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Journal of Magnetic Resonance Imaging :... Aug 2022
Topics: Humans; Magnetic Fields; Magnetic Resonance Imaging
PubMed: 34989441
DOI: 10.1002/jmri.28060 -
IEEE Transactions on Medical Imaging Aug 2021This paper describes a high-resolution 3D navigation and tracking system using magnetic field gradients, that can replace X-Ray fluoroscopy in high-precision surgeries....
This paper describes a high-resolution 3D navigation and tracking system using magnetic field gradients, that can replace X-Ray fluoroscopy in high-precision surgeries. Monotonically varying magnetic fields in X, Y and Z directions are created in the field-of-view (FOV) to produce magnetic field gradients, which encode each spatial point uniquely. Highly miniaturized, wireless and battery-less devices, capable of measuring their local magnetic field, are designed to sense the gradient field. One such device can be attached to an implant inside the body and another to a surgical tool, such that both can simultaneously measure and communicate the magnetic field at their respective locations to an external receiver. The relative location of the two devices on a real-time display can enable precise surgical navigation without using X-Rays. A prototype device is designed consisting of a micro-chip fabricated in 65nm CMOS technology, a 3D magnetic sensor and an inductor-coil. Planar electromagnetic coils are designed for creating the 3D magnetic field gradients in a 20×20×10 cm of scalable FOV. Unambiguous and orientation-independent spatial encoding is achieved by: (i) using the gradient in the total field magnitude instead of only the Z-component; and (ii) using a combination of the gradient fields to correct for the non-linearity and non-monotonicity in X and Y gradients. The resultant X and Y FOV yield ≥90% utilization of their respective coil-span. The system is tested in vitro to demonstrate a localization accuracy of m in 3D, the highest reported to the best of our knowledge.
Topics: Electromagnetic Phenomena; Equipment Design; Fluoroscopy; Humans; Magnetic Fields; Magnetic Resonance Imaging; Magnetics; Surgery, Computer-Assisted
PubMed: 33819153
DOI: 10.1109/TMI.2021.3071120 -
Medical Physics Jul 2023The integration of magnetic resonance tomography into clinical linear accelerators provides high-contrast, real-time imaging during treatment and facilitates...
BACKGROUND
The integration of magnetic resonance tomography into clinical linear accelerators provides high-contrast, real-time imaging during treatment and facilitates online-adaptive workflows in radiation therapy treatments. The associated magnetic field also bends the trajectories of charged particles via the Lorentz force, which may alter the dose distribution in a patient or a phantom and affects the dose response of dosimetry detectors.
PURPOSE
To perform an experimental and Monte Carlo-based determination of correction factors , which correct the response of ion chambers in the presence of external magnetic fields in high-energy photon fields.
METHODS
The response variation of two different types of ion chambers (Sun Nuclear SNC125c and SNC600c) in strong external magnetic fields was investigated experimentally and by Monte Carlo simulations. The experimental data were acquired at the German National Metrology Institute, PTB, using a clinical linear accelerator with a nominal photon energy of 6 MV and an external electromagnet capable of generating magnetic flux densities of up to 1.5 T in opposite directions. The Monte Carlo simulation geometries corresponded to the experimental setup and additionally to the reference conditions of IAEA TRS-398. For the latter, the Monte Carlo simulations were performed with two different photon spectra: the 6 MV spectrum of the linear accelerator used for the experimental data acquisition and a 7 MV spectrum of a commercial MRI-linear accelerator. In each simulation geometry, three different orientations of the external magnetic field, the beam direction and the chamber orientation were investigated.
RESULTS
Good agreement was achieved between Monte Carlo simulations and measurements with the SNC125c and SNC600c ionization chambers, with a mean deviation of 0.3% and 0.6%, respectively. The magnitude of the correction factor strongly depends on the chamber volume and on the orientation of the chamber axis relative to the external magnetic field and the beam directions. It is greater for the SNC600c chamber with a volume of 0.6 cm than for the SNC125c chamber with a volume of 0.1 cm . When the magnetic field direction and the chamber axis coincide, and they are perpendicular to the beam direction, the ion chambers exhibit a calculated overresponse of less than 0.7(6)% (SNC600c) and 0.3(4)% (SNC125c) at 1.5 T and less than 0.3(0)% (SNC600c) and 0.1(3)% (SNC125c) for 0.35 T for nominal beam energies of 6 MV and 7 MV. This chamber orientation should be preferred, as may increase significantly in other chamber orientations. Due to the special geometry of the guard ring, no dead-volume effects have been observed in any orientation studied. The results show an intra-type variation of 0.17% and 0.07% standard uncertainty (k=1) for the SNC125c and SNC600c, respectively.
