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ACS Nano Dec 2022Magnetic nanorobotic swarms can mimic collective functions of organisms in nature and be programmed for flexible spatiotemporal control. In this work, different...
Magnetic nanorobotic swarms can mimic collective functions of organisms in nature and be programmed for flexible spatiotemporal control. In this work, different assemblies of magnetic nanoparticle (MNP) swarms were constructed. Temperature-sensitive hydrogels were used as carriers to fix the distribution and ensure the stability of the swarm structure and the biocompatibility of the microrobot. Under three different outfield assembly strategies (gravitational field, gradient magnetic field, and uniform magnetic field), six different assembly modes of MNP are encapsulated (three unilateral unfolding assemblies with different microsphere profiles, unilateral chain assembly, and two symmetric chain assemblies with different magnetic chain positions). Their differences in the execution of motion, magnetothermal effects, and release of loaded DOX drugs were explored. The results showed that the symmetrical chain assembly with the magnetic chain distributed on the outside showed the best performance due to the advantage of the magnetic moment. It has a speed of up to 600 μm/s and a temperature rise rate of up to 1.5 °C/min. The present work provides an excellent solution to the poor MNP cluster distribution stability problem and enriches the assembly control scheme of microrobots in medical, catalytic, and three-dimensional-printing fields.
Topics: Hydrogels; Magnetic Fields; Magnetics; Motion; Microspheres
PubMed: 36469837
DOI: 10.1021/acsnano.2c08626 -
Journal of Comparative Physiology. A,... Jan 2022As the largest and most diverse vertebrate group on the planet, fishes have evolved an impressive array of sensory abilities to overcome the challenges associated with... (Review)
Review
As the largest and most diverse vertebrate group on the planet, fishes have evolved an impressive array of sensory abilities to overcome the challenges associated with navigating the aquatic realm. Among these, the ability to detect Earth's magnetic field, or magnetoreception, is phylogenetically widespread and used by fish to guide movements over a wide range of spatial scales ranging from local movements to transoceanic migrations. A proliferation of recent studies, particularly in salmonids, has revealed that fish can exploit Earth's magnetic field not only as a source of directional information for maintaining consistent headings, but also as a kind of map for determining location at sea and for returning to natal areas. Despite significant advances, much about magnetoreception in fishes remains enigmatic. How fish detect magnetic fields remains unknown and our understanding of the evolutionary origins of vertebrate magnetoreception would benefit greatly from studies that include a wider array of fish taxa. The rich diversity of life-history characteristics that fishes exhibit, the wide variety of environments they inhabit, and their suitability for manipulative studies, make fishes promising subjects for magnetoreception studies.
Topics: Animal Migration; Animals; Fishes; Humans; Magnetic Fields; Magnetics; Sensation
PubMed: 35031832
DOI: 10.1007/s00359-021-01527-w -
Journal of the Royal Society, Interface Aug 2022Hundreds of studies have found that weak magnetic fields can significantly influence various biological systems. However, the underlying mechanisms behind these... (Review)
Review
Hundreds of studies have found that weak magnetic fields can significantly influence various biological systems. However, the underlying mechanisms behind these phenomena remain elusive. Remarkably, the magnetic energies implicated in these effects are much smaller than thermal energies. Here, we review these observations, and we suggest an explanation based on the radical pair mechanism, which involves the quantum dynamics of the electron and nuclear spins of transient radical molecules. While the radical pair mechanism has been studied in detail in the context of avian magnetoreception, the studies reviewed here show that magnetosensitivity is widespread throughout biology. We review magnetic field effects on various physiological functions, discussing static, hypomagnetic and oscillating magnetic fields, as well as isotope effects. We then review the radical pair mechanism as a potential unifying model for the described magnetic field effects, and we discuss plausible candidate molecules for the radical pairs. We review recent studies proposing that the radical pair mechanism provides explanations for isotope effects in xenon anaesthesia and lithium treatment of hyperactivity, magnetic field effects on the circadian clock, and hypomagnetic field effects on neurogenesis and microtubule assembly. We conclude by discussing future lines of investigation in this exciting new area of quantum biology.
