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Applied Spectroscopy Apr 2022This Focal Point Review paper discusses the developments of biomedical Raman and infrared spectroscopy, and the recent strive towards these technologies being regarded... (Review)
Review
This Focal Point Review paper discusses the developments of biomedical Raman and infrared spectroscopy, and the recent strive towards these technologies being regarded as reliable clinical tools. The promise of vibrational spectroscopy in the field of biomedical science, alongside the development of computational methods for spectral analysis, has driven a plethora of proof-of-concept studies which convey the potential of various spectroscopic approaches. Here we report a brief review of the literature published over the past few decades, with a focus on the current technical, clinical, and economic barriers to translation, namely the limitations of many of the early studies, and the lack of understanding of clinical pathways, health technology assessments, regulatory approval, clinical feasibility, and funding applications. The field of biomedical vibrational spectroscopy must acknowledge and overcome these hurdles in order to achieve clinical efficacy. Current prospects have been overviewed with comment on the advised future direction of spectroscopic technologies, with the aspiration that many of these innovative approaches can ultimately reach the frontier of medical diagnostics and many clinical applications.
Topics: Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Vibration
PubMed: 34041957
DOI: 10.1177/00037028211021846 -
Physical Chemistry Chemical Physics :... May 2022
Topics: Humans; Lasers; Spectrum Analysis; Time Factors
PubMed: 35575020
DOI: 10.1039/d2cp90063g -
Advanced Materials (Deerfield Beach,... Jul 2021When analyzing biological phenomena and processes, multiplexed biodetection has many advantages over single-factor biodetection and is highly relevant to both human... (Review)
Review
When analyzing biological phenomena and processes, multiplexed biodetection has many advantages over single-factor biodetection and is highly relevant to both human health issues and advancements in the life sciences. However, many key problems with current multiplexed biodetection strategies remain unresolved. Herein, the main issues are analyzed and summarized: 1) generating sufficient signal to label targets, 2) improving the signal-to-noise ratio to ensure total detection sensitivity, and 3) simplifying the detection process to reduce the time and labor costs of multiple target detection. Then, available solutions made possible by designing and controlling the properties of micro- and nanomaterials are introduced. The aim is to emphasize the role that micro-/nanomaterials can play in the improvement of multiplexed biodetection strategies. Through analyzing existing problems, introducing state-of-the-art developments regarding relevant materials, and discussing future directions of the field, it is hopeful to help promote necessary developments in multiplexed biodetection and associated scientific research.
Topics: Biosensing Techniques; Equipment Design; Equipment Failure Analysis; Humans; Indicators and Reagents; Nanostructures; Reproducibility of Results; Sensitivity and Specificity; Signal-To-Noise Ratio; Spectrometry, Fluorescence; Spectrum Analysis, Raman
PubMed: 34137090
DOI: 10.1002/adma.202004734 -
Zentralblatt Fur Chirurgie Apr 2020
Topics: Diagnosis, Computer-Assisted; Humans; Image Processing, Computer-Assisted; Intraoperative Care; Machine Learning; Spectrum Analysis; Viscera
PubMed: 32268383
DOI: 10.1055/a-1030-3232 -
FEBS Letters Oct 2022
Topics: Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman
PubMed: 36215224
DOI: 10.1002/1873-3468.14498 -
Chemical Society Reviews Nov 2022The use of imaging technologies has been critical in deciphering biological phenomena, structures, and mechanisms across a wide range of spatial scales. The spatial... (Review)
Review
The use of imaging technologies has been critical in deciphering biological phenomena, structures, and mechanisms across a wide range of spatial scales. The spatial resolution of traditional imaging modalities cannot meet the needs of high-precision research and diagnosis in biomedical fields. Plasmon resonance is the light-matter interaction that allows localizing far-field radiation in the near field with an intense electromagnetic field, enhancing the nanometric ablation, elastic/inelastic scattering of the adsorbate, and photoluminescence of the fluorophore nearby. Further, plasmon resonance scattering of nanoparticles can sensitively indicate the local environmental changes. This is accomplished by combining the spatially resolved capability with molecular spectrometry techniques such as Raman, infrared, fluorescence, , leading to a series of excellent imaging techniques to interrogate diverse biological processes from the tissue to subcellular level. In this tutorial review, we first provide the fundamental aspects of plasmonics. Then we give a systematic discussion of the working principle of these plasmon-based imaging techniques with an emphasis on the achievable spatial resolutions: surface-enhanced Raman spectroscopy (micrometre to nanometre), tip-enhanced ablation and ionization mass spectrometry (submicrometre), scattering-type scanning near-field optical microscopy (nanometre), tip-enhanced Raman spectroscopy (nanometre), tip-enhanced fluorescence spectroscopy (nanometre), and plasmon/molecular ruler microscopy (nanometre to angstrom). We also review the recent developments of the bioimaging applications of these techniques and expect that the plasmon-based techniques will not only pave a new way to decipher mysteries in life sciences but also hold great potential to be extended from fundamental research studies to real-life biomedical applications.
Topics: Surface Plasmon Resonance; Spectrum Analysis, Raman; Microscopy; Nanoparticles
PubMed: 36378240
DOI: 10.1039/d2cs00525e -
Journal of the American Chemical Society Sep 2019Carbohydrates possess a variety of distinct features with stereochemistry playing a particularly important role in distinguishing their structure and function.... (Review)
Review
Carbohydrates possess a variety of distinct features with stereochemistry playing a particularly important role in distinguishing their structure and function. Monosaccharide building blocks are defined by a high density of chiral centers. Additionally, the anomericity and regiochemistry of the glycosidic linkages carry important biological information. Any carbohydrate-sequencing method needs to be precise in determining all aspects of this stereodiversity. Recently, several advances have been made in developing fast and precise analytical techniques that have the potential to address the stereochemical complexity of carbohydrates. This perspective seeks to provide an overview of some of these emerging techniques, focusing on those that are based on NMR and MS-hybridized technologies including ion mobility spectrometry and IR spectroscopy.
Topics: Carbohydrate Sequence; Carbohydrates; Spectrum Analysis; Structure-Activity Relationship
PubMed: 31403778
DOI: 10.1021/jacs.9b06406 -
Analytical Sciences : the International... Dec 2022
Topics: Spectroscopy, Near-Infrared; Spectrum Analysis, Raman
PubMed: 36372817
DOI: 10.1007/s44211-022-00202-7 -
Nature Biomedical Engineering Aug 2019
Topics: Absorbable Implants; Animals; Biocompatible Materials; Blood; Blood Chemical Analysis; Brain; Equipment Design; Mice; Needles; Optics and Photonics; Spectrum Analysis; Temperature
PubMed: 31391593
DOI: 10.1038/s41551-019-0441-0 -
Analytical Chemistry Jan 2021
Review
Topics: Forensic Sciences; Humans; Mass Spectrometry; Radiochemistry; Spectrophotometry, Infrared; Spectrum Analysis, Raman; X-Ray Absorption Spectroscopy; X-Ray Diffraction
PubMed: 32926769
DOI: 10.1021/acs.analchem.0c03571