CONCLUSION
Magnetic field correction factors for two different ion chambers and for typical clinical photon beam qualities were presented and compared with the few data existing in the literature. The correction factors may be applied in clinical reference dosimetry for existing MRI-linear accelerators.
Topics: Humans; Monte Carlo Method; Radiometry; Photons; Magnetic Resonance Imaging; Magnetic Fields
PubMed: 36897832
DOI: 10.1002/mp.16345 -
International Journal of Molecular... Apr 2023The influence of magnetic fields on chemical reactions, including biological ones, has been and still is a topical subject in the field of scientific research....
The influence of magnetic fields on chemical reactions, including biological ones, has been and still is a topical subject in the field of scientific research. Experimentally discovered and theoretically substantiated magnetic and spin effects in chemical radical reactions form the basis of research in the field of spin chemistry. In the present work, the effect of a magnetic field on the rate constant of the bimolecular spin-selective recombination of radicals in the bulk of a solution is considered theoretically for the first time, taking into account the hyperfine interaction of radical spins with their magnetic nuclei. In addition, the paramagnetic relaxation of unpaired spins of the radicals and the non-equality of their g-factors that also influence the recombination process are taken into account. It is found that the reaction rate constant can vary in magnetic field from a few to half a dozen percent, depending on the relative diffusion coefficient of radicals, which is determined by the solution viscosity. It is shown that the consideration of hyperfine interactions gives rise to the presence of resonances in the dependence of the rate constant on the magnetic field. The magnitudes of the magnetic fields of these resonances are determined by the hyperfine coupling constants and difference in the g-factors of the recombining radicals. Analytical expressions for the reaction rate constant of the bulk recombination for magnetic fields larger than hfi (hyperfine interaction) constants are obtained. In general, it is shown for the first time that accounting for hyperfine interactions of radical spins with magnetic nuclei significantly affects the dependence of the reaction rate constant of the bulk radical recombination on the magnetic field.
Topics: Magnetic Fields; Recombination, Genetic
PubMed: 37108719
DOI: 10.3390/ijms24087555 -
Journal of the Royal Society, Interface Sep 2020Several groups of mammals use the Earth's magnetic field for orientation, but their magnetosensory organ remains unknown. The Ansell's mole-rat (, Bathyergidae,...
Several groups of mammals use the Earth's magnetic field for orientation, but their magnetosensory organ remains unknown. The Ansell's mole-rat (, Bathyergidae, Rodentia) is a microphthalmic subterranean rodent with innate magnetic orientation behaviour. Previous studies on this species proposed that its magnetoreceptors are located in the eye. To test this hypothesis, we assessed magnetic orientation in mole-rats after the surgical removal of their eyes compared to untreated controls. Initially, we demonstrate that this enucleation does not lead to changes in routine behaviours, including locomotion, feeding and socializing. We then studied magnetic compass orientation by employing a well-established nest-building assay under four magnetic field alignments. In line with previous studies, control animals exhibited a significant preference to build nests in magnetic southeast. By contrast, enucleated mole-rats built nests in random magnetic orientations, suggesting an impairment of their magnetic sense. The results provide robust support for the hypothesis that mole-rats perceive magnetic fields with their minute eyes, probably relying on magnetite-based receptors in the cornea.
Topics: Animals; Locomotion; Magnetic Fields; Magnetics; Mole Rats; Orientation
PubMed: 32993431
DOI: 10.1098/rsif.2020.0513 -
Marine Drugs Sep 2021Magnetic fields in biological systems is a promising research field; however, their application for microalgae has not been fully exploited. This work aims to measure...
