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Anti-cancer Agents in Medicinal... 2023According to a 2020 WHO study, cancer is responsible for one in every six fatalities. One in four patients die due to side effects and intolerance to chemotherapy,... (Review)
Review
According to a 2020 WHO study, cancer is responsible for one in every six fatalities. One in four patients die due to side effects and intolerance to chemotherapy, making it a leading cause of patient death. Compared to traditional tumor therapy, emerging treatment methods, including immunotherapy, gene therapy, photothermal therapy, and photodynamic therapy, have proven to be more effective. The aim of this review is to highlight the role of gold nanoparticles in advanced cancer treatment. A systematic and extensive literature review was conducted using the Web of Science, PubMed, EMBASE, Google Scholar, NCBI, and various websites. Highly relevant literature from 141 references was chosen for inclusion in this review. Recently, the synergistic benefits of nano therapy and cancer immunotherapy have been shown, which could allow earlier diagnosis, more focused cancer treatment, and improved disease control. Compared to other nanoparticles, the physical and optical characteristics of gold nanoparticles appear to have significantly greater effects on the target. It has a crucial role in acting as a drug carrier, biomarker, anti-angiogenesis agent, diagnostic agent, radiosensitizer, cancer immunotherapy, photodynamic therapy, and photothermal therapy. Gold nanoparticle-based cancer treatments can greatly reduce current drug and chemotherapy dosages.
Topics: Humans; Gold; Metal Nanoparticles; Nanoparticles; Photochemotherapy; Neoplasms; Phototherapy
PubMed: 37842886
DOI: 10.2174/0118715206268664231004040210 -
Photodiagnosis and Photodynamic Therapy Dec 2022Photodynamic therapy (PDT) is an adjunctive treatment that aims to inactivate microorganisms through an oxidative reaction produced by irradiating a photosensitizing... (Review)
Review
BACKGROUND
Photodynamic therapy (PDT) is an adjunctive treatment that aims to inactivate microorganisms through an oxidative reaction produced by irradiating a photosensitizing agent. The quest for improved root canal disinfection has sought supplementary methods when performing chemomechanical procedures. From this perspective, PDT protocols were proposed as an auxiliary approach in endodontics. Thus, the aim of this study was to investigate publication metrics and research trends related to this scope.
METHODS
This review is reported in accordance with the PRISMA 2020 recommendations. Two blinded and independent reviewers systematically searched five electronic databases until December 2021. The acquired bibliometric parameters were analyzed through descriptive statistics and graphical mappings with VOSViewer software.
RESULTS
The search retrieved 342 studies from 84 journals originating from 33 countries. About 85% of the included studies were published over the last decade. Most of the available evidence is laboratory-based (74.5%), and the main clinical outcomes evaluated were microbiological load reduction and postoperative pain. Mayram Pourhajibagher is the researcher with the most publications as the first author (n = 16). Tehran University of Medical Sciences carried out the highest number of studies (n = 29), and Photodiagnosis and Photodynamic Therapy is the journal that most published on the theme (n = 111).
CONCLUSIONS
This bibliometric analysis mapped and discussed the scientific progress and publication metrics in PDT in endodontic research. Additionally, future perspectives were highlighted and should focus on discovering new photosensitizer agents, standardizing optimal photoactivation protocols, and conducting more clinical-oriented research.
Topics: Photochemotherapy; Iran; Endodontics; Photosensitizing Agents; Bibliometrics
PubMed: 35907620
DOI: 10.1016/j.pdpdt.2022.103039 -
Photobiomodulation, Photomedicine, and... Oct 2019
Topics: Brain Diseases; Female; Forecasting; History, 20th Century; Humans; Male; Periodicals as Topic; Photochemotherapy; Phototherapy; Psychotropic Drugs
PubMed: 31549918
DOI: 10.1089/photob.2019.4733 -
Photobiomodulation, Photomedicine, and... Jul 2019The aim of this review is to discuss and compare the extensive range of biomedical applications of photo- and sono-activated Rose Bengal (RB). RB is a xanthene dye... (Review)
Review
The aim of this review is to discuss and compare the extensive range of biomedical applications of photo- and sono-activated Rose Bengal (RB). RB is a xanthene dye that due to its interesting photo- and sono-sensitive properties is gaining attention in the scientific field. This study is a literature review using the database PubMed. As a photosensitizer, RB converts the triplet oxygen molecule into reactive oxygen species after irradiation with green light (532 nm). This mechanism allows for the use of photo-activated RB in photochemical tissue bonding, photodynamic therapy, antimicrobial therapy and cancer treatment, photothrombotic animal models, and other applications, including tissue engineering and treatment of tauopathies. As a sono-sensitive compound, RB is applied for sonodynamic therapy, cancer treatment, and antimicrobial therapy. This review outlines the versatility and effectiveness of photo- and sono-activated RB in numerous biomedical applications.
