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Journal of Breast Imaging Mar 2023Evaluate lesion visibility and radiologist confidence during contrast-enhanced mammography (CEM)-guided biopsy.
OBJECTIVE
Evaluate lesion visibility and radiologist confidence during contrast-enhanced mammography (CEM)-guided biopsy.
METHODS
Women with BI-RADS ≥4A enhancing breast lesions were prospectively recruited for 9-g vacuum-assisted CEM-guided biopsy. Breast density, background parenchymal enhancement (BPE), lesion characteristics (enhancement and conspicuity), radiologist confidence (scale 1-5), and acquisition times were collected. Signal intensities in specimens were analyzed. Patient surveys were collected.
RESULTS
A cohort of 28 women aged 40-81 years (average 57) had 28 enhancing lesions (7/28, 25% malignant). Breast tissue was scattered (10/28, 36%) or heterogeneously dense (18/28, 64%) with minimal (12/28, 43%), mild (7/28, 25%), or moderate (9/28, 32%) BPE on CEM. Twelve non-mass enhancements, 11 masses, 3 architectural distortions, and 2 calcification groups demonstrated weak (12/28, 43%), moderate (14/28, 50%), or strong (2/28, 7%) enhancement. Specimen radiography demonstrated lesion enhancement in 27/28 (96%). Radiologists reported complete lesion removal on specimen radiography in 8/28 (29%). Average time from contrast injection to specimen radiography was 18 minutes (SD = 5) and, to post-procedure mammogram (PPM), 34 minutes (SD = 10). Contrast-enhanced mammography PPM was performed in 27/28 cases; 13/19 (68%) of incompletely removed lesions on specimen radiography showed residual enhancement; 6/19 (32%) did not. Across all time points, average confidence was 2.2 (SD = 1.2). Signal intensities of enhancing lesions were similar to iodine. Patients had an overall positive assessment.
CONCLUSION
Lesion enhancement persisted through PPM and was visible on low energy specimen radiography, with an average "confident" score. Contrast-enhanced mammography-guided breast biopsy is easily implemented clinically. Its availability will encourage adoption of CEM.
Topics: Female; Humans; Contrast Media; Mammography; Breast; Biopsy, Needle; Image-Guided Biopsy
PubMed: 38416936
DOI: 10.1093/jbi/wbac096 -
Scientific Reports May 2020We proposed to compare the accuracy and effectiveness of digital breast tomosynthesis (DBT), plus digital or synthetic mammography, with digital mammography alone in... (Meta-Analysis)
Meta-Analysis
We proposed to compare the accuracy and effectiveness of digital breast tomosynthesis (DBT), plus digital or synthetic mammography, with digital mammography alone in women attending population-based breast cancer screenings. We performed a systematic review and included controlled studies comparing DBT with digital mammography for breast cancer screening. Search strategies were applied to the MEDLINE, Embase, LILACS, and CENTRAL databases. With moderate quality of evidence, in 1,000 screens, DBT plus digital mammography increased the overall and invasive breast cancer rates by 3 and 2 (RR 1.36, 95% CI 1.18 to 1.58 and RR 1.51, 95% CI 1.27 to 1.79, respectively). DBT plus synthetic mammography increased both overall and invasive breast cancer rates by 2 (RR 1.38, 95% CI 1.24 to 1.54 and RR 1.37, 95% CI 1.22 to 1.55, respectively). DBT did not improve recall, false positive and false negative rates. However due to heterogeneity the quality of evidence was low. For women attending population-based breast cancer screenings, DBT increases rates of overall and invasive breast cancer. There is no evidence with high or moderate quality showing that DBT compared with digital mammography decreases recall rates, as well as false positive and false negative rates.
Topics: Breast Neoplasms; Early Detection of Cancer; Female; Humans; Mammography; Mass Screening; Publication Bias; Reproducibility of Results; Sensitivity and Specificity
PubMed: 32409756
DOI: 10.1038/s41598-020-64802-x -
Journal of Clinical Neuroscience :... Oct 2023Insertion of ventriculoperitoneal (VP) shunt and deep brain stimulation (DBS) are common neurosurgical procedures. Concerns have been raised regarding the safety of... (Review)
Review
Insertion of ventriculoperitoneal (VP) shunt and deep brain stimulation (DBS) are common neurosurgical procedures. Concerns have been raised regarding the safety of mammography in this patient cohort due to the risk of damaging the VP shunt tubing or DBS implantable pulse generator, and the degradation in mammography image quality secondary to the implanted devices. Based on a review of the current literature, the authors propose that mammography is safe in patients with VP shunts and DBS, and should be performed routinely as a part of population screening.
Topics: Female; Humans; Breast Neoplasms; Deep Brain Stimulation; Early Detection of Cancer; Mammography; Ventriculoperitoneal Shunt
PubMed: 37625219
DOI: 10.1016/j.jocn.2023.08.019 -
Radiation Protection Dosimetry Dec 2019The objective of this study was to survey breast dose in screening mammography, establish institutional doses and compare them with the corresponding dose values. Three...
