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Polish Journal of Pathology : Official... 2021Juvenile psammomatoid ossifying fibroma (JPOF) is an uncommon benign and locally aggressive tumor. We report an unusual head tumour with extremely rare extensiveness and...
Juvenile psammomatoid ossifying fibroma (JPOF) is an uncommon benign and locally aggressive tumor. We report an unusual head tumour with extremely rare extensiveness and aggressivness. The patient was 18-year-old female with three-day-lasting headache and repetitive oral bleeding. Computed tomography revealed a large, well-circumscribed, expansile mass occupying ethmoid cells, nasal cavities and ventral part of the sphenoid sinus, with extention into the anterior cranial fossa. Pterional craniotomy was carried out. On one-year follow-up recurrence of the lesion was identified and the second surgery was performed. The lesion is under supervision now, due to incomplete removal.
Topics: Adolescent; Bone Neoplasms; Female; Fibroma, Ossifying; Humans; Tomography, X-Ray Computed
PubMed: 35048642
DOI: 10.5114/pjp.2021.111779 -
Archivos de Bronconeumologia Jul 2021
Topics: Fibroma; Humans; Skin Neoplasms; Trachea
PubMed: 35698956
DOI: 10.1016/j.arbr.2019.11.029 -
The Breast Journal Nov 2020Breast fibromatosis is a rare histologically benign tumor with local aggressive potential, and imaging and clinical findings of breast fibromatosis require attention. We...
Breast fibromatosis is a rare histologically benign tumor with local aggressive potential, and imaging and clinical findings of breast fibromatosis require attention. We retrospectively evaluated the images of 20 patients with histologically proven breast fibromatosis on mammography, magnetic resonance imaging (MRI), and ultrasonography. The lesions were assessed concerning the location, fascia involvement, imaging characteristics, and follow-up outcomes. Altogether, there were 22 lesions: 10 lesions involved the superficial fascia system including four lesions additionally involving the deep fascia and pectoralis major, and 12 lesions were inside the glandular parenchyma with two lesions originated from the prior surgery site. The detection rates of mammography, ultrasound, and MRI for breast fibromatosis were 33.3% (3/9), 90% (18/20), and 100% (3/3), respectively. We found that fascia involvement may be a characteristic of breast fibromatosis. The lesion located inside glandular parenchyma is prone to be underestimated, whereas combined MR with ultrasound is recommended for the diagnosis. The complete excision with negative margins is important for a good prognosis.
Topics: Breast; Breast Neoplasms; Female; Fibroma; Fibromatosis, Aggressive; Humans; Magnetic Resonance Imaging; Mammography; Retrospective Studies
PubMed: 32754995
DOI: 10.1111/tbj.14008 -
Head and Neck Pathology Mar 2020Clinically, radiologically, and pathologically, chondroid neoplasms of the skull can be diagnostically challenging due to overlapping features in each of these domains.... (Review)
Review
Clinically, radiologically, and pathologically, chondroid neoplasms of the skull can be diagnostically challenging due to overlapping features in each of these domains. Compounding the problem for the pathologist, there is also significant morphologic, immunophenotypic, and molecular genetic overlap between benign and malignant cartilaginous lesions, and the majority of these lesions are encountered quite rarely in routine surgical pathology practice. Each of these factors contribute to the diagnostic difficulty posed by these lesions, highlighting the importance of radiologic-pathologic correlation in the diagnosis. This review is intended to provide an update for surgical pathologists on some of the most commonly encountered chondroid neoplasms in the skull, and includes the following lesions: chondromyxoid fibroma, synovial chondromatosis, chondrosarcoma and variants, and chordoma and variants. For each of these lesions, the differential diagnosis and useful ancillary tests will be discussed in the context of a broad range of additional primary and secondary lesions.
Topics: Chondromatosis, Synovial; Chondrosarcoma; Chordoma; Fibroma; Humans; Skull Neoplasms
PubMed: 31950468
DOI: 10.1007/s12105-019-01091-5 -
The American Journal of Dermatopathology Dec 2021Immunohistochemistry is useful and often necessary for the diagnosis of many histopathological entities, including atypical fibroxanthoma (AFX), which is typically...
