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International Journal of Environmental... Oct 2022In the present study, PbO electrodes, doped with different doses of Er (0%, 0.5%, 1%, 2%, and 4%), were fabricated and characterized. Surface morphology characterization...
In the present study, PbO electrodes, doped with different doses of Er (0%, 0.5%, 1%, 2%, and 4%), were fabricated and characterized. Surface morphology characterization by SEM-EDS and XRD showed that Er was successfully doped into the PbO catalyst layer and the particle size of Er-PbO was reduced significantly. Electrochemical oxidation of sulfamerazine (SMR) in the Er-PbO anode system obeyed te pseudo first-order kinetic model with the order of 2% Er-PbO > 4% Er-PbO > 1% Er-PbO > 0.5% Er-PbO > 0% PbO. For 2% Er-PbO, was 1.39 h, which was only 0.93 h for 0% PbO. Effects of different operational parameters on SMR degradation in 2% Er-PbO anode system were investigated, including the initial pH of the electrolyte and current density. Under the situation of an initial pH of 3, a current density of 30 mA·cm, a concentration of SMR 30 mg L, and 0.2 M NaSO used as supporting electrolyte, SMR was totally removed in 3 h, and COD mineralization efficiency was achieved 71.3% after 6 h electrolysis. Furthermore, the degradation pathway of SMR was proposed as combining the active sites identification by density functional calculation (DFT) and intermediates detection by LC-MS. Results showed that Er-PbO has great potential for antibiotic wastewater treatment in practical applications.
Topics: Sulfonamides; Sulfamerazine; Water Pollutants, Chemical; Oxides; Electrodes; Sulfanilamide; Oxidation-Reduction; Anti-Bacterial Agents; Titanium
PubMed: 36294088
DOI: 10.3390/ijerph192013503 -
Molecules (Basel, Switzerland) Apr 2023A novel, molecularly imprinted, upconversion fluorescence probe (UCNP@MIFP) for sulfonamide sensing was fabricated by Pickering emulsion polymerization using UCNP@SiO...
A Novel Sulfonamide, Molecularly Imprinted, Upconversion Fluorescence Probe Prepared by Pickering Emulsion Polymerization and Its Adsorption and Optical Sensing Performance.
A novel, molecularly imprinted, upconversion fluorescence probe (UCNP@MIFP) for sulfonamide sensing was fabricated by Pickering emulsion polymerization using UCNP@SiO particles as the stabilizer and sulfamethazine/sulfamerazine as the co-templates. The synthesis conditions of the UCNP@MIFP were optimized, and the synthesized probe was characterized by scanning electron microscopy, Fourier transform infrared spectrometer, thermogravimetric analyzer, and fluorescence spectrometer. The UCNP@MIFPs showed a good adsorption capacity and a fast kinetic feature for the template. The selectivity experiment revealed that the UCNP@MIFP has a broad-spectrum molecular recognition capability. Good linear relationships were obtained over the concentration range of 1-10 ng/mL for sulfamerazine, sulfamethazine, sulfathiazole, and sulfafurazole, with low limits of detection in the range of 1.37-2.35 ng/mL. The prepared UCNP@MIFP has the potential to detect four sulfonamide residues in food and environmental water.
PubMed: 37110624
DOI: 10.3390/molecules28083391 -
Journal of Chemical Information and... Nov 2019Molecular fingerprints are an efficient and widely used method for similarity-driven virtual screening. Most fingerprint methods can be distinguished by the class of...
Molecular fingerprints are an efficient and widely used method for similarity-driven virtual screening. Most fingerprint methods can be distinguished by the class of structural features considered. The Connected Subgraph Fingerprint (CSFP) overcomes this limitation and regards all structural features of a compound. This results in a more complete feature space and high adaptive potential to certain application scenarios. The novel descriptor surpasses widely used fingerprint methods in some cases and opens the way for topological search in combinatorial fragment spaces.
