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Annals of the Royal College of Surgeons... Feb 2020Elastofibroma is a rare soft-tissue tumour. This study retrospectively analysed and summarised the clinical, imaging and typical pathological features, together with the...
OBJECTIVE
Elastofibroma is a rare soft-tissue tumour. This study retrospectively analysed and summarised the clinical, imaging and typical pathological features, together with the short- and long-term surgical outcomes of patients with pathologically confirmed soft-tissue elastofibroma to improve their management.
MATERIALS AND METHODS
We enrolled 73 patients with pathologically confirmed soft-tissue elastofibroma from January 2010 to December 2018. The general, clinical, diagnostic and treatment-related data, operation notes, pathological examination results and follow-up status were obtained by reviewing inpatient medical records. Disease onset age, sex, tumour location and size were statistically analysed using the chi square and rank sum tests.
RESULTS
A total of 90 lesions from 73 patients were examined. Among these, 56 patients had single lesions: 27 were under the right scapula, 26 were under the left scapula, 1 at the umbilicus, 1 on the aortic valve, 1 on the right hip and 17 at the bilateral inferior angles of the scapula. The average age at onset was 56.4 years (range: 6-82 years). The male-to-female incidence ratio was about one to three. Tumour diameter and follow-up duration ranged from 2cm to 12cm and from one month to nine years, respectively; recurrence was not observed. The main postoperative complication was wound effusion, occurring in 24 sites among the 90 lesions, corresponding to an incidence rate of 26.7%.
CONCLUSIONS
A correct diagnosis of elastofibroma can be made prior to surgical resection by examining typical clinical features and characteristic imaging findings. Short- and long-term outcomes of local excision are good, with no further recurrence.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Child; Female; Fibroma; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Neoplasm Recurrence, Local; Postoperative Complications; Retrospective Studies; Sex Factors; Surgical Procedures, Operative; Treatment Outcome; Young Adult
PubMed: 31233334
DOI: 10.1308/rcsann.2019.0089 -
Journal of Cutaneous Pathology Feb 2024So far, confusion exists regarding the question of whether hereditary perifollicular fibromas and fibrofolliculomas can be distinguished from each other. Here,...
So far, confusion exists regarding the question of whether hereditary perifollicular fibromas and fibrofolliculomas can be distinguished from each other. Here, histopathological arguments are presented to clarify this terminological problem. In 1977, Birt et al. described a large kindred affected with hereditary multiple "fibrofolliculomas," which they thought were "a hitherto unrecognized pilar hamartoma," but they never claimed the fibrofolliculomas were part of a syndrome. A careful microscopic comparison shows, however, that the tumors are clinically and histopathologically identical to perifollicular fibromas, as first described by Burnier and Rejšek in 1925. Their familial occurrence was discovered in 1971 by Civatte and Le Tréguilly. Before 1977, the term "perifollicular fibroma" was used for these skin tumors. By contrast, Hornstein and Knickenberg described in 1975 perifollicular fibromas as a cutaneous marker of a syndrome characterized by a predisposition to colon cancer and pneumothorax. Later, two French groups erroneously proposed the term "Birt-Hogg-Dubé syndrome" to describe the co-occurrence of fibrofolliculomas, trichodiscomas, and acrochordons, which was contrary to what Birt et al. had in mind. Hence, today, we should discriminate between the hereditary nonsyndromic perifollicular fibromas, as documented by Civatte and Le Tréguilly and later by Birt et al., and the syndromic perifollicular fibromas, as delineated by Hornstein and Knickenberg.
Topics: Humans; Skin Neoplasms; Fibroma; Hair Diseases; Hamartoma; Syndrome
PubMed: 37649357
DOI: 10.1111/cup.14522 -
Surgical Pathology Clinics Dec 2020Pediatric fibroblastic/myofibroblastic tumors are rare but include a wide variety of benign to malignant tumors. Given their uncommon frequency, they may present as a... (Review)
Review
Pediatric fibroblastic/myofibroblastic tumors are rare but include a wide variety of benign to malignant tumors. Given their uncommon frequency, they may present as a diagnostic dilemma. This article is focused on using clinical and pathologic clues in conjunction with the increasingly relevant and available molecular techniques to classify, predict prognosis, and/or guide treatment in these tumors.
Topics: Child; Diagnosis, Differential; Fasciitis; Fibroma; Fibrosarcoma; Hamartoma; Humans; Myofibroma
PubMed: 33183731
DOI: 10.1016/j.path.2020.08.009 -
Journal of Gastrointestinal Surgery :... Jan 2024
Topics: Humans; Stomach Neoplasms; Upper Gastrointestinal Tract; Digestive System Neoplasms; Fibroma
PubMed: 38353082
DOI: 10.1016/j.gassur.2023.10.003 -
The Canadian Veterinary Journal = La... Feb 2022A 12-year-old, spayed female, Maltese dog with a round and firm mass on the dorsal part of the left rear paw and a cervical mass was brought to the clinic. The paw mass...
