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Scientific Reports Feb 2023The associations between blood pressure and cannabis use remain inconsistent. The purpose of our study was to examine gender stratified associations of cannabis use and...
The associations between blood pressure and cannabis use remain inconsistent. The purpose of our study was to examine gender stratified associations of cannabis use and blood pressure [systolic, diastolic blood pressure (BP), pulse pressure (PP)] levels among the general UK Biobank population based study. Among 91,161 volunteers of the UK Biobank population, cannabis use status was assessed by questionnaire and range as heavy, moderate, low and never users. Associations between cannabis use and BP were estimated using multiple gender linear regressions. In adjusted covariates models, lifetime heavy cannabis use was associated with decrease in both SBP, DBP and PP in both genders, but with a higher effect among women (for SBP in men, b = - 1.09 (0.27), p < 0.001; in women, b = - 1.85 (0.36), p < 0.001; for DBP in men, b = - 0.50 (0.15), p < 0.001; in women, b = - 0.87 (0.17), p < 0.001; and for PP in men, b = - 0.60 (0.20), p < 0.001; in women, b = - 0.97 (0.27), p < 0.001. Among men, lower SBP and DBP levels were observed with participants without dyslipidemia and lower PP in participants with high income levels. Among women, lower SBP, DBP and PP were observed with current smokers, moderate/low alcohol levels and participants without dyslipidemia. Current cannabis use was associated with lower SBP levels in men (b = - 0.63 (0.25), p = 0.012) and in women (b = - 1.17 (0.31), p < 0.001). Same results were observed for DBP and PP. Negative association between BP in men was found but not in women. The small association in BP differences between heavy users and never users remains too small to adopt cannabis-blood pressure public policy in clinical practice.
Topics: Humans; Male; Female; Blood Pressure; Cannabis; Hallucinogens; Social Class; Hypertension
PubMed: 36740601
DOI: 10.1038/s41598-022-22841-6 -
Frontiers in Public Health 2023Transitioning from marriage to widowhood presents inevitable and significant challenges for many older adults. This study explored the impact of widowhood on a range of...
BACKGROUND
Transitioning from marriage to widowhood presents inevitable and significant challenges for many older adults. This study explored the impact of widowhood on a range of mental health outcomes, including pulse pressure and fasting blood glucose levels, among older adults in nursing homes.
METHODS
This cross-sectional study utilized cluster random sampling to recruit participants, with data analyzed from 388 older Chinese adults. Psychosocial traits were assessed using the Perceived Social Support from Family scale (PSS-Fa) for family support, the Generalized Anxiety Disorder 7-item scale (GAD-7) for anxiety symptoms, and the 9-item Patient Health Questionnaire (PHQ-9) for depressive symptoms and suicidal ideation. Propensity score matching (PSM) was employed to control for confounding factors. A multivariate linear regression analysis was performed to explore the relationship between widowhood, mental health outcomes, pulse pressure, and fasting blood glucose levels.
RESULTS
After applying PSM, the sample size was refined to 268 ( = 134 for both married and widowed groups) from the initial 388, excluding 120 unmatched cases. Widowed older adults were found to have notably lower family support ( = -0.81, = 0.002), increased depressive symptoms ( = 1.04, = 0.043), elevated pulse pressure ( = 8.90, < 0.001), and higher fasting blood glucose levels ( = 3.22, = 0.027). These associations exhibited greater beta values compared to pre-matching analysis.
CONCLUSION
Our findings revealed that widowed participants had reduced family support, an increased risk of depressive symptoms, heightened pulse pressure, and elevated fasting blood glucose in comparison to their married counterparts. Interventions focusing on social support, mental health, and cardiovascular well-being could be advantageous for this at-risk group.
Topics: Female; Humans; Middle Aged; Aged; Widowhood; Blood Glucose; Mental Health; Blood Pressure; Cross-Sectional Studies; Propensity Score
PubMed: 37954046
DOI: 10.3389/fpubh.2023.1257133 -
Journal of Cardiac Surgery Aug 2021Recent reports have revealed better clinical outcomes for extracorporeal cardiopulmonary resuscitation (ECPR) than conventional cardiopulmonary resuscitation (CPR). In...
BACKGROUND
Recent reports have revealed better clinical outcomes for extracorporeal cardiopulmonary resuscitation (ECPR) than conventional cardiopulmonary resuscitation (CPR). In this retrospective study, we attempted to identify predictors associated with successful weaning off extracorporeal membrane oxygenation (ECMO) support after ECPR.