The objective of this study was to survey breast dose in screening mammography, establish institutional doses and compare them with the corresponding dose values. Three hundred women between the ages of 40 and 80 years old participated in the study. All mammographic examinations were performed with a digital mammography system. The women characteristics (age, weight, height, BMI), technical and exposure parameters (anode/filter material, projection, compressed breast thickness (CBT), compression force, tube voltage, tube load), the entrance surface dose (ESD) and the average glandular dose (AGD) were recorded. The mean, median, 75th and 95th percentiles of the AGD and ESD distributions were estimated for all examinations, for right and left breast, as well as for CBT within 55-65 mm, for Cranio-Caudal (CC) and Medio-Lateral Oblique (MLO) projections. A statistical analysis was also performed, to investigate the impact of the recorded parameters on the ESD and AGD. The mean/median values of the ESD and AGD for all examinations, for CC and MLO projections were 4.60/4.29 and 5.42/5.25 mGy and 1.18/1.13 and 1.32/1.30 mGy, respectively. The mean/median values of the ESD and AGD for CC and MLO projections at CBT range 55-65 mm were 5.29/5.08 and 5.56/5.42 mGy and 1.30/1.24 and 1.36/1.32 mGy, respectively. The 75th percentile for CC and MLO projections were estimated 5.79 and 6.17 mGy, as well as 1.41 and 1.48 mGy in terms of ESD and AGD values, respectively. The 95th percentile of the ESD and AGD for CC and MLO projections were also 7.40 and 7.53 mGy and 1.76 and 1.78 mGy, respectively. The tube voltage, tube load, age and CBT had a significant influence on the dose values. The estimated values were found to be comparable, or in most cases lower, than the corresponding 75th and 95th percentile values from previous studies.
Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Neoplasms; Early Detection of Cancer; Female; Health Facilities; Humans; Mammography; Middle Aged; Organs at Risk; Radiation Dosage; Radiation Exposure; Radiographic Image Enhancement; Relative Biological Effectiveness; Risk Assessment
PubMed: 30753684
DOI: 10.1093/rpd/ncz005 -
Journal of Medical Radiation Sciences Sep 2020As an efficient, effective and moderately inexpensive modality, mammography has been implemented as a cancer screening tool and in diagnostic management. However,... (Review)
Review
INTRODUCTION
As an efficient, effective and moderately inexpensive modality, mammography has been implemented as a cancer screening tool and in diagnostic management. However, appropriate breast compression is necessary for optimal outcomes. Current key measures of compression force are subjective and variable, giving rise to the concept of a 'personalised' pressure-standardisation protocol.
METHODS
A scoping review of the literature was performed using the Arksey and O'Malley framework to explore the existing force- and pressure-standardisation protocols in clinical application. A comprehensive search strategy and standardised study selection and evaluation were completed. This synthesis of existing knowledge can lead to the implementation of mechanically standardised mammographic compression pressure as a feasible tailored approach to clinical practice. Four databases (PubMed, MEDLINE, Embase and Scopus) were searched from the databases' inception to 13 December 2019 for relevant information, and eighteen articles were selected for analysis.
RESULTS
In addition to current protocol comparison, emerging key concepts include the reasoning behind standardisation, the benefits of improved diagnostic outcomes/decreased pain with negligible change in image quality and average glandular dose (AGD), and the recommendation of a 10kPa (approximate) pressure-standardisation protocol. Research to date is largely based abroad (Netherlands), with a strong focus on screening practices. Consequently, several gaps in the current literature were identified as potential directions for future investigation.
CONCLUSIONS
As a suggested mammographic guideline, compression pressures of approximately 10kPa aid in image acquisition reproducibility both within and between women; pain levels decrease, with minimal variations to breast thickness, AGD and image quality.
Topics: Breast; Humans; Mammography; Pain; Pressure; Reference Standards
PubMed: 32420700
DOI: 10.1002/jmrs.400 -
Cancer Imaging : the Official... Jan 2023Contrast-enhanced mammography (CEM) is becoming a widely adopted modality in breast imaging over the past few decades and exponentially so over the last few years, with... (Review)
Review
Contrast-enhanced mammography (CEM) is becoming a widely adopted modality in breast imaging over the past few decades and exponentially so over the last few years, with strong evidence of high diagnostic performance in cancer detection. Evidence is also growing indicating comparative performance of CEM to MRI in sensitivity with fewer false positive rates. As application of CEM ranges from potential use in screening dense breast populations to staging of known breast malignancy, increased familiarity with the modality and its implementation, and disease processes encountered becomes of great clinical significance. This review emphasizes expected normal findings on CEM followed by a focus on examples of the commonly encountered benign and malignant pathologies on CEM.
Topics: Humans; Female; Mammography; Breast Neoplasms; Breast Density; Contrast Media; Breast; Magnetic Resonance Imaging; Sensitivity and Specificity
PubMed: 36691077
DOI: 10.1186/s40644-023-00526-1 -
Academic Radiology Oct 2019A linear array of carbon nanotube-enabled x-ray sources allows for stationary digital breast tomosynthesis (sDBT), during which projection views are collected without...
