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European Journal of Dermatology : EJD Jun 2023
Topics: Humans; Pityriasis Lichenoides; Brentuximab Vedotin; Lymphoma, T-Cell, Peripheral; Exanthema
PubMed: 37594350
DOI: 10.1684/ejd.2023.4494 -
Indian Dermatology Online Journal 2020
PubMed: 32695726
DOI: 10.4103/idoj.IDOJ_455_18 -
Journal Der Deutschen Dermatologischen... Dec 2023
PubMed: 38082509
DOI: 10.1111/ddg.15253_g -
Acta Dermato-venereologica Mar 2020The aim of this prospective study in a phototherapy unit was to describe adverse events (AEs) associated with discontinuation of phototherapy in a clinical setting. A... (Observational Study)
Observational Study
The aim of this prospective study in a phototherapy unit was to describe adverse events (AEs) associated with discontinuation of phototherapy in a clinical setting. A total of 872 included patients received 1,256 courses of phototherapy treatment: 76.9% narrow-band UVB (NBUVB); 9.6% systemic psoralen plus UVA (PUVA); 11.4% topical PUVA; and 2.1% UVA. Approximately a fifth of the treatments (n = 240, 19.1%) were associated with AEs, the most frequent of which was erythema (8.8%). Systemic PUVA had the highest rate of AEs (32.5%). Mycosis fungoides was the dermatosis with the highest rate of AE (36.9%). A total of 216 (17.2%) patients stopped treatment: 23.6% because of AEs (4.1% of all treatments). Treatment suspension due to AEs was associated with PUVA, both topical and systemic (p < 0.001), and diagnoses of mycosis fungoides (p <0.001), palmoplantar psoriasis (p = 0.002), hand eczema (p = 0.002) and pityriasis lichenoides (p = 0.01). In conclusion, one in every 5 patients receiving phototherapy had an AE, but few stopped treatment for this reason.
Topics: Adult; Aged; Dermatitis, Phototoxic; Eczema; Erythema; Female; Humans; Male; Middle Aged; Mycosis Fungoides; PUVA Therapy; Pain; Patient Dropouts; Pityriasis Lichenoides; Prospective Studies; Psoriasis; Skin Neoplasms
PubMed: 32179932
DOI: 10.2340/00015555-3453 -
Clinical and Experimental Dermatology Feb 2022
Abrupt onset of Sweet syndrome, pityriasis rubra pilaris, pityriasis lichenoides et varioliformis acuta and erythema multiforme: unravelling a possible common trigger, the COVID-19 vaccine.
Topics: 2019-nCoV Vaccine mRNA-1273; Aged; Aged, 80 and over; BNT162 Vaccine; COVID-19; COVID-19 Vaccines; Erythema Multiforme; Female; Humans; Male; Middle Aged; Pityriasis Lichenoides; Pityriasis Rubra Pilaris; SARS-CoV-2; Sweet Syndrome
PubMed: 34617317
DOI: 10.1111/ced.14970 -
Translational Pediatrics Apr 2024Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare and severe variant of pityriasis lichenoides et varioliformis acuta, characterized by a rapid onset of...
BACKGROUND
Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare and severe variant of pityriasis lichenoides et varioliformis acuta, characterized by a rapid onset of painful, necrotic skin lesions and systemic symptoms. The diagnosis of FUMHD is complex, hinging on the clinical presentation, histopathological findings, and exclusion of other severe dermatoses. The key diagnostic criteria include sudden development of ulceronecrotic papules and plaques, fever, and evidence of systemic disease. Due to the rarity of FUMHD, there is no consensus on optimal treatment, reflecting a significant gap in the dermatological practice.
CASE DESCRIPTION
This report details a multimodal approach tailored to our 13-year-old patient, incorporating systemic corticosteroids, immunosuppressive therapy, and intensive supportive care. The strategy was designed to address the acute and aggressive nature of the disease while mitigating potential systemic complications. The report emphasizes on the intricate, multi-layered care required to manage FUMHD, illustrating the challenges and considerations in treating this complex condition. It underscored the necessity of a personalized, comprehensive care plan that extends beyond medical intervention to include psychological and social support. The outcome of our patient was encouraging, with a marked reduction in cutaneous manifestations and improvement in systemic symptoms.
CONCLUSIONS
It was found that prevention and care of skin injuries and complications, as well as the protection of patient's mental state during the development of the disease, are very important. Therefore, early diagnosis, prompt treatment, close monitoring of infection indicators, and specialized care are essential to improve the prognosis of patients with FUMHD.
PubMed: 38715678
DOI: 10.21037/tp-23-520 -
Journal of the American Academy of... Jun 2022Data regarding Asian patients with mycosis fungoides (MF) are limited.
