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Journal of Dentistry (Shiraz, Iran) Sep 2022Osteoblastoma is a solitary benign bone-forming neoplasm, which comprises 1% of all primary bone tumors. Multifocal benign osteoblastoma of the jaws is very rare....
Osteoblastoma is a solitary benign bone-forming neoplasm, which comprises 1% of all primary bone tumors. Multifocal benign osteoblastoma of the jaws is very rare. Osteoblastoma must be differentiated from other similar bone-forming lesions such as osteoid osteoma and osteosarcoma for correct diagnosis and proper treatment planning. Therefore, precise examination of the patient and correlation with radiographic and histological features are essential for the best treatment and prognosis. This study reports a rare case of multifocal osteoblastoma in a 30-year-old female, involving the mandible and the maxilla, which was treated by surgical excision, iliac bone graft reconstruction, and implantation. Complete surgical excision is necessary to treat osteoblastoma with a good prognosis. The patient was followed-up for four years postoperatively, and there were no signs of recurrence in the panoramic view or the clinical examination.
PubMed: 36506877
DOI: 10.30476/DENTJODS.2021.90454.1491 -
Journal of Clinical Imaging Science 2022The performance of preoperative embolization on a spinal tumor can be a useful adjunctive procedure that minimizes blood loss and complications, particularly for both...
The performance of preoperative embolization on a spinal tumor can be a useful adjunctive procedure that minimizes blood loss and complications, particularly for both metastatic and non-metastatic hypervascular tumors. We discuss two cases of hypervascular spinal tumors that were successfully treated with preoperative embolization and surgery. The first patient was an 18-year-old man who presented with cervical and shoulder pain for two months without paralysis or weakness. Magnetic resonance imaging revealed a tumor located in the D2 posterior vertebral arch that extended into the spinal canal and compressed the spinal cord. The second patient was a 68-year-old man with back pain that radiated to the legs for ten days. Magnetic resonance imaging revealed a mass in the L4 vertebral body. Both patients received tumor embolization and surgery. After surgery, neither patient experienced any major complications. Histological examination revealed osteoblastoma in the first patient and plasmacytoma in the second patient.
PubMed: 35673594
DOI: 10.25259/JCIS_20_2022 -
Der Pathologe Mar 2020Osteoid osteoma and osteoblastoma are the most important benign osteoid-forming tumors. They grow slowly and are well differentiated. Histologically, the tumor cells... (Review)
Review
Osteoid osteoma and osteoblastoma are the most important benign osteoid-forming tumors. They grow slowly and are well differentiated. Histologically, the tumor cells show no atypia and no increased mitoses. In typical cases, they can be clearly diagnosed. However, the rare cases on the dividing line between osteoblastoma and osteosarcoma are extremely problematic. In these cases, molecular genetic investigations should contribute to finding the correct diagnosis in the future.Juvenile highly malignant osteosarcoma is the most important malignant osteoid-forming tumor. About 40 years ago, neoadjuvant chemotherapy was introduced for the mostly young patients. This therapy highly significantly improved prognosis. However, a plateau phase was quickly reached and the last several decades have seen no further progress in conventional therapeutic approaches. There is no doubt that further progress can only be achieved on the basis of new molecular genetic and cell biological findings. The target-therapeutic strategies derived from these findings will be discussed in this review.The rare parosteal osteosarcoma and the even rarer periosteal osteosarcoma are mostly not highly malignant tumors that are located on the surface of bone. The parosteal osteosarcoma is usually G1 and the periosteal osteosarcoma G2. Occasionally, the differential diagnosis between a parosteal osteosarcoma and a fibrous dysplasia is difficult. In such rare cases, the detection of GNAS mutations in fibrous dysplasia can prove useful. In contrast to chondromas and chondrosarcomas, periosteal osteosarcomas do not contain IDH1 and IDH2 mutations.
Topics: Bone Neoplasms; Diagnosis, Differential; Humans; Osteoblastoma; Osteoma, Osteoid; Osteosarcoma
PubMed: 32078700
DOI: 10.1007/s00292-020-00763-2 -
Bulletin Du Cancer Nov 2020Benign and malign tumors can affect the temporomandibular joint (TMJ) as any other articulation. Nevertheless, TMJ tumors are rare and mostly benign. Their clinical... (Review)
Review
Benign and malign tumors can affect the temporomandibular joint (TMJ) as any other articulation. Nevertheless, TMJ tumors are rare and mostly benign. Their clinical expression is varied including symptomatology similar to TMJ dysfunctional disorders, otologic or neurologic pathologies. In some cases, they remain totally asymptomatic. Hence, diagnosis is difficult since the symptomatology can be misleading with TMJ dysfunctional disorders or otologic disorders wrongly diagnosed. There is thus frequently a long delay between symptoms onset and diagnosis. The great variety of TMJ lesions explains the wide range of possible treatment modalities, mostly based on surgery. We provide here a review of the lesions originating from the TMJ. Tumoral or cystic mandibular lesion affecting the TMJ through local extension will not be discussed. Osteoma, osteoid osteoma, osteoblastoma, chondroma, osteochondroma, chondroblastoma, tenosynovial giant cell tumors, giant cell lesions, non-ossifying fibroma, hemangioma, lipoma or Langerhans cell histiocytosis are all possible diagnosis among the benign tumors found in the TMJ. Pseudotumors include synovial chondromatosis and aneurysmal bone cyst. Finally, malign tumors of the TMJ include mainly sarcomas (osteosarcoma, chondrosarcoma, synovial sarcoma, Ewing sarcoma, and fibrosarcoma), but also multiple myeloma and secondary metastases. We will review the clinical, radiological and histological aspects of each of these lesions. The treatment and the recurrence risk will also be discussed.
