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Pathologie (Heidelberg, Germany) Dec 2023The situation regarding digital pathology in Austria is manageable compared to other countries. Active Austrian examples are the consortium EMPAIA, the private-public... (Review)
Review
The situation regarding digital pathology in Austria is manageable compared to other countries. Active Austrian examples are the consortium EMPAIA, the private-public partnership Bigpicture, the Austrian Society for Clinical Pathology and Molecular Pathology (OEGPath), the company TissueGnostics, and the Austrian Platform for Personalized Medicine (OEPPM).
Topics: Austria; Telepathology; Pathology, Clinical; Pathology, Molecular; Precision Medicine
PubMed: 37987811
DOI: 10.1007/s00292-023-01278-2 -
Clinical and Translational Medicine Mar 2021
Topics: Diagnostic Imaging; Humans; Molecular Imaging; Molecular Medicine; Spatio-Temporal Analysis
PubMed: 33784006
DOI: 10.1002/ctm2.347 -
Analytical Methods : Advancing Methods... Sep 2021As the COVID-19 pandemic continues to escalate globally and acquires new mutations, accurate diagnostic technologies continue to play a vital role in controlling and... (Review)
Review
As the COVID-19 pandemic continues to escalate globally and acquires new mutations, accurate diagnostic technologies continue to play a vital role in controlling and understanding the epidemiology of this disease. A plethora of technologies have enabled the diagnosis of individuals, informed clinical management, aided population-wide screening to determine transmission rates and identified cases within the wider community and high-risk settings. This review explores the application of molecular diagnostics technologies in controlling the spread of COVID-19, and the key factors that affect the sensitivity and specificity of the tests used.
Topics: COVID-19; Humans; Pandemics; Pathology, Molecular; SARS-CoV-2; Sensitivity and Specificity
PubMed: 34473144
DOI: 10.1039/d1ay00947h -
Cytopathology : Official Journal of the... Sep 2021
Topics: Humans; Pathology, Molecular; Precision Medicine
PubMed: 34390522
DOI: 10.1111/cyt.13000 -
Sovremennye Tekhnologii V Meditsine 2022The development of high-throughput technologies has sharply increased the opportunities to research the human body at the molecular, cellular, and organismal levels in... (Review)
Review
The development of high-throughput technologies has sharply increased the opportunities to research the human body at the molecular, cellular, and organismal levels in the last decade. Rapid progress in biotechnology has caused a paradigm shift in population-based studies. Advances in modern biomedical sciences, including genomic, genome-wide, post-genomic research and bioinformatics, have contributed to the emergence of molecular epidemiology focused on the study of the personalized molecular mechanism of disease development and its extrapolation to the population level. The work of research teams at the intersection of information technology and medicine has become the basis for highlighting digital epidemiology, the important tools of which are machine learning, the ability to work with real world data, and accumulated big data. The developed approaches accelerate the process of collecting and processing biomedical data, testing new scientific hypotheses. However, new methods are still in their infancy, they require testing of application under various conditions, as well as standardization. This review highlights the role of omics and digital technologies in population-based studies.
Topics: Humans; Computational Biology; Genomics; Molecular Epidemiology; Machine Learning; Research
PubMed: 37179982
DOI: 10.17691/stm2022.14.4.07 -
European Journal of Hospital Pharmacy :... Sep 2020
Topics: Clinical Competence; High-Throughput Nucleotide Sequencing; Humans; Medical Oncology; Molecular Medicine; Neoplasms; Workforce
PubMed: 32839254
DOI: 10.1136/ejhpharm-2019-002134 -
Vaccine Feb 2020Whole genome sequence analysis has revealed the phylogenetic structure of Vibrio cholerae and has shown that the current seventh pandemic is highly clonal, emerging from... (Review)
Review
Whole genome sequence analysis has revealed the phylogenetic structure of Vibrio cholerae and has shown that the current seventh pandemic is highly clonal, emerging from a single source. Such analysis has the potential to become a powerful public health tool as we build public sequence databases, and as the speed of sequencing and analysis increases. Examples of such studies, as applied to different settings of the disease cholera, are described and discussed.
Topics: Cholera; Genome, Bacterial; Global Health; Humans; Molecular Epidemiology; Pandemics; Phylogeny; Vibrio cholerae
PubMed: 31345641
DOI: 10.1016/j.vaccine.2019.07.038 -
Trends in Molecular Medicine May 2022
Topics: Humans; Molecular Medicine
PubMed: 35410766
DOI: 10.1016/j.molmed.2022.03.008 -
Virchows Archiv : An International... Feb 2024Neoplasias of the hepatopancreatobiliary tract are growing in numbers, have the poorest prognosis of all major cancer entities, and thus represent a rising clinical... (Review)
Review
Neoplasias of the hepatopancreatobiliary tract are growing in numbers, have the poorest prognosis of all major cancer entities, and thus represent a rising clinical problem. Their molecular diagnostic has dramatically improved, contributing to tumor subtyping, definition of malignancy, and uncovering cases with hereditary predisposition. Most of all, predictive molecular testing allows to identify cases amenable to treatment with the rising number of approved targeted drugs, immune-oncological treatment, and clinical trials. In this review, the current state of molecular testing and its contribution to clinical decision-making are outlined.
Topics: Humans; Pathology, Molecular; Pancreatic Neoplasms; Genetic Predisposition to Disease; Molecular Diagnostic Techniques; Medical Oncology
PubMed: 38429607
DOI: 10.1007/s00428-024-03744-5 -
The Journal of Small Animal Practice Jul 2021Molecular pathology is a developing sub-microscopic discipline of pathology that studies the effects of molecular variations and mutations on disease processes. The... (Review)
Review
Molecular pathology is a developing sub-microscopic discipline of pathology that studies the effects of molecular variations and mutations on disease processes. The ultimate goal of molecular pathology in cancer is to predict risk, facilitate diagnosis and improve prognostication based on a complete understanding of the biological impact of specific molecular variations, mutations and dysregulations. This knowledge will provide the basis for customised cancer treatment, so-called precision medicine. Rapid developments in genomics have placed this field at the forefront of clinical molecular pathology and there are already a number of well-established genetic tests available for clinical use including PCR of antigen receptor rearrangement and KIT mutational analysis. Moving beyond tests assessing a single gene, there are significant research efforts utilising genomics to predict cancer risk, forecast aggressive behaviour and identify druggable mutations and therapeutic biomarkers. Researchers are also investigating the use of circulating cells and nucleic acid for clinically useful low morbidity genomic assessments. If we are to realise the full potential of molecular pathology and precision medicine there are a number of challenges to overcome. These include developing our understanding of the underlying biology (in particular intra-tumoural heterogeneity), methodological standardisation of assays, provision of adequate infrastructure and production of novel therapeutics backed by high-quality clinical data supporting the precision medicine approach. The era of molecular pathology holds the potential to revolutionise veterinary cancer care, but its impact on clinical practice will depend upon the extent to which the inherent challenges can be overcome.
Topics: Animals; Genomics; Mutation; Neoplasms; Pathology, Molecular; Precision Medicine
PubMed: 33974272
DOI: 10.1111/jsap.13330