Topics: Animals; Biology; Birds; Magnetic Fields
PubMed: 35919980
DOI: 10.1098/rsif.2022.0325 -
Optomagnetic biosensors: Volumetric sensing based on magnetic actuation-induced optical modulations.Biosensors & Bioelectronics Nov 2022In comparison to alternative nanomaterials, magnetic micron/nano-sized particles show unique advantages, e.g., easy manipulation, stable signal, and high contrast. By... (Review)
Review
In comparison to alternative nanomaterials, magnetic micron/nano-sized particles show unique advantages, e.g., easy manipulation, stable signal, and high contrast. By applying magnetic actuation, magnetic particles exert forces on target objects for highly selective operation even in non-purified samples. We herein describe a subgroup of magnetic biosensors, namely optomagnetic biosensors, which employ alternating magnetic fields to generate periodic movements of magnetic labels. The optical modulation induced by the dynamics of magnetic labels is then analyzed by photodetectors, providing information of, e.g., hydrodynamic size changes of the magnetic labels. Optomagnetic sensing mechanisms can suppress the noise (by performing lock-in detection), accelerate the reaction (by magnetic force-enhanced molecular collision), and facilitate homogeneous/volumetric detection. Moreover, optomagnetic sensing can be performed using a low magnetic field (<10 mT) without sophisticated light sources or pickup coils, further enhancing its applicability for point-of-care tests. This review concentrates on optomagnetic biosensing techniques of different concepts classified by the magnetic actuation strategy, i.e., magnetic field-enhanced agglutination, rotating magnetic field-based particle rotation, and oscillating magnetic field-induced Brownian relaxation. Optomagnetic sensing principles applied with different actuation strategies are introduced as well. For each representative optomagnetic biosensor, a simple immunoassay strategy-based application is introduced (if possible) for methodological comparison. Thereafter, challenges and perspectives are discussed, including minimization of nonspecific binding, on-chip integration, and multiplex detection, all of which are key requirements in point-of-care diagnostics.
Topics: Biosensing Techniques; Immunoassay; Magnetic Fields; Magnetics; Magnetite Nanoparticles
PubMed: 35841765
DOI: 10.1016/j.bios.2022.114560 -
Scientific Reports May 2022Numerous organisms use the Earth's magnetic field as a sensory cue for migration, body alignment, or food search. Despite some contradictory reports, yet it is generally...
Numerous organisms use the Earth's magnetic field as a sensory cue for migration, body alignment, or food search. Despite some contradictory reports, yet it is generally accepted that humans do not sense the geomagnetic field. Here, we demonstrate that a magnetic field resonance mechanism mediates light-dependent magnetic orientation in men, using a rotary chair experiment combined with a two-alternative forced choice paradigm. Two groups of subjects were classified with different magnetic orientation tendencies depending on the food context. Magnetic orientation of the subjects was sensitive to the wavelength of incident light and was critically dependent on blue light reaching the eyes. Importantly, it appears that a magnetic field resonance-dependent mechanism mediates these responses, as evidenced by disruption or augmentation of the ability to orient by radiofrequency magnetic fields at the Larmor frequency and the dependence of these effects on the angle between the radiofrequency and geomagnetic fields. Furthermore, inversion of the vertical component of the geomagnetic field revealed a non-canonical inclination compass effect on the magnetic orientation. These results establish the existence of a human magnetic sense and suggest an underlying quantum mechanical magnetoreception mechanism.
Topics: Humans; Magnetic Fields; Magnetics; Male; Orientation; Radio Waves; Vibration
PubMed: 35637212
DOI: 10.1038/s41598-022-12460-6 -
Food Research International (Ottawa,... Apr 2023The novel freezing technologies including electrostatic field assisted freezing (EF), static magnetic field assisted freezing (MF), electrostatic field combined with...
The novel freezing technologies including electrostatic field assisted freezing (EF), static magnetic field assisted freezing (MF), electrostatic field combined with static magnetic field assisted freezing (EMF) were conducted on model food to facilitate comparing their application effect. The results show that the effect of EMF treatment was best, which significantly changed the freezing parameters of the sample. Compared with the control, the phase transition time and total freezing time were shortened by 17.2% and 10.5%, respectively; the proportion of the sample free water content detected by low-field nuclear magnetic resonance was significantly decreased; the gel strength and hardness were significantly improved; the protein secondary and tertiary structures were better maintained; the ice crystal area was reduced by 49.28%. Inverted fluorescence and scanning electron microscopic results indicated that the gel structure of EMF treatment samples was better than MF and EF. MF was less effective in maintaining the quality of frozen gel model.
Topics: Freezing; Food Preservation; Food; Magnetic Resonance Spectroscopy; Magnetic Fields
PubMed: 36914313
DOI: 10.1016/j.foodres.2023.112566 -
Cells Mar 2022The importance of magnetic micro- and nanoparticles for applications in biomedical technology is widely recognised. Many of these applications, including tissue... (Review)
Review
The importance of magnetic micro- and nanoparticles for applications in biomedical technology is widely recognised. Many of these applications, including tissue engineering, cell sorting, biosensors, drug delivery, and lab-on-chip devices, require remote manipulation of magnetic objects. High-gradient magnetic fields generated by micromagnets in the range of 10-10 T/m are sufficient for magnetic forces to overcome other forces caused by viscosity, gravity, and thermal fluctuations. In this paper, various magnetic systems capable of generating magnetic fields with required spatial gradients are analysed. Starting from simple systems of individual magnets and methods of field computation, more advanced magnetic microarrays obtained by lithography patterning of permanent magnets are introduced. More flexible field configurations can be formed with the use of soft magnetic materials magnetised by an external field, which allows control over both temporal and spatial field distributions. As an example, soft magnetic microwires are considered. A very attractive method of field generation is utilising tuneable domain configurations. In this review, we discuss the force requirements and constraints for different areas of application, emphasising the current challenges and how to overcome them.
