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International Endodontic Journal Nov 2021Cemental tears are an important condition of relevance to Endodontics but are often overlooked. A cemental tear is the partial or complete detachment of the cementum... (Review)
Review
Cemental tears are an important condition of relevance to Endodontics but are often overlooked. A cemental tear is the partial or complete detachment of the cementum from the cemento-dentinal junction or along the incremental line within the body of cementum. The limited attention received is most likely due to the limited awareness amongst dental professionals and challenges in accurately diagnosing them, resulting in misdiagnosis and erroneous treatment. The aim of this review is to describe the: (i) epidemiology and predisposing factors; (ii) clinical, radiographic and histological features and (iii) the clinical management and treatment outcomes of cemental tear. The review included 37 articles published in English that comprised eight observational studies and 29 case reports. The prevalence of cemental tears was reported to be lower than 2%; whilst the incidence remains unknown. Internal factors due to the inherent structural weakness of cementum and its interface with the dentine, and external factors that are associated with stress have been proposed as the two mechanisms responsible for the development and propagation of cemental tears. Predisposing factors that have been implicated were tooth type, gender, age, previous root canal treatment, history of dental trauma, occlusal trauma and excessive occlusal force; however, evidence is limited. Common clinical and radiographic manifestations of cemental tears resemble the presentations of primary endodontic diseases, primary periodontal diseases and combined endodontic-periodontal lesions. Clinical management tended to focus on complete removal of the torn fragments and periodontal treatment, often combined with regenerative treatment. In this article, a new classification for cemental tears is developed that consists of classes 0 to 6 and stages A, B, C and D based on the: (i) location and accessibility of the torn cemental fragment; (ii) the pattern and extension of the associated bony defect in relation to the root length and (iii) the number of root surface/s affected by the cemental tear/s and the associated bony defect. Recommendations for treatment strategies are also provided and linked to the classification to aid in streamlining the process of treatment decision making.
Topics: Dental Cementum; Endodontics; Humans; Root Canal Therapy; Tooth Fractures; Tooth Injuries
PubMed: 34403513
DOI: 10.1111/iej.13611 -
Current Opinion in Allergy and Clinical... Oct 2022Immunobiologicals have surfaced to become a new cornerstone of treatment for a wide spectrum of inflammatory disorders with an immune basis. The targets have ranged from... (Review)
Review
PURPOSE OF REVIEW
Immunobiologicals have surfaced to become a new cornerstone of treatment for a wide spectrum of inflammatory disorders with an immune basis. The targets have ranged from autoimmune conditions to transplantation, and now more into atopic inflammatory disorders with primary targets of asthma and atopic dermatitis.
RECENT FINDINGS
The clinical information garnered from these studies have provided an initial snapshot on the potential adverse effects of the immunobiologicals on the ocular surface as well as providing a potential opening of their use in the treatment of various chronic ocular surface and intraocular inflammatory disorders that have previously been relegated to limited therapeutic options primarily to the broad anti-inflammatory use of glucocorticosteroids.
SUMMARY
The use of immunobiologicals provides a more directed therapeutic approach to many of the ocular inflammatory disorders, as we continue to appreciate more of their underlying immunopathophysiology of ocular surface disorder,s including ocular allergy and tear film dysfunction.
