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Soft Matter Apr 2022Making a hydrogel-based first-aid bandage with green resources, desirable biocompatibility, universal adhesive properties, low cost and simple production is a...
Making a hydrogel-based first-aid bandage with green resources, desirable biocompatibility, universal adhesive properties, low cost and simple production is a long-standing research aspiration. Considering this, three naturally existing organic acids, namely tannic acid, thioctic acid and phytic acid, were used to construct a novel adhesive gel (TATAPA hydrogel) for epidermal tissue bandage applications. This hydrogel could be synthesized under mild conditions with no need for a freeze-thawing shaping procedure, and was transparent, moldable and stretchable with good stability under continuous water immersion. In lap-shear tests, the TATAPA hydrogel could adhere to various hydrophilic and hydrophobic surfaces. Moreover, in the case of skin tissue adhesion, the hydrogel could be easily peeled off from the skin, meeting wearability requirements. Rheological tests showed that the hydrogel possessed thermal sensitive properties derived from multi-supramolecular interactions. The methicillin-resistant (MRSA)-infected burn wound test demonstrated that the hydrogel had desirable antibacterial activity and was beneficial for wound healing. A femoral artery bleeding assay was also used to reveal that the TATAPA hydrogel could be directly pasted onto the bleeding site for hemostasis. Overall, this hydrogel demonstrates potential as a surgical bioadhesive for a broad range of medical applications.
Topics: Adhesives; Anti-Bacterial Agents; Bandages; Hydrogels; Methicillin-Resistant Staphylococcus aureus; Phytic Acid; Tannins; Thioctic Acid
PubMed: 35322837
DOI: 10.1039/d2sm00058j -
International Journal of Biological... Dec 2023In this study, chitosan (CS) and phytic acid (PA) were employed as raw materials to synthesize a range of chitosan-phytic acid complexes (CP) with different ratios...
In this study, chitosan (CS) and phytic acid (PA) were employed as raw materials to synthesize a range of chitosan-phytic acid complexes (CP) with different ratios (CS:PA = 12:1, 9:1, 6:1, 3:1, 1:1). The structures and elemental compositions of the compounds were characterized using Fourier-Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy with Energy-Dispersive X-ray Spectroscopy (SEM-EDS). The thermal stability of the synthesized materials was analyzed using a Thermogravimetric Analyzer (TG). Electrochemical testing was conducted to explore the corrosion inhibition effect of the modified inhibitors with varying ratios on Q235 steel in 3.5 wt% NaCl solution. Additionally, Scanning Electron Microscopy (SEM) was utilized to investigate the surface morphology of the immersed samples. When the CS:PA ratio was 3:1, CP exhibited an impressive corrosion inhibition efficiency of 94.9 %. Furthermore, the antimicrobial properties of CP were evaluated using the colony plate counting method. At a CS:PA ratio of 1:1, CP demonstrated the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) at 0.1250 % and 0.5000 %, respectively. This research introduces a novel green corrosion inhibitor capable of simultaneously reducing the electrochemical corrosion of Q235 while inhibiting biocorrosion, avoiding the antagonistic effects arising from the simultaneous use of biocides and corrosion inhibitors in the system.
Topics: Phytic Acid; Chitosan; Corrosion; Spectroscopy, Fourier Transform Infrared; Anti-Bacterial Agents
PubMed: 37729982
DOI: 10.1016/j.ijbiomac.2023.126905 -
Journal of the Science of Food and... Jan 2022Flaxseed is a rich source of protein, omega-3 fatty acids, lignans, and dietary fiber. However, it also contains phytic acid, which inhibits mineral absorption and has...
BACKGROUND
Flaxseed is a rich source of protein, omega-3 fatty acids, lignans, and dietary fiber. However, it also contains phytic acid, which inhibits mineral absorption and has the potential to adversely affect the properties of bread. Microfluidization prevents these negative effects, reduces the amount of phytic acid, and improves functional properties. In this study, the possibility of using full-fat and defatted flaxseed flours as well as microfluidized flaxseed flours in bread formulation was investigated. For this purpose, crude and microfluidized flaxseed flours were added to the bread in different proportions (0, 25, 50, and 75 g kg ), and the effects of the partial replacement of wheat flour with flaxseed flours on the functional, quality, and sensory properties of breads were analyzed. The effects of the microfluidization process on the antioxidant properties, phenolic, dietary fiber, and phytic acid content of flaxseed were also observed.
