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The Journal of Craniofacial SurgeryTo investigate the clinical characteristics of oral and maxillofacial tumors in children and adolescents.
PURPOSE
To investigate the clinical characteristics of oral and maxillofacial tumors in children and adolescents.
METHODS
This is a retrospective study of patients who had oral and maxillofacial tumors under the age of 18 years and were treated at the Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology from January 1990 to July 2021 (31 y). Their general conditions, pathological diagnosis, gender, age, and anatomical location were counted to analyze their morbidity and composition characteristics.
RESULTS
This study contained 5405 cases, including 2903 male patients and 2502 female patients, with a median age of 9 years. Peak incidence was observed in the 14 to 18 years age group. The mandible (22.15%), maxilla (11.75%), and tongue (9.25%) were the most common sites of incidence. Malignant and intermediate type tumors accounted for 13.04%, benign tumors and tumor-like lesions for 55.67%, most often occurs in the maxillofacial bone, of which fibro-osseous lesions constitute an important part. Cysts accounted for 31.29%. Among the tumors occurring in the jaws, the most common malignant type was sarcoma, and ameloblastoma was the most common benign tumor. Malignant jaw tumors were mostly treated by resection, 10.64% by fibular flap reconstruction. While benign jaw tumors and tumor-like lesions were mostly treated by resection or curettage.
CONCLUSIONS
The distribution of anatomical location and pathological types of oral and maxillofacial tumors in children has certain characteristics, so that the selection of their treatment options is different from that of adults due to the consideration of the growth and developmental characteristics of children.
Topics: Adult; Humans; Child; Male; Female; Adolescent; Retrospective Studies; Jaw Neoplasms; Ameloblastoma; Surgery, Oral; Soft Tissue Neoplasms
PubMed: 37271868
DOI: 10.1097/SCS.0000000000009371 -
BMJ Case Reports Oct 2020Hemangiopericytoma (HPC) is a rare vascular tumour and difficult to diagnose clinically. Incidence is reported in fourth to fifth decade of life.With female...
Hemangiopericytoma (HPC) is a rare vascular tumour and difficult to diagnose clinically. Incidence is reported in fourth to fifth decade of life.With female predominance, 3%-5% cases affect the oral cavity, sinus lining and meninges. The patient presented with 8×6 cm swelling on her face, evaluation reported it to be HPC. Bilateral maxillary artery embolisation, wide local excision of the lesion, preserving the left eye and its function, was done. No recurrence is reported at 1-year follow-up. Response of such lesions to radiotherapy is questionable; with no lymphadenopathy and adequate encapsulation, embolisation of feeder vessel followed by a wide local excision of the lesion seems to be a fairly good option of treatment.
Topics: Adult; Diagnosis, Differential; Female; Hemangiopericytoma; Humans; Maxilla; Maxillary Neoplasms; Neurosurgical Procedures; Nose; Nose Neoplasms; Orbit; Orbital Neoplasms; Tomography, X-Ray Computed; Ultrasonography
PubMed: 33012722
DOI: 10.1136/bcr-2020-239135 -
Oral Surgery, Oral Medicine, Oral... Feb 2023
Topics: Humans; Mandible; Mandibular Neoplasms; Diagnosis, Differential
PubMed: 36229371
DOI: 10.1016/j.oooo.2022.06.015 -
Virchows Archiv : An International... Jan 2020According to the WHO, mesenchymal tumours of the maxillofacial bones are subdivided in benign and malignant maxillofacial bone and cartilage tumours, fibro-osseous and... (Review)
Review
According to the WHO, mesenchymal tumours of the maxillofacial bones are subdivided in benign and malignant maxillofacial bone and cartilage tumours, fibro-osseous and osteochondromatous lesions as well as giant cell lesions and bone cysts. The histology always needs to be evaluated considering also the clinical and radiological context which remains an important cornerstone in the classification of these lesions. Nevertheless, the diagnosis of maxillofacial bone tumours is often challenging for radiologists as well as pathologists, while an accurate diagnosis is essential for adequate clinical decision-making. The integration of new molecular markers in a multidisciplinary diagnostic approach may not only increase the diagnostic accuracy but potentially also identify new druggable targets for precision medicine. The current review provides an overview of the clinicopathological and molecular findings in maxillofacial bone tumours and discusses the diagnostic value of these genetic aberrations.
Topics: Chondrosarcoma; Facial Bones; Fibrous Dysplasia of Bone; Granuloma, Giant Cell; Humans; Maxillary Neoplasms; Skull Neoplasms
PubMed: 31838586
DOI: 10.1007/s00428-019-02726-2 -
European Annals of Otorhinolaryngology,... Dec 2021
Topics: Humans; Palatal Neoplasms; Palate
PubMed: 33933402
DOI: 10.1016/j.anorl.2021.04.002 -
Journal of the American Veterinary... Aug 2019
Topics: Animals; Carcinoma, Squamous Cell; Cat Diseases; Cats; Female; Mandibular Neoplasms
PubMed: 31298650
DOI: 10.2460/javma.255.3.309 -
Oral Oncology Nov 2023Although complete excision is the standard of care for ameloblastoma, a subset of recurrent and/or metastasizing ameloblastomas are difficult to treat surgically. Over... (Review)
Review
Although complete excision is the standard of care for ameloblastoma, a subset of recurrent and/or metastasizing ameloblastomas are difficult to treat surgically. Over the past decade, several recurrent mutations in the mitogen-activated protein kinase pathway genes have been identified in ameloblastoma, based on which the efficacy of targeted therapy has been investigated. However, most of the literature has focused on BRAF V600E mutations, the most common oncogenic mutations in ameloblastoma. Hence, this study aims to review the current knowledge of targetable genetic alterations in ameloblastoma from a broader perspective. In addition, the therapeutic potential of immunotherapy for ameloblastoma will be briefly discussed in the context of tumoral PD-L1 expression and the tumor immune microenvironment.
