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Environmental Pollution (Barking, Essex... Jan 2023The widespread coexistence of hydrophilic organic compounds and microplastics (MPs) in the environment has greatly increased their associated environmental problems. To...
The widespread coexistence of hydrophilic organic compounds and microplastics (MPs) in the environment has greatly increased their associated environmental problems. To evaluate the potential carrier effect of oxygen-containing MPs on coexisting pollutants, adsorption behaviors of four hydrophilic organic compounds (benzoic acid, sulfamethoxazole, sulfamerazine and ciprofloxacin) on MPs (pristine and weathered polyamide (PA)) were studied in the aquatic environment. The results showed that the surface morphology, size, oxygen content, molecular structure, surface charge and crystallinity of PA were changed after weathering, and the weathering degree of PA treated with heat-activated potassium persulfate was the highest. The main adsorption mechanisms included hydrogen bonding, hydrophobic interaction, charge-assisted hydrogen bonding, and electrostatic interaction. Hydrogen bonding and hydrophobic interaction contributed to the adsorption, while electrostatic interaction weakened the adsorption under the specific pH conditions. The formation of charge-assisted hydrogen bonding (CAHB) was also verified through pH influence experiments, and this force can overcome the electrostatic repulsion. The high adsorption of KPA (PA weathered by KSO) under alkaline conditions was well explained by the formation of homonuclear CAHB due to the increase of oxygen-containing functional groups compared to the other three PA. Additionally, weathering did not always enhance the adsorption of hydrophilic organic compounds on PA, which was related to the changes in surface charge, crystallinity and hydrophilicity of PA. Overall, the physical and chemical properties (e.g., specific surface area, oxygen content, molecular structure) of PA after weathering and its trend of adsorption were different from other oxygen-free MPs in this study. This work can provide basic data for environmental risk of MPs and contribute to clarify and understand the processes of oxygenated MPs in the aquatic environment.
Topics: Microplastics; Plastics; Nylons; Adsorption; Water Pollutants, Chemical; Organic Chemicals; Hydrophobic and Hydrophilic Interactions
PubMed: 36481467
DOI: 10.1016/j.envpol.2022.120818 -
Foods (Basel, Switzerland) Jan 2022A multiclass and multiresidue method for simultaneously screening and confirming veterinary drugs, mycotoxins, and pesticides in bovine milk was developed and validated...
Multiclass Comparative Analysis of Veterinary Drugs, Mycotoxins, and Pesticides in Bovine Milk by Ultrahigh-Performance Liquid Chromatography-Hybrid Quadrupole-Linear Ion Trap Mass Spectrometry.
A multiclass and multiresidue method for simultaneously screening and confirming veterinary drugs, mycotoxins, and pesticides in bovine milk was developed and validated with ultrahigh-performance liquid chromatography-hybrid quadrupole-linear ion trap mass spectrometry (UHPLC-Qtrap-MS). A total of 209 targeted contaminants were effectively extracted using an optimized QuEChERS method. Quantitative and qualitative confirmation were achieved simultaneously by multiple reaction monitoring-information-dependent acquisition-enhanced product ion (MRM-IDA-EPI) scan mode. The validation results exhibited a good sensitivity with the LOQs of 0.05-5 μg/kg, which was satisfactory for their MRLs in China or EU. The recoveries of in-house spiked samples were in the range of 51.20-129.76% with relative standard deviations (RSD) between replicates ( = 3) 0.82% and 19.76%. The test results of 140 milk samples from supermarkets and dairy farms in China showed that cloxacillin, aflatoxin M1, acetamiprid, and fipronil sulfone were found with lower concentrations. Combined with the residue results from the literature, penicillin G and cloxacillin (beta-lactams), enrofloxacin and ciprofloxacin (fluoroquinolones), and sulfamerazine (sulfonamides) were more frequently detected in different countries and need to receive more attention regarding their monitoring and control.
PubMed: 35159483
DOI: 10.3390/foods11030331 -
Dalton Transactions (Cambridge, England... Jul 2020In this work, the dispersive solid-phase extraction of sulfonamide antibiotics was evaluated using magnetic porous carbons derived from cobalt(ii)-based metal-organic...
In this work, the dispersive solid-phase extraction of sulfonamide antibiotics was evaluated using magnetic porous carbons derived from cobalt(ii)-based metal-organic frameworks. By direct carbonization under the inert atmosphere of Co-SIM-1, Co-MOF-74 and Co-DABCO MOFs, different magnetic porous carbons were prepared and characterized to study their structural, morphological, chemical and textural properties. Their performance for the simultaneous extraction of three sulfonamides (sulfadiazine, sulfamerazine and sulfamethazine), prior to HPLC analysis, was also evaluated, obtaining the best results (>95%) in the case of C/Co-SIM-1 carbon, probably due to its bimodal pore structure, high surface area and large amount of surface defects. Using this adsorbent, the effect of the solution pH and contact time on the adsorption of the sulfonamides, and the reusability of the carbon were studied.
