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Zhonghua Bing Li Xue Za Zhi = Chinese... May 2023
Topics: Child; Humans; Malacoplakia; Intestines
PubMed: 37106292
DOI: 10.3760/cma.j.cn112151-20220801-00667 -
Indian Journal of Urology : IJU :... 2020Malacoplakia is an inflammatory lesion which can affect any organ in the body but predominantly affects the genitourinary system and mainly the bladder. Malacoplakia of...
Malacoplakia is an inflammatory lesion which can affect any organ in the body but predominantly affects the genitourinary system and mainly the bladder. Malacoplakia of the bladder has variable presentations and is associated with urinary infection or immunosuppression. Mullerianosis of the bladder is a rare lesion that consists of two out of the three tissues, endometriosis, endocervicosis, or endosalpingiosis. It is usually associated with a previous cesarean section or pelvic surgery. The diagnosis is confirmed on histopathological examination. Malacoplakia and mullerianosis are usually isolated lesions of the bladder. We present a unique case of coexistence of malacoplakia and mullerianosis in the urinary bladder, reported for the first time in the literature.
PubMed: 33376273
DOI: 10.4103/iju.IJU_134_20 -
Histopathology Oct 2022Prostatic malakoplakia (MP) is rare, with only case reports and small series (< five patients) available in the literature. In this study we analysed an international...
Prostatic malakoplakia (MP) is rare, with only case reports and small series (< five patients) available in the literature. In this study we analysed an international multi-institutional series of 49 patients with prostatic MP to more clearly define its clinicopathological features. The median age was 67 years and the median serum prostate-specific antigen (PSA) was 7.5 ng/ml. MP was clinically manifest in most cases (28 of 45 patients with data available, 62%). Of 43 patients with detailed clinical history available, 21 (49%) had concurrent or metachronous malignancies (including prostate cancer). Diabetes or insulin resistance was present in 11 patients (26%). Additionally, three patients had a history of solid organ transplantation and one had HIV. Of note, six of 34 patients (18%) without concurrent prostate cancer had an abnormal digital rectal examination and/or lesions on magnetic resonance imaging (MRI) with prostate imaging reporting and data system (PIRADS) scores 4-5. The initial diagnosis was made on core biopsies (25 of 49, 51%), transurethal resection specimens (12 of 49, 24%), radical prostatectomies (10 of 49, 20%), Holmium-laser enucleation (one of 49, 2%) and cystoprostatectomy (one of 49, 2%). Tissue involvement was more commonly diffuse or multifocal (40 of 49, 82%). Von Kossa and periodic acid-Schiff stains were positive in 35 of 38 (92%) and 26 of 27 lesions (96%), respectively. Of note, two cases were received in consultation by the authors with a preliminary diagnosis of mesenchymal tumour/tumour of the specialised prostatic stroma. The present study suggests that prostatic MP is often associated with clinical findings that may mimic those of prostate cancer in a subset of patients. Moreover, MP may be found incidentally in patients with concurrent prostate cancer.
Topics: Aged; Humans; Magnetic Resonance Imaging; Malacoplakia; Male; Prostate; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms
PubMed: 35876721
DOI: 10.1111/his.14729 -
Nephrologie & Therapeutique Jun 2022Cutaneous malakoplakia is a rare pseudo-tumor that occurs in immunocompromised patients. It is a reaction to an infection caused by Gram negative bacteria. The clinical...
Cutaneous malakoplakia is a rare pseudo-tumor that occurs in immunocompromised patients. It is a reaction to an infection caused by Gram negative bacteria. The clinical presentation is nonspecific and the diagnosis is histological. The evolution is recurrent and the combination of a surgical treatment, antibiotics and adaptation of immunosuppressive therapy is necessary to cure the disease. The emergence of antibiotic resistance in bacteria responsible for the pathology can complicate the treatment and require additional microbial sampling. We report a case that occurred in a renal transplant patient with a complex diagnostic and therapeutic management.
Topics: Anti-Bacterial Agents; Humans; Immunocompromised Host; Kidney Transplantation; Malacoplakia; Neoplasms
PubMed: 35260345
DOI: 10.1016/j.nephro.2021.10.007 -
Diagnostic Pathology Aug 2023Malakoplakia is a rare inflammatory disease of the urogenital tract. There have been no reports of malakoplakia expressing anaplastic lymphoma kinase (ALK) to date....
BACKGROUND
Malakoplakia is a rare inflammatory disease of the urogenital tract. There have been no reports of malakoplakia expressing anaplastic lymphoma kinase (ALK) to date. Here, we present one case of malakoplakia with aberrant ALK expression by immunohistochemistry and discuss the clinical significance.
CASE PRESENTATION
A 65-year-old Chinese woman with a history of diabetes presented with solid masses in the liver and kidney and elevated lesions on the mucosal surface of the colon. Right nephrectomy and partial liver resection were performed. Microscopically, sheets of histiocytes with poor intercellular adhesion were seen, with Michaelis-Gutmann bodies present in both the intracellular and extracellular interstitium. CD10-, CD68-, and CD163-positive cells were present, with Michaelis-Gutmann bodies confirmed by staining with Alcian blue, periodic acid-Schiff (PAS), periodic acid-Schiff with diastase, Von Kossa, and Prussian blue. Aberrant ALK1 and ALK (D5F3) expression was observed in the cytoplasm and nucleus of cells. However, ALK gene mutation was not detected by fluorescence in situ hybridization or whole exome next-generation sequencing. NGS revealed nine individual somatic gene mutations: GOT1L1, GLIS2, SPOUT1, TMEM97, MUC3A, NSD2, SFXN5, ADAD1 and RAD50. The significance of the somatic gene mutations detected in this study is not clear, and the relationship between them and malakoplakia cannot be clarified by existing scientific studies. The pathological diagnosis was malakoplakia with aberrant ALK expression by immunohistochemistry. The antibiotics imipenem and vancomycin were started based on the results of drug sensitivity analysis and the patient was subsequently discharged. She experienced no discomfort during 30 months of follow-up.
