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International Journal of Gynaecology... Apr 2023Evidence has shown significant benefits of aspirin for preventing pre-eclampsia. (Review)
Review
BACKGROUND
Evidence has shown significant benefits of aspirin for preventing pre-eclampsia.
OBJECTIVES
The objective of this study was to systematically review recommendations from clinical practice guidelines and other recommendation documents on aspirin for the prevention of pre-eclampsia.
SEARCH STRATEGY
Ten databases were searched for statements from December 1, 2013, to January 1, 2022.
SELECTION CRITERIA
Without language restrictions, the most recent version of documents was considered.
DATA COLLECTION AND ANALYSIS
Two authors independently extracted recommendations. Guideline quality was assessed using a modified AGREE-II instrument and the AGREE-REX tool.
MAIN RESULTS
Out of 48 statements on the prevention of pre-eclampsia, 46 had recommendations on use of aspirin. Of them, 39 were supported by evidence from systematic reviews or randomized controlled trials. Three statements reported aspirin's significant reductions in preterm pre-eclampsia and one in perinatal death. Concerning quality, 41% of statements were rated as high quality in all domains of the AGREE-II tool, 15% were rated high quality in all domains of the AGREE-REX tool, and 11% were rated high quality in all domains on both tools.
CONCLUSIONS
While 96% of statements advocated for use of aspirin, only 9% reported a significant reduction in preterm pre-eclampsia or perinatal death. Based on the AGREE tools, future statements could use methodological improvement.
Topics: Pregnancy; Female; Infant, Newborn; Humans; Aspirin; Pre-Eclampsia; Perinatal Death
PubMed: 36129381
DOI: 10.1002/ijgo.14471 -
Archives of Gynecology and Obstetrics Jan 2020Oxidative stress is thought to play an important role in the pathophysiology of pre-eclampsia. Polymorphism of Glutathione S-transferase P1 (GSTP1) protect cells against... (Review)
Review
PURPOSE
Oxidative stress is thought to play an important role in the pathophysiology of pre-eclampsia. Polymorphism of Glutathione S-transferase P1 (GSTP1) protect cells against the cytotoxic effects of reactive compounds. Published data on the association between the GSTP1 polymorphism and pre-eclampsia risk are controversial. A meta-analysis was performed to assess whether the polymorphisms of GSTP1 are associated with pre-eclampsia risk.
METHODS
Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases were searched to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for GSTP1 polymorphism and pre-eclampsia were appropriately derived from fixed-effects or random effects models.
RESULTS
A total of six studies were enrolled in this meta-analysis. The pooled analyses revealed that GSTP1 polymorphism was not associated with pre-eclampsia risk. Heterogeneity among studies was founded in allele contrast. Galbraith plot analyses were performed to assess the source of heterogeneity and one study was found to be contributor of heterogeneity. The heterogeneity decreased significantly after excluding that study.
CONCLUSION
Present meta-analysis demonstrates that GSTP1 polymorphism may be not correlated with pre-eclampsia risk.
Topics: Female; Genetic Predisposition to Disease; Glutathione S-Transferase pi; Humans; Oxidative Stress; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Risk Factors
PubMed: 31875251
DOI: 10.1007/s00404-019-05411-6 -
Critical Care Nursing QuarterlyHypertension has been shown to have long-term cardiovascular effects if left untreated. Hypertension also has been shown to affect women during pregnancy, which can be...
Hypertension has been shown to have long-term cardiovascular effects if left untreated. Hypertension also has been shown to affect women during pregnancy, which can be detrimental not only to the patient but also to the fetus. Early identification and treatment are paramount to prevent adverse outcomes. This article details the epidemiology, clinical presentation, diagnosis, and treatment of essential hypertension in women, gestational hypertension, preeclampsia, and eclampsia.
Topics: Pregnancy; Female; Humans; Hypertension; Pre-Eclampsia; Hypertension, Pregnancy-Induced
PubMed: 37684733
DOI: 10.1097/CNQ.0000000000000480 -
Cardiovascular Journal of AfricaThis review aimed to establish the impact of pre-eclampsia and HIV infection on cardiac function. Cardiovascular diseases have been reported to affect pregnancies... (Review)
Review
This review aimed to establish the impact of pre-eclampsia and HIV infection on cardiac function. Cardiovascular diseases have been reported to affect pregnancies complicated by both HIV and pre-eclampsia. Pre-eclampsia has been found to be associated with both systolic and diastolic dysfunction. Currently it has been found that there may be a dual, bidirectional pathophysiology, where placenta-mediated factors can influence cardiac function, or pre-existing cardiovascular disease can predispose to pre-eclampsia. Cardiovascular disease, HIV and pre-eclampsia are major health challenges individually and are interrelated with regard to pathophysiology. It has been found that both pre-eclampsia and HIV contribute to cardiac dysfunction as does the impact of antiretroviral therapy. Further research is needed to investigate the link between these diseases for the development of novel therapeutic interventions.