A 12-year-old, spayed female, Maltese dog with a round and firm mass on the dorsal part of the left rear paw and a cervical mass was brought to the clinic. The paw mass was contiguous to the adjacent tendon; it was composed of neoplastic mesenchymal cells and had scattered foci of calcification with chondroid differentiation microscopically. The neoplastic cells were positive for vimentin and S100, but negative for desmin and smooth muscle actin. Microscopic features and immunohistochemistry results were consistent with calcifying aponeurotic fibroma (CAF). The cervical mass was composed of polygonal cells forming acini with marked anisocytosis and anisokaryosis and diagnosed as thyroid follicular carcinoma. No recurrence or metastasis occurred during follow-up. To the best of our knowledge, this is the first case of canine CAF with features identical to its human counterparts. Key clinical message: This report describes the rare case of calcifying aponeurotic fibroma on the paw in a dog. This is apparently the first case in the veterinary literature with identical clinical and pathological features to the human counterpart.
Topics: Animals; Calcinosis; Dog Diseases; Dogs; Female; Fibroma; Fibroma, Ossifying; Soft Tissue Neoplasms
PubMed: 35110769
DOI: No ID Found -
Asian Journal of Surgery Nov 2022
Topics: Duodenum; Fibroma; Humans; Soft Tissue Neoplasms; Stomach Neoplasms
PubMed: 35701273
DOI: 10.1016/j.asjsur.2022.05.150 -
Archives of Pathology & Laboratory... Dec 2019Ossifying fibromyxoid tumor (OFMT) is a rare, slow-growing mesenchymal neoplasm of uncertain histogenesis with intermediate malignant potential. (Review)
Review
CONTEXT.—
Ossifying fibromyxoid tumor (OFMT) is a rare, slow-growing mesenchymal neoplasm of uncertain histogenesis with intermediate malignant potential.
OBJECTIVE.—
To highlight the most important diagnostic features, including morphologic, immunohistochemical, and molecular findings; to provide comparisons to other entities in the differential diagnosis; and to provide a summary of the clinical features and outcomes in cases reported to date.
DATA SOURCES.—
The data sources include recently published literature encompassing OFMT and tumors in the histologic differential diagnosis, and cases from institutional files.
CONCLUSIONS.—
Ossifying fibromyxoid tumor is important to recognize because of its low-grade morphology but potential for recurrence and metastasis. Recent molecular analysis has expanded the morphologic spectrum of OFMT, with additional cases discovered that are enriched for aggressive behavior. The diagnosis can often be rendered through a combination of morphology and coexpression of S100 protein and desmin, although only a minority of cases described contain all of these primary features. In cases that do not have all of these features, a high index of suspicion guided by morphology and exclusion of other tumors in the histologic differential diagnosis can lead to the correct diagnosis. Growing access to molecular genetic testing will become increasingly important for correct diagnosis of tumors at the ends of the morphologic spectrum.
Topics: Diagnosis, Differential; Fibroma, Ossifying; Humans; Soft Tissue Neoplasms
PubMed: 31765250
DOI: 10.5858/arpa.2019-0371-RA -
Actas Dermo-sifiliograficas Apr 2022
Topics: Fibroma; Humans; Skin Diseases
PubMed: 35623736
DOI: 10.1016/j.ad.2020.05.019 -
Journal of Stomatology, Oral and... Feb 2020Ameloblastic fibroma are rare mixed tumors composed by both epithelial and mesenchymal tissues. They mostly affect the posterior mandibular sector in young adults. Here...
Ameloblastic fibroma are rare mixed tumors composed by both epithelial and mesenchymal tissues. They mostly affect the posterior mandibular sector in young adults. Here we report an atypical case affecting a very young patient in an unusual localization. We describe the management of the case and discuss the origin of this little know lesion.
Topics: Fibroma; Humans; Mandible; Odontogenic Tumors; Young Adult
PubMed: 31055094
DOI: 10.1016/j.jormas.2019.04.015 -
Advanced Emergency Nursing Journal 2020Fibromatosis colli is a rare, usually self-limiting condition caused by a benign tumor in the sternocleidomastoid muscle. The tumor occurs most often during infancy and...
Fibromatosis colli is a rare, usually self-limiting condition caused by a benign tumor in the sternocleidomastoid muscle. The tumor occurs most often during infancy and can be clinically associated with torticollis. Accurate diagnosis of fibromatosis colli is important to avoid unnecessary invasive interventions. Radiographic imaging is fundamental to differentiating this benign tumor from other causes of neck masses/swelling in infants. In this article, we discuss the case of a 4-month old child who presented with a head tilt and had imaging that favored a diagnosis of fibromatosis colli.
Topics: Female; Fibroma; Humans; Infant; Muscle Neoplasms; Neck Muscles
PubMed: 32000186
DOI: 10.1097/TME.0000000000000285