Topics: Algorithms; Anti-Bacterial Agents; Computer Graphics; Drug Design; Models, Chemical; Molecular Structure; Pharmaceutical Preparations; Sulfamerazine; Sulfonamides
PubMed: 31652055
DOI: 10.1021/acs.jcim.9b00571 -
Chemosphere Jun 2023The removal of antibiotics in wastewater has attracted increasing attention. Herein, a superior photosensitized photocatalytic system was developed with acetophenone...
The removal of antibiotics in wastewater has attracted increasing attention. Herein, a superior photosensitized photocatalytic system was developed with acetophenone (ACP) as the guest photosensitizer, bismuth vanadate (BiVO) as the host catalyst and poly dimethyl diallyl ammonium chloride (PDDA) as the bridging complex, and used for the removal of sulfamerazine (SMR), sulfadiazine (SDZ) and sulfamethazine (SMZ) in water under simulated visible light (λ > 420 nm). The obtained ACP-PDDA-BiVO nanoplates attained a removal efficiency of 88.9%-98.2% for SMR, SDZ and SMZ after 60 min reaction and achieved kinetic rate constant approximately 10, 4.7 and 13 times of BiVO, PDDA-BiVO and ACP-BiVO, respectively, for SMZ degradation. In the guest-host photocatalytic system, ACP photosensitizer was found to have a great superiority in enhancing the light absorption, promoting the surface charge separation-transfer and efficient generation of holes (h) and superoxide radical (·O), greatly contributing to the photoactivity. The SMZ degradation pathways were proposed based on the identified degradation intermediates, involving three main pathways of rearrangement, desulfonation and oxidation. The toxicity of intermediates was evaluated and the results demonstrated that the overall toxicity was reduced compared with parent SMZ. This catalyst maintained 92% photocatalytic oxidation performance after five cyclic experiments and displayed a co-photodegradation ability to others antibiotics (e.g., roxithromycin, ciprofloxacin et al.) in effluent water. Therefore, this work provides a facile photosensitized strategy for developing guest-host photocatalysts, which enabling the simultaneous antibiotics removal and effectively reduce the ecological risks in wastewater.
Topics: Anti-Bacterial Agents; Photolysis; Photosensitizing Agents; Wastewater; Light; Bismuth; Vanadates; Sulfamethazine; Sulfadiazine; Sulfamerazine; Water; Catalysis
PubMed: 36905996
DOI: 10.1016/j.chemosphere.2023.138362 -
The Science of the Total Environment Feb 2021The in-situ advanced anaerobic digestion (AAD) enhanced with zero-valent iron powder (ZVI) under mesophilic condition was investigated to remove 5 antibiotics...
The in-situ advanced anaerobic digestion (AAD) enhanced with zero-valent iron powder (ZVI) under mesophilic condition was investigated to remove 5 antibiotics (sulfamerazine (SMR), sulfamethoxazole (SMZ), ofloxacin (OFL), tetracycline (TC), and roxithromycin (ROX)) and 11 antibiotic resistance genes (ARGs) (AAC (6')-IB-CR, qnrS, ermF, ermT, ermX, sul1, sul2, sul3, tetA, tetB, and tetG) in sewage sludge. The effects of different ZVI dosages, antibiotic concentrations, and solid retention time (SRTs) on the removal were explored. Also, the correlation coefficient of antibiotics and ARGs, microbial community structure, biogas production and methane yield were analyzed. All conducted treatments operated stably, and the modified Gompertz model described the cumulative methane yield well. The antibiotics, with the exception of OFL, were effectively removed in the sewage sludge at a dosage of 1000 mg/L ZVI, SRT 20 d, and an antibiotic concentration of 20 μg/L during AAD. The removal rates of SMZ, SMR, TC, and ROX reached 97.39%, 74.54%, 78.61%, and 56.58%, respectively. AAC (6')-IB-CR and tetB could be effectively reduced during the in-situ AAD. Through the redundancy analysis, AAC (6')-IB-CR, ermT, ermX, sul2, tetB, and tetG had strong positive correlations with the antibiotics in the reactor. The principle component analysis revealed that the community structure was similar when the SRT was 10 d and 20 d at the same amount of ZVI and antibiotic concentrations in the sludge. Under the operating parameters of 1000 mg/L ZVI dosage, SRT 20 d, and an antibiotic concentration of 20 μg/L, Erysipelotrichia, Verrucomicrobia, Clostridia, Caldiserica, and Alphaproteobacteria of the class were dominated microorganisms in the anaerobic digestion.