METHODS
The demographic and clinical data of 30 ECPR patients aged over 18 years treated between August 2016 and January 2019 were analyzed. All clinical data were retrospectively collected. The primary endpoint was successful weaning off ECMO support after ECPR. Patients were divided into two groups based on successful or unsuccessful weaning off ECMO support (Weaned (n = 14) vs. Failed (n = 16)).
RESULTS
Univariate logistic regression analysis showed that age, CPR duration, ECMO complications, and loss of pulse pressure significantly predicted the results of weaning off ECMO support. However, multivariate logistic regression analysis showed that only CPR duration and loss of pulse pressure independently predicted unsuccessful weaning from ECMO support.
CONCLUSION
We conclude that long CPR duration and loss of pulse pressure after ECPR predict unsuccessful weaning from ECMO. However, unlike CPR duration, loss of pulse pressure during post-ECPR was related to subsequent management. In patients with reduced pulse pressure after ECPR, careful management is warranted because this reduction is closely associated with unsuccessful weaning off ECMO support after ECPR.
Topics: Adult; Blood Pressure; Cardiopulmonary Resuscitation; Extracorporeal Membrane Oxygenation; Humans; Middle Aged; Retrospective Studies; Time Factors
PubMed: 33993537
DOI: 10.1111/jocs.15614 -
Hypertension Research : Official... May 2023The aim of this study was to assess the trends in blood pressure (BP) levels and the corresponding prevalence of hypertension among elderly individuals in China from...
The aim of this study was to assess the trends in blood pressure (BP) levels and the corresponding prevalence of hypertension among elderly individuals in China from 2008 to 2018. This serial cross-sectional analysis was based on data from the last four waves of the Chinese Longitudinal Healthy Longevity Survey (N = 38086). Linear regression analyses were performed to assess linear trends in mean systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP). Logistic regression was used to examine trends in the prevalence of hypertension across the four waves. An ordinal regression model was used to assess risk factors for BP status. From 2008 to 2018, an increase of 0.8-3.3% in BP and at least an 8.2% increase in the prevalence of hypertension were observed among older adults and oldest-old adults (aged 65-79 years and ≥ 80 years) (all P < 0.001). Furthermore, the increasing magnitude of the prevalence of hypertension in the participants aged 65-79 years was greater than that in those aged ≥ 80 years. Region, BMI and living alone were factors associated with different BP statuses. After adjustment for demographic and behavioral characteristics, an increasing trend in mean SBP and PP was found in both men and women, whereas the mean DBP increased only in men. A significant increase occurred in hypertension prevalence, SBP and PP, whereas DBP remained stable in elderly Chinese individuals from 2008 to 2018. Comprehensive strategies need to be implemented for the prevention and management of hypertension among older adults in China.
Topics: Male; Aged; Humans; Female; Aged, 80 and over; Blood Pressure; Cross-Sectional Studies; Hypertension; Blood Pressure Determination; China
PubMed: 36750610
DOI: 10.1038/s41440-023-01183-4 -
Internal Medicine Journal Jan 2021Despite multiple studies, it has not been possible to account for the normal changes of blood pressure that occur from infancy to old age. We sought a comprehensive... (Review)
Review
Despite multiple studies, it has not been possible to account for the normal changes of blood pressure that occur from infancy to old age. We sought a comprehensive explanation, by linking brachial pressure with the well documented changes in the arterial pulse waveform, whose peak and nadir determine systolic, diastolic and pulse pressure in brachial arteries. Changes in humans arterial pulse wave contour from birth to old age can be readily explained on (i) growth, with increasing length of the body from birth to adolescence, and adult height maintained thereafter, and (ii) degeneration and dilation of the aorta from elastic fibre fracture throughout life, causing progressive increase in aortic pressure wave amplitude from early return of wave reflection, and summation of incident with reflected waves in systole. These changes throughout life complement arterial pulse waveform analysis and explain brachial cuff pressure values, with optimal pulse wave pattern for cardiac interaction apparent in adolescence.