RESULT
Flaxseed flours increased the dietary fiber, phenolic contents, and antioxidant activities of breads. The crumb color became darker with increasing level of flaxseed flours, and their addition also detrimentally affected the sensory properties of breads. It was seen that the microfluidization process has beneficial effects on functional properties of full-fat and defatted flaxseed flours, as well as on their quality characteristics.
CONCLUSION
The study showed that flaxseed flour is a rich source of functional compounds, and it is even possible to further improve these functional properties with microfluidization treatment. Microfluidized flaxseed flour can also be used as a promising alternative functional food to enrich breads. © 2021 Society of Chemical Industry.
Topics: Bread; Dietary Fiber; Flax; Flour; Food Additives; Food Handling; Humans; Phytic Acid; Seeds; Taste; Triticum
PubMed: 34143439
DOI: 10.1002/jsfa.11378 -
Chemosphere Jun 2022Carob waste (CW) is an agro-biomass material abundant in nature with potential use for eco-friendly remediation. However, like many biomass-based adsorbents, it suffers...
Carob waste (CW) is an agro-biomass material abundant in nature with potential use for eco-friendly remediation. However, like many biomass-based adsorbents, it suffers from its low adsorption capacity for organic/inorganic pollutants. Therefore, modification using physical and/or chemical means is commonly applied to improve the adsorptive properties of biomass-based adsorbents. In this study, carob waste (CW) and carob waste functionalized with phytic acid (PA-CW), as an ecofriendly product, were applied for the first time for Cr(VI) elimination. Various methods were applied for the material characterization like Fourier-transform infrared spectroscopy, powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA and DTG), X-ray photoelectron spectroscopy (XPS), specific surface area and porosity measurements. The results proved that both CW and PA-CW own appropriate features for efficient adsorption. Bach experiments revealed that the optimum parameters for Cr(VI) (100 mg/mL) removal at 25 °C were pH 2, 0.05 and 0.025 g as adsorbent dose for CW and PA-CW, respectively, over 120 min contact time. The kinetic of adsorption was well-described by the pseudo-second order model, whereas the isotherm modeling fitted well the modified Langmuir model. CW and PA-CW achieved respectively maximum adsorption capacities of 212.4 and 387.9 mg/g, which are among the highest values so far reported for biomass-based adsorbent materials. These results confirmed that CW and PA-CW could be alternative cost-effective adsorbents even for high concentrations of Cr(VI) in industrial wastewaters along with their reduction capacity.
Topics: Adsorption; Chromium; Galactans; Hydrogen-Ion Concentration; Kinetics; Mannans; Phytic Acid; Plant Gums; Spectroscopy, Fourier Transform Infrared; Water Pollutants, Chemical
PubMed: 35257706
DOI: 10.1016/j.chemosphere.2022.134188 -
AAPS PharmSciTech May 2024The primary factor underlying the virulence of Candida albicans is its capacity to form biofilms, which in turn leads to recurrent complications. Over-the-counter...
The primary factor underlying the virulence of Candida albicans is its capacity to form biofilms, which in turn leads to recurrent complications. Over-the-counter antifungal treatments have proven ineffective in eliminating fungal biofilms and the inflammatory cytokines produced during fungal infections. Chitosan nanoparticles offer broad and versatile therapeutic potential as both antifungal agents and carriers for antifungal drugs to combat biofilm-associated Candida infections. In our study, we endeavoured to develop chitosan nanoparticles utilising chitosan and the antifungal crosslinker phytic acid targeting C. albicans. Phytic acid, known for its potent antifungal and anti-inflammatory properties, efficiently crosslinks with chitosan. The nanoparticles were synthesised using the ionic gelation technique and subjected to analyses including Fourier transform infrared spectroscopy, dynamic light scattering, and zeta potential analysis. The synthesised nanoparticles exhibited dimensions with a diameter (Dh) of 103 ± 3.9 nm, polydispersity index (PDI) of 0.33, and zeta potential (ZP) of 37 ± 2.5 mV. These nanoparticles demonstrated an antifungal effect with a minimum inhibitory concentration (MIC) of 140 ± 2.2 µg/mL, maintaining cell viability at approximately 90% of the MIC value and reducing cytokine levels. Additionally, the nanoparticles reduced ergosterol content and exhibited a 62% ± 1.2 reduction in biofilm susceptibility, as supported by colony-forming unit (CFU) and XTT assays-furthermore, treatment with nanoparticles reduced exopolysaccharide production and decreased secretion of aspartyl protease by C. albicans. Our findings suggest that the synthesised nanoparticles effectively combat Candida albicans infections. In vivo studies conducted on a mouse model of vaginal candidiasis confirmed the efficacy of the nanoparticles in combating fungal infections in vivo.
