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Ophthalmology Nov 2022
Topics: Humans; Cataract; Cataract Extraction
PubMed: 35773077
DOI: 10.1016/j.ophtha.2022.03.018 -
The Pan African Medical Journal 2023
Topics: Humans; Cataract; Cataract Extraction
PubMed: 37426466
DOI: 10.11604/pamj.2023.45.16.39806 -
Canadian Journal of Ophthalmology.... Aug 2020
Topics: Cataract; Cataract Extraction; Eye Diseases, Hereditary; Humans
PubMed: 32386954
DOI: 10.1016/j.jcjo.2020.02.005 -
Journal Francais D'ophtalmologie Oct 2019
Topics: Cataract; Humans; Middle Aged
PubMed: 31227268
DOI: 10.1016/j.jfo.2019.03.024 -
Experimental Eye Research Feb 2020Congenital cataracts, the most common cause of visual impairment and blindness in children worldwide, have diverse etiologies. According to statistics analysis, about... (Review)
Review
Congenital cataracts, the most common cause of visual impairment and blindness in children worldwide, have diverse etiologies. According to statistics analysis, about one quarter of congenital cataracts caused by genetic defects. Various mutations of more than one hundred genes have been identified in hereditary cataracts so far. In this review, we briefly summarize recent developments about the genetics, molecular mechanisms, and treatments of congenital cataracts. The studies of these pathogenic mutations and molecular genetics is making it possible for us to comprehend the underlying mechanisms of cataractogenesis and providing new insights into the preventive, diagnostic and therapeutic approaches of cataracts.
Topics: Cataract; Humans; Lens, Crystalline; Molecular Biology
PubMed: 31770519
DOI: 10.1016/j.exer.2019.107872 -
QJM : Monthly Journal of the... Sep 2019
Topics: Adult; Cataract; Humans; Lens Capsule, Crystalline; Male; Pedigree; Phacoemulsification; Treatment Outcome; Vision Disorders
PubMed: 30721999
DOI: 10.1093/qjmed/hcz038 -
Indian Journal of Ophthalmology Nov 2023
Topics: Humans; Infant, Newborn; Cataract; Eye; Iatrogenic Disease; Retinopathy of Prematurity; Gestational Age; Retrospective Studies; Laser Coagulation
PubMed: 37869997
DOI: 10.4103/IJO.IJO_2744_23 -
Current Opinion in Ophthalmology Jan 2023We discuss the preoperative, intraoperative, and postoperative considerations for cataract surgery in eyes with high myopia. We also reviewed the recent literature on... (Review)
Review
PURPOSE OF REVIEW
We discuss the preoperative, intraoperative, and postoperative considerations for cataract surgery in eyes with high myopia. We also reviewed the recent literature on refractive outcomes and complications of cataract surgery in myopic eyes.
RECENT FINDINGS
Several novel intraocular lens (IOL) power calculation formulas have recently been developed to optimize refractive outcomes. Haigis formula is the most accurate among the third-generation IOL formulas. Novel formulas such as Barrett Universal II, Kane, and modified Wang-Koch adjustment for Holladay I formula provide a better refractive prediction compared with old formulas. Intraoperatively, the chopping technique is preferred to minimize pressure on weak zonules and reduce the incidence of posterior capsule rupture. Anterior capsular polishing is recommended to reduce the risk of postoperative capsular contraction syndrome (CCS). Postoperatively, complications such as refractive surprises, intraocular pressure spikes, and CCS remain higher in myopic eyes. Only 63% of myopic patients with axial length more than 26 mm achieve a visual acuity at least 20/40 after cataract surgery, mainly because of coexisting ocular comorbidities.
SUMMARY
There are multiple preoperative, intraoperative, and postoperative considerations when performing cataract surgery in myopic eyes. Further research is needed to optimize the refractive outcomes in these eyes and determine the best IOL formula. Surgeons should be adept and knowledgeable with different techniques to manage intraoperative complications.
Topics: Humans; Cataract
PubMed: 36473016
DOI: 10.1097/ICU.0000000000000914 -
Tidsskrift For Den Norske Laegeforening... Nov 2020Elevated serum ferritin levels are common findings in clinical practice, usually caused by inflammation, liver disease, high alcohol consumption or malignancy, although...
BACKGROUND
Elevated serum ferritin levels are common findings in clinical practice, usually caused by inflammation, liver disease, high alcohol consumption or malignancy, although it can occur in association with rare genetic conditions.
CASE PRESENTATION
We describe a male in his sixties with persistent hyperferritinaemia without associated iron overload and subsequent development of cataract. The patient himself suggested hyperferritinaemia-cataract syndrome as a diagnosis, which was subsequently confirmed with mutation analysis of the light chain ferritin (FTL) gene. Such mutations are inherited in an autosomal dominant pattern.
INTERPRETATION
Mutations in FTL are known to interfere with the balance between iron levels and ferritin production. When common causes of hyperferritinaemia are excluded, rare conditions should be considered in order to avoid unnecessary procedures and treatment. Genetic analyses are available for all clinicians and should be requested upon the right indications.
Topics: Cataract; Ferritins; Genetic Testing; Humans; Iron Metabolism Disorders; Male; Mutation; Pedigree
PubMed: 33172243
DOI: 10.4045/tidsskr.20.0255 -
Current Opinion in Ophthalmology Jan 2023To review most recent studies and clinical trials regarding pathogenesis, treatment, and prevention of inflammation after the cataract surgery. (Review)
Review
PURPOSE OF REVIEW
To review most recent studies and clinical trials regarding pathogenesis, treatment, and prevention of inflammation after the cataract surgery.
RECENT FINDINGS
FLACS gave opportunity to evaluate inflammatory cytokines in the aqueous humour right after the laser procedure, which led to acknowledging the inflammation pathogenesis during the phacoemulsification. Although there is still a lack of evidence, which would prove the long-term benefit of NSAIDs, they are indicated and effective when risk factors for PCME are present. PREMED studies showed that combination of NSAID and steroids after the surgery for healthy subjects is cost-effective. The triamcinolone injection together with topical steroids and NSAIDs for diabetic patients after the cataract surgery was the most cost-effective in preventing PCME according to the PREMED. Dropless cataract surgery is another emerging topic: dexamethasone implants and suspensions look promising as we await more clinical trials with drug-loaded IOLs.
SUMMARY
Inflammation after the cataract surgery can be prevented, and these methods are one of the most essential topics with growing phacoemulsification rate. Topical NSAIDs are cost-effective not only for patients with risk factors for PCME but also for healthy subjects. New dropless techniques are being successfully introduced in the clinical practice.
Topics: Humans; Cataract
PubMed: 36305352
DOI: 10.1097/ICU.0000000000000912