Topics: Anaerobiosis; Anti-Bacterial Agents; Drug Resistance, Microbial; Iron; Sewage
PubMed: 32911148
DOI: 10.1016/j.scitotenv.2020.142077 -
Environmental Science & Technology Sep 2023The spatiotemporal bioaccumulation, trophic transfer of antibiotics, and regulation of the phytoplankton biological pump were quantitatively evaluated in the Pearl...
The spatiotemporal bioaccumulation, trophic transfer of antibiotics, and regulation of the phytoplankton biological pump were quantitatively evaluated in the Pearl River, South China. The occurrence of antibiotics in organisms indicated a significant spatiotemporal trend associated with the life cycle of phytoplankton. Higher temporal bioaccumulation factors (BAFs) were found in phytoplankton at the bloom site, while lower BAFs of antibiotics in organisms could not be explained by phytoplankton biomass dilution but were attributed to the low bioavailability of antibiotics, which was highly associated with distribution coefficients ( = 0.480-0.595, < 0.05). Such lower BAFs of antibiotics in phytoplankton at higher biomass sites hampered the entry of antibiotics into food webs, and trophic dilutions were subsequently observed for antibiotics except for ciprofloxacin (CFX) and sulfamerazine (SMZ) at sites with blooms in all seasons. Distribution of CFX, norfloxacin (NFX), and sulfapyridine (SPD) showed further significant positive relationships with the plasma protein fraction ( = 0.275-0.216, < 0.05). Both mean BAFs and trophic magnification factors (TMFs) were significantly negatively correlated with phytoplankton biomass ( = 0.661-0.741, < 0.05). This study highlights the importance of the biological pump in the regulation of spatiotemporal variations in bioaccumulation and trophic transfer of antibiotics in anthropogenic-impacted eutrophic rivers in subtropical regions.
Topics: Anti-Bacterial Agents; Rivers; Bioaccumulation; Ciprofloxacin; Membrane Transport Proteins; Phytoplankton
PubMed: 37667590
DOI: 10.1021/acs.est.3c03478 -
Chemosphere Aug 2019To develop an efficient and reusable heterogeneous Fenton-like catalyst is a great challenge for its application in practical water treatment. Effective oxygen vacancy...
To develop an efficient and reusable heterogeneous Fenton-like catalyst is a great challenge for its application in practical water treatment. Effective oxygen vacancy (OVs)-promoted FeO-CeO catalyst was prepared by a sol-gel method, and applied in the heterogeneous Fenton-like reaction of the sulfamerazine (SMR) degradation. The FeO-CeO catalyst showed good activity and stability, and total SMR conversion was achieved in the Fenton-like reaction after 75 min at pH 3.0 and 45 °C under O atmosphere. Moreover, the SMR removal was significantly enhanced under O atmosphere. The surface-bounded OH radicals played a dominant role for the SMR degradation. The FeO-CeO catalyst remarkably promoted the generation of OH in the Fenton-like reaction under O atmosphere, mostly because abundant OVs on the catalyst surface not only accelerated electron transfer to promote the HO decomposition, but also oxygen molecules, adsorbed on OVs, formed O/HO and promoted the Fe/Fe redox cycle.
Topics: Atmosphere; Ferric Compounds; Oxygen; Sulfamerazine
PubMed: 31051355
DOI: 10.1016/j.chemosphere.2019.04.125 -
Analytical Chemistry Jun 2021In recent years, ensuring the rational use and effective control of antibiotics has been a major focus in the eco-environment, which requires an effective monitoring...
Improving SERS Sensitivity toward Trace Sulfonamides: The Key Role of Trade-Off Interfacial Interactions among the Target Molecules, Anions, and Cations on the SERS Active Surface.