Topics: Chitosan; Biofilms; Nanoparticles; Antifungal Agents; Animals; Candida albicans; Mice; Microbial Sensitivity Tests; Phytic Acid; Female; Candidiasis; Particle Size; Drug Carriers; Cross-Linking Reagents; Cytokines
PubMed: 38724834
DOI: 10.1208/s12249-024-02829-3 -
Journal of Hazardous Materials Aug 2022Developing an emulsion separation material with one-step in-situ purifying capability and improved security in applications, especially for subsequent scale-up, is...
Developing an emulsion separation material with one-step in-situ purifying capability and improved security in applications, especially for subsequent scale-up, is valuable but remains a challenge. Herein, the amphiphilic sponge (PA@RGO@MS) was prepared via impregnation and in-situ growth of the negatively charged hydrophilic phytic acid (PA) and the hydrophobic reduced graphene oxide (RGO) on the surface of the melamine sponge (MS) and applied in emulsion purification. The mechanics, wettability, absorption performance of the PA@RGO@MS were analyzed to identify its potential for stable demulsification. Results show that the PA@RGO@MS could purify emulsions (turbidity removal rate = 99.7%; TOC removal rate = 94.14%) in-situ in one step by simple shock absorption, profited from the hydrophilic and demulsification capability of PA, oil absorption of RGO, and wide reaction and storage space of MS. Targeting the emulsion with distinct properties (density, viscosity, and concentration) of the oil phase, the PA@RGO@MS could efficiently enable the purification. Meanwhile, the powerful flame-retardant granted from PA ensures the safe shipment and storage of sponges. The favorable cyclability (turbidity removal rate > 98.5% and TOC removal rate > 89.5% after 10 cycles) and diversified operating modes enhance the practical value of the PA@RGO@MS.
Topics: Emulsions; Graphite; Phytic Acid; Water; Wettability
PubMed: 35490636
DOI: 10.1016/j.jhazmat.2022.129003 -
International Journal of Molecular... Aug 2022The use of flexible polyurethane foam (FPUF) is severely limited due to its flammability and dripping, which can easily cause major fire hazards. Therefore, choosing an...
The use of flexible polyurethane foam (FPUF) is severely limited due to its flammability and dripping, which can easily cause major fire hazards. Therefore, choosing an appropriate flame retardant to solve this problem is an urgent need. A coating was prepared on the FPUF surface by dipping with phytic acid (PA), Fe(SO)·HO, and laponite (LAP). The influence of PA-Fe/LAP coating on FPUF flame-retardant performance was explored by thermal stability, flame retardancy, combustion behavior, and smoke density analysis. FPUF/PA-Fe/LAP has a good performance in the small fire test, which can pass the UL-94 V-0 rating and the limiting oxygen index reaches 24.5%. Meanwhile, the peak heat release rate values and maximum smoke density of FPUF/PA-Fe/LAP are reduced by 38.7% and 38.5% compared with those of neat FPUF. After applying PA-Fe/LAP coating, the value of fire growth rate index decreases from 10.5 kW/(m·s) to 5.1 kW/(m·s), dramatically reducing the fire risk. Encouragingly, the effect of PA-Fe/LAP coating on cyclic compression and permanent deformation is small, which is close to that of neat FPUF. This work provides an effective strategy for making a flame-retardant FPUF with antidripping and keeping mechanical properties.
Topics: Flame Retardants; Iron; Phytic Acid; Polyurethanes; Silicates; Smoke
PubMed: 36012407
DOI: 10.3390/ijms23169145 -
European Journal of Oral Sciences Apr 2021We evaluated the effect of phytic acid on matrix metalloproteinase (MMP)- or cysteine cathepsin (CC)-mediated dentin degradation. Demineralized dentin beams were divided...