Topics: Humans; Ameloblastoma; Precision Medicine; Jaw Neoplasms; Proto-Oncogene Proteins B-raf; Mutation; Tumor Microenvironment
PubMed: 37816291
DOI: 10.1016/j.oraloncology.2023.106585 -
Head and Neck Pathology Jun 2020The goal of this study was to investigate the immunolocalization of inositol 1,4,5-trisphosphate receptor (IP3R) and vacuolar ATPase (V-ATPase) in ameloblastomas with...
The goal of this study was to investigate the immunolocalization of inositol 1,4,5-trisphosphate receptor (IP3R) and vacuolar ATPase (V-ATPase) in ameloblastomas with special attention to the invasive front. Thirty-seven cases of previously diagnosed formalin-fixed paraffin-embedded (FFPE) human ameloblastoma samples were selected for this study. The samples were grouped according to the predominant histologic pattern and comprised twelve plexiform, eighteen follicular, and seven unicystic ameloblastomas. Of the unicystic variants, six demonstrated purely luminal and intraluminal growth, and one displayed mural extension. One granular cell variant was included in the follicular ameloblastoma group. All specimens were evaluated for IP3R and V-ATPase expression by immunohistochemistry (IHC). IP3R was positive in columnar cells, similar to ameloblasts, and non-peripheral cells in all samples. In the area of tumor protrusion and front of invasion, membranous and cystoplasmic IP3R expression was observed. In contrast, areas adjacent to tumoral protrusion demonstrated only membranous staining patterns. V-ATPase was not expressed in peripheral columnar cells of the unicystic and granular cell variants of ameloblastoma; however, strong staining was present in these cells in plexiform ameloblastomas, follicular ameloblastomas, and areas of mural growth of unicystic ameloblastomas. In areas of tumor protrusion, reactivity for V-ATPase was observed with both membranous and cytoplasmic staining, while other areas showed only membranous V-ATPase. These findings suggest that concomitant immunolocalization of IP3R and V-ATPase, with both cytoplasmic and membranous expression in the peripheral columnar cells, may indicate the invasive potential of ameloblastomas. Furthermore, these results suggest the tumoral spread of ameloblastomas may be correlated with the autophagy process and channelopathy. The expression of these proteins could establish a baseline for future research and provide therapeutic targets for treatment of ameloblastomas.
Topics: Ameloblastoma; Biomarkers, Tumor; Humans; Immunohistochemistry; Inositol 1,4,5-Trisphosphate Receptors; Jaw Neoplasms; Vacuolar Proton-Translocating ATPases
PubMed: 31183746
DOI: 10.1007/s12105-019-01044-y -
The Journal of Craniofacial Surgery 2020Ameloblastoma is the second most common odontogenic tumor arising in the maxillary bones. The WHO classified ameloblastoma in: solid/multicystic (SMA); unicystic;...
Ameloblastoma is the second most common odontogenic tumor arising in the maxillary bones. The WHO classified ameloblastoma in: solid/multicystic (SMA); unicystic; peripheral and desmoplastic. A conservative or radical approach may be performed for SMA treatment to achieve total excision of the lesion.In this case report, a 47-year-old woman, presented a deformation of the left mandibular region and paresthesia of the left hemi-labium, at the ortopanoramic x-ray (OPT) a multilocular osteolytic lesion and the rhizalysis of dental elements 3.7, 3.6, 3.5, 3.4 and the inclusion of 3.8 was appreciated; the CT exam showed erosion of the mandibular canal roof and of the vestibular cortex in the mental nerve region. The patient was subjected to the extraction of the elements in rhizalysis and of 3.8 and subsequently to the enucleation of the lesion followed by an extensive peripheral ostectomy performed with a piezoelectric device. The patient underwent to OPT and CT examinations follow-up and after 5 years was subjected to implant surgery, at the same time of the implant's placement, bone biopsies were performed using core drills in order to evaluate the bone histologically. The patient showed complete clinical and radiographic healing; the histological examination demonstrates the formation of lamellar bone.
Topics: Ameloblastoma; Biopsy, Fine-Needle; Chin; Dermabrasion; Female; Humans; Mandibular Neoplasms; Microsurgery; Middle Aged; Wound Healing
PubMed: 31842085
DOI: 10.1097/SCS.0000000000005903 -
Journal of Stomatology, Oral and... Jun 2022
Topics: Aged; Female; Humans; Mandible; Mandibular Neoplasms; Radiography, Panoramic
PubMed: 34186227
DOI: 10.1016/j.jormas.2021.06.014