Magnetic fields in biological systems is a promising research field; however, their application for microalgae has not been fully exploited. This work aims to measure the enzymatic activity and non-enzymatic activity of two microalgae species in terms of superoxide dismutase (SOD), catalase (CAT), and carotenoids, respectively, in response to static magnetic fields-induced stress. Two magnet configurations (north and south) and two exposure modes (continuous and pulse) were applied. Two microalgae species were considered, the and . The SOD activity increased by up to 60% in under continuous exposure. This trend was also found for CAT in the continuous mode. Conversely, under the pulse mode, its response was hampered as the SOD and CAT were reduced. For , SOD increased by up to 62% with the south configuration under continuous exposure. In terms of CAT, there was a higher activity of up to 19%. Under the pulsed exposure, SOD activity was up to 115%. The CAT in this microalga was increased by up to 29%. For , a significant increase of over 40% in violaxanthin production was obtained compared to the control, when the microalgae were exposed to SMF as a pulse. Depending on the exposure mode and species, this methodology can be used to produce oxidative stress and obtain an inhibitory or enhanced response in addition to the significant increase in the production of antioxidant pigments.
Topics: Animals; Magnetic Fields; Microalgae; Oxidative Stress
PubMed: 34564189
DOI: 10.3390/md19090527 -
Acta Biomaterialia Sep 2021Magnetic fiber composites combining superparamagnetic iron oxide nanoparticles (SPIONs) and electrospun fibers have shown promise in tissue engineering fields....
Assessing the combination of magnetic field stimulation, iron oxide nanoparticles, and aligned electrospun fibers for promoting neurite outgrowth from dorsal root ganglia in vitro.
Magnetic fiber composites combining superparamagnetic iron oxide nanoparticles (SPIONs) and electrospun fibers have shown promise in tissue engineering fields. Controlled grafting of SPIONs to the fibers post-electrospinning generates biocompatible magnetic composites without altering desired fiber morphology. Here, for the first time, we assess the potential of SPION-grafted scaffolds combined with magnetic fields to promote neurite outgrowth by providing contact guidance from the aligned fibers and mechanical stimulation from the SPIONs in the magnetic field. Neurite outgrowth from primary rat dorsal root ganglia (DRG) was assessed from explants cultured on aligned control and SPION-grafted electrospun fibers as well as on non-grafted fibers with SPIONs dispersed in the culture media. To determine the optimal magnetic field stimulation to promote neurite outgrowth, we generated a static, alternating, and linearly moving magnet and simulated the magnetic flux density at different areas of the scaffold over time. The alternating magnetic field increased neurite length by 40% on control fibers compared to a static magnetic field. Additionally, stimulation with an alternating magnetic field resulted in a 30% increase in neurite length and 62% increase in neurite area on SPION-grafted fibers compared to DRG cultured on PLLA fibers with untethered SPIONs added to the culture media. These findings demonstrate that SPION-grafted fiber composites in combination with magnetic fields are more beneficial for stimulating neurite outgrowth on electrospun fibers than dispersed SPIONs. STATEMENT OF SIGNIFICANCE: Aligned electrospun fibers improve axonal regeneration by acting as a passive guidance cue but do not actively interact with cells, while magnetic nanoparticles can be remotely manipulated to interact with neurons and elicit neurite outgrowth. Here, for the first time, we examine the combination of magnetic fields, magnetic nanoparticles, and aligned electrospun fibers to enhance neurite outgrowth. We show an alternating magnetic field alone increases neurite outgrowth on aligned electrospun fibers. However, combining the alternating field with magnetic nanoparticle-grafted fibers does not affect neurite outgrowth compared to control fibers but improves outgrowth compared to freely dispersed magnetic nanoparticles. This study provides the groundwork for utilizing magnetic electrospun fibers and magnetic fields as a method for promoting axonal growth.
Topics: Animals; Ganglia, Spinal; Magnetic Fields; Magnetic Iron Oxide Nanoparticles; Neurites; Neuronal Outgrowth; Rats; Tissue Scaffolds
PubMed: 34271170
DOI: 10.1016/j.actbio.2021.06.049 -
Ecotoxicology and Environmental Safety Jan 2021Previous studies showed contradictory results of static magnetic field (SMF) influence on behavior, hematological parameters and organ damage. The aim of this study was...