PubMed: 32558858
DOI: 10.1039/d0dt01215g -
Journal of Hazardous Materials Jan 2022The preparation of hierarchical porous covalent organic frameworks (HP-COFs) is of great significance due to their inherent porosity and low density. However, it is...
The preparation of hierarchical porous covalent organic frameworks (HP-COFs) is of great significance due to their inherent porosity and low density. However, it is still very challenging owing to the poor machinability of COFs. Herein, a simple and cost-efficient strategy for the synthesis of HP-COFs was proposed. In particular, p-toluenesulfonic acid and NaCl, both of which can be recycled, are utilized as catalyst and template, respectively. The resulting HP-TpBD-900 featuring abundant macropore and mesopore as well as large specific surface area (~700 m g) possessed self-floating ability and was turned out to be a promising adsorbent for the efficient removal of sulfamerazine (SMR) in aqueous solution. The maximum adsorption capacity is 168 mg g, which is more than twice in comparison to that of material prepared without NaCl template. In addition, no significant decrease in adsorption capacity was observed after 5 cycles. Furthermore, the density functional theory (DFT) method was utilized to elucidate the adsorption mechanism, which could be dominated by hydrogen bonding and C-H···π interaction. This work not only provides a new strategy for the synthesis of HP-COFs, but also contributes to boosting the application of COFs in the field of wastewater treatment.
PubMed: 34325291
DOI: 10.1016/j.jhazmat.2021.126702 -
Pharmaceuticals (Basel, Switzerland) Nov 2022This study constructs a machine learning method to simultaneously analyze the thermodynamic behavior of many polymer-drug systems. The solubility temperature of...
This study constructs a machine learning method to simultaneously analyze the thermodynamic behavior of many polymer-drug systems. The solubility temperature of Acetaminophen, Celecoxib, Chloramphenicol, D-Mannitol, Felodipine, Ibuprofen, Ibuprofen Sodium, Indomethacin, Itraconazole, Naproxen, Nifedipine, Paracetamol, Sulfadiazine, Sulfadimidine, Sulfamerazine, and Sulfathiazole in 1,3-bis[2-pyrrolidone-1-yl] butane, Polyvinyl Acetate, Polyvinylpyrrolidone (PVP), PVP K12, PVP K15, PVP K17, PVP K25, PVP/VA, PVP/VA 335, PVP/VA 535, PVP/VA 635, PVP/VA 735, Soluplus analyzes from a modeling perspective. The least-squares support vector regression (LS-SVR) designs to approximate the solubility temperature of drugs in polymers from polymer and drug types and drug loading in polymers. The structure of this machine learning model is well-tuned by conducting trial and error on the kernel type (i.e., Gaussian, polynomial, and linear) and methods used for adjusting the LS-SVR coefficients (i.e., leave-one-out and 10-fold cross-validation scenarios). Results of the sensitivity analysis showed that the Gaussian kernel and 10-fold cross-validation is the best candidate for developing an LS-SVR for the given task. The built model yielded results consistent with 278 experimental samples reported in the literature. Indeed, the mean absolute relative deviation percent of 8.35 and 7.25 is achieved in the training and testing stages, respectively. The performance on the largest available dataset confirms its applicability. Such a reliable tool is essential for monitoring polymer-drug systems' stability and deliverability, especially for poorly soluble drugs in polymers, which can be further validated by adopting it to an actual implementation in the future.
PubMed: 36422535
DOI: 10.3390/ph15111405 -
Journal of Hazardous Materials Apr 2020Dissipation potential of four algae viz. Haematococcus pluvialis, Selenastrum capricornutum, Scenedesmus quadricauda and Chlorella vulgaris was investigated against ten...
