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Scientific Reports Jan 2021The present study has focused on the degradation of phenazopyridine (PhP) as an emerging contaminant through catalytic ozonation by novel plasma treated natural limonite...
The present study has focused on the degradation of phenazopyridine (PhP) as an emerging contaminant through catalytic ozonation by novel plasma treated natural limonite (FeOOH·xHO, NL) under argon atmosphere (PTL/Ar). The physical and chemical characteristics of samples were evaluated with different analyses. The obtained results demonstrated higher surface area for PTL/Ar and negligible change in crystal structure, compared to NL. It was found that the synergistic effect between ozone and PTL/Ar nanocatalyst was led to highest PhP degradation efficiency. The kinetic study confirmed the pseudo-first-order reaction for the PhP degradation processes included adsorption, peroxone and ozonation, catalytic ozonation with NL and PTL/Ar. Long term application (6 cycles) confirmed the high stability of the PTL/Ar. Moreover, different organic and inorganic salts as well as the dissolved ozone concentration demonstrated the predominant role of hydroxyl radicals and superoxide radicals in PhP degradation by catalytic Ozonation using PTL/Ar. The main produced intermediates during PhP oxidation by PTL/Ar catalytic ozonation were identified using LC-(+ESI)-MS technique. Finally, the negligible iron leaching, higher mineralization rate, lower electrical energy consumption and excellent catalytic activity of PTL/Ar samples demonstrate the superior application of non-thermal plasma for treatment of NL.
PubMed: 33441829
DOI: 10.1038/s41598-020-80200-9 -
Frontiers in Chemistry 2021Nanosized titanium oxide (TiO)-based photocatalysts have exhibited great potential for the degradation of organic contaminants, while their weak absorption of visible...
Preparation and Characterization of Reduced Graphene Oxide /TiO Blended Polyphenylene sulfone Antifouling Composite Membrane With Improved Photocatalytic Degradation Performance.
Nanosized titanium oxide (TiO)-based photocatalysts have exhibited great potential for the degradation of organic contaminants, while their weak absorption of visible light limits the photocatalytic efficiency. Herein, a novel reduced graphene oxide/TiO-polyphenylenesulfone (rGO/TiO-PPSU) hybrid ultrafiltration membrane has been successfully prepared via a non-solvent induced phase-separation method, in which the synergistic coupling between the rGO and TiO could endowed the fabricated membranes with visible-light-driven efficient photocatalytically degradation of organic pollutants and outstanding photocatalytic and antifouling properties. Compared with the PPSU membranes prepared with Graphene oxide and TiO, respectively, the rGO/TiO-PPSU membrane demonstrated significant photodegradation towards phenazopyridine hydrochloride (PhP) solution under ultraviolet light (improved about 71 and 43%) and visible light (improved about 153 and 103%). The permeability and flux recovery rates of the membrane indicated that the high flux of the rGO/TiO-PPSU membrane can be greatly restored after fouling, due to the improved self-cleaning properties under visible light static irradiation. With the properties of high performance of photocatalytic degradation and good self-cleaning ability, the rGO/TiO-PPSU membrane would have great potential in water treatment.
PubMed: 34738005
DOI: 10.3389/fchem.2021.753741 -
Urology Aug 2019Phenazopyridine is a common, well-tolerated medication with minimal side effects. Severe side effects are rare and include methemoglobinemia in setting of overdose,...
Phenazopyridine is a common, well-tolerated medication with minimal side effects. Severe side effects are rare and include methemoglobinemia in setting of overdose, elderly patients, renal insufficiency, and chronic use. Here, we report a case of methemoglobinemia-induced perioperative hypoxia in an adolescent patient without renal insufficiency or overdose which has not been reported previously. This case underscores the importance of judicious use of this medication in all patients but notably in pediatric patients and those with chronic lung disease.
Topics: Adolescent; Humans; Hypoxia; Male; Methemoglobinemia; Phenazopyridine; Postoperative Complications
PubMed: 30917912
DOI: 10.1016/j.urology.2019.03.017 -
Pharmaceutical Research Nov 2019The intracellular fraction of unbound compound (f) is an important parameter for accurate prediction of drug binding to intracellular targets. f is the result of a...
PURPOSE
The intracellular fraction of unbound compound (f) is an important parameter for accurate prediction of drug binding to intracellular targets. f is the result of a passive distribution process of drug molecules partitioning into cellular structures. Initial observations in our laboratory showed an up to 10-fold difference in the f of a given drug for different cell types. We hypothesized that these differences could be explained by the phospholipid (PL) composition of the cells, since the PL cell membrane is the major sink of unspecific drug binding. Therefore, we determined the f of 19 drugs in cell types of different origin.
METHOD
The cells were characterized for their total PL content and we used mass spectrometric PL profiling to delineate the impact of each of the four major cellular PL subspecies: phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI). The cell-based experiments were compared to cell-free experiments that used beads covered by PL bilayers consisting of the most abundant PL subspecies.
RESULTS
PC was found to give the largest contribution to the drug binding. Improved correlations between the cell-based and cell-free assays were obtained when affinities to all four major PL subspecies were considered. Together, our data indicate that f is influenced by PL composition of cells.
CONCLUSION
We conclude that cellular PL composition varies between cell types and that cell-specific mixtures of PLs can replace cellular assays for determination of f as a rapid, small-scale assay covering a broad dynamic range. Graphical Abstract.
Topics: Biological Availability; Biological Transport; Caffeine; Cell Line; Cell Membrane; Computer Simulation; Cytoplasm; Drug Interactions; Humans; Models, Biological; Phenazopyridine; Phospholipids
PubMed: 31701258
DOI: 10.1007/s11095-019-2717-1 -
International Urogynecology Journal Jun 2021
Topics: Anesthetics, Local; Humans; Phenazopyridine; Preoperative Care; Urinary Retention
PubMed: 33595673
DOI: 10.1007/s00192-021-04722-0