We evaluated the effect of phytic acid on matrix metalloproteinase (MMP)- or cysteine cathepsin (CC)-mediated dentin degradation. Demineralized dentin beams were divided into five groups (n = 12) and treated with 1%, 2%, or 3% phytic acid or with 37% phosphoric acid. Untreated demineralized beams served as controls. After incubation for 1 or 3 wk, dry mass loss was determined and aliquots of incubation media were analysed for cross-linked telopeptide of type I collagen (ICTP) fragments for MMP-mediated and c-terminal telopeptide of type I collagen (CTX) for cathepsin-k-mediated degradation. The direct effect of phytic acid was evaluated using MMP activity assay. Data were analysed using repeated-measures anova. ICTP releases with 1% and 2% phytic acid treatment were statistically significantly lower than those following phosphoric acid treatment at 3 wk. The CTX release for phytic acid-treated beams at 3 wk was not significantly different from that of untreated control beams, but it was significantly lower than that of phosphoric acid-treated beams. Their MMP activities at 3 wk were not significantly different from those of the controls but they were significantly lower than those seen for phosphoric acid-treated beams. Compared to phosphoric acid, phytic acid treatment resulted in a reduced dentinal host-derived endogenous enzymatic activity and collagen degradation.
Topics: Collagen Type I; Dentin; Matrix Metalloproteinases; Phytic Acid
PubMed: 33644893
DOI: 10.1111/eos.12771 -
Journal of Agricultural and Food... Sep 2022Nonalcoholic fatty liver disease (NAFLD) induced by obesity is a grave threat to human health. Phytic acid (PA) is a natural compound found in high-fiber diets, such as...
Nonalcoholic fatty liver disease (NAFLD) induced by obesity is a grave threat to human health. Phytic acid (PA) is a natural compound found in high-fiber diets, such as soybeans. This study investigated the effects and mechanisms of PA on obesity, hepatic lipid metabolism, and gut-liver axis homeostasis in high-fat diet (HFD)-fed mice. PA was observed to significantly inhibit obesity and alleviate liver steatosis in mice. PA improved HFD-induced liver inflammation, oxidative stress and fibrosis. Moreover, PA improved HFD-induced colonic inflammation, gut barrier damage and systemic inflammation in mice. Furthermore, PA effectively ameliorated the decreased diversity and gut microbiota composition in HFD-fed mice. Additionally, PA decreased the abundance of harmful bacteria and and increased the abundance of probiotic bacteria and . Thus, PA is effective in restoring the homeostasis of the gut-liver axis. It further provides a theoretical basis for the prevention and treatment of NAFLD in patients with obesity by the rational intake of foods containing PA.
Topics: Animals; Diet, High-Fat; Humans; Inflammation; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Oxidative Stress; Phytic Acid
PubMed: 36040330
DOI: 10.1021/acs.jafc.2c04406 -
Food Research International (Ottawa,... May 2021Phytic acid (PA) is the primary phosphorus reserve in cereals and legumes which serves the biosynthesis needs of growing tissues during germination. It is generally... (Review)
Review
Phytic acid (PA) is the primary phosphorus reserve in cereals and legumes which serves the biosynthesis needs of growing tissues during germination. It is generally considered to be an anti-nutritional factor found in grains because it can bind to minerals, proteins, and starch, limiting their bioavailability. However, this same mineral binding property can also confer a number of health benefits such as reducing the risk of certain cancers, supporting heart health, and managing renal stones. In addition, the ability of PA to bind minerals allows it to be used in certain food quality applications such as stabilizing the green color of vegetables, preventing lipid peroxidation, and reducing enzymatic browning in fruits/vegetables. These beneficial properties create a potential for added-value applications in the utilization of PA in many new areas. Many possible processing techniques for the preparation of raw materials in the food industry can be used to reduce the concentration of PA in foods to mitigate its anti-nutritional effects. In turn, the recovered PA by-products could be available for novel uses. In this review, a general overview of the beneficial and anti-nutritional effects of PA will be discussed and then dephytinization methods will be explained.
Topics: Edible Grain; Food Handling; Minerals; Nutritive Value; Phytic Acid
PubMed: 33992384
DOI: 10.1016/j.foodres.2021.110284