Topics: Adult; Aorta; Arterial Pressure; Blood Pressure; Brachial Artery; Humans; Longevity; Systole
PubMed: 32175664
DOI: 10.1111/imj.14815 -
IEEE Reviews in Biomedical Engineering 2022Noninvasive continuous blood pressure estimation is a promising alternative to minimally invasive blood pressure measurement using cuff and invasive catheter... (Review)
Review
Noninvasive continuous blood pressure estimation is a promising alternative to minimally invasive blood pressure measurement using cuff and invasive catheter measurement, because it opens the way to both long-term and continuous blood pressure monitoring in ecological situation. The most current estimation algorithm is based on pulse transit time measurement where at least two measured signals need to be acquired. From the pulse transit time values, it is possible to estimate the continuous blood pressure for each cardiac cycle. This measurement highly depends on arterial properties which are not easily accessible with common measurement techniques; but these properties are needed as input for the estimation algorithm. With every change of input arterial properties, the error in the blood pressure estimation rises, thus a periodic calibration procedure is needed for error minimization. Recent research is focused on simplified constant arterial properties which are not constant over time and uses only linear model based on initial measurement. The elaboration of continuous calibration procedures, independent of recalibration measurement, is the key to improving the accuracy and robustness of noninvasive continuous blood pressure estimation. However, most models in literature are based on linear approximation and we discuss here the need for more complete calibration models.
Topics: Blood Pressure; Blood Pressure Determination; Calibration; Humans; Monitoring, Physiologic; Pulse Wave Analysis
PubMed: 34487496
DOI: 10.1109/RBME.2021.3109643 -
Scientific Reports Nov 2023Data on the relationship between arterial pulsatile hemodynamics and aortic root geometry, using invasive hemodynamic measurement, has been scarce. Thus, this study...
Data on the relationship between arterial pulsatile hemodynamics and aortic root geometry, using invasive hemodynamic measurement, has been scarce. Thus, this study aimed to assess the relationship between invasively measured aortic pulse pressure (aPP) and the diameter of ascending aorta (AoD). We analyzed 665 subjects (64.3 ± 11.0 years; 34.6% female) who underwent elective invasive coronary angiography (ICA) for the evaluation of coronary artery disease. Transthoracic echocardiography was performed on the same day, and AoD was measured at the level of 1 cm above the sinotubular junction at the end-diastole. Body surface area (BSA)-adjusted AoD (AoD/BSA) was used for the analysis. A pig-tail catheter was used to measure aortic pressures at a level approximately 3 cm above the aortic valve just before ICA. aPP was calculated as the difference between systolic and diastolic pressures of the aorta. In multiple linear regression analyses, aPP (β = 0.259; P < 0.001) was found to be significantly correlated with AoD/BSA even after controlling for potential confounders. This correlation power was stronger than aortic systolic pressure (β = 0.189; P < 0.001) and brachial pulse pressure (β = 0.091; P = 0.018) at the same multivariable analyses. In conclusion, our study demonstrated a significant association between invasively measured aPP and AoD/BSA, providing stronger evidence for the link between central aortic pulsatile hemodynamics and aortic root geometry.
Topics: Humans; Female; Male; Arterial Pressure; Aorta, Thoracic; Aorta; Blood Pressure; Coronary Artery Disease
PubMed: 38036600
DOI: 10.1038/s41598-023-48597-1 -
Annals of Palliative Medicine Jul 2021This study aims to evaluate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in mechanically ventilated...
BACKGROUND
This study aims to evaluate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in mechanically ventilated patients with thoracic kyphosis.
METHODS
A total of 35 patients diagnosed with thoracic kyphosis undergoing corrective surgery were studied. For all patients, the Vigileo/FloTrac system was used for analysis. Hemodynamic data such as mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), stroke volume index (SVI), cardiac output (CO), cardiac output index (CI), SVV, and PPV were recorded before and after volume expansion (VE). Fluid responsiveness was defined as an increase in SVI ≥10% (ΔSVI ≥10%). Patients were divided into responders and non-responders as determined by changes in ΔSVI ≥10% and <10%. Nonparametric Wilcoxon rank sum test was used to compare the hemodynamic parameters of Responders and Non-responders before and after VE. Pearson correlation analysis was used to analyze the values of SVV, PPV and ΔSVI. The receiver operating characteristic (ROC) curve of each hemodynamic index was drawn to determine its accuracy and threshold.
RESULTS
Two patients were excluded. There was no significant difference in patients' characteristics between Responders and Non-responders. After VE, there were no significant changes in HR, MAP, and SV in both responders and non-responders, but CI were significantly changed in the two groups. SVI and CO increased significantly in responders before and after VE, but not in non-responders. VE also caused decreases of PPV and SVV in both responders and non-responders. Before VE, the SVV and PPV correlated with ΔSVI in responders (r=0.621, r=0.569, respectively, P<0.05), but neither the SVV nor PPV correlated with ΔSVI in non-responders (P>0.05). The areas under the ROC curves of patients with thoracic kyphosis were 0.872 (95% CI: 0.719-1.000) for SVV and 0.833 (95% CI: 0.667-1.000) for PPV. The threshold of the SVV of patients with thoracic kyphosis was 13.5%, and the threshold of PPV was 14.5%.