Dissipation potential of four algae viz. Haematococcus pluvialis, Selenastrum capricornutum, Scenedesmus quadricauda and Chlorella vulgaris was investigated against ten antibiotics (sulfamerazine, sulfamethoxazole, sulfamonomethoxine, trimethoprim, clarithromycin, azithromycin, roxithromycin, lomefloxacin, levofloxacin and flumequine) in a series of synthetic wastewater batch culture experiments, maintained at 20, 50 and 100 μg L initial concentration levels and incubated over a period of 40 days. Generally, the antibiotic removal was achieved with overall dissipation percentage (%) varying among the algal species and different antibiotics. Biodegradation was the major antibiotic removal mechanism from the dissolved fraction, with minor contributions of bioadsorption, bioaccumulation, and abiotic factors. The antibiotics dissipation followed the pseudo-first-order-kinetics with the fastest antibiotic degradation rate achieved by H. pluvialis. The Monod kinetics was successfully applied to explain the relationship between the algal growth and the removal of antibiotics and nutrients in the batch cultures. S. capricornutum and C. vulgaris showed more affinity for the macrolides and fluoroquinolones than sulfonamides, while, H. pluvialis and S. quadiricauda showed relatively higher preference for sulfonamides than the other antibiotic groups. A total of 10 transformation products were identified and the transformation pathway was proposed, accordingly. Most of the transformation products had lower toxicity compared with their parent antibiotics.
Topics: Anti-Bacterial Agents; Biodegradation, Environmental; Chlorella vulgaris; Chlorophyceae; Kinetics; Microalgae; Risk Assessment; Scenedesmus; Wastewater
PubMed: 31911384
DOI: 10.1016/j.jhazmat.2019.121985 -
Analytical Chemistry Jul 2023It is an urgent need to develop simple and high-throughput methods for simultaneously screening and detecting multiple or groups of sulfonamides (SAs) in animal-derived...
Regulating the Growth Rate of Gold Nanobipyramids via a HCl-NADH-Ascorbic Acid System toward a Dual-Channel Multicolor Colorimetric Immunoassay for Simultaneously Screening and Detecting Multiple Sulfonamides.
It is an urgent need to develop simple and high-throughput methods for simultaneously screening and detecting multiple or groups of sulfonamides (SAs) in animal-derived foods since various SAs were alternately used in animal husbandry to avoid generating drug resistance. We herein developed a novel HCl-reduced nicotinamide adenine dinucleotide I (NADH)-ascorbic acid (AA)-mediated gold nanobipyramids (AuNBPs) growth system, which can precisely regulate the growth rate of AuNBPs, to generate two colorful and stable AA-corresponding multicolor signal channels with different sensitivities. Based on the HCl-NADH-AA-mediated AuNBP growth system, we further developed a dual-channel multicolor immunoassay for simultaneously realizing rapid screening and detection of 5 SAs (sulfamethazine, sulfamethoxydiazine, sulfisomidine, sulfamerazine, and sulfamonomethoxine) by using a paper-based analytical device for sensitively and stably reading out the signal and a broad-specificity anti-SAs antibody as a bio-receptor. The developed immunoassay has more color changes, a wider linear range, excellent specificity and stability, and two multicolor signal channels (L-channel and H-channel) with different sensitivities. The H-channel exhibited 7-8 SAs-corresponding color changes and can be used to detect 5 target SAs with a visual detection limit of 0.1-0.5 ng/mL and a spectrometry detection limit of 0.05-0.16 ng/mL. The L-channel exhibited 7-9 SAs-corresponding color changes and can be used to detect 5 target SAs with a visual detection limit of 2.0-6.0 ng/mL and a spectrometry detection limit of 0.40-1.47 ng/mL. The developed immunoassay was successfully used to simultaneously screen and detect low-concentration and high-concentration of target SAs in milk and fish muscle samples with a recovery of 85-110% and an RSD ( = 5) < 8%. The visual detection limit of our immunoassay is much lower than the maximum residue limit of total SAs in edible tissue. All above features make our immunoassay a promising assay for simultaneously realizing the rapid screening and quantitative determination of multiple SA residues in food by bare eye observation. It must be mentioned that our immunoassay may be expended as a general method for the simultaneous visual screening and detection of other drugs using the corresponding antibody as a recognition probe.
Topics: Animals; Sulfonamides; NAD; Gold; Colorimetry; Ascorbic Acid; Antibodies; Sulfanilamide; Immunoassay; Limit of Detection
PubMed: 37382204
DOI: 10.1021/acs.analchem.3c01928 -
Water Research Aug 2021Sulfonamide antibiotics (SAs) are typical antibiotics and have attracted increasing concerns about their wide occurrence in environment as well as potential risk for...
