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Annals of Allergy, Asthma & Immunology... Aug 2020
Topics: Adult; Aged; Aged, 80 and over; Allergens; Anti-Bacterial Agents; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Intradermal Tests; Male; Middle Aged; Teicoplanin; Young Adult
PubMed: 32416230
DOI: 10.1016/j.anai.2020.05.006 -
Clinics in Chest Medicine Mar 2024Sarcoidosis frequently affects the eye and can do so in many different ways. Sarcoidosis causing uveitis can have distinctive features that facilitate identifying... (Review)
Review
Sarcoidosis frequently affects the eye and can do so in many different ways. Sarcoidosis causing uveitis can have distinctive features that facilitate identifying sarcoidosis as the cause of the uveitis. Progress is being made in elucidating ocular sarcoidosis, as for example, by transcriptomics, genetics, therapy, and imaging.
Topics: Humans; Sarcoidosis; Uveitis
PubMed: 38245371
DOI: 10.1016/j.ccm.2023.08.003 -
Dermatitis : Contact, Atopic,... 2020: Wine, beer, liquor, and spirits are widely consumed in many cultures across the globe, and for some individuals, ingestion, cutaneous contact, or other exposure can... (Review)
Review
: Wine, beer, liquor, and spirits are widely consumed in many cultures across the globe, and for some individuals, ingestion, cutaneous contact, or other exposure can lead to dermatologic findings. However, there currently exist no comprehensive reviews on alcohol-related dermatitis. Herein, we will provide an overview of alcohol-related dermatitis and contact urticaria, including the epidemiology and clinical manifestations, potential allergens found in alcoholic beverages, testing approaches, and strategies for allergen avoidance.
Topics: Alcoholic Beverages; Balsams; Beer; Chromium; Citrus; Cobalt; Dermatitis; Dermatitis, Allergic Contact; Food Preservatives; Gold; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Isothiocyanates; Nickel; Propylene Glycol; Sulfites; Urticaria; Wine
PubMed: 32217881
DOI: 10.1097/DER.0000000000000579 -
The Journal of the Association of... Dec 2020Heerfordt's-Waldenström syndrome is a very rare presentation of neurosarcoidosis characterized by parotid gland enlargement, facial palsy, anterior uveitis and fever....
Heerfordt's-Waldenström syndrome is a very rare presentation of neurosarcoidosis characterized by parotid gland enlargement, facial palsy, anterior uveitis and fever. World over only few cases of this syndrome have been reported. We present such a case of Heerfordt-Waldenström syndrome.
Topics: Central Nervous System Diseases; Facial Paralysis; Humans; Sarcoidosis; Syndrome; Uveoparotid Fever
PubMed: 33247650
DOI: No ID Found -
Clinics in Chest Medicine Mar 2024Diagnosis of sarcoidosis depends on a compatible clinical and imaging presentation, histologic finding of non-necrotizing granulomatous inflammation, and exclusion of... (Review)
Review
Diagnosis of sarcoidosis depends on a compatible clinical and imaging presentation, histologic finding of non-necrotizing granulomatous inflammation, and exclusion of alternative causes of granulomatous diseases. This study has reviewed the diagnostic algorithms and approaches of sarcoidosis.
Topics: Humans; Sarcoidosis, Pulmonary; Sarcoidosis; Diagnostic Imaging; Biopsy
PubMed: 38245363
DOI: 10.1016/j.ccm.2023.06.005 -
Respiratory Medicine and Research Mar 2020Multiple problems may be encountered during the diagnosis of sarcoidosis: at first diagnose sarcoidosis in an appropriate clinical setting, secondly, identify any... (Review)
Review
Multiple problems may be encountered during the diagnosis of sarcoidosis: at first diagnose sarcoidosis in an appropriate clinical setting, secondly, identify any manifestation to be linked to sarcoidosis at diagnosis work-up and during evolution; thirdly, recognize "danger" in sarcoidosis and parasarcoidosis syndromes, and finally, diagnose sarcoidosis recovery. Diagnosis is often delayed as presentation may be diverse, non-specific, or atypical. Diagnosis of sarcoidosis is based on three criteria: a compatible presentation; evidence of non-caseating granulomas and exclusion of any alternative diagnosis. However, even when all criteria are fulfilled, the probability of sarcoidosis diagnosis varies from definite to only possible depending upon the presence of more or less characteristic radio-clinical and histopathological findings and on the epidemiological context. Bilateral hilar lymphadenopathy and/or diffuse lung micronodules mainly along lymphatics are the most frequent highly suggestive findings. Evidence of granulomas relies on superficial biopsies of clinically suspected lesion when present or most often by bronchial endoscopy. The diagnosis of sarcoidosis may be difficult in absence of thoracic or skin manifestations and may require the benefit of hindsight before being definitive. Differential diagnoses, mainly tuberculosis, must be considered. The diagnosis of events during evolution relies on serial clinical, pulmonary function, radiographic evaluation and on extrapulmonary manifestations work-up, including electrocardiogram and blood biology. Affected organs need to be related to sarcoidosis using an appropriate diagnostic assessment instrument. To declare the recovery of sarcoidosis, all manifestations must have disappeared spontaneously or after 3-5 years post-treatment without relapse.
