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Advances in Cancer Research 2021
Topics: Animals; Autophagy; Cellular Senescence; Humans; Medical Oncology; Neoplasms
PubMed: 33858602
DOI: 10.1016/S0065-230X(21)00041-5 -
Bioanalysis Mar 2021
Topics: Antineoplastic Agents; Biological Assay; Humans; Neoplasms
PubMed: 33661024
DOI: 10.4155/bio-2021-0014 -
The Lancet. Oncology Mar 2022
Topics: Air Pollution; Climate Change; Global Health; History, 21st Century; Humans; Medical Oncology; Neoplasms
PubMed: 35240078
DOI: 10.1016/S1470-2045(22)00069-9 -
Cancer Cell Feb 2021Comorbid conditions among cancer survivors are not a stranger to oncologists, but the conditions change when the cancer therapy toolbox expands. New interdisciplinary...
Comorbid conditions among cancer survivors are not a stranger to oncologists, but the conditions change when the cancer therapy toolbox expands. New interdisciplinary fields are recognized. We ask clinicians from psycho-oncology, cardio-oncology, and neurology to tell us how the fields have progressed and what to expect when we are standing at the crossroads of cancer.
Topics: Cancer Survivors; Humans; Medical Oncology; Neoplasms
PubMed: 33561392
DOI: 10.1016/j.ccell.2021.01.018 -
Nature Cancer Jun 2023Advances in molecular diagnostics have enabled the identification of targetable driver pathogenic variants, forming the basis of precision oncology care. However, the... (Review)
Review
Advances in molecular diagnostics have enabled the identification of targetable driver pathogenic variants, forming the basis of precision oncology care. However, the adoption of new technologies, such as next-generation sequencing (NGS) panels, can exacerbate healthcare disparities. Here, we summarize data on use patterns of advanced biomarker testing, highlight the disparities in both accessing NGS testing and using this data to match patients to appropriate personalized therapies and propose multidisciplinary strategies to address inequities looking forward.
Topics: Humans; Neoplasms; Precision Medicine; Medical Oncology; High-Throughput Nucleotide Sequencing
PubMed: 37248397
DOI: 10.1038/s43018-023-00568-1 -
Clinics in Laboratory Medicine Sep 2022Proper treatment of the patient with cancer depends on an accurate diagnosis of the tumor and is further directed by prognostic and more recently therapeutic molecular... (Review)
Review
Proper treatment of the patient with cancer depends on an accurate diagnosis of the tumor and is further directed by prognostic and more recently therapeutic molecular signatures in the era of precision medicine. Molecular oncology testing provides diagnostic, prognostic, and therapeutic information derived from the tumor genome. The aim of this review is to provide valuable information to laboratories for choosing optimal clinical specimens for molecular oncology testing by evaluating the strengths and weaknesses of different sample types from the procurement, processing, and pre-analytic selection matching to different test platforms.
Topics: Humans; Medical Oncology; Molecular Diagnostic Techniques; Neoplasms; Precision Medicine; Prognosis
PubMed: 36150817
DOI: 10.1016/j.cll.2022.04.002 -
Experimental and Clinical... Jan 2024
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Seminars in Cancer Biology Sep 2022Genomic profiling technologies have enabled the development of targeted therapies designed to target specific biomarkers and molecular pathways involved in the... (Review)
Review
Genomic profiling technologies have enabled the development of targeted therapies designed to target specific biomarkers and molecular pathways involved in the pathophysiology of tumor initiation, metastasis, and drug resistance. In recent years, clinical trials with innovative design focus on the development of novel agents based on specific patient molecular alterations or other tumor characteristics and include patients with heterogenous tumor types. Precision oncology studies with innovative design associated with novel dose-finding approaches and data analysis focusing on subgroups of patients are characteristic of master protocols. Real-world data, patient-reported outcomes, and N-of-1 trials enhance the knowledge base of evidence to deliver personalized treatment to patients. Master protocols accelerate drug development by enabling simultaneous multiple sub-studies that match the patient's tumor molecular profile with experimental treatment arms. However, the increased flexibility of precision oncology trials is often associated with small subpopulations of patients, which may be underpowered to draw statistically robust conclusions. Despite their limitations, innovative clinical trials continue to rapidly translate the emerging discoveries of novel drugs into unprecedented clinical outcomes in patients with cancer and to accelerate the implementation of precision oncology.
Topics: Humans; Medical Oncology; Neoplasms; Precision Medicine
PubMed: 33022355
DOI: 10.1016/j.semcancer.2020.09.006 -
Bulletin Du Cancer Sep 2020
Topics: Humans; Medical Oncology; Neoplasms; Professional-Patient Relations
PubMed: 32951685
DOI: 10.1016/j.bulcan.2020.09.001 -
Pediatric Annals Jan 2022Childhood cancer is the leading cause of nonaccidental death in children and adolescents. Over the past 50 years, development of novel therapies and improvements in... (Review)
Review
Childhood cancer is the leading cause of nonaccidental death in children and adolescents. Over the past 50 years, development of novel therapies and improvements in supportive care have led to improvements in long-term survival rates. However, there remains great morbidity associated with cancer treatment among childhood cancer survivors, and the outcomes for patients who relapse remain poor. The introduction of precision medicine, an approach that uses the understanding of genetic and biochemical profiles of a disease (as enabled by next-generation sequencing) to tailor treatment to a patient, has quickly started to change the diagnostic and therapeutic landscape of pediatric oncology. With its use, a better understanding of tumor biology, improved classification systems for various cancers, and genetically and molecularly targeted therapeutic strategies have been developed. We review the implementation of precision medicine in pediatric oncology and its effect on diagnosis, management, and treatment of pediatric cancers. .
Topics: Adolescent; Child; Humans; Medical Oncology; Neoplasms; Precision Medicine
PubMed: 35020508
DOI: 10.3928/19382359-20211209-01