In recent years, ensuring the rational use and effective control of antibiotics has been a major focus in the eco-environment, which requires an effective monitoring method. However, on-site rapid detection of antibiotics in water environments remains a challenging issue. In this study, surface-enhanced Raman spectroscopy (SERS) was used to systematically achieve selective, rapid, and highly sensitive detection of sulfonamides, based on their fingerprint characteristics. The results show that the trade-off between the competitive and coadsorption behaviors of target molecules and agglomerates (inorganic salts) on the surface of the SERS substrate determines whether the molecules can be detected with high sensitivity. Based on this, the qualitative differentiation and quantitative detection of three structurally similar antibiotics, sulfadiazine, sulfamerazine, and sulfamethazine, were achieved, with the lowest detectable concentration being 1 μg/L for sulfadiazine and 50 μg/L for sulfamerazine and sulfamethazine.
Topics: Anions; Cations; Sulfadiazine; Sulfanilamide; Sulfonamides
PubMed: 34115465
DOI: 10.1021/acs.analchem.1c01530 -
Journal of Chromatography. B,... Aug 2021A composite adsorbent composed of metallic copper (Cu), polypyrrole (PPy), halloysite nanotubes (HNTs) and magnetite nanoparticles (FeO) was developed to extract and...
A composite adsorbent composed of metallic copper (Cu), polypyrrole (PPy), halloysite nanotubes (HNTs) and magnetite nanoparticles (FeO) was developed to extract and enrich sulfonamides by dispersive magnetic solid phase extraction. The composite could adsorb sulfonamides via hydrogen bonding and hydrophobic, π-π and π-electron-metal interactions. The extraction conditions were optimized and the developed composite adsorbent was characterized and provided a large surface area that enhanced extraction efficiency for sulfonamides. Coupled with high performance liquid chromatography, the adsorbent was used to quantitatively determine sulfonamides found in milk samples. The response of the developed method exhibited linearity from 5.0 to 150.0 μg kg for sulfathiazole, and from 2.5 to 100.0 μg kg for sulfamerazine, sulfamonomethoxine and sulfadimethoxine. Limits of detection were between 2.5 and 5.0 μg kg. Recoveries of sulfonamides in milk samples ranged from 83.0 to 99.2% with RSDs lower than 6%. The developed composite adsorbent showed good reproducibility and reusability.
Topics: Animals; Chromatography, High Pressure Liquid; Clay; Copper; Drug Residues; Limit of Detection; Linear Models; Magnetite Nanoparticles; Milk; Nanocomposites; Polymers; Pyrroles; Reproducibility of Results; Sulfonamides
PubMed: 34418797
DOI: 10.1016/j.jchromb.2021.122900 -
Journal of Hazardous Materials Sep 2020In this study, a novel Al°-CNTs-CuO composite, capable of activating O to generate HO and further to reactive oxygen species (ROSs) at a wide pH range, was synthetized,...
In this study, a novel Al°-CNTs-CuO composite, capable of activating O to generate HO and further to reactive oxygen species (ROSs) at a wide pH range, was synthetized, characterized and applied for the degradation of sulfamerazine. In the activation of O by Al°-CNTs-CuO composite, HO was generated from the reaction of O with Al°-CNTs, which could be catalytically decomposed into O and OH by CuO, the formed Cu(II) could be rapidly reduced to CuO by Al°-CNTs in composite, which made Al°-CNTs-CuO composite reusable and decreased the leaching of copper ions into solution. The removal efficiency of SMR and TOC was 73.91 % and 56.80 %, respectively at initial pH = 5.8, T = 20 °C, O flow rate = 100 mL/min, Al°-CNTs-CuO dosage = 2 g/L, SMR = 50 mg/L, and reaction time = 60 min. The removal efficiency of SMR kept almost unchanged and the concentration of copper ions in solution was below 0.5 mg/L. The Al°-CNTs-CuO/O process could be used as a novel catalyst for the degradation of refractory organic contaminants in water and wastewater by Fenton-like process at a wide pH range through the in situ generation of HO.
Topics: Anti-Bacterial Agents; Catalysis; Hydrogen Peroxide; Hydrogen-Ion Concentration; Sulfamerazine
PubMed: 32353730
DOI: 10.1016/j.jhazmat.2020.122751