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ACS Applied Bio Materials Nov 2023Cancer phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has been extensively studied in recent years because of its noninvasive... (Review)
Review
Cancer phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has been extensively studied in recent years because of its noninvasive properties, high efficiency, improved selectivity, and reduced side effects. Gold nanoclusters (AuNCs) have the advantages of high biocompatibility, high biosafety, excellent photoresponse, and high tumor penetration ability. This review analyzes the use of AuNCs in tumor phototherapy in recent years from three aspects, namely, AuNCs in PDT, AuNCs in PTT, and AuNCs in combination therapy, and presents the high potential of AuNCs in cancer phototherapy. This review aims to provide readers with the unique advantages, diversified application approaches, and bright application prospects of AuNCs in phototherapy and to provide insights into strategies for applying AuNCs to tumor phototherapy.
Topics: Humans; Gold; Photochemotherapy; Phototherapy; Neoplasms; Combined Modality Therapy
PubMed: 37828759
DOI: 10.1021/acsabm.3c00518 -
Advanced Healthcare Materials Aug 2022Wound healing is a complex biological process that involves tissue regeneration. Traditional wound dressings are dry, cannot provide a moist environment for wound... (Review)
Review
Wound healing is a complex biological process that involves tissue regeneration. Traditional wound dressings are dry, cannot provide a moist environment for wound healing, and do not have high antibacterial properties. Hydrogels, which are capable of retaining large amounts of water, can create a moist healing environment. Currently, phototherapies have exhibited a high potential for the treatment of bacterial infections. Therefore, combining hydrogels with phototherapy can adequately overcome the shortcomings of traditional wound treatment methods and show great potential for wound healing owing to their high efficiency, low irritation, and good antibacterial performance. In this review, the application of hydrogels combined with phototherapy in wound healing is summarized. First, the basic principles of photodynamic therapy and photothermal therapy are briefly introduced. In addition, the progress of the application of hydrogel combined with phototherapy in wound healing is systematically investigated. Finally, the challenges and prospects of combining hydrogel with phototherapy in wound healing are discussed.
Topics: Anti-Bacterial Agents; Bandages; Hydrogels; Phototherapy; Wound Healing
PubMed: 35751637
DOI: 10.1002/adhm.202200494 -
Journal of Biophotonics Nov 2023Hematomas resulted from trauma are very common, and the efficacy of existing treatment techniques is limited. Phototherapy can be used to expedite healing and improve...
Hematomas resulted from trauma are very common, and the efficacy of existing treatment techniques is limited. Phototherapy can be used to expedite healing and improve the appearance of the damaged tissue. Efficient phototherapy requires determination of chromophore composition in hematoma, which can be provided by the optoacoustic (OA) technique, as it combines high spatial resolution and optical contrast. Here, we conducted experiments on photodegradation of bilirubin in gelatin slin phantoms. We have demonstrated that the OA technique allows monitoring of bilirubin concentration during photodegradation, and also distinguishing bilirubin concentration in depth. The obtained results suggest that OA monitoring may be used for efficient hematoma phototherapy.
Topics: Humans; Bilirubin; Photolysis; Phototherapy; Photoacoustic Techniques; Hematoma
PubMed: 37345342
DOI: 10.1002/jbio.202200339 -
Journal of Controlled Release :... Feb 2020Black phosphorus nanosheets (BP NSs), a kind of attractive two-dimensional materials, have been widely used in optoelectronics, transistors and photocatalysis. Recently,... (Review)
Review
Black phosphorus nanosheets (BP NSs), a kind of attractive two-dimensional materials, have been widely used in optoelectronics, transistors and photocatalysis. Recently, growing interest has been attracted to explore the application of BP NSs for cancer therapy in view of their unique properties. BP NSs have high surface area and negative charge, which can load drug, targeting molecules, photosensitizer, magnetic nanoparticles etc. They are also potential candidates for cancer phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) by virtue of extensive near-infrared absorbance. Furthermore, BP NSs exhibit biodegradable and compatible nature to avoid toxicity in vivo. In this review, the preparation and properties of BP NSs are firstly summarized. More importantly, multifunctional platform based on BP NSs for cancer therapy such as photothermal therapy, photodynamic therapy, chemotherapy, antibacterial therapy, chemo-/photothermal combined therapy, photothermal/gene- combined therapy, chemo-/photothermal/gene- combined therapy and chemo-/photothermal/photodynamic combined therapy is reviewed in detail. And the future perspectives of BP NSs is finally discussed.
