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Systematic Reviews Mar 2023Comfort is a primary patient objective and central to patient experience, and thus, maximising comfort is a universal goal for healthcare. However, comfort is a complex...
BACKGROUND
Comfort is a primary patient objective and central to patient experience, and thus, maximising comfort is a universal goal for healthcare. However, comfort is a complex concept that is difficult to operationalise and evaluate, resulting in a lack of scientific and standardised comfort care practices. The Comfort Theory developed by Kolcaba has been the most widely known for its systematisation and projection and most of the global publications regarding comfort care were based on this theory. To develop international guidance on theory-informed comfort care, a better understanding about the evidence on the effects of interventions guided by the Comfort Theory is needed.
OBJECTIVES
To map and present the available evidence on the effects of interventions underpinned by Kolcaba's Comfort theory in healthcare settings.
METHODS
The mapping review will follow Campbell Evidence and Gap Maps guideline and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews Protocols guidelines. An intervention-outcome framework has been developed based on Comfort Theory and the classification of pharmacological and non-pharmacological interventions via consultation with stakeholders. Eleven electronic databases (MEDLINE, CINAHL, PsycINFO, Embase, AMED, Cochrane Library, JBI Library of Systematic Reviews, Web of Science, Scopus, CNKI and Wan Fang) and grey literature sources (Google Scholar, Baidu Scholar and The Comfort Line) will be searched for primary studies and systematic reviews between 1991 and 2023 written in English and Chinese as the papers regarding Comfort Theory were first published in 1991. Additional studies will be identified by reference