CONCLUSION
This is the first reported case of malakoplakia with aberrant ALK expression, it should be differentiated from ALK-positive histiocytosis to avoid misdiagnosis.
Topics: Female; Humans; Aged; Anaplastic Lymphoma Kinase; Immunohistochemistry; Malacoplakia; In Situ Hybridization, Fluorescence; Periodic Acid
PubMed: 37644531
DOI: 10.1186/s13000-023-01383-z -
Journal of the American Veterinary... Dec 2021A 4-month-old 5.9-kg sexually intact female French Bulldog was presented because of recurrent urinary tract infections in combination with pollakiuria, hematuria, and...
CASE DESCRIPTION
A 4-month-old 5.9-kg sexually intact female French Bulldog was presented because of recurrent urinary tract infections in combination with pollakiuria, hematuria, and urinary incontinence.
CLINICAL FINDINGS
A diagnosis of malakoplakia was made on the basis of results of hematologic and serum biochemical testing, abdominal ultrasonography, bacterial culture, and cystoscopic biopsies of the urinary bladder wall. Biopsy samples were sent for routine histologic examination and fluorescence in situ hybridization to confirm the presence of intracellular and subendothelial bacteria.
TREATMENT AND OUTCOME
Treatment with enrofloxacin was started after the diagnosis of malakoplakia was confirmed. During treatment, polypoid changes in the urinary bladder decreased dramatically but did not disappear. On follow-up ultrasonography after 12 weeks of treatment, marked improvement was visible and results of repeated bacterial culture and fluorescence in situ hybridization of bladder wall samples were negative. The patient was free from clinical signs and had an ultrasonographically normal urinary bladder 59 weeks after antimicrobial treatment was discontinued.
CLINICAL RELEVANCE
Malakoplakia, a granulomatous disease characterized by impaired histiocytes that are unable to completely digest phagocytized bacteria, is a very rare disease in dogs, but early suspicion of the condition is essential to allow timely diagnosis and avoid disease progression and the need for prolonged treatment. Malakoplakia should be considered in young dogs with chronic urinary tract infections; the diagnosis can be made through a combination of histologic examination and fluorescence in situ hybridization of bladder wall biopsy samples.
Topics: Animals; Dog Diseases; Dogs; Female; In Situ Hybridization, Fluorescence; Malacoplakia; Urinary Bladder; Urinary Bladder Diseases; Urinary Tract Infections
PubMed: 34968189
DOI: 10.2460/javma.20.12.0676 -
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke... Feb 2022
Topics: Humans; Malacoplakia; Palatine Tonsil
PubMed: 35196766
DOI: 10.3760/cma.j.cn115330-20210317-00134 -
Clinical and Experimental Dermatology Aug 2022Cutaneous malakoplakia (CM) is a rare, chronic, granulomatous disease characterized histopathologically by Michaelis-Gutmann bodies (MGB). Verruciform xanthoma (VX) is a...
Cutaneous malakoplakia (CM) is a rare, chronic, granulomatous disease characterized histopathologically by Michaelis-Gutmann bodies (MGB). Verruciform xanthoma (VX) is a rare, benign lesion characterized histopathologically by epithelial papillomatous hyperplasia, local hyperkeratosis with incomplete keratosis, infiltration of foam cells and inflammatory cells in the papillary dermis. We present an elderly Chinese man with CM and coexisting VX with histological confirmation of MGB.
Topics: Aged; Dermis; Humans; Keratosis; Malacoplakia; Male; Xanthomatosis
PubMed: 35357037
DOI: 10.1111/ced.15207 -
Journal of the American Animal Hospital... 2019
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Cystitis; Dog Diseases; Dogs; Female; Malacoplakia; Urinary Bladder Diseases; Urinary Tract Infections
PubMed: 31433228
DOI: 10.5326/JAAHA-MS-6794 -
International Urology and Nephrology Jun 2024This study aims to explore the clinical diagnosis and treatment methods of bladder malakoplakia (MUB) to enhance the understanding of the disease. (Review)
Review
OBJECTIVE
This study aims to explore the clinical diagnosis and treatment methods of bladder malakoplakia (MUB) to enhance the understanding of the disease.
METHODS
A retrospective analysis of the diagnosis and treatment processes of three cases of MUB treated in our department was conducted. Relevant literature from both domestic and international sources was reviewed to provide a comprehensive analysis.
RESULTS
All three patients underwent transurethral resection of bladder lesions combined with antibiotic therapy, and two of them received transurethral instillation of gemcitabine. There were two cases with two recurrences each, and one case with four recurrences, with the latter also concurrently presenting with unilateral ureteral malakoplakia. Postoperative pathology confirmed MUB in all three cases. Close follow-up revealed no significant recurrence in the patients.
CONCLUSION
The effective diagnosis rate is increased by conducting multiple deep, repetitive, and randomly selected live tissue examinations. The definitive diagnosis of MUB relies on pathological histological examination. Treatment involving a combination of antibiotics and transurethral resection of bladder lesions proves to be effective. Exploring the use of bladder instillation of gemcitabine widens the spectrum of MUB treatment methods.
Topics: Humans; Malacoplakia; Male; Middle Aged; Aged; Female; Urinary Bladder Diseases; Anti-Bacterial Agents; Gemcitabine; Retrospective Studies; Deoxycytidine
PubMed: 38236373
DOI: 10.1007/s11255-023-03920-7