Topics: Humans; Nanoparticles; Neoplasms; Phosphorus; Photochemotherapy; Phototherapy
PubMed: 31837354
DOI: 10.1016/j.jconrel.2019.12.013 -
Molecules (Basel, Switzerland) Mar 2023The intriguing properties of metal sulfide nanoparticles (=MxSy-NPs), particularly transition metal dichalcogenides, are discussed for their use in diverse biological... (Review)
Review
The intriguing properties of metal sulfide nanoparticles (=MxSy-NPs), particularly transition metal dichalcogenides, are discussed for their use in diverse biological applications. Herein, recent advances in MxSy-NPs-based imaging (MRI, CT, optical and photoacoustic) and phototherapy (photothermal and photodynamic) are presented. Also, recent made progress in the use of immuno-phototherapy combinatorial approaches in vitro and in vivo are reported. Furthermore, challenges in nanomaterials-based therapies and future research directions by applying MxSy-NPs in combinatorial therapies are envisaged.
Topics: Humans; Nanoparticles; Phototherapy; Metal Nanoparticles; Diagnostic Imaging; Sulfides; Neoplasms
PubMed: 36985525
DOI: 10.3390/molecules28062553 -
Molecules (Basel, Switzerland) May 2023Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is a non-invasive and effective approach used for cancer treatment, in which... (Review)
Review
Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is a non-invasive and effective approach used for cancer treatment, in which phototherapeutic agents are irradiated with an appropriate light source to produce cytotoxic reactive oxygen species (ROS) or heat to ablate cancer cells. Unfortunately, traditional phototherapy lacks a facile imaging method to monitor the therapeutic process and efficiency in real time, usually leading to severe side effects due to high levels of ROS and hyperthermia. To realize precise cancer treatment methods, it is highly desired to develop phototherapeutic agents possessing an imaging ability to evaluate the therapeutic process and efficacy in real time during cancer phototherapy. Recently, a series of self-reporting phototherapeutic agents were reported to monitor PDT and PTT processes by combining optical imaging technologies with phototherapy. Due to the real-time feedback provided by optical imaging technology, therapeutic responses or dynamic changes in the tumor microenvironment could be evaluated in a timely manner, thereby achieving personalized precision treatment and minimizing toxic side effects. In this review, we focus on the advances in the development of self-reporting phototherapeutic agents for a cancer phototherapy evaluation based on optical imaging technology to realize precision cancer treatments. Additionally, we propose the current challenges and future directions of self-reporting agents for precision medicine.
Topics: Humans; Reactive Oxygen Species; Phototherapy; Photochemotherapy; Optical Imaging; Photothermal Therapy; Nanoparticles; Neoplasms; Photosensitizing Agents; Tumor Microenvironment
PubMed: 37241733
DOI: 10.3390/molecules28103992 -
Journal of Materials Chemistry. B Mar 2024Light-triggered phototherapies, such as photodynamic therapy (PDT) and photothermal therapy (PTT), have shown strong therapeutic efficacy with minimal invasiveness and... (Review)
Review
Light-triggered phototherapies, such as photodynamic therapy (PDT) and photothermal therapy (PTT), have shown strong therapeutic efficacy with minimal invasiveness and systemic toxicity, offering opportunities for tumor-specific therapies. Phototherapies not only induce direct tumor cell killing, but also trigger anti-tumor immune responses by releasing various immune-stimulating factors. In recent years, conventional phototherapies have been combined with cancer immunotherapy as synergistic therapeutic modalities to eradicate cancer by exploiting the innate and adaptive immunity. These combined photoimmunotherapies have demonstrated excellent therapeutic efficacy in preventing tumor recurrence and metastasis compared to phototherapy alone. This review covers recent advancements in combined photoimmunotherapy, including photoimmunotherapy (PIT), PDT-combined immunotherapy, and PTT-combined immunotherapy, along with their underlying anti-tumor immune response mechanisms. In addition, the challenges and future research directions for light-triggered cancer immunotherapy are discussed.