Topics: Bone Cysts, Aneurysmal; Bone Neoplasms; Chondroblastoma; Chondroma; Chondrosarcoma; Diagnosis, Differential; Fibrosarcoma; Giant Cell Tumor of Bone; Giant Cell Tumor of Tendon Sheath; Hemangioma; Histiocytosis, Langerhans-Cell; Humans; Lipoma; Multiple Myeloma; Osteoblastoma; Osteochondroma; Osteoma; Osteoma, Osteoid; Osteosarcoma; Sarcoma, Ewing; Sarcoma, Synovial; Temporomandibular Joint; Temporomandibular Joint Disorders
PubMed: 33059872
DOI: 10.1016/j.bulcan.2020.05.015 -
Foot (Edinburgh, Scotland) Dec 2020Osteoblastoma is a relatively rare, benign, bone-forming tumor, commonly observed in the second and third decades of life. Spine and the long tubular bones are the most... (Review)
Review
Osteoblastoma is a relatively rare, benign, bone-forming tumor, commonly observed in the second and third decades of life. Spine and the long tubular bones are the most common sites of involvement. Osteoblastoma is infrequently seen in other sites, including the bones of hand and foot. A rare case of a 35-year-old man that presented an osteoblastoma of the cuboid bone is reported. The patient was treated with surgical resection and grafting. After the intervention, the patient recovered with no clinical and radiological evidence of recurrence after one year of follow-up. Several cases of osteoblastoma-like variant of osteosarcoma of the cuboid have been previously reported, but, to our knowledge, this is the first case of conventional and isolated osteoblastoma involving the cuboid bone reported in the literature.
Topics: Adult; Bone Neoplasms; Humans; Male; Osteoblastoma; Tarsal Bones
PubMed: 33039906
DOI: 10.1016/j.foot.2020.101691 -
BMC Musculoskeletal Disorders Apr 2020To analyze the features of CT, MRI and PET/CT and their diagnostic value for spinal osteoblastomas (OBs).
BACKGROUND
To analyze the features of CT, MRI and PET/CT and their diagnostic value for spinal osteoblastomas (OBs).
METHODS
The radiological and clinical data of 21 patients with histopathologically-confirmed spinal OBs were analyzed retrospectively.
RESULTS
Sixteen of the 21 cases were benign and 5 were aggressive OBs. Tumors were located in the lumbar (n = 11), cervical (n = 4), thoracic (n = 5), and sacral (n = 1) spinal regions. Nineteen cases were centered in the posterior elements of the spine, 13 of which extended into the vertebral body. Punctate or nodular calcifications were found in all cases on CT with a complete sclerotic rim (n = 12) or incomplete sclerotic rim (n = 8). The flare phenomenon (indicative of surrounding tissue inflammation) was found in 17/21 cases on CT, thin in 11 cases and thick in 6 cases, and in 19/19 cases on MRI, thin in 1 case and thick in 18 cases. On F-FDG PET/CT, all cases (8/8) were metabolically active with the SUVmax of 12.3-16.0; the flare sign was observed in 8 cases, including 7 cases of hypometabolism and 1 case of coexistence of hypermetabolism and hypometabolism. Based on CT, 3, 12, and 6 cases were classified as Enneking stage 1, 2 and 3, respectively. Of 19 cases with MRI, 1 and 18 cases were classified as Enneking stage 2 and 3, respectively.
CONCLUSIONS
Spinal OB has multiple unique characteristic radiological features. Although a larger sample size is needed, combining CT, MRI and PET may be beneficial to optimize preoperative diagnosis and care of patients with OBs.
Topics: Adolescent; Adult; Algorithms; Child; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Osteoblastoma; Positron-Emission Tomography; Retrospective Studies; Spinal Neoplasms; Tomography, X-Ray Computed; Young Adult
PubMed: 32290828
DOI: 10.1186/s12891-020-03252-y -
Disease Markers 2022This study is aimed at exploring the clinical manifestations and prognostic factors of osteosarcoma.