CONCLUSIONS
Both SVV and PPV can be used as effective indictors to monitor volume changes in patients with thoracic kyphosis.
Topics: Blood Pressure; Fluid Therapy; Hemodynamics; Humans; Kyphosis; Stroke Volume
PubMed: 34154341
DOI: 10.21037/apm-21-1211 -
Journal of the College of Physicians... Feb 2021To evaluate the prevalence of arterial stiffness in patients on hemodialysis and related factors that aggravate the condition.
OBJECTIVE
To evaluate the prevalence of arterial stiffness in patients on hemodialysis and related factors that aggravate the condition.
STUDY DESIGN
Prospective-cohort study.
PLACE AND DURATION OF STUDY
Department of Nephrology, Firat University Hospital, Turkey, from August to October 2019.
METHODOLOGY
Central blood pressure (BP), augmentation index (AIx) and aortic pulse wave velocity score (PWVs) were assessed using the mobil-o-graph pulse wave velocity system. Increased arterial stiffness (AS) wgnas defined by the aortic PWV of >10 m/s.
RESULTS
The mean PVWs were 8.14 ± 2.39 m/s the mean AIx was 21.23 ± 11.58 m/s, and AS was 33.7% in hemodialysis patients. Systolic blood pressure, pulse rate, pulse pressure, central systolic blood pressure, older age, HD vintage, HT vintage, creatinine, CRP and neutrophil leukocyte ratio (NLR), were related factors with AS. Multivariate linear regression analysis showed that systolic blood pressure (β=0.322; 95% CI: 0.007-0.042; p = 0.006), and age of patients (β=0.787; 95% CI: 0.095-0.127; p<0.001) were independent determinants of PWVs.
CONCLUSION
The frequency of AS was 33.7% in hemodialysis patients without a history of cardiovascular disease. Increased age and systolic blood pressure were independent factors affecting PWV. Effective blood pressure control therapy can reduce AS in hemodialysis patients. Key Words: Pulse wave velocity, Arterial stiffness, Cardiovasculer disease, Systolic blood pressure, Hemodialysis.
Topics: Aged; Blood Pressure; Cohort Studies; Humans; Prospective Studies; Pulse Wave Analysis; Renal Dialysis; Turkey; Vascular Stiffness
PubMed: 33645178
DOI: 10.29271/jcpsp.2021.02.138 -
American Journal of Hypertension Oct 2019To compare in individuals with type 1 diabetes the prediction of incident coronary artery disease (CAD) by components of resting blood pressure-systolic, diastolic,... (Comparative Study)
Comparative Study
BACKGROUND
To compare in individuals with type 1 diabetes the prediction of incident coronary artery disease (CAD) by components of resting blood pressure-systolic, diastolic, pulse pressure, and mean arterial pressure.
METHODS
In 605 participants without known CAD at baseline and followed sequentially for 25 years, we used Cox modeling built for each blood pressure component associated with incident CAD, overall and stratified by age (<35 and ≥35 years) or hemoglobin A1c (HbA1c) (<9% and ≥9%).
RESULTS
Baseline mean age and diabetes duration were 27 and 19 years, respectively. We observed an early asymptote and then fall in diastolic blood pressure in their late 30s and early 40s in this group of type 1 diabetes individuals, followed by an early rise of pulse pressure. Adjusted hazard ratios (HR) (95% con) for CAD associated with 1 SD pressure increase were 1.35 (1.17, 1.56) for systolic pressure; 1.30 (1.12, 1.51) for diastolic pressure; 1.20 (1.03, 1.39) for pulse pressure; and 1.35 (1.17, 1.56) for mean arterial pressure. Pulse pressure emerged as a strong predictor of CAD at age ≥ 35 years (HR: 1.49 [1.15, 1.94]) and for HbA1c ≥ 9% (HR: 1.32 [1.01, 1.72]).
CONCLUSIONS
Individuals with type 1 diabetes may manifest early vascular aging by an early decline in diastolic blood pressure and rise in pulse pressure, the latter parameter becoming a comparable to systolic blood pressure in predictor incident CAD in those aged over 35 years and those with poor glycemic control.
Topics: Adult; Age of Onset; Arterial Pressure; Biomarkers; Blood Pressure; Coronary Artery Disease; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin; Humans; Incidence; Male; Pennsylvania; Prognosis; Risk Assessment; Risk Factors; Time Factors; Young Adult
PubMed: 31214692
DOI: 10.1093/ajh/hpz099