Topics: Bronchoscopy; Diagnosis, Differential; Diagnostic Techniques, Respiratory System; Humans; Sarcoidosis; Sarcoidosis, Pulmonary
PubMed: 32035337
DOI: 10.1016/j.resmer.2019.09.002 -
Clinics in Chest Medicine Mar 2024This article focuses on the monitoring of pulmonary sarcoidosis. The monitoring of sarcoidosis is, in part, focused on serial change in major organ involvement but also... (Review)
Review
This article focuses on the monitoring of pulmonary sarcoidosis. The monitoring of sarcoidosis is, in part, focused on serial change in major organ involvement but also includes diagnostic re-evaluation and review of change in quality of life. Recent criteria for progression of fibrotic interstitial lung disease are adapted to pulmonary sarcoidosis. The frequency and nature of monitoring are discussed, integrating baseline risk stratification and strategic treatment goals. Individual variables used to identify changes in pulmonary disease severity are discussed with a focus on their flaws and the need for a multidimensional approach. Other key monitoring issues are covered briefly.
Topics: Humans; Sarcoidosis, Pulmonary; Quality of Life; Sarcoidosis; Lung Diseases, Interstitial; Lung
PubMed: 38245370
DOI: 10.1016/j.ccm.2023.08.002 -
Frontiers in Immunology 2023Major histocompatibility complex (MHC) class Ib molecules present antigens to subsets of T cells primarily involved in host defense against pathogenic microbes and...
Major histocompatibility complex (MHC) class Ib molecules present antigens to subsets of T cells primarily involved in host defense against pathogenic microbes and influence the development of immune-mediated diseases. The MHC class Ib molecule MHC-related protein 1 (MR1) functions as a platform to select MR1-restricted T cells, including mucosal-associated invariant T (MAIT) cells in the thymus, and presents ligands to them in the periphery. MAIT cells constitute an innate-like T-cell subset that recognizes microbial vitamin B metabolites and plays a defensive role against microbes. In this study, we investigated the function of MR1 in allergic contact dermatitis (ACD) by examining wild-type (WT) and MR1-deficient (MR1) mice in which ACD was induced with 2,4-dinitrofluorobenzene (DNFB). MR1 mice exhibited exaggerated ACD lesions compared with WT mice. More neutrophils were recruited in the lesions in MR1 mice than in WT mice. WT mice contained fewer MAIT cells in their skin lesions following elicitation with DNFB, and MR1 mice lacking MAIT cells exhibited a significant increase in IL-17-producing αβ and γδ T cells in the skin. Collectively, MR1 mice displayed exacerbated ACD from an early phase with an enhanced type 3 immune response, although the precise mechanism of this enhancement remains elusive.
Topics: Animals; Mice; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Histocompatibility Antigens Class I; Interleukin-17; Minor Histocompatibility Antigens
PubMed: 37409131
DOI: 10.3389/fimmu.2023.1215478 -
MMW Fortschritte Der Medizin Oct 2023
Review
Topics: Humans; Sarcoidosis, Pulmonary; Sarcoidosis
PubMed: 37828333
DOI: 10.1007/s15006-023-2845-8 -
Allergy, Asthma, and Clinical... Apr 2023With ongoing COVID-19 vaccination schedules and the popularity of cosmetic fillers, it is important to examine and record associated adverse reactions to a more general...
BACKGROUND
With ongoing COVID-19 vaccination schedules and the popularity of cosmetic fillers, it is important to examine and record associated adverse reactions to a more general audience of health care professionals. Case reports exist in subspecialty journals outlining reactions after SARS-CoV-2 infection and vaccination. This is one of the first cases published in Canada, and it highlights priorities and challenges faced by physicians in assessing and managing patients presenting with adverse reactions post vaccination.
CASE PRESENTATION
We present a case of a 43 -year-old women with delayed type 4 hypersensitivity reaction to hyaluronic acid cosmetic filler triggered by COVID-19 mRNA vaccination. We outline the clinical presentation, diagnosis, complications, and treatment of a late inflammatory reaction to hyaluronic acid filler and highlight the treatment priorities for clinicians faced with similar presentations.
CONCLUSION
The differential diagnosis of delayed onset nodules formation post filler injection is broad and includes redistribution of fillers, inflammatory reaction to biofilm, and delayed hypersensitivity reaction. As result, in order to make the right diagnosis, administer the appropriate treatment and achieve great cosmetic results, we highly recommend seeking expert opinion from dermatologist, plastic surgeon and allergist immunologist in a timely manner.
PubMed: 37076880
DOI: 10.1186/s13223-023-00788-1