OBJECTIVE
This study is aimed at exploring the clinical manifestations and prognostic factors of osteosarcoma.
METHODS
The clinical data of patients with osteosarcoma who were treated in our hospital from January 2018 to March 2020 were selected for retrospective analysis. The general information of the patients, including age, gender, tumor diameter, tumor location, tumor type, surgical method, and Enneking stage, distant disease metastasis, KPS score, and the number of postoperative adjuvant chemotherapy, were grouped by prognosis for statistical analysis. The clinical characteristics, morbidity and mortality, and prognostic factors of patients were statistically analyzed.
RESULTS
Among the 83 patients in this group, there were 52 males and 31 females, 59 tumors > 10 cm in diameter and 24 tumors < 10 cm in diameter, 16 tumors in the upper limbs and 67 tumors in the lower limbs, 25 tumors in osteoblastoma, 16 tumors in chondroblastoma, 42 tumors in fibroblastoma, 62 tumors in stage II, and 21 tumors in stage III of Enneking stage, 10 tumors in distant metastasis, and 10 tumors in distant metastasis. The death rate of this group was 19.28% (16/83). Multifactor regression analysis confirmed that the Enneking stage III, distant metastasis, KPS score < 70, and the number of postoperative adjuvant chemotherapy < 6 were important factors influencing the death of osteosarcoma ( < 0.05).
CONCLUSION
Enneking stage III, distant metastasis, KPS score < 70, and the number of postoperative adjuvant chemotherapy < 6 are important influencing factors of osteosarcoma death. Clinical practice can take corresponding preventive and control measures according to the existence of these factors to ensure a good prognosis.
Topics: Bone Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Male; Osteosarcoma; Prognosis; Retrospective Studies
PubMed: 35968499
DOI: 10.1155/2022/1599112 -
Journal of Comparative Pathology Oct 2019A 7-year-old neutered male domestic shorthair cat was presented with chronic lameness in the right forelimb. A cystic bony lesion was identified in the distal right...
A 7-year-old neutered male domestic shorthair cat was presented with chronic lameness in the right forelimb. A cystic bony lesion was identified in the distal right humerus and amputation was performed. The epiphyseal trabecular bones of the capitulum and trochlea was replaced by a tan to pink, expansile mass that was surrounded by a thin rim of cortical bone. Microscopically, the tumour was composed of a bland, osteoid producing spindle cell population within a well-vascularized fibrous stroma. Radiographical and histological features were consistent with osteoblastoma. Osteoblastoma and the related osteoid osteoma are uncommon, benign osteoblastic tumours that are reported rarely in animals. These tumours should be considered as differential diagnoses for slow growing, cystic bony lesions in cats.
Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Humerus; Male; Neoplasms, Bone Tissue; Osteoblastoma
PubMed: 31690411
DOI: 10.1016/j.jcpa.2019.08.007 -
Otology & Neurotology : Official... Feb 2022This report describes osteoblastoma of the temporal bone found on a well-child visit. The relevant clinical, radiographic, and histologic features are described. The...
This report describes osteoblastoma of the temporal bone found on a well-child visit. The relevant clinical, radiographic, and histologic features are described. The tumor was completely resected via a transtemporal approach. The differential diagnosis for these tumors include osteoma, giant cell tumor, histiocytosis, aneurysmal bone cyst and sarcoma. Histologic findings are critical for determining the proper diagnosis.
Topics: Bone Cysts, Aneurysmal; Bone Neoplasms; Diagnosis, Differential; Humans; Osteoblastoma; Osteoma, Osteoid; Temporal Bone
PubMed: 35015753
DOI: 10.1097/MAO.0000000000003381 -
Diagnostics (Basel, Switzerland) Apr 2023Vertebra plana is a rare radiologic condition characterized by a uniform loss of height of a vertebral body that represents a diagnostic challenge for surgeons. The... (Review)
Review
Vertebra plana is a rare radiologic condition characterized by a uniform loss of height of a vertebral body that represents a diagnostic challenge for surgeons. The purpose of this study was to review all possible differential diagnoses that may present with a vertebra plana (VP) described in the current literature. For that purpose, we performed a narrative literature review in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, analyzing 602 articles. Patient demographics, clinical presentation, imaging characteristics and diagnoses were investigated. VP is not a pathognomonic feature of Langerhans cell histiocytosis, but other oncologic and non-oncologic conditions should be considered. The list of differential diagnoses, based on our literature review, can be recalled with the mnemonic HEIGHT OF HOMO: H-Histiocytosis; E-Ewing's sarcoma; I-Infection; G-Giant cell tumor; H-Hematologic neoplasms; T-Tuberculosis; O-Osteogenesis imperfecta; F-Fracture; H-Hemangioma; O-Osteoblastoma; M-Metastasis; O-Osteomyelitis, chronic.
PubMed: 37189540
DOI: 10.3390/diagnostics13081438