Immunohistochemistry is useful and often necessary for the diagnosis of many histopathological entities, including atypical fibroxanthoma (AFX), which is typically considered a diagnosis of exclusion after ruling out spindle cell melanoma, sarcomatoid carcinoma, and other spindle cell tumors. AFX is a superficial fibrohistiocytic tumor previously believed to be related to pleomorphic sarcoma (formerly known as malignant fibrous histiocytoma), but is now considered a distinct clinicopathological entity. AFXs commonly express CD68, smooth muscle actin, and lysozyme and are usually negative for melanocytic markers such as HMB45 and S100. However, immunohistochemistry can sometimes be misleading, especially when used without other relevant markers in making a histopathologic diagnosis. HMB45 is a glycoprotein marker of premelanosomes and is often helpful in identifying melanoma because it stains melanosomes in the epidermis, dermis, and nevi glycocomplexes. We report a case of AFX which was strongly positive for HMB45, but negative for all other melanocytic markers. This case emphasizes the potential pitfall of relying on a single immunohistochemical marker to make the diagnosis, especially of melanoma, and also is one of the only rare reported cases of AFXs which are HMB45+.
Topics: Aged; Biomarkers, Tumor; Fibroma; Humans; Male; Skin Neoplasms; Staining and Labeling; Xanthomatosis; gp100 Melanoma Antigen
PubMed: 34132658
DOI: 10.1097/DAD.0000000000001995 -
Head and Neck Pathology Mar 2020This manuscript provides an overview of pleomorphic spindle cell tumors presenting on sun-damaged skin of the elderly and includes discussions of atypical fibroxanthoma,... (Review)
Review
This manuscript provides an overview of pleomorphic spindle cell tumors presenting on sun-damaged skin of the elderly and includes discussions of atypical fibroxanthoma, pleomorphic dermal sarcoma, spindle cell and metaplastic squamous cell carcinoma, spindle cell and dedifferentiated melanoma and poorly differentiated cutaneous angiosarcoma. These tumors share many of the clinical presenting and histological features, making confident diagnosis challenging. A reliable and robust diagnosis is necessary to predict behavior as the biologic potential of these tumors ranges from benign (e.g. atypical fibroxanthoma) to outright malignant with poor survival rates (e.g. cutaneous angiosarcoma). The salient clinical, histologic and immunohistochemical characteristics are discussed in detail with emphasis on distinguishing features and differential diagnosis to provide the reader with a better understanding of these entities and helpful clues for a more robust diagnosis.
Topics: Carcinoma, Squamous Cell; Fibroma; Head and Neck Neoplasms; Hemangiosarcoma; Humans; Melanoma; Sarcoma; Skin Neoplasms
PubMed: 31950467
DOI: 10.1007/s12105-019-01084-4 -
Stomatologiia 2022Hyaline juvenile fibromatosis is a rare genetic disease, which is associated with ANTXR2 gene defect. Almost all organs and systems of the body are affected in this...
Hyaline juvenile fibromatosis is a rare genetic disease, which is associated with ANTXR2 gene defect. Almost all organs and systems of the body are affected in this pathology. There are clinical symptoms: joint contracture, hyperpigmentation, skin damage like nodules, which can have different sizes, locations and forms, throughout the body, fibromatosis of the gums, internal organs damages (splenomegaly, hepatomegaly, anomalies of the kidneys and other organs), osteoporosis, increased susceptibility to infectious diseases, mental underdevelopment. In this article we describe clinical case of 6-old patient witht hyaline juvenile fibromatosis. The diagnosis was made on the basis of the clinical picture, additional research methods and the results of molecular genetic testing. The patient underwent a number of surgical interventions, histological examination of the surgical material and symptomatic therapy.
