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Die Ophthalmologie Jul 2022
Topics: Cataract; Cataract Extraction; Humans; Lens Implantation, Intraocular
PubMed: 35394196
DOI: 10.1007/s00347-022-01619-1 -
Journal of Cataract and Refractive... Feb 2023
Topics: Humans; Pupil; Cataract; Cataract Extraction; Surgeons
PubMed: 36700886
DOI: 10.1097/j.jcrs.0000000000001087 -
JAMA Ophthalmology Mar 2023
Topics: Humans; Cornea; Cataract Extraction; Cataract
PubMed: 36757687
DOI: 10.1001/jamaophthalmol.2022.6308 -
Archivos de La Sociedad Espanola de... Dec 2023
Topics: Humans; Spain; Cataract Extraction; Lens, Crystalline; Cataract; Dementia
PubMed: 37595791
DOI: 10.1016/j.oftale.2023.06.019 -
Journal of Cataract and Refractive... Jan 2023
Topics: Humans; Cataract; Cataract Extraction; Surgeons
PubMed: 36573761
DOI: 10.1097/j.jcrs.0000000000001051 -
Experimental Animals Nov 2019Visual impairment leads to a decrease in quality of life. Cataract is the most commonly observed ocular disease in humans that causes vision disorders. The risk factors... (Review)
Review
Visual impairment leads to a decrease in quality of life. Cataract is the most commonly observed ocular disease in humans that causes vision disorders. The risk factors associated with cataract development include aging, infections, eye injuries, environmental causes, such as radiation and exposure to ultraviolet rays in sunlight, and genetic mutations. Additionally, several cataract patients display phenotypic heterogeneity, suggesting the role of genetic modifiers in the modulation of severity and onset time of cataractogenesis. However, the genetic modifiers associated with cataract have not been identified in humans yet. In contrast, the identification and mapping of genetic modifiers have been successfully carried out in mice and rats. In this review, we focus on the genetic modifiers of cataract in the rodent models.
Topics: Animals; Cataract; Disease Models, Animal; Mice; Rats
PubMed: 31105106
DOI: 10.1538/expanim.19-0020 -
Neuropediatrics Aug 2021Hypomyelination and congenital cataract (HCC) is characterized by congenital cataract, progressive neurologic impairment, and diffuse myelin deficiency. This autosomal... (Review)
Review
Hypomyelination and congenital cataract (HCC) is characterized by congenital cataract, progressive neurologic impairment, and diffuse myelin deficiency. This autosomal recessive disorder is caused by homozygous variant in the gene. Five consanguineous Tunisian patients, belonging to three unrelated families, underwent routine blood tests, electroneuromyography, and magnetic resonance imaging of the brain. The direct sequencing of exons was performed for the patients and their relatives. We summarized the 30 previously published HCC cases. All of our patients were carriers of a previously reported c.414 + 1G > T (IVS5 + 1G > T) variant, but the clinical spectrum was variable. Despite the absence of a phenotype-genotype correlation in HCC disease, screening of this splice site variant should be performed in family members at risk.
Topics: Cataract; Consanguinity; Hereditary Central Nervous System Demyelinating Diseases; Humans; Pedigree
PubMed: 34192786
DOI: 10.1055/s-0041-1728654 -
Clinical & Experimental Ophthalmology Sep 2021Cataract is a leading cause of blindness and vision impairment globally. Cataract surgery is one of the most frequently performed operations worldwide, but good quality... (Review)
Review
BACKGROUND
Cataract is a leading cause of blindness and vision impairment globally. Cataract surgery is one of the most frequently performed operations worldwide, but good quality services are not universally available. This scoping review aims to summarise the nature and extent of published literature on interventions to improve the quality of services for age-related cataract globally.
METHODS
We used the dimensions of quality adopted by WHO-effectiveness, safety, people-centredness, timeliness, equity, integration and efficiency-to which we added planetary health. On 17 November 2019, we searched MEDLINE, Embase and Global Health for manuscripts published since 1990, without language or geographic restrictions. We included studies that reported quality-relevant interventions and excluded studies focused on technical aspects of surgery or that only involved children (younger than 18 years). Screening of titles/abstracts, full-text review and data extraction were performed by two reviewers independently. Studies were grouped thematically and results synthesised narratively.
RESULTS
Most of the 143 included studies were undertaken in high-income countries (n = 93, 65%); 29 intervention groups were identified, most commonly preoperative education (n = 17, 12%) and pain/anxiety management (n = 16, 11%). Efficiency was the quality element most often assessed (n = 58, 41%) followed by people-centredness (n = 40, 28%), while integration (n = 4) and timeliness (n = 3) were infrequently reported, and no study reported outcomes related to planetary health.
CONCLUSION
Evidence on interventions to improve quality of cataract services shows unequal regional distribution. There is an urgent need for more evidence relevant to low- and middle-income countries as well as across all quality elements, including planetary health.
Topics: Cataract; Cataract Extraction; Child; Global Health; Humans
PubMed: 34291550
DOI: 10.1111/ceo.13976 -
Medecine Sciences : M/S 2020The eye has two converging lenses arranged in series: the cornea and the lens. They combine their powers. The image, which is naturally defocused ad infinitum, by... (Review)
Review
The eye has two converging lenses arranged in series: the cornea and the lens. They combine their powers. The image, which is naturally defocused ad infinitum, by crossing them successively, focuses on the retina to be seen clearly. Edema can cause the cornea to lose transparency while the clouding of lens leads to cataract. The loss of transparency of one or both lenses significantly affects the vision. Treating cataracts is a common practice. However, this can lead to the permanent loss of transparency of the cornea. A graft of the latter must then be carried out. How does this sometimes come about?
Topics: Cataract; Corneal Edema; Corneal Opacity; Corneal Transplantation; Disease Progression; Humans
PubMed: 32821051
DOI: 10.1051/medsci/2020132 -
Current Opinion in Ophthalmology Jan 2023The purpose of this review is to provide an overview of updates in the diagnosis and management of pediatric cataracts, with an emphasis on recent discoveries in the... (Review)
Review
PURPOSE OF REVIEW
The purpose of this review is to provide an overview of updates in the diagnosis and management of pediatric cataracts, with an emphasis on recent discoveries in the last two years.
RECENT FINDINGS
Pediatric cataracts remain an infrequent but significant disease with vision threatening consequences. Although much of the management has not changed historically, more recent updates, particularly borrowed from adult cataract management, have influenced the field of cataract management in children. Even these studies emphasize that pediatric cataracts are a distinct clinical entity from adult-onset cataracts, and further research is needed to optimize the diagnosis and management of cataracts in childhood.
SUMMARY
This is an overview of the recent advancements in the diagnosis of management of pediatric cataracts, with advancements that originate from the adult cataract surgery field in addition to studies that challenge classical surgical techniques to make cataract surgery safer and to promote amblyopia therapy.
Topics: Child; Humans; Cataract
PubMed: 36413417
DOI: 10.1097/ICU.0000000000000918