Topics: Cell Separation; Magnetic Fields; Magnetics; Magnets; Nanoparticles
PubMed: 35326401
DOI: 10.3390/cells11060950 -
International Journal of Molecular... Sep 2022The magneto-mechanical approach is a powerful technique used in many different applications in biomedicine, including remote control enzyme activity, cell receptors,... (Review)
Review
The magneto-mechanical approach is a powerful technique used in many different applications in biomedicine, including remote control enzyme activity, cell receptors, cancer-selective treatments, mechanically-activated drug releases, etc. This approach is based on the use of a combination of magnetic nanoparticles and external magnetic fields that have led to the movement of such nanoparticles with torques and forces (enough to change the conformation of biomolecules or even break weak chemical bonds). However, despite many theoretical and experimental works on this topic, it is difficult to predict the magneto-mechanical effects in each particular case, while the important results are scattered and often cannot be translated to other experiments. The main reason is that the magneto-mechanical effect is extremely sensitive to changes in any parameter of magnetic nanoparticles and the environment and changes in the parameters of the applied magnetic field. Thus, in this review, we (1) summarize and propose a simplified theoretical explanation of the main factors affecting the efficiency of the magneto-mechanical approach; (2) discuss the nature of the MNP-mediated mechanical forces and their order of magnitude; (3) show some of the main applications of the magneto-mechanical approach in the control over the properties of biological systems.
Topics: Magnetic Fields; Magnetics; Nanoparticles
PubMed: 36232435
DOI: 10.3390/ijms231911134 -
Progress in Biophysics and Molecular... Mar 2023As one of the common variable magnetic fields, rotating magnetic field (RMF) plays a crucial role in modern human society. The biological effects of RMF have been... (Review)
Review
As one of the common variable magnetic fields, rotating magnetic field (RMF) plays a crucial role in modern human society. The biological effects of RMF have been studied for over half a century, and various results have been discovered. Several reports have shown that RMF can inhibit the growth of various types of cancer cells in vitro and in vivo and improve clinical symptoms of patients with advanced cancer. It can also affect endogenous opioid systems and rhythm in central nerve systems, promote nerve regeneration and regulate neural electrophysiological activity in the human brain. In addition, RMF can influence the growth and metabolic activity of some microorganisms, alter the properties of fermentation products, inhibit the growth of some harmful bacteria and increase the susceptibility of antibiotic-resistant bacteria to common antibiotics. Besides, there are other biological effects of RMF on blood, bone, prenatal exposure, enzyme activity, immune function, aging, parasite, endocrine, wound healing, and plants. These discoveries demonstrate that RMF have great application potential in health care, medical treatment, fermentation engineering, and even agriculture. However, in some cases like pregnancy, RMF exposure may need to be avoided. Finally, the specific mechanisms of RMF's biological effects remain unrevealed, despite various hypotheses and theories. It does not prevent us from using it for our good.
Topics: Humans; Rotation; Aging; Bone and Bones; Anti-Bacterial Agents; Magnetic Fields
PubMed: 36574882
DOI: 10.1016/j.pbiomolbio.2022.12.006 -
Drug Delivery Dec 2023Magnetic Drug Targeting (MDT) is of particular interest to researchers because of its good loading efficiency, targeting accuracy, and versatile use in vivo.... (Review)
Review
Magnetic Drug Targeting (MDT) is of particular interest to researchers because of its good loading efficiency, targeting accuracy, and versatile use in vivo. Cardiovascular Disease (CVD) is a global chronic disease with a high mortality rate, and the development of more precise and effective treatments is imminent. A growing number of studies have begun to explore the feasibility of MDT in CVD, but an up-to-date systematic summary is still lacking. This review discusses the current research status of MDT from guiding magnetic fields, magnetic nanocarriers, delivery channels, drug release control, and safety assessment. The current application status of MDT in CVD is also critically introduced. On this basis, new insights into the existing problems and future optimization directions of MDT are further highlighted.
Topics: Humans; Cardiovascular Diseases; Drug Delivery Systems; Drug Liberation; Magnetic Fields
PubMed: 37702067
DOI: 10.1080/10717544.2023.2256495