Topics: Fibroma; Humans; Hyalin; Receptors, Peptide
PubMed: 35362706
DOI: 10.17116/stomat202210102169 -
Ophthalmology Feb 2023
Topics: Humans; Eyelids; Blepharoplasty; Fibroma
PubMed: 35927075
DOI: 10.1016/j.ophtha.2022.06.005 -
Radiographics : a Review Publication of... Aug 2023Fibroblastic and myofibroblastic tumors are a variable group of neoplasms ranging from benign to malignant. These lesions may affect patients of any age group but are...
Fibroblastic and myofibroblastic tumors are a variable group of neoplasms ranging from benign to malignant. These lesions may affect patients of any age group but are more frequently encountered in the pediatric population. Patient clinical presentation depends on the location, growth pattern, adjacent soft-tissue involvement, and pathologic behavior of these neoplasms. In the 2020 update to the World Health Organization (WHO) classification system, these tumors are classified on the basis of their distinct biologic behavior, histomorphologic characteristics, and molecular profiles into four tumor categories: benign (eg, fibrous hamartoma of infancy, nodular fasciitis, proliferative fasciitis, fibroma of the tendon sheath, calcifying aponeurotic fibroma); intermediate, locally aggressive (eg, desmoid fibromatosis); intermediate, rarely metastasizing (eg, dermatofibrosarcoma protuberans, myxoinflammatory fibroblastic sarcoma, low-grade myofibroblastic sarcoma, infantile fibrosarcoma); and malignant (eg, sclerosing epithelioid fibrosarcomas; low-grade fibromyxoid sarcoma; myxofibrosarcoma; fibrosarcoma, not otherwise specified). Detection of various components of solid tumors at imaging can help in prediction of the presence of corresponding histopathologic variations, thus influencing diagnosis, prognosis, and treatment planning. For example, lesions with a greater myxoid matrix or necrotic components tend to show higher signal intensity on T2-weighted MR images, whereas lesions with hypercellularity and dense internal collagen content display low signal intensity. In addition, understanding the radiologic-pathologic correlation of soft-tissue tumors can help to increase the accuracy of percutaneous biopsy and allow unnecessary interventions to be avoided. RSNA, 2023 Quiz questions for this article are available in the supplemental material.
Topics: Humans; Child; Adult; Neoplasms, Fibrous Tissue; Soft Tissue Neoplasms; Fibroma; Fibrosarcoma; Skin Neoplasms; Diagnosis, Differential; Fasciitis
PubMed: 37440448
DOI: 10.1148/rg.230005 -
Medicine Sep 2021Plexiform fibromyxoma (PF) is a rare mesenchymal neoplasm which can be misdiagnosed as the gastrointestinal stromal tumor. This tumor almost formed a lobulated... (Review)
Review
Plexiform fibromyxoma (PF) is a rare mesenchymal neoplasm which can be misdiagnosed as the gastrointestinal stromal tumor. This tumor almost formed a lobulated intramural/submucosal mass in the gastric antrum and prepyloric area. It was considered as a benign tumor that exhibited no recurrence, metastasis, or tumor-related mortality. In this study, we reported 2 cases of gastric PF. The first case was a PF patient coexisting with gastric adenocarcinoma. The second case occurred in the gastric upper body close to gastric fundus. They underwent distal gastrectomy and laparoscopic partial gastric resection, respectively. Both of them exhibited a plexiform growth pattern in the submucosa, muscularis propria, and subserosal adipose tissues. The nodules were composed of abundant myxoid or fibromyxoid matrix riching in small thin-walled blood vessels and bland-looking spindle cells. The first case partially showed staggered growth pattern of PF and adenocarcinoma. Immunohistochemically, the spindle cells were diffusely immunoreactive for SMA and vimentin, and focally immunoreactive for CD10. It was important to distinguish the PF from other spindle cell tumors involving the stomach.
Topics: Adenocarcinoma; Adult; Diagnosis, Differential; Female; Fibroma; Gastrectomy; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Multiple Primary; Stomach Neoplasms
PubMed: 34516510
DOI: 10.1097/MD.0000000000027164