Topics: Dermatitis, Atopic; Eye; Eye Diseases; Humans; Hypersensitivity
PubMed: 36094133
DOI: 10.1097/ACI.0000000000000845 -
Clinical & Experimental Optometry Jan 2020Ophthalmic lens design concerns the control of spectacle lens aberrations which occur when the eye rotates away from the optical centre of the lens. The most significant... (Review)
Review
Ophthalmic lens design concerns the control of spectacle lens aberrations which occur when the eye rotates away from the optical centre of the lens. The most significant aberrations are oblique astigmatism and mean oblique error (power error). A brief review of these aberrations is given, explaining how the lens designer can control them using just the bending of the lens, and what results can be achieved using simple spherical and toroidal surfaces. Before 1985, aspherical surfaces were used only for post-cataract spectacle lenses and high-power magnifiers. Today, aspherical surfaces are used by all major lens manufacturers to produce thinner, lighter and more attractive best-form lenses in the normal power range. Aspherical surfaces are employed because the surface itself is astigmatic and the surface astigmatism is used to combat aberrational astigmatism due to oblique incidence. The various types of aspherical surface and how the surface astigmatism arises is described, before considering how this feature is used to produce flatter, thinner lenses. In the case of astigmatic prescriptions, the surface requires different asphericities along its principal meridians and the geometry of these atoroidal surfaces is also described. The advent of free-form manufacturing techniques requires the lens designer to convert the surface description to the (x,y,z) co-ordinates needed to generate the surface. Examples of how these co-ordinates can be obtained from the equation to the surface are given for toroidal and aspherical surfaces. In the case of free-form progressive surfaces, the pre-determined z-co-ordinates must be added to the z-co-ordinates of the prescription surface to obtain the final free-form surface. In the case of optimised prescription surfaces, on-board software will analyse the result by ray tracing to obtain the final z-co-ordinates.
Topics: Equipment Design; Eyeglasses; Humans; Optics and Photonics; Refraction, Ocular; Visual Acuity
PubMed: 31222837
DOI: 10.1111/cxo.12930 -
Advances in Colloid and Interface... Oct 2022The need for improved anti-icing surfaces is the demand of the time and closely related to many important aspects of our lives as surface icing threatens not only... (Review)
Review
The need for improved anti-icing surfaces is the demand of the time and closely related to many important aspects of our lives as surface icing threatens not only industrial production but also human safety. Freezing on a cold surface is usually a heterogeneous nucleation process induced by the substrate. Creating an anti-icing surface is mainly achieved by changing surface morphology and chemistry to regulate the interaction between the surface and the water/ice to inhibit freezing on the surface. In this paper, recent research progress in the creation of biomimetic anti-icing surfaces is reviewed. Firstly, basic strategies of bionic anti-icing are introduced, and then bionic anti-icing surface strategies are reviewed according to four aspects: the process of ice formation, including condensate self-removing, inhibiting ice nucleation, reducing ice adhesion, and melting accumulated ice on the surface. The remaining challenges and the direction of future development of biomimetic anti-icing surfaces are also discussed.
Topics: Biomimetics; Freezing; Humans; Ice; Surface Properties
PubMed: 36007284
DOI: 10.1016/j.cis.2022.102756 -
Science China. Technological Sciences 2022Antibacterial surfaces are surfaces that can resist bacteria, relying on the nature of the material itself. It is significant for safe food and water, human health, and... (Review)
Review
Antibacterial surfaces are surfaces that can resist bacteria, relying on the nature of the material itself. It is significant for safe food and water, human health, and industrial equipment. Biofilm is the main form of bacterial contamination on the material surface. Preventing the formation of biofilm is an efficient way to develop antibacterial surfaces. The strategy for constructing the antibacterial surface is divided into bacteria repelling and bacteria killing based on the formation of the biofilm. Material surface wettability, adhesion, and steric hindrance determine bacteria repelling performance. Bacteria should be killed by surface chemistry or physical structures when they are attached to a material surface irreversibly. Killing approaches are usually in the light of the cell membrane of bacteria. This review summarizes the fabrication methods and applications of antibacterial surfaces from the view of the treatment of the material surfaces. We also present several crucial points for developing long-term stability, no drug resistance, broad-spectrum, and even programable antibacterial surfaces.