RATIONALE AND OBJECTIVES
A linear array of carbon nanotube-enabled x-ray sources allows for stationary digital breast tomosynthesis (sDBT), during which projection views are collected without the need to move the x-ray tube. This work presents our initial clinical experience with a first-generation sDBT device.
MATERIALS AND METHODS
Following informed consent, women with a "suspicious abnormality" (Breast Imaging Reporting and Data System 4), discovered by digital mammography and awaiting biopsy, were also imaged by the first generation sDBT. Four radiologists participated in this paired-image study, completing questionnaires while interpreting the mammograms and sDBT image stacks. Areas under the receiver operating characteristic curve were used to measure reader performance (likelihood of correctly identifying malignancy based on pathology as ground truth), while a multivariate analysis assessed preference, as readers compared one modality to the next when interpreting diagnostically important image features.
RESULTS
Findings from 43 women were available for analysis, in whom 12 cases of malignancy were identified by pathology. The mean areas under the receiver operating characteristic curve was significantly higher (p < 0.05) for sDBT than mammography for all breast density categories and breast thicknesses. Additionally, readers preferred sDBT over mammography when evaluating mass margins and shape, architectural distortion, and asymmetry, but preferred mammography when characterizing microcalcifications.
CONCLUSION
Readers preferred sDBT over mammography when interpreting soft-tissue breast features and were diagnostically more accurate using images generated by sDBT in a Breast Imaging Reporting and Data System 4 population. However, the findings also demonstrated the need to improve microcalcification conspicuity, which is guiding both technological and image-processing design changes in future sDBT devices.
Topics: Adult; Breast; Breast Neoplasms; Female; Humans; Image Processing, Computer-Assisted; Mammography; Middle Aged; Multimodal Imaging; Nanotubes, Carbon; Radiographic Image Enhancement
PubMed: 30660473
DOI: 10.1016/j.acra.2018.12.026 -
European Radiology Nov 2023
To think it, wish it, even want it-but do it! Quality control measures in mammography image interpretation: radiologists' attitudes and preferences vs perceived obstacles and limitations.
Topics: Humans; Mammography; Breast; Radiologists
PubMed: 37653048
DOI: 10.1007/s00330-023-10062-y -
Clinical Radiology Mar 2024Architectural distortion (AD) is the third most common abnormality detected on mammograms. In the absence of an accurate non-invasive tool to evaluate ADs, clinical... (Review)
Review
Architectural distortion (AD) is the third most common abnormality detected on mammograms. In the absence of an accurate non-invasive tool to evaluate ADs, clinical management often requires surgical excision for histological diagnosis. This problem is expected to worsen with the growing use of digital breast tomosynthesis (DBT) and the resultant increasing detection of ADs. There is therefore a great clinical need for a diagnostic imaging tool to complement non-enhanced mammography for the evaluation of AD. Contrast-enhanced mammography (CEM) is an emerging breast imaging method that uses contrast media and the principle of dual-energy subtraction to evaluate vascularity of suspicious breast lesions. CEM, a cost-effective alternative to breast magnetic resonance imaging (MRI), can be used to evaluate AD by juxtaposing CEM images with non-enhanced mammograms for comparison. In this review, the authors aim to provide readers with an overview of the interpretation of AD on CEM using imaging examples. Relevant imaging features of CEM and their respective significance will be matched with information from a literature review. Finally, the authors would like to highlight the added value of CEM in relevant clinical applications in the assessment of AD.
Topics: Humans; Female; Mammography; Breast; Contrast Media; Magnetic Resonance Imaging; Early Detection of Cancer; Breast Neoplasms
PubMed: 38114374
DOI: 10.1016/j.crad.2023.11.021 -
Radiation Protection Dosimetry Aug 2022Optimization in mammography remains the most important tool in practice. In the optimization process, we look for a balanced relationship between image quality and...
Optimization in mammography remains the most important tool in practice. In the optimization process, we look for a balanced relationship between image quality and patient dose. For mammographic examinations, the diagnostic reference levels (DRLs) are expressed as the average glandular dose (AGD) based on the thickness of the compressed breast. The aim of this study was to analyse DRL compliance in diagnostic mammography at 16 mammography screening centres using an automated system for tracking patient doses during the period between January 2020 and December 2020 and to subsequently propose new DRLs for the screening mammography centres in Slovakia. The new DRLs were ~20% lower than the existing national DRLs in diagnostic mammography in Slovakia and significantly lower than the achievable AGD levels published in the fourth edition of the European Guidelines for Quality Assurance in Breast Cancer Screening and Diagnosis.
Topics: Breast Neoplasms; Diagnostic Reference Levels; Early Detection of Cancer; Female; Humans; Mammography; Radiation Dosage; Slovakia
PubMed: 36005968
DOI: 10.1093/rpd/ncac095