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European Journal of Dermatology : EJD Apr 2021
Topics: Adult; Cyclosporine; Female; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Pemphigoid Gestationis; Pregnancy; Retreatment; Steroids; Treatment Failure
PubMed: 34001471
DOI: 10.1684/ejd.2021.4006 -
Mayo Clinic Proceedings Feb 2021
Topics: Biopsy; Diagnosis, Differential; Female; Humans; Pemphigoid Gestationis; Pregnancy; Pruritus; Young Adult
PubMed: 33549261
DOI: 10.1016/j.mayocp.2020.10.037 -
Journal of the European Academy of... Jun 2023
Topics: Pregnancy; Female; Humans; Pemphigoid Gestationis; Antibodies, Monoclonal, Humanized; Pemphigoid, Bullous
PubMed: 36688319
DOI: 10.1111/jdv.18911 -
Actas Dermo-sifiliograficas Oct 2019
Topics: Adult; Female; Humans; Mouth Diseases; Pemphigoid Gestationis; Pregnancy; Remission, Spontaneous
PubMed: 30732852
DOI: 10.1016/j.ad.2018.02.038 -
Journal of the European Academy of... Sep 2022
Topics: Female; Humans; Omalizumab; Pemphigoid Gestationis; Pemphigoid, Bullous; Pregnancy; Pregnancy Complications
PubMed: 35592910
DOI: 10.1111/jdv.18227 -
The American Journal of Dermatopathology Jan 2021Flame figures represent a characteristic but nondiagnostic histological finding in eosinophilic dermatoses. Some bullous autoimmune diseases with a predominant...
Flame figures represent a characteristic but nondiagnostic histological finding in eosinophilic dermatoses. Some bullous autoimmune diseases with a predominant eosinophilic infiltrate, such as bullous pemphigoid, pemphigoid gestationis, and pemphigus vegetans, may show them. However, it is rare to find them in predominant neutrophilic bullous dermatoses such as linear immunoglobulin A. We present a 60-year-old man with a history of chronic urticaria, which presented a bullous disease after an acute parvovirus B19 infection. The histological findings showed an exceptional linear immunoglobulin A bullous dermatosis with an eosinophilic infiltrate in the dermis forming "flame figures." The clinical and histopathological findings for this entity may be identical to those of other dermatoses. For this reason, combining these findings with direct immunofluorescence analysis is essential for correct diagnosis of this bullous disease.
Topics: Adrenal Cortex Hormones; Anti-Allergic Agents; Antibodies, Viral; Eosinophils; Erythema Infectiosum; Histamine Antagonists; Host-Pathogen Interactions; Humans; Immunoglobulin M; Linear IgA Bullous Dermatosis; Male; Middle Aged; Parvovirus B19, Human; Skin; Treatment Outcome
PubMed: 32472771
DOI: 10.1097/DAD.0000000000001690 -
SAGE Open Medical Case Reports 2019Polymorphic eruption of pregnancy, formerly known as pruritic and urticarial papules and plaques of pregnancy, is an uncommon cutaneous eruption that can affect women...
Polymorphic eruption of pregnancy, formerly known as pruritic and urticarial papules and plaques of pregnancy, is an uncommon cutaneous eruption that can affect women during their third trimester of pregnancy. As its name implies, it has a variety of morphologies and it is important to consider other diagnoses, such as pemphigoid gestationis, which polymorphic eruption of pregnancy can mimic. Sometimes, as in this case, polymorphic eruption of pregnancy can have a targetoid morphology reminiscent of erythema multiforme. A thorough workup and conservative management plan helps reassure the patient that the correct approach is being taken during the challenging period of a pregnancy nearing completion.
PubMed: 31662850
DOI: 10.1177/2050313X19882841 -
Der Hautarzt; Zeitschrift Fur... Mar 2020Pemphigoid gestationis (PG) is a blistering autoimmune skin disease, typically occurring in the second and third trimester of pregnancy. Aberrant expression of major...
Pemphigoid gestationis (PG) is a blistering autoimmune skin disease, typically occurring in the second and third trimester of pregnancy. Aberrant expression of major histocompatibility complex (MHC) class II molecules on the chorionic villi seems to lead to antibody production against bullous pemphigoid (BP)-180. We report a case of PG in a woman whose pregnancy was achieved using egg donation. Since the entire fetal genome is allogeneic to the mother, augmented immune reaction in egg-donated pregnancies appears to trigger the occurrence of PG.
Topics: Adult; Autoimmune Diseases; Blister; Female; Humans; Pemphigoid Gestationis; Pemphigoid, Bullous; Pregnancy; Pregnancy Outcome; Skin Diseases, Vesiculobullous; Urticaria
PubMed: 31950210
DOI: 10.1007/s00105-019-04518-w -
Cureus Mar 2024Background Autoimmune vesiculobullous diseases (AIBDs) are a group of diseases characterized by blisters of the skin/mucosa due to the presence of circulating...
Background Autoimmune vesiculobullous diseases (AIBDs) are a group of diseases characterized by blisters of the skin/mucosa due to the presence of circulating autoantibodies against antigens in the epidermis or the dermo-epidermal junction. Direct immunofluorescence (DIF) for immunoglobulin (Ig)G, IgC3, and IgA on fresh-frozen tissue is the gold standard diagnostic test for AIBDs. However, DIF in the absence of frozen tissue is challenging for the diagnosis of AIBDs. This study aimed to analyze the practical utility of DIF using paraffin-embedded skin biopsy rather than fresh frozen tissue for the diagnosis of AIBDs. Methodology This cross-sectional comparative study included 30 cases of AIBDs. DIF for IgG and IgA was performed on paraffin-embedded tissue (PE-DIF) after proteinase digestion on histopathologically confirmed 15 pemphigus vulgaris (PV), three pemphigus foliaceous (PF), four bullous pemphigoid (BP), three dermatitis herpetiformis (DH), three subcorneal pustular dermatosis (SCPD), and one case each of linear IgA disease and pemphigoid gestationis (PG). PE-DIF staining pattern was compared with the DIF on fresh frozen tissue (FF-DIF). Results All cases of PV and PF showed an intercellular IgG chicken wire staining pattern similar to FF-DIF. However, background staining was more intense in PV cases while less intense in PF cases. Three BP cases showed linear IgG staining in PE-DIF. DH, SCPD, linear IgA disease, and PG cases did not show IgG positivity. Out of three DH cases, two cases showed granular IgA positivity while linear IgA positivity along the basement membrane was seen in a single case of linear IgA disease. Negative IgG staining was observed in SCPD. Immunofluorescence in PE-DIF was rapidly deteriorating than in FF-DIF. Conclusions DIF done on paraffin-embedded tissue can be used as a supplement and salvage technique with histopathology for the diagnosis of AIBDs, particularly when a cryostat facility for frozen tissue is not available and the patient is unable to undergo a second biopsy procedure.
PubMed: 38665766
DOI: 10.7759/cureus.56916 -
Journal of the American Academy of... Jun 2024
PubMed: 38906262
DOI: 10.1016/j.jaad.2024.05.087