PubMed: 35018171
DOI: 10.1007/s11431-021-1962-x -
Sensors (Basel, Switzerland) Mar 2020Designing and development of electrochemical biosensors enable molecule sensing and quantification of biochemical compositions with multitudinous benefits such as... (Review)
Review
Designing and development of electrochemical biosensors enable molecule sensing and quantification of biochemical compositions with multitudinous benefits such as monitoring, detection, and feedback for medical and biotechnological applications. Integrating bioinspired materials and electrochemical techniques promote specific, rapid, sensitive, and inexpensive biosensing platforms for (e.g., point-of-care testing). The selection of biomaterials to decorate a biosensor surface is a critical issue as it strongly affects selectivity and sensitivity. In this context, smart biomaterials with the intrinsic self-assemble capability like bacterial surface (S-) layer proteins are of paramount importance. Indeed, by forming a crystalline two-dimensional protein lattice on many sensors surfaces and interfaces, the S-layer lattice constitutes an immobilization matrix for small biomolecules and lipid membranes and a patterning structure with unsurpassed spatial distribution for sensing elements and bioreceptors. This review aims to highlight on exploiting S-layer proteins in biosensor technology for various applications ranging from detection of metal ions over small organic compounds to cells. Furthermore, enzymes immobilized on the S-layer proteins allow specific detection of several vital biomolecules. The special features of the S-layer protein lattice as part of the sensor architecture enhances surface functionalization and thus may feature an innovative class of electrochemical biosensors.
Topics: Biosensing Techniques; Electrochemical Techniques; Humans; Ions; Membrane Glycoproteins; Metals; Point-of-Care Testing
PubMed: 32204503
DOI: 10.3390/s20061721 -
Asia-Pacific Journal of Ophthalmology... Dec 2020The ocular surface is exposed continuously to the environment and, as a consequence, to a variety of different microbes. After the results of the Human Microbiome... (Review)
Review
The ocular surface is exposed continuously to the environment and, as a consequence, to a variety of different microbes. After the results of the Human Microbiome Project became publicly available, international research groups started to focus interest on exploring the ocular surface microbiome and its physiopathological relationship to the eye. For example, numerous research studies the existence of the ocular surface's bacterial flora, typically gathering cultures from healthy patients and finding few variations in the bacterial species. More recently, culture-independent methods, including 16S ribosomal ribonucleic acid (rRNA) gene sequencing, are being used to define the ocular microbiome. These newer methods suggest that the microbial communities have a greater diversity than previously reported. These communities seem to serve an immune-modulating function and maintain relationships with other microbes and organs, even distant ones. This review summarizes the literature exploring the ocular microbiome, both in health and in different diseases.
Topics: Bacteria; Eye; Humans; Microbiota; RNA, Ribosomal, 16S
PubMed: 33323705
DOI: 10.1097/APO.0000000000000330 -
Journal of Functional Biomaterials Dec 2023Biomimetic dental implants are regarded as one of the recent clinical advancements in implant surface modification. Coatings with varying thicknesses and roughness may... (Review)
Review
Biomimetic dental implants are regarded as one of the recent clinical advancements in implant surface modification. Coatings with varying thicknesses and roughness may affect the dental implant surface's chemical inertness, cell adhesion, and antibacterial characteristics. Different surface coatings and mechanical surface changes have been studied to improve osseointegration and decrease peri-implantitis. The surface medication increases surface energy, leading to enhanced cell proliferation and growth factors, and, consequently, to a rise in the osseointegration process. This review provides a comprehensive update on the numerous biomimetic coatings used to improve the surface characteristics of dental implants and their applications in two main categories: coating to improve osseointegration, including the hydroxyapatite layer and nanocomposites, growth factors (BMPs, PDGF, FGF), and extracellular matrix (collagen, elastin, fibronectin, chondroitin sulfate, hyaluronan, and other proteoglycans), and coatings for anti-bacterial performance, covering drug-coated dental implants (antibiotic, statin, and bisphosphonate), antimicrobial peptide coating (GL13K and human beta defensins), polysaccharide antibacterial coatings (natural chitosan and its coupling agents) and metal elements (silver, zinc, and copper).
PubMed: 38248682
DOI: 10.3390/jfb15010015