Topics: Humans; Pregnancy; Female; Pre-Eclampsia; HIV Infections; Pregnancy Complications, Infectious; Risk Factors
PubMed: 37171281
DOI: 10.5830/CVJA-2023-005 -
The Veterinary Clinics of North... Jul 2023Pregnancy toxemia is a common metabolic disease of late pregnant ewes and does, which potentially has devastating impacts on health and performance. This metabolic... (Review)
Review
Pregnancy toxemia is a common metabolic disease of late pregnant ewes and does, which potentially has devastating impacts on health and performance. This metabolic syndrome is not only one of over conditioned animals but is more typically associated with inadequate energy intake to support pregnancy requirements leading to body protein and fat mobilization. Blood chemistries provide insight into diagnosis and possibly may predict responsiveness to treatment and outcome. Early recognition of the disease with appropriate intervention is the best approach to minimizing the impact of this disease in the sheep flock or goat herd.
Topics: Pregnancy; Female; Animals; Sheep; Pre-Eclampsia; Goats; Sheep Diseases; Goat Diseases
PubMed: 37032302
DOI: 10.1016/j.cvfa.2023.02.010 -
MMW Fortschritte Der Medizin Feb 2022
Review
Topics: Female; Humans; Pre-Eclampsia; Pregnancy
PubMed: 35146683
DOI: 10.1007/s15006-021-0640-y -
Best Practice & Research. Clinical... Nov 2022Twin pregnancies are an important risk factor for preeclampsia, a hypertensive disorder of pregnancy that is associated with a significant risk of maternal and perinatal... (Review)
Review
Twin pregnancies are an important risk factor for preeclampsia, a hypertensive disorder of pregnancy that is associated with a significant risk of maternal and perinatal morbidity. Given the burden of preeclampsia, the identification of women at high risk in early pregnancy is essential to allow for preventive strategies and close monitoring. In singleton pregnancies, the risk factors for preeclampsia are well established, and a combined first-trimester prediction model has been shown to adequately predict preterm disease. Furthermore, intervention with low-dose aspirin at 150 mg/day in those identified as high-risk reduces the rate of preterm preeclampsia by 62%. In contrast, risk factors for preeclampsia in twin pregnancies are less established, the proposed screening models have shown poor performance with high false-positive rates, and the benefit of aspirin for the prevention of preeclampsia is not clearly demonstrated. In this review, we examine the literature assessing prediction and prevention of preeclampsia in twin pregnancies.
Topics: Female; Pregnancy; Infant, Newborn; Humans; Pregnancy, Twin; Pre-Eclampsia; Aspirin; Pregnancy Trimester, First; Hypertension
PubMed: 35450774
DOI: 10.1016/j.bpobgyn.2022.03.008 -
Nature Medicine Sep 2023
Topics: Female; Pregnancy; Humans; Epigenome; Pre-Eclampsia
PubMed: 37640857
DOI: 10.1038/s41591-023-02499-x -
Kidney International Aug 2023
Topics: Pregnancy; Humans; Female; Pre-Eclampsia; Placenta; Kidney
PubMed: 37479381
DOI: 10.1016/j.kint.2023.04.030 -
Revue Medicale de Liege Jun 2024Preeclampsia is a pregnancy-specific condition characterized by gestational hypertension associated with proteinuria or organ dysfunction after 20 weeks of gestation. It... (Review)
Review
Preeclampsia is a pregnancy-specific condition characterized by gestational hypertension associated with proteinuria or organ dysfunction after 20 weeks of gestation. It complicates 2 to 8 % of pregnancies worldwide and represents the leading cause of maternal and fetal mortality in developed countries. The only definitive treatment remains termination of pregnancy and delivery of the placenta. Prompt assessment of maternal and fetal status should be held in search of severity criteria and adequate management of this condition according to gestational age. Foremost concerns for pregnant patients are impending eclampsia or placental abruption, while fetal complications arise from placental insufficiency and risks associated with premature pregnancy termination. The sole efficient prophylaxis of preeclampsia in current state of evidence is aspirin at a dosage of 160 mg per day in high risk patients. Preeclampsia is now recognized as a high-risk factor for cardiovascular, renal, and neurological diseases and should therefore be considered as an opportunity for screening and prevention.
Topics: Humans; Pregnancy; Pre-Eclampsia; Female; Risk Factors
PubMed: 38869138
DOI: No ID Found