Sulfonamide antibiotics (SAs) are typical antibiotics and have attracted increasing concerns about their wide occurrence in environment as well as potential risk for human health. In this study, we applied a novel advanced oxidation process in SAs degradation by combining molybdenum sulfide and peracetic acid (MoS/PAA). Reactive oxygen species (ROS) including HO, CHC(O)O, CHC(O)OO, and O were generated from PAA by MoS activation and contributed to SAs degradation. The effects of initial pH, the dosages of PAA and MoS, and humic acid for SAs degradation were further evaluated by selecting sulfamethoxazole (SMX) as a target SA in the MoS/PAA process. Results suggested that the optimum pH for SMX removal was 3, where the degradation efficiency of SMX was higher than 80% after reaction for 15 min. Increasing PAA (0.075-0.45 mM) or MoS (0.1-0.4 g/L) dosages facilitated the SMX degradation, while the presence of humic acids retarded the SMX removal. This MoS/PAA process also showed good efficiencies in removing other SAs including sulfaguanidine, sulfamonomethoxine and sulfamerazine. Their possible degradation pathways were proposed based on the products identification and DFT calculation, showing that apart from the oxidation of amine groups to nitro groups in SAs, MoS/PAA induced SO extrusion reaction for SAs that contained six-membered heterocyclic moieties.
Topics: Anti-Bacterial Agents; Disulfides; Humans; Hydrogen Peroxide; Molybdenum; Oxidation-Reduction; Peracetic Acid; Sulfamethoxazole; Sulfonamides; Water Pollutants, Chemical
PubMed: 34107364
DOI: 10.1016/j.watres.2021.117291 -
Molecules (Basel, Switzerland) Feb 2023Developing a simple and efficient method for removing organic micropollutants from aqueous systems is crucial. The present study describes the preparation and...
Developing a simple and efficient method for removing organic micropollutants from aqueous systems is crucial. The present study describes the preparation and application, for the first time, of novel MXene-decorated bismuth ferrite nanocomposites (BiFeO/MXene) for the removal of six sulfonamides including sulfadiazine (SDZ), sulfathiazole (STZ), sulfamerazine (SMZ), sulfamethazine (SMTZ), sulfamethoxazole (SMXZ) and sulfisoxazole (SXZ). The properties of BiFeO/MXene are enhanced by the presence of BiFeO nanoparticles, which provide a large surface area to facilitate the removal of sulfonamides. More importantly, BiFeO/MXene composites demonstrated remarkable sulfonamide adsorption capabilities compared to pristine MXene, which is due to the synergistic effect between BiFeO and MXene. The kinetics and isotherm models of sulfonamide adsorption on BiFeO/MXene are consistent with a pseudo-second-order kinetics and Langmuir model. BiFeO/MXene had appreciable reusability after five adsorption-desorption cycles. Furthermore, BiFeO/MXene is stable and retains its original properties upon desorption. The present work provides an effective method for eliminating sulfonamides from water by exploiting the excellent texture properties of BiFeO/MXene.
Topics: Sulfonamides; Bismuth; Sulfanilamide; Water; Nanocomposites; Adsorption; Water Pollutants, Chemical; Kinetics
PubMed: 36838529
DOI: 10.3390/molecules28041541 -
Environmental Science and Pollution... Aug 2021As a class of synthetic sulfur drugs, sulfonamides (SAs) have been used to treat diseases and promote organism growth. Different concentrations of SAs have been detected...
As a class of synthetic sulfur drugs, sulfonamides (SAs) have been used to treat diseases and promote organism growth. Different concentrations of SAs have been detected in the water environment, which has threatened the ecological environment. In this study, the contamination of 9 SAs in water, sediments, and 8 fish species from the Hangbu-Fengle River, China, were analyzed using UPLC-MS/MS. The total SA concentrations in surface water, sediments, and fish were ND-5.064 ng/L, ND-5.052 ng/g dry weight (d.w.), and ND-1.42 ng/g wet weight (w.w.), respectively. The major compounds were sulfadiazine (SDZ), sulfamerazine (SMZ), and sulfamethoxazole (SMX) in water and fish. The SA levels of in fish from different habitat preferences revealed a spatial difference, with the order of demersal species > pelagic species. Moreover, the SA concentrations were affected by trophic guilds, indicating their decrease in the order of piscivorous fish > omnivorous fish > planktivorous fish > herbivorous fish. The obtained bioaccumulation factors showed that SMZ and SMX have strong bioenrichments in Ophiocephalus argus Cantor and Pelteobagrus fulvidraco. The risk assessment indicated that SAs did not pose significant health threats to the organisms. This research is the first report of SA contamination in the Hangbu-Fenle River, which can provide an important scientific basis for their pollution prevention and ecological risk assessment in the aquatic environment.
Topics: Animals; Anti-Bacterial Agents; Bioaccumulation; China; Chromatography, Liquid; Environmental Monitoring; Fishes; Rivers; Sulfonamides; Tandem Mass Spectrometry; Water Pollutants, Chemical
PubMed: 33842998
DOI: 10.1007/s11356-021-13850-5