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Current Rheumatology Reviews 2024Panniculitis was first described in the nineteenth century and is characterized by inflammation of the subcutaneous fat. It may be categorized in septal or lobular... (Review)
Review
Panniculitis was first described in the nineteenth century and is characterized by inflammation of the subcutaneous fat. It may be categorized in septal or lobular subtypes, but other histopathological features (e.g., presence of vasculitis, nature of inflammatory infiltrates, characteristics of fat necrosis) are also important for diagnostic purposes. Clinically, panniculitis is characterized by the presence of subcutaneous nodules, and both ulcerative and nonulcerative clinical subtypes have been proposed. In this review, we aimed to describe the occurrence of panniculitis in autoinflammatory disorders (AIDs) and related diseases. Among monogenic AIDs, panniculitis is common in IFN-mediated disorders. Panniculitis is a distinctive feature in proteasome-associated autoinflammatory syndromes (PRAAS), including chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome and Nakajo-Nishimura syndrome. On the other hand, erythema nodosum corresponds to the most common clinical form of panniculitis and is common in polygenic AIDs, such as Behçet's syndrome, inflammatory bowel disease, and sarcoidosis. Cytophagic histiocytic panniculitis, lipoatrophic panniculitis of children, and otulipenia are rare disorders that may also present with inflammation of the subcutaneous fat. Therefore, panniculitis can identify a specific subgroup of patients with AIDs and may potentially be regarded as a cardinal sign of autoinflammation.
Topics: Humans; Panniculitis; Hereditary Autoinflammatory Diseases; Inflammation
PubMed: 37921131
DOI: 10.2174/0115733971254702231020060633 -
Phlebology Mar 2023We aimed to clarify whether acute lipodermatosclerosis (LDS) progress to chronic LDS without continued compression therapy. (Review)
Review
OBJECTIVES
We aimed to clarify whether acute lipodermatosclerosis (LDS) progress to chronic LDS without continued compression therapy.
METHODS
Between April 2015 and November 2021, 30 patients with acute/subacute LDS, which was diagnosed clinically by presence of isolated, poorly demarcated, tender erythema, and induration limited to the lower leg(s), visited our clinic and were able to be followed up for longer than a year. We reviewed their treatment results and the post-treatment courses.
RESULTS
In all cases, the symptoms in the acute phase subsided with compression bandages. After the discontinuation of compression therapy, 18 legs (56%) progressed to chronic LDS, and 14 legs (44%) did not. In the legs without progression, subcutaneous tissue in the affected leg was thicker compared with that in the contralateral leg (median 19.1 mm vs. 13.4 mm, < 0.05) on the initial visit. In the legs with progression, the difference in subcutaneous tissue thickness between the affected and unaffected legs was not significant (10.0 mm vs. 7.6 mm).
CONCLUSIONS
Our findings suggest that in legs which later progress to chronic LDS, subcutaneous tissue contraction due to panniculitis is already present during the acute phase; therefore, long-term compression therapy is unlikely to improve the prognosis.
Topics: Humans; Scleroderma, Localized; Dermatitis; Panniculitis; Leg
PubMed: 36529929
DOI: 10.1177/02683555221147473 -
Internal Medicine (Tokyo, Japan) Sep 2020A 44-year-old woman presented to our hospital with abdominal pain. Abdominal ultrasonography and computed tomography showed a mass-like change in the lesser omentum...
A 44-year-old woman presented to our hospital with abdominal pain. Abdominal ultrasonography and computed tomography showed a mass-like change in the lesser omentum between the liver and stomach. Esophagogastroduodenoscopy revealed a submucosal tumor-like change, and endoscopic ultrasonography (EUS) revealed that the mass was located outside of the stomach wall. We performed EUS fine-needle aspiration and diagnosed panniculitis of the lesser omentum. Based on these findings, we suggest that mass-like lesions in the lesser omentum and submucosal tumor-like changes in the anterior wall on the lesser curvature side of the stomach be evaluated for the possibility of panniculitis of the lesser omentum.
