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Neurologic Clinics Feb 2024
Topics: Humans; Multiple Sclerosis
PubMed: 37980125
DOI: 10.1016/j.ncl.2023.08.001 -
La Revue Du Praticien Apr 2020
Topics: Disease Progression; Humans; Multiple Sclerosis
PubMed: 32877115
DOI: No ID Found -
La Revue Du Praticien Apr 2022"Pregnancy and multiple sclerosis Pregnancy is a possibility for a patient with multiple sclerosis, but it is best to anticipate and plan for it. Pregnancy does not...
"Pregnancy and multiple sclerosis Pregnancy is a possibility for a patient with multiple sclerosis, but it is best to anticipate and plan for it. Pregnancy does not worsen the disability in the long term. The risk of relapse in the 3 months postpartum depends on the risk of relapse in the year preceding the pregnancy; it is therefore preferable to plan a pregnan¬cy when the multiple sclerosis is stabilized. The main¬tenance of background treatment in preconception or during pregnancy depends on the type of medication, the risk for the child (miscarriage, malformations) but also the risk of rebound in the mother. Pregnancy fol-low-up and mode of delivery are comparable to those of the general population. Epidural analgesia is not contraindicated. The decision to breastfeed must take into account the patient's wishes and the severity of the disease (contraindication of breastfeeding with certain background treatments). There is no validated preventive treatment for postpartum relapses."
Topics: Breast Feeding; Child; Female; Humans; Multiple Sclerosis; Postpartum Period; Pregnancy; Pregnancy Complications; Recurrence
PubMed: 35638982
DOI: No ID Found -
Seminars in Neurology Apr 2020
Topics: Brain Diseases; Child; Child, Preschool; Humans; Infant; Multiple Sclerosis; Neurology; Pediatrics
PubMed: 32268414
DOI: 10.1055/s-0040-1709146 -
International Journal of Molecular... May 2024Neuroinflammatory conditions in the central nervous system (CNS) are implicated in the pathogenesis of several neuroimmune disorders such as acquired demyelinating...
Neuroinflammatory conditions in the central nervous system (CNS) are implicated in the pathogenesis of several neuroimmune disorders such as acquired demyelinating syndromes, autoimmune encephalopathies, acute or chronic bacterial and viral CNS infections as well as multiple sclerosis (MS) [...].
Topics: Humans; Neuroinflammatory Diseases; Animals; Multiple Sclerosis; Central Nervous System; Inflammation
PubMed: 38892158
DOI: 10.3390/ijms25115973 -
Frontiers in Immunology 2021An individualized innovative disease management is of great importance for people with multiple sclerosis (pwMS) to cope with the complexity of this chronic,... (Review)
Review
An individualized innovative disease management is of great importance for people with multiple sclerosis (pwMS) to cope with the complexity of this chronic, multidimensional disease. However, an individual state of the art strategy, with precise adjustment to the patient's characteristics, is still far from being part of the everyday care of pwMS. The development of digital twins could decisively advance the necessary implementation of an individualized innovative management of MS. Through artificial intelligence-based analysis of several disease parameters - including clinical and para-clinical outcomes, multi-omics, biomarkers, patient-related data, information about the patient's life circumstances and plans, and medical procedures - a digital twin paired to the patient's characteristic can be created, enabling healthcare professionals to handle large amounts of patient data. This can contribute to a more personalized and effective care by integrating data from multiple sources in a standardized manner, implementing individualized clinical pathways, supporting physician-patient communication and facilitating a shared decision-making. With a clear display of pre-analyzed patient data on a dashboard, patient participation and individualized clinical decisions as well as the prediction of disease progression and treatment simulation could become possible. In this review, we focus on the advantages, challenges and practical aspects of digital twins in the management of MS. We discuss the use of digital twins for MS as a revolutionary tool to improve diagnosis, monitoring and therapy refining patients' well-being, saving economic costs, and enabling prevention of disease progression. Digital twins will help make precision medicine and patient-centered care a reality in everyday life.
Topics: Artificial Intelligence; Clinical Decision-Making; Health Status; Humans; Multiple Sclerosis; Patient-Centered Care; Patient-Specific Modeling; Precision Medicine; Prognosis
PubMed: 34012452
DOI: 10.3389/fimmu.2021.669811 -
Multiple Sclerosis and Related Disorders Nov 2019
Topics: Fatigue; Humans; Multiple Sclerosis; Prodromal Symptoms
PubMed: 31812240
DOI: 10.1016/j.msard.2019.101453 -
Multiple Sclerosis (Houndmills,... Apr 2020Severity score represents disease duration-adjusted mean rank of disability in multiple sclerosis (MS) patients from the reference population. This measure allows one to... (Review)
Review
Severity score represents disease duration-adjusted mean rank of disability in multiple sclerosis (MS) patients from the reference population. This measure allows one to compare the relative rates of disease progression among patients, patient subgroups, and across epochs, which opens up new question of what accounts for the observed differences in severity, and can be used to assess correlation between disease severity and clinical, radiologic, immunologic, genetic, and environmental variables of interest. Severity score can also prove useful for developing prognostic tools in MS. This article discusses the diverse applications of severity score concept in MS research, and (re)introduces Herbert's proposal of severity-based MS classification in the context of variability of MS severity.
Topics: Disease Progression; Humans; Multiple Sclerosis; Severity of Illness Index
PubMed: 31965877
DOI: 10.1177/1352458519880125 -
Neurology Nov 2021
Topics: Adult; Child; Humans; Magnetic Resonance Imaging; Multiple Sclerosis; White Matter
PubMed: 34607920
DOI: 10.1212/WNL.0000000000012866 -
The New England Journal of Medicine Feb 2024
Topics: Humans; Multiple Sclerosis
PubMed: 38354146
DOI: 10.1056/NEJMe2314434