the temporal lobe. We analyzed... (Review)
Review
OBJECTIVE
Déjà-vu is a mental phenomenon commonly experienced during temporal lobe seizures and can be evoked by electrical stimulation of the temporal lobe. We analyzed reproducible déjà-vu experiences evoked by stimulating the insula in two patients with pharmacoresistant temporal lobe epilepsy.
METHODS
We reviewed video-electroencephalography (EEG) recordings from extraoperative electrical cortical stimulation sessions. In addition, we performed the directed transfer function (DTF) effective connectivity measure of monopolar signals in Patient 1. To highlight elective changes due to each stimulation, we subtracted pre-stimulation DTF matrices from early poststimulation matrices. This analysis was performed for both non-inducing-déjàvu stimulation (control matrix) and déjà-vu-inducing stimulation (active matrix). Finally, the control matrix was subtracted from the active matrix.
RESULTS
Comparison of effective connectivity during control stimulation versus déjà-vu-inducing stimulation revealed a reversal of connectivity levels in three main regions: the contralateral inferior insula (the ipsilateral insula could not be analyzed), bilateral mesiotemporal regions and the ipsilateral superior frontal gyrus. The drivers of evoked déjà-vu were the mesiotemporal regions (mainly ipsilateral) and the ipsilateral superior frontal gyrus.
SIGNIFICANCE
Although our findings are possibly anecdotal, the insula may (in rare instances) remotely generate unexpected déjà-vu. If confirmed by further studies, this might change the assessment strategy for possible causes of anterior temporal lobectomy failure.
Topics: Deja Vu; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Humans; Temporal Lobe
PubMed: 35770780
DOI: 10.1684/epd.2022.1433 -
Memory (Hove, England) Aug 2021A recent laboratory study by Cleary and Claxton [2018. Déjà vu: An illusion of prediction. , (4), 635-644....
A recent laboratory study by Cleary and Claxton [2018. Déjà vu: An illusion of prediction. , (4), 635-644. http://journals.sagepub.com/doi/full/10.1177/0956797617743018] documented a relationship between déjà vu and feelings of premonition. During instances of retrieval failure, participants reported stronger feelings of prediction during déjà vu than non-déjà vu states, despite displaying no actual predictive ability in such instances. The present study further explored the link between déjà vu reports and feelings of prediction. Although feelings of prediction were more likely to occur during reports of déjà vu than non-déjà vu, they were not the sole defining feature of déjà vu, accounting for just over half of all reported déjà vu states. Instances of déjà vu that were accompanied by feelings of prediction were associated with greater feelings of familiarity than instances that were not. This was shown by a greater likelihood of reporting that the scene felt familiar and also by a higher rated intensity of the feeling of familiarity elicited by the scene when it did feel familiar. Though the present study was mainly descriptive in characterising the interrelations between déjà vu, feelings of prediction, and familiarity, the full pattern points toward the possibility that high familiarity intensity may contribute to the feeling of prediction during déjà vu.
Topics: Deja Vu; Emotions; Humans; Illusions; Recognition, Psychology
PubMed: 30384796
DOI: 10.1080/09658211.2018.1503686