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Alimentary Pharmacology & Therapeutics Apr 2023
PubMed: 36952266
DOI: 10.1111/apt.17444 -
The Behavioral and Brain Sciences Nov 2023On Barzykowski and Moulin's continuum hypothesis, déjà vu and involuntary autobiographical memories (IAMs) share their underpinning neurocognitive processes. A...
On Barzykowski and Moulin's continuum hypothesis, déjà vu and involuntary autobiographical memories (IAMs) share their underpinning neurocognitive processes. A discontinuity issue for them is that familiarity and episodic recollection exhibit different neurocognitive signatures. This issue can be overcome, I say, provided the authors are ready to distinguish a déjà vécu/episodic IAM continuity and a déjà vu/semantic IAM continuity.
Topics: Humans; Recognition, Psychology; Memory, Episodic; Semantics
PubMed: 37961835
DOI: 10.1017/S0140525X23000225 -
Journal of Insurance Medicine (New... Jan 2021
Topics: COVID-19; HIV Infections; Humans; Insurance Carriers; Insurance, Life; SARS-CoV-2; Severe Acute Respiratory Syndrome
PubMed: 33971005
DOI: 10.17849/insm-49-1-5-10.1 -
The Lancet. Infectious Diseases Feb 20235 months into the monkeypox epidemic, there are no proven therapies and no comparative safety and efficacy data in the treatment of affected individuals. The question... (Review)
Review
5 months into the monkeypox epidemic, there are no proven therapies and no comparative safety and efficacy data in the treatment of affected individuals. The question remains whether we, as a scientific and medical community, will apply the lessons learned from the past decade of outbreaks that well conducted randomised controlled trials can be ethically, safely, and efficiently performed to guide clinical decision making so that the right drug is used for the right patient at the right time. Furthermore, the robust level of evidence from randomised controlled trials is highly relevant to advocating for equitable access to new treatments in low-income and middle-income countries. As with COVID-19, we need to pair optimal supportive care with rigorously designed double-blind randomised controlled trials to elucidate safe and effective therapies for monkeypox. The need remains for the funding and development of predesigned, adaptive trial protocols for diseases with epidemic or pandemic potential that can be timely pulled off the shelf and launched early in an outbreak, leveraging ready clinical trial networks and infrastructure for rapid discovery and implementation of new treatments.
Topics: Humans; COVID-19; Mpox (monkeypox); Double-Blind Method; Pandemics; Disease Outbreaks; Randomized Controlled Trials as Topic
PubMed: 36400066
DOI: 10.1016/S1473-3099(22)00722-8 -
The Behavioral and Brain Sciences Nov 2023Barzykowski and Moulin argue that déjà vu is a natural product of autobiographical memory retrieval. Their proposal fails to account for three salient properties of...
Barzykowski and Moulin argue that déjà vu is a natural product of autobiographical memory retrieval. Their proposal fails to account for three salient properties of déjà vu experiences: Their strangeness, their infrequency, and their characteristically sudden onset. Accounting for these properties is necessary for proper integration of déjà vu into autobiographical memory research.
Topics: Humans; Memory, Episodic
PubMed: 37961780
DOI: 10.1017/S0140525X23000237 -
Journal of the American College of... Nov 2023
Topics: Humans; United States; Transcatheter Aortic Valve Replacement; Europe; Aortic Valve Stenosis
PubMed: 37877905
DOI: 10.1016/j.jacc.2023.09.002 -
Annals of Neurology Nov 2023Familial mesial temporal lobe epilepsy (FMTLE) is an important focal epilepsy syndrome; its molecular genetic basis is unknown. Clinical descriptions of FMTLE vary...
OBJECTIVE
Familial mesial temporal lobe epilepsy (FMTLE) is an important focal epilepsy syndrome; its molecular genetic basis is unknown. Clinical descriptions of FMTLE vary between a mild syndrome with prominent déjà vu to a more severe phenotype with febrile seizures and hippocampal sclerosis. We aimed to refine the phenotype of FMTLE by analyzing a large cohort of patients and asked whether common risk variants for focal epilepsy and/or febrile seizures, measured by polygenic risk scores (PRS), are enriched in individuals with FMTLE.
METHODS
We studied 134 families with ≥ 2 first or second-degree relatives with temporal lobe epilepsy, with clear mesial ictal semiology required in at least one individual. PRS were calculated for 227 FMTLE cases, 124 unaffected relatives, and 16,077 population controls.
RESULTS
The age of patients with FMTLE onset ranged from 2.5 to 70 years (median = 18, interquartile range = 13-28 years). The most common focal seizure symptom was déjà vu (62% of cases), followed by epigastric rising sensation (34%), and fear or anxiety (22%). The clinical spectrum included rare cases with drug-resistance and/or hippocampal sclerosis. FMTLE cases had a higher mean focal epilepsy PRS than population controls (odds ratio = 1.24, 95% confidence interval = 1.06, 1.46, p = 0.007); in contrast, no enrichment for the febrile seizure PRS was observed.
INTERPRETATION
FMTLE is a generally mild drug-responsive syndrome with déjà vu being the commonest symptom. In contrast to dominant monogenic focal epilepsy syndromes, our molecular data support a polygenic basis for FMTLE. Furthermore, the PRS data suggest that sub-genome-wide significant focal epilepsy genome-wide association study single nucleotide polymorphisms are important risk variants for FMTLE. ANN NEUROL 2023;94:825-835.
Topics: Humans; Child, Preschool; Child; Adolescent; Young Adult; Adult; Middle Aged; Aged; Epilepsy, Temporal Lobe; Genome-Wide Association Study; Seizures, Febrile; Magnetic Resonance Imaging; Electroencephalography; Syndrome; Hippocampus
PubMed: 37597255
DOI: 10.1002/ana.26765 -
The Behavioral and Brain Sciences Nov 2023Déjà vu and involuntary autobiographical memories (IAMs) are differentiated by a number of factors including metacognition. In contrast to IAMs, déjà vu activates...
Déjà vu and involuntary autobiographical memories (IAMs) are differentiated by a number of factors including metacognition. In contrast to IAMs, déjà vu activates regions associated with self-awareness including the right dorsolateral prefrontal cortex.
Topics: Humans; Deja Vu; Brain; Perception; Metacognition
PubMed: 37961797
DOI: 10.1017/S0140525X23000201 -
The Behavioral and Brain Sciences Nov 2023In our target article, we presented the idea that involuntary autobiographical memories (IAMs) and déjà vu may both be based on the same retrieval processes. Our core...
In our target article, we presented the idea that involuntary autobiographical memories (IAMs) and déjà vu may both be based on the same retrieval processes. Our core claim was thus straightforward: Both can be described as "involuntary" or spontaneous cognitions, where IAMs deliver content and déjà vu delivers only the feeling of retrieval. Our proposal resulted in 27 commentaries covering a broad range of perspectives and approaches. The majority of them have not only amplified our key arguments but also pushed our ideas further by offering extensions, refinements, discussing possible implications and providing additional empirical, neuroscientific and clinical support. The discussion launched by the commentaries proves to us the importance of bringing IAMs and déjà vu into mainstream discussions of memory retrieval processes.
Topics: Humans; Memory, Episodic; Cognition; Emotions
PubMed: 37961810
DOI: 10.1017/S0140525X23002765 -
The British Journal of General Practice... 2021
Topics: Health Status Disparities; Humans
PubMed: 33632678
DOI: 10.3399/bjgp21X714941