Topics: Adult; Biopsy, Fine-Needle; Endosonography; Female; Humans; Omentum; Panniculitis, Peritoneal; Tomography, X-Ray Computed
PubMed: 32461523
DOI: 10.2169/internalmedicine.4300-19 -
Dermatologic Clinics Apr 2024Neutrophilic panniculitides are a heterogeneous group of inflammatory disorders encompassing many different entities. This review article focuses on the epidemiology,... (Review)
Review
Neutrophilic panniculitides are a heterogeneous group of inflammatory disorders encompassing many different entities. This review article focuses on the epidemiology, pathogenesis, clinicopathological features, diagnosis, and treatment of selected diseases. Patients often seek care due to systemic involvement, but the variable presentation of panniculitides can present a diagnostic challenge. Most therapeutic modalities for neutrophilic disorders are anecdotal at best with a notable lack of standardization of the responses to medications. There is an urgent need for a larger multi-institutional collaboration to address the unmet needs of these challenging, yet rare conditions.
Topics: Humans; Panniculitis
PubMed: 38423687
DOI: 10.1016/j.det.2023.08.005 -
QJM : Monthly Journal of the... Mar 2024
Topics: Humans; Panniculitis, Peritoneal; Mesentery
PubMed: 38039181
DOI: 10.1093/qjmed/hcad266 -
Medicina 2021
Topics: Humans; Pancreas; Pancreatic Neoplasms; Panniculitis
PubMed: 34633973
DOI: No ID Found -
RoFo : Fortschritte Auf Dem Gebiete Der... Nov 2021
Topics: Breast; Diagnosis, Differential; Humans; Panniculitis
PubMed: 33772496
DOI: 10.1055/a-1425-9104 -
Revista Espanola de Enfermedades... Oct 2019Pancreatic panniculitis (PP) is an infrequent manifestation of pancreatic pathology (2%). This condition has mainly been described in association with acute and chronic...
Pancreatic panniculitis (PP) is an infrequent manifestation of pancreatic pathology (2%). This condition has mainly been described in association with acute and chronic pancreatitis, in males aged 40-60 years with chronic alcoholism, as was the case of this patient. However, it might also be the outset manifestation of a pancreatic neoplasm.
Topics: Adult; Humans; Male; Pancreatitis, Alcoholic; Pancreatitis, Chronic; Panniculitis
PubMed: 31545069
DOI: 10.17235/reed.2019.6116/2018 -
Arteriosclerosis, Thrombosis, and... May 2020The immune system plays an important role in obesity-induced adipose tissue inflammation and the resultant metabolic dysfunction, which can lead to hypertension,... (Review)
Review
The immune system plays an important role in obesity-induced adipose tissue inflammation and the resultant metabolic dysfunction, which can lead to hypertension, dyslipidemia, and insulin resistance and their downstream sequelae of type 2 diabetes mellitus and cardiovascular disease. While macrophages are the most abundant immune cell type in adipose tissue, other immune cells are also present, such as B cells, which play important roles in regulating adipose tissue inflammation. This brief review will overview B-cell subsets, describe their localization in various adipose depots and summarize our knowledge about the function of these B-cell subsets in regulating adipose tissue inflammation, obesity-induced metabolic dysfunction and atherosclerosis.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents; Atherosclerosis; Autoimmunity; B-Lymphocyte Subsets; Cell Communication; Cytokines; Humans; Immunotherapy; Inflammation Mediators; Panniculitis; Phenotype; Signal Transduction
PubMed: 32131612
DOI: 10.1161/ATVBAHA.119.312467 -
Journal of Clinical Rheumatology :... Aug 2020
Topics: Arthritis; Humans; Pancreatitis; Panniculitis
PubMed: 30273266
DOI: 10.1097/RHU.0000000000000914