BACKGROUND
Data regarding Asian patients with mycosis fungoides (MF) are limited.
OBJECTIVE
We aimed to investigate the clinical profile and long-term outcomes of patients with MF in Korea.
METHODS
A retrospective review of 223 patients with MF who were followed up for more than 6 months or died of MF within 6 months of diagnosis was performed.
RESULTS
Approximately 96.4% and 3.6% of the patients had an early stage and advanced stage, respectively. The mean age at diagnosis was 44.8 years. The mean duration of symptoms before diagnosis was 47.0 months. Various subtypes were noted, including mycosis fungoides palmaris et plantaris (21.5%), folliculotropic (8.5%), pityriasis lichenoides-like (6.7%), ichthyosiform (4.0%), lichenoid purpura-like (2.7%), and hypopigmented (2.2%) MF. Juvenile patients accounted for 16.6%. The higher the skin T stage, the poorer the response to treatment. The 10-year overall survival was 96.8% in early-stage patients and 25.0% in advanced-stage patients. General prognosis was favorable, while recurrence and subtype switching were seen in 29.4% and 2.7% of patients, respectively.
LIMITATIONS
Our patients may not represent all Korean patients with MF.
CONCLUSION
MF in Korea has a high proportion of variants, a younger age at onset, and favorable prognosis. A high index of suspicion and skin biopsy are needed for early diagnosis.
Topics: Biopsy; Humans; Mycosis Fungoides; Pityriasis Lichenoides; Prognosis; Retrospective Studies; Skin; Skin Neoplasms
PubMed: 34197872
DOI: 10.1016/j.jaad.2021.06.860 -
Journal Der Deutschen Dermatologischen... Feb 2020
Topics: Biopsy; Dermatologic Agents; Diagnosis, Differential; Glucocorticoids; Herpes Simplex; Humans; Infant; Male; Methotrexate; Methylprednisolone; Mucocutaneous Lymph Node Syndrome; Pityriasis Lichenoides; Skin; Treatment Outcome
PubMed: 31814284
DOI: 10.1111/ddg.13989 -
Journal of Drugs in Dermatology : JDD May 2020Pityriasis lichenoides chronica, a papulosquamous disorder often considered a subtype of pityriasis lichenoides. It is considered a clonal T-cell disorder, which may be...
BACKGROUND
Pityriasis lichenoides chronica, a papulosquamous disorder often considered a subtype of pityriasis lichenoides. It is considered a clonal T-cell disorder, which may be associated with cutaneous T-cell lymphoma that may develops in response to foreign antigens.
CASE PRESENTATION
We present a 38-year-old male patient with ankylosing spondylitis who was on treatment with etanercept. After 8 weeks of treatment, the patient presented with scaly erythematous papules, on the back and arms. He was diagnosed clinically with pityriasis lichenoides chronica.
CONCLUSION
Pityriasis lichenoides chronica should be included among the broad clinical spectrum of chronic inflammatory skin diseases which may occur during treatment with TNF-alpha antagonists. J Drugs Dermatol. 2020;19(5): doi:10.36849/JDD.2020.2191.
Topics: Administration, Cutaneous; Adult; Etanercept; Glucocorticoids; Humans; Male; Pityriasis Lichenoides; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha
PubMed: 32484616
DOI: No ID Found -
A Case Report of Pityriasis Lichenoides-Like Mycosis Fungoides in Children: A Challenging Diagnosis.Korean Journal of Family Medicine Jul 2021Primary cutaneous lymphomas are rare diseases among the general population, and even rarer in children. Mycosis fungoides (MF) is the most commonly diagnosed form in...
Primary cutaneous lymphomas are rare diseases among the general population, and even rarer in children. Mycosis fungoides (MF) is the most commonly diagnosed form in childhood. Several atypical clinical variants of MF have been reported, and pityriasis lichenoides-like MF (PL-like MF) is a recently described subtype. We report about a rare case of PL-like MF in an 11-year-old Malay boy with a 2-year history of multiple scaly erythematous papules associated with progressive and generalized hypopigmentation. This case report illustrates the significant dilemma in the diagnosis of the disease, particularly in the early stages, because its symptoms can mimic those of many common childhood inflammatory skin disorders. Later, the widespread hypopigmentation obscured the characteristic lesions, leading to misdiagnosis. Moreover, due to unfamiliarity of the disease, the diagnosis of PL-like MF was missed and delayed until only 2 years after the onset of the dermatosis. Therefore, primary care practitioners must have a high index of suspicion for this cutaneous neoplasm in children with persistent or worsening skin lesions, not responding to standard therapy, to ensure timely referral, diagnosis, and treatment.
PubMed: 32434301
DOI: 10.4082/kjfm.20.0036