Topics: Humans; Photochemotherapy; Photosensitizing Agents; Rose Bengal
PubMed: 31180251
DOI: 10.1089/photob.2018.4604 -
British Journal of Nursing (Mark Allen... May 2020Psoriasis is a chronic, multisystem inflammatory disease, predominantly affecting the skin and joints, which is present in 2-3% of the world's population. Narrow band...
Psoriasis is a chronic, multisystem inflammatory disease, predominantly affecting the skin and joints, which is present in 2-3% of the world's population. Narrow band ultraviolet B (NB-UVB) and Psoralen + ultraviolet A (PUVA) are recognised, effective and, in the case of UVB, economical second-line treatments for psoriasis where topical therapies fail to control the disease or are an impracticable option due to the extent of skin involvement. This article examines the history of phototherapy and photochemotherapy and looks at current phototherapy treatments used for psoriasis. It discusses side effects of treatment and regimens that can be followed to increase effectiveness of treatment and minimise risks. The role of the nurse phototherapist is also discussed.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Female; Humans; Male; Middle Aged; Photochemotherapy; Psoriasis; Skin Neoplasms; Treatment Outcome; Ultraviolet Therapy
PubMed: 32463760
DOI: 10.12968/bjon.2020.29.10.547 -
Photodiagnosis and Photodynamic Therapy Jun 2023Chronic liver diseases (CLDs) are a major public health problem. Despite the progress achieved in fighting against viral hepatitis, the emergence of non-alcoholic fatty... (Review)
Review
Chronic liver diseases (CLDs) are a major public health problem. Despite the progress achieved in fighting against viral hepatitis, the emergence of non-alcoholic fatty liver disease might pose a serious challenge to the public's health in the coming decades. Medical management of CLDs represents a substantial burden on the public health infrastructures. The health care cost of these diseases is an additional burden that weighs heavily on the economies of developing countries. Effective management of CLDs requires the adoption of reliable and cost-effective screening and diagnosing methods to ensure early detection and accurate clinical assessment of these diseases. Vibrational spectroscopies have emerged as universal analytical methods with promising applications in various industrial and biomedical fields. These revolutionary analytical techniques rely on analyzing the interaction between a light beam and the test sample to generate a spectral fingerprint. This latter is defined by the analyte's chemical structure and the molecular vibrations of its functional groups. Raman spectroscopy and surface-enhanced Raman spectroscopy have been used in combination with various chemometric tests to diagnose a wide range of malignant, metabolic and infectious diseases. The aim of the current review is to cast light on the use of these optical sensing methods in the diagnosis of CLDs. The vast majority of research works that investigated the potential application of these spectroscopic techniques in screening and detecting CLDs were discussed here. The advantages and limitations of these modern analytical methods, as compared with the routine and gold standard diagnostic approaches, were also reviewed in details.
Topics: Humans; Spectrum Analysis, Raman; Photochemotherapy; Photosensitizing Agents; Liver Diseases; Vibration
PubMed: 36965755
DOI: 10.1016/j.pdpdt.2023.103505 -
Photodiagnosis and Photodynamic Therapy Jun 2021Cancer therapy has undergone tremendous advancements in the past few years. The drawbacks of most of these therapies have encouraged researchers to obtain further... (Review)
Review
Cancer therapy has undergone tremendous advancements in the past few years. The drawbacks of most of these therapies have encouraged researchers to obtain further insight into the complex chemical, biochemical and biological processes ongoing in the evolving cancer cells. These studies have led to an advent of reactive oxygen species mediated therapies to target and disrupt the cancer pathology. Photodynamic therapy (PDT) has emerged as a potent candidate for oxidative stress mediated non-invasive technique for rapid diagnosis and treatment of cancer. Towards this, biomacromolecules derived hybrid nanomaterials have contributed largely in the development of various therapeutics and theranostics for efficacious cancer management that can assist PDT. This review summarizes various hybrid biomaterials and advanced techniques that have been explored widely in the past few years for PDT application. The article also mentions some of the important in-vitro and in-vivo developments and observations explored by employing these materials for PDT application. The article also describes the interactions of these materials at the biological interface and the probable mechanism that assist in generation of oxidative stress and subsequent cell death.
