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Nature Aug 2019
Topics: Cannabidiol; Cannabis; Double-Blind Method; Dronabinol; Drug Combinations; Humans; Motor Neuron Disease
PubMed: 31462792
DOI: 10.1038/d41586-019-02532-5 -
Journal of Nuclear Cardiology :... Dec 2020
Topics: Double-Blind Method; Humans; Perfusion Imaging; Technetium Tc 99m Sestamibi; Tomography, X-Ray Computed; Ursodeoxycholic Acid
PubMed: 30825111
DOI: 10.1007/s12350-019-01663-6 -
Nederlands Tijdschrift Voor Geneeskunde Sep 2021Personalized care is a topical issue: the demand for an optimal, individualized treatment instead of uniformity and strict guidelines in increasing. Implementing these...
Personalized care is a topical issue: the demand for an optimal, individualized treatment instead of uniformity and strict guidelines in increasing. Implementing these ideals in clinical practice often appears to be challenging, as a result of heterogeneity in treatment effects and the influence of patient-specific factors. N-of-1 trials are double-blind, randomized, placebo-controlled trials in an individual patient and can be used to objectively examine the (side)effects of a specific drug, and to compare two or more drugs or variants of the same drug. The results can be used when aiming of deprescribing, but also for evaluating patient-reported intolerances or (in)effectiveness. This article discusses the use and advantages of N-of-1-trials in clinical practice, and addresses its specific concerns and possibilities. The N-of-1-trial is an effective, cost-reducing method to evaluate the effects of a certain drug, which is accessible to nearly every physician and can contribute to safe and effective personalized medicine.
Topics: Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Humans; Randomized Controlled Trials as Topic
PubMed: 34854642
DOI: No ID Found -
American Journal of Respiratory and... May 2022
Topics: Chronic Disease; Cough; Double-Blind Method; Humans; Idiopathic Pulmonary Fibrosis
PubMed: 35202560
DOI: 10.1164/rccm.202201-0083ED -
Expert Review of Anticancer Therapy Apr 2021This evaluation emphasizes the main points of the original article 'Position paper: new insights into the immunobiology and dynamics of tumor-host interactions require...
This evaluation emphasizes the main points of the original article 'Position paper: new insights into the immunobiology and dynamics of tumor-host interactions require adaptations of clinical studies' by Sprenger et al. and provides further justification for the use of an alternative approach in the design of human clinical trials for new investigational drugs in the field of immuno-oncology. Standard trial design utilizing the double blind placebo trial approach, while effective for drugs that directly treat tumors, is too costly, slow, and not effective for drugs and protocols that depend on activation of the immune system for killing of tumors. This paper has proposed through the use of detailed diagnostic profiling, small groups of patients with similar tumor microenvironment characteristics be grouped to determine the clinical benefit of immunological combinations that enter clinical trials. In addition, mega data from larger trials in which patients are subcategorized as above can provide the necessary data as a substitute for current double blind placebo trials which do not take into account the immune status of the host and tumor. There needs to be evolution of the clinical trial landscape so that it matches the exponential growth of the field of immunotherapy.
Topics: Double-Blind Method; Humans; Immunotherapy; Neoplasms; Tumor Microenvironment
PubMed: 33435760
DOI: 10.1080/14737140.2021.1875822 -
Anaesthesia Jun 2020
Topics: Anesthetics; Cross-Over Studies; Double-Blind Method; Neuromuscular Blockade; Sugammadex
PubMed: 32383511
DOI: 10.1111/anae.15002 -
Indian Journal of Gastroenterology :... Oct 2023
Topics: Humans; Crohn Disease; Double-Blind Method
PubMed: 37145231
DOI: 10.1007/s12664-023-01355-7 -
Zhongguo Zhen Jiu = Chinese Acupuncture... Mar 2022This device is an auxiliary device with reasonable design for placebo acupuncture research, so as to make double-blind placebo acupuncture control possible. This new...
This device is an auxiliary device with reasonable design for placebo acupuncture research, so as to make double-blind placebo acupuncture control possible. This new auxiliary acupuncture device includes an acupuncture device and a placebo acupuncture device with exactly the same appearance. Both of them are composed of a hemispherical base and a telescopic tube. Through the rotation of the telescopic tube in the notch of the base, the insertion angle of needles can be adjusted from 15 degrees to 165 degrees. The operation of twisting and lifting and inserting can be carried out through the horizontal rotation and vertical sliding of the telescopic tube. A silicone needle pad is arranged in the base, which can simulate the blocking feeling of skin and muscle during needle insertion. The bottom of the base is attached with hydrogel, which has good fixity. The auxiliary device is applicable to multiple parts of the human body and can effectively reduce the risk of unblinding.
Topics: Acupuncture Therapy; Biomedical Research; Double-Blind Method; Humans; Needles; Skin
PubMed: 35272418
DOI: 10.13703/j.0255-2930.20210227-k0001 -
Anaesthesia May 2020
Topics: Anesthetics; Animals; Cross-Over Studies; Double-Blind Method; Gryllidae; Neuromuscular Blockade; Sugammadex
PubMed: 31808146
DOI: 10.1111/anae.14907 -
Surgery For Obesity and Related... Sep 2019
Topics: Anesthesia, Intravenous; Bariatric Surgery; Desflurane; Double-Blind Method; Humans; Nausea; Pain
PubMed: 31405816
DOI: 10.1016/j.soard.2019.06.035