Topics: Humans; Photochemotherapy; Phototherapy; Neoplasms; Immunotherapy
PubMed: 38353138
DOI: 10.1039/d3tb02842a -
Dermatologic Therapy Jun 2022Phototherapy is a recommended treatment regimen for different scleroderma spectrum disorders, but so far it has been included neither by European nor by worldwide... (Review)
Review
Phototherapy is a recommended treatment regimen for different scleroderma spectrum disorders, but so far it has been included neither by European nor by worldwide experts committee in recommendations for the treatment of systemic sclerosis (SSc). The aim of the study was to revisit the utility of dermatological phototherapy in patients with SSc. PubMed using medical subject headings was searched to identify studies evaluating response to dermatological phototherapy in SSc patients. Both UVA1 (340-400 nm) and PUVA (psoralen plus UVA) treatments were found to reduce skin thickening and increase skin elasticity, therefore allowing for the improvement of joint tension mobility, especially in hands. At least several papers showed efficacy of phototherapy in patients who remained non-responsive to previous immunosuppressive therapies. The most probable mechanisms of action of phototherapy in SSc include inhibition of T-cells and prevention from dermal fibrosis. Although most data on the efficacy of phototherapy come from small experimental studies and case reports, phototherapy based on UVA of wavelength manifests relatively mild spectrum of side effects and this should be considered as a treatment option for SSc with dominant cutaneous involvement.
Topics: Humans; Phototherapy; Scleroderma, Localized; Scleroderma, Systemic; Ultraviolet Therapy
PubMed: 35357072
DOI: 10.1111/dth.15478 -
Biomaterials Science Oct 2020The emerging anti-tumor immunotherapy has made significant progress in clinical application. However, single immunotherapy is not effective for all anti-tumor... (Review)
Review
The emerging anti-tumor immunotherapy has made significant progress in clinical application. However, single immunotherapy is not effective for all anti-tumor treatments, owing to the low objective response rate and the risk of immune-related side effects. Meanwhile, photothermal therapy (PTT) has attracted significant attention because of its non-invasiveness, spatiotemporal controllability and small side effects. Combining PTT with immunotherapy overcomes the issue that single photothermal therapy cannot eradicate tumors with metastasis and recurrence. However, it improves the therapeutic effect of immunotherapy, as the photothermal therapy usually promotes release of tumor-related antigens, triggers immune response by the immunogenic cell death (ICD), thereby, endowing unique synergistic mechanisms for cancer therapy. This review summarizes recent research advances in utilizing nanomedicines for PTT in combination with immunotherapy to improve the outcome of cancer treatment. The strategies include immunogenic cell death, immune agonists and cancer vaccines, immune checkpoint blockades and tumor specific monoclonal antibodies, and small-molecule immune inhibitors. The combination of synergized PTT-immunotherapy with other therapeutic strategies is also discussed.
Topics: Humans; Immunotherapy; Nanomedicine; Neoplasms; Phototherapy; Photothermal Therapy
PubMed: 32996922
DOI: 10.1039/d0bm01158d -
Expert Opinion on Drug Safety Apr 2020: Psoriasis is a chronic inflammatory skin disease that waxes and wanes, and long-term remission can be difficult to achieve regardless of disease severity. Currently,... (Review)
Review
: Psoriasis is a chronic inflammatory skin disease that waxes and wanes, and long-term remission can be difficult to achieve regardless of disease severity. Currently, numerous treatment options are available for psoriasis including steroid and non-steroid topical agents, phototherapy, oral systemic agents, and biologics, with many more therapeutic agents under development.: This article will review various combination therapy strategies such as rotational therapy and sequential therapy and describe a variety of safe and effective combination therapies for the treatment of psoriasis. Two or more agents with different mechanisms of action and safety profiles can be used to achieve and/or maintain adequate disease control while minimizing the toxicity of treatments. Combination therapy can also be used when a single agent is not enough for treating recalcitrant disease. Choosing a combination regimen that maximizes safety and efficacy while considering patient usability and compliance can be a challenge.: Given the various treatment options currently available for psoriasis and more agents under development, combination therapy will continue to be a valuable treatment strategy for any patient with psoriasis. It is crucial for clinicians to carefully consider the fine balance between safety and efficacy when combining various therapeutic agents.
Topics: Biological Products; Combined Modality Therapy; Dermatologic Agents; Drug Development; Drug Therapy, Combination; Humans; Phototherapy; Psoriasis; Severity of Illness Index
PubMed: 31985309
DOI: 10.1080/14740338.2020.1722640