Topics: Biocompatible Materials; Oxidative Stress; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species
PubMed: 33737219
DOI: 10.1016/j.pdpdt.2021.102259 -
Journal of Burn Care & Research :... Nov 2023Light is an efficient technique that has a significant influence on contemporary medicine. Photodynamic therapy (PDT), which involves the combined action of... (Review)
Review
Light is an efficient technique that has a significant influence on contemporary medicine. Photodynamic therapy (PDT), which involves the combined action of photosensitizers (PSs), oxygen, and light, has emerged as a therapeutically promising method for treating a broad variety of solid tumors and infectious diseases. Photodynamic therapy is minimally invasive, has few side effects, lightens scars, and reduces tissue loss while preserving organ structure and function. In particular, PDT has a high healing potential for wounds (PDT stimulates wound healing by enhancing re-epithelialization, promoting angiogenesis as well as modulating skin homeostasis). Wound healing involves interactions between many different processes, including coagulation, inflammation, angiogenesis, cellular migration, and proliferation. Poor wound healing with diabetes or extensive burns remains a difficult challenge. This review emphasizes PDT as a potential research field and summarizes PDT's role in wound healing, including normal wounds, chronic wounds, and aging wounds.
Topics: Humans; Photochemotherapy; Burns; Wound Healing; Skin; Photosensitizing Agents
PubMed: 37747820
DOI: 10.1093/jbcr/irad146 -
Methods in Molecular Biology (Clifton,... 2022Advance of nanomaterials and nanotechnology has offered new possibilities for photodynamic therapy (PDT). Large amount of different kinds of sensitizers and targeting... (Review)
Review
Advance of nanomaterials and nanotechnology has offered new possibilities for photodynamic therapy (PDT). Large amount of different kinds of sensitizers and targeting moieties can now be loaded in nanometer's volume, which not only results in the improvement of the efficacy of PDT, but also enables the control of image-guided PDT with unprecedented precision and variation. This chapter shall overview the recently most studied inorganic nanomaterials for PDT.
Topics: Nanostructures; Nanotechnology; Photochemotherapy; Photosensitizing Agents
PubMed: 35505021
DOI: 10.1007/978-1-0716-2099-1_16 -
Photodiagnosis and Photodynamic Therapy Jun 2021Cancer remains a main public health issue and the second cause of mortality worldwide. Photodynamic therapy is a clinically approved therapeutic option. Effective... (Review)
Review
Cancer remains a main public health issue and the second cause of mortality worldwide. Photodynamic therapy is a clinically approved therapeutic option. Effective photodynamic therapy induces cancer damage and death through a multifactorial manner including reactive oxygen species-mediated damage and killing, vasculature damage, and immune defense activation. Anticancer efficiency depends on the improvement of photosensitizers drugs used in photodynamic therapy, their selectivity, enhanced photoproduction of reactive species, absorption at near-infrared spectrum, and drug-delivery strategies. Both experimental and clinical studies using first- and second-generation photosensitizers had pointed out the need for developing improved photosensitizers for photodynamic applications and achieving better therapeutic outcomes. Bioconjugation and encapsulation with targeting moieties appear as a main strategies for the development of photosensitizers from their precursors. Factors influencing cellular biodistribution and uptake are briefly discussed, as well as their roles as cancer diagnostic and therapeutic (theranostics) agents. The two-photon photodynamic approach using third-generation photosensitizers is present as an attempt in treating deeper tumors. Although significant advances had been made over the last decade, the development of next-generation photosensitizers is still mainly in the developmental stage.
Topics: Drug Delivery Systems; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Tissue Distribution
PubMed: 33453423
DOI: 10.1016/j.pdpdt.2020.102091