Previous studies showed contradictory results of static magnetic field (SMF) influence on behavior, hematological parameters and organ damage. The aim of this study was to investigate influence of subchronic continuous exposure to upward and downward oriented SMF of moderate intensity on behavior, hematological characteristics, heart and kidney tissue of spontaneously hypertensive rats. SH rats exposed to downward oriented SMF demonstrated lack of anxious-like behavior. SMF of either orientation caused decrease in the number of platelets in peripheral blood, granulocytes in the spleen and bone marrow and increase in the number of erythrocytes in the spleen, in both exposed groups. We also demonstrated that spontaneously hypertensive rats exposed to upward oriented SMF exhibited decreased lymphocytes count in blood, decreased bone marrow erythrocytes count and rats exposed to downward oriented SMF had increased lymphocytes count in bone marrow. The results showed adverse effect of differently oriented SMF on hematological parameters of spontaneously hypertensive rats. Also, exposure to different oriented SMF didn't affect their heart and kidney morphological characteristics.
Topics: Animals; Hypertension; Magnetic Fields; Rats; Rats, Inbred SHR; Spleen
PubMed: 32898814
DOI: 10.1016/j.ecoenv.2020.111085 -
Environmental Research Feb 2021A stressful heavy metal circumstance disfavors production of acetate from bicarbonate reduction in the biocathode of microbial electrosynthesis system (MES) with...
A stressful heavy metal circumstance disfavors production of acetate from bicarbonate reduction in the biocathode of microbial electrosynthesis system (MES) with simultaneous function of heavy metal removal/recovery. It is of great interest to explore effective approaches to moderate the heavy metal stress with achievement of simultaneous enhanced acetate production and heavy metal removal in MES. Herein, a magnetic field strength of 100 mT was successfully employed to moderate Cr(VI) stress, achieving simultaneous production of acetate at a rate of 1.48 ± 0.01 mg/L/h and Cr(VI) removal at a rate of 1.67-2.42 mg/L/h in the Serratia marcescens Q1 catalyzed cathode of MES under periodical addition of bicarbonate and Cr(VI), 1.35-fold (acetate production) and 1.34-1.46 times (Cr(VI) removal) of those in the controls in the absence of magnetic field. This simultaneous efficient acetate production and Cr(VI) removal was regulated by the magnetic field and the stressful Cr(VI), which induced the S. marcescens to physiologically release additive amounts of extracellular polymeric substances with a compositional diversity and containing the electrochemically active c-type cytochromes to facilitate extracellular electron transfer. This study confirmed the importance of magnetic field in developing the S. marcescens catalytic activity for moderating Cr(VI) stress, and thus provided a feasible approach for simultaneous efficient acetate production and Cr(VI) removal/recovery in MES, from waters contaminated with Cr(VI).
Topics: Acetates; Chromium; Electrodes; Magnetic Fields
PubMed: 33271144
DOI: 10.1016/j.envres.2020.110550 -
Food Research International (Ottawa,... Sep 2022This study aimed to investigate the effects of low intensity alternating magnetic field on the submerged fermentation of Grifola frondosa, and its possible mechanism was...
This study aimed to investigate the effects of low intensity alternating magnetic field on the submerged fermentation of Grifola frondosa, and its possible mechanism was also explored. Under the optimal shaking flask conditions, amino acids in mycelium with magnetic field treatment significantly increased, and the morphology of mycelium obviously changed. During the scale-up magnetic field-assisted fermentation, Mycelium biomass increased by 12%. The yield of polysaccharides and relative dissolved oxygen in the fermentation broth was higher than in the control group. Transcriptome sequencing results showed that the expression of genes related to amino acid metabolism increased significantly after magnetic treatment. In addition, magnetic field stimulation enhanced the mycelium biomass by upregulation the expression of genes related to cell repair and stress response. This study suggested that applying a magnetic field in submerged fermentation of G frondosa is an innovative approach to produce metabolites.
Topics: Fermentation; Grifola; Magnetic Fields; Mycelium; Polysaccharides
PubMed: 35940752
DOI: 10.1016/j.foodres.2022.111537