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The Veterinary Clinics of North... Jan 2024The health of the skin and coat of a cat is connected to the behavioral health of the animal. Stressed animals can cause lesions to their skin and coat such as alopecia,... (Review)
Review
The health of the skin and coat of a cat is connected to the behavioral health of the animal. Stressed animals can cause lesions to their skin and coat such as alopecia, ulcers, and self-mutilation. On the other hand, localized or systemic health problems can cause stress, or pain, and therefore can increase overgrooming and poor skin health. When treating overgrooming and related skin lesions, all the physical and behavioral causes must be addressed through a multimodal approach.
Topics: Animals; Cats; Skin Diseases; Skin; Alopecia; Behavior, Animal; Pain; Cat Diseases
PubMed: 37852882
DOI: 10.1016/j.cvsm.2023.09.004 -
Journal of Cosmetic Dermatology Aug 2019While dermatologists focus on practices to promote anti-aging, thinning hair that frames a more rejuvenated face can affect age perception and cosmesis. (Review)
Review
BACKGROUND
While dermatologists focus on practices to promote anti-aging, thinning hair that frames a more rejuvenated face can affect age perception and cosmesis.
OBJECTIVES
To characterize the effects of age-related hair changes on age determination and perceived attractiveness.
METHODS
A search was conducted for articles on intrinsic and extrinsic aging as it relates to hair. Key studies on the hair aging process and its effects on self-perception, confidence, and anti-aging were reviewed.
RESULTS
According to several studies, hair density peaks about 27 years of age or earlier and then decreases from the mid-thirties onward. This serves as an opportunity to prevent or treat hair loss in a similar way we treat aging skin. Without optimizing appearance of hair, overall cosmesis to foster self-perception can be curtailed despite multiple efforts to rejuvenate and restore the aging face.
CONCLUSION
The discrepancy between rejuvenated faces and thinner appearing hair that frames the face highlights the importance of a holistic approach to the anti-aging consultation. To more comprehensively address the aesthetic patient, we need to promote awareness of the onset of these hair changes in order to incorporate prevention and therapeutic strategies to preserve hair to complement overall appearance.
Topics: Adult; Aging; Alopecia; Cosmetic Techniques; Esthetics; Female; Hair; Humans; Rejuvenation; Self Concept
PubMed: 31012988
DOI: 10.1111/jocd.12960 -
The Journal of Family Practice Mar 2022This patient's nonadherence to treatment and lack of precautionary steps exacerbated this condition.
This patient's nonadherence to treatment and lack of precautionary steps exacerbated this condition.
Topics: Alopecia; Cicatrix; Exanthema; Humans
PubMed: 35507810
DOI: 10.12788/jfp.0366 -
Acta Dermato-venereologica Aug 2022
Topics: Alopecia; Humans; Hypohidrosis; Nail Diseases; Nails, Malformed; Propylthiouracil
PubMed: 35971830
DOI: 10.2340/actadv.v102.2690 -
ACS Applied Materials & Interfaces Apr 2023Androgenetic alopecia (AGA) is the most common type of progressive hair loss in both men and women that severely reduces life quality and affects patients' self-esteem....
Androgenetic alopecia (AGA) is the most common type of progressive hair loss in both men and women that severely reduces life quality and affects patients' self-esteem. Due to the shortcomings of traditional therapeutic formulations (e.g., topical minoxidil and oral finasteride), such as low bioavailability, frequent dosing, and significant side effects, there is an urgent need to develop a safe and effective strategy for AGA treatment. Here, we report a water-soluble microneedle (MN) patch integrated with biodegradable minoxidil (MXD)-loaded microspheres for long-acting AGA treatment with reduced administration frequency and improved patient compliance. When the patch pierces the skin, the MNs rapidly dissolve and deliver MXD-encapsulated polylactic--glycolic acid (PLGA) microspheres into the skin, which, subsequently act as drug reservoirs for the sustained release of the therapeutics for over 2 weeks. Additionally, the application of the MN patch provided a mechanical stimulation on mouse skin, which was also helpful for hair regrowth. Compared with the topical MXD solutions that have been commercialized on the market and require daily application, the long-acting MN patch contains a much lower drug amount and shows a similar or superior hair regeneration effect in AGA mice while only requiring monthly or weekly administration. These encouraging results suggest a simple, safe, and effective strategy for long-acting hair regeneration in clinics.
Topics: Female; Mice; Animals; Minoxidil; Microspheres; Administration, Topical; Alopecia; Hair; Treatment Outcome
PubMed: 36975753
DOI: 10.1021/acsami.2c22814 -
Journal of Cutaneous Medicine and... Nov 2023
Topics: Humans; Folliculitis; Alopecia; Hair
PubMed: 36820473
DOI: 10.1177/12034754231156562 -
The Journal of Dermatological Treatment Dec 2023To achieve international expert consensus and give recommendations on best practices in hair transplantation surgery, focusing on pre- and post-transplantation care.
AIM
To achieve international expert consensus and give recommendations on best practices in hair transplantation surgery, focusing on pre- and post-transplantation care.
METHODS
A modified Delphi method was used to reach consensus. An international scientific committee developed an 81-statement questionnaire. A panel of 38 experts in hair transplantation from 17 countries across 4 continents assessed the questionnaire.
RESULTS
Two consensus rounds were carried out, with 59 out of 81 statements (73%) reaching consensus. Expert recommendations emphasize the correct selection of candidates for hair transplantation and the need for patients to have received adequate medical treatment for alopecia before transplant. Comorbidities should be assessed and considered while planning surgery, and an individualized plan for perioperative care should be drawn up before transplant. Certain medications associated with increased risk of bleeding should be withdrawn before surgery. Specific recommendations for post-transplantation care are given. After transplantation, patients should gradually resume their normal haircare regimen. Close follow-up should be carried out during the first year after transplant.
CONCLUSIONS
This study presents numerous consensus-based recommendations on general aspects of hair transplantation, including candidate selection, medical therapy prior to transplantation, anesthesia, and resuming haircare after transplantation.
Topics: Humans; Skin Transplantation; Alopecia; Consensus; Hair
PubMed: 37477225
DOI: 10.1080/09546634.2023.2232065 -
Dermatologic Therapy Nov 2020Androgenetic alopecia (AGA) is the most common disease associated with hair loss in both females and males. Given the high prevalence of AGA and limited therapeutic... (Review)
Review
Androgenetic alopecia (AGA) is the most common disease associated with hair loss in both females and males. Given the high prevalence of AGA and limited therapeutic methods and the high cost of hair transplantation and ease of use or platelet-rich plasma (PRP) therapies, this systematic review study was conducted to evaluate the effect of PRP on AGA of women. In this systematic review study, English-language articles were searched on PubMed, ISI web of knowledge, and Google Scholar by the end of 2019 with a combination of keywords. Finally, six articles were evaluated. The total number of subjects in this systematic review study was 92 people in six studies. All studies were clinical trials. Most of the studied had been conducted as a pilot study. Follow-up period for patients varied from 6 to 12 months. Except for one study, other studies have reported a positive therapeutic effect for PRP. The major limitation of the studies was the pilot nature and small sample size of these studies. According to the limited studies included in this systematic review, PRP treatment had a positive effect on the improvement of AGA, increasing hair density, and improving hair diameter in affected women.
Topics: Alopecia; Female; Hair; Humans; Male; Pilot Projects; Platelet-Rich Plasma; Treatment Outcome
PubMed: 32588941
DOI: 10.1111/dth.13835 -
Journal of Drugs in Dermatology : JDD Jul 2022The Novel Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus two and primarily affects the epithelium of the airways. Multiple...
The Novel Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus two and primarily affects the epithelium of the airways. Multiple cutaneous manifestations of COVID-19 have been reported in the literature. Case reports citing many different types of exanthems and enanthems have been reported to correspond with the initial presentation and diagnosis of COVID-19. Some researchers have even described cutaneous symptoms linked to COVID-19 as an important presenting sign of the infection with COVID-19 in otherwise asymptomatic or minimally symptomatic patients. Hair loss has emerged as a frequently noted side effect of infection with COVID-19 and has been observed in many patients who have recovered from a documented COVID-19 illness. Given the prevalence of the onset of hair loss in patients who have overcome COVID-19, we designed this retrospective study in order to evaluate the prevalence of hair loss, along with histological findings if hair loss was present and response to treatment in 100 patients who presented to our outpatient dermatology clinic for various dermatological conditions and reported a history of having recovered from COVID-19. J Drugs Dermatol. 2022;21(7):724-727. doi:10.36849/JDD.6661.
Topics: Alopecia; COVID-19; Humans; Prevalence; Retrospective Studies; SARS-CoV-2
PubMed: 35816057
DOI: 10.36849/JDD.6661 -
Journal of the American Academy of... Mar 2022Frontal fibrosing alopecia (FFA) is a progressive, scarring alopecia of the frontotemporal scalp that poses a substantial burden on quality of life. Large-scale global...
BACKGROUND
Frontal fibrosing alopecia (FFA) is a progressive, scarring alopecia of the frontotemporal scalp that poses a substantial burden on quality of life. Large-scale global profiling of FFA is lacking, preventing the development of effective therapeutics.
OBJECTIVE
To characterize FFA compared to normal and alopecia areata using broad molecular profiling and to identify biomarkers linked to disease severity.
METHODS
This cross-sectional study assessed 33,118 genes in scalp using RNA sequencing and 350 proteins in serum using OLINK high-throughput proteomics. Disease biomarkers were also correlated with clinical severity and a fibrosis gene set.
RESULTS
Genes differentially expressed in lesional FFA included markers related to Th1 (IFNγ/CXCL9/CXCL10), T-cell activation (CD2/CD3/CCL19/ICOS), fibrosis (CXCR3/FGF14/FGF22/VIM/FN1), T-regulatory (FOXP3/TGFB1/TGFB3), and Janus kinase/JAK (JAK3/STAT1/STAT4) (Fold changes [FCH]>1.5, FDR<.05 for all). Only one protein, ADM, was differentially expressed in FFA serum compared to normal (FCH>1.3, FDR<.05). Significant correlations were found between scalp biomarkers (IL-36RN/IL-25) and FFA severity, as well as between JAK/STAT and fibrosis gene-sets (r>.6; P <.05).
LIMITATIONS
This study was limited by a small sample size and predominantly female FFA patients.
CONCLUSION
Our data characterize FFA as an inflammatory condition limited to scalp, involving Th1/JAK skewing, with associated fibrosis and elevated T-regulatory markers, suggesting the potential for disease reversibility with JAK/STAT inhibition.
Topics: Alopecia; Alopecia Areata; Biomarkers; Cross-Sectional Studies; Female; Fibrosis; Humans; Lichen Planus; Quality of Life; Scalp
PubMed: 34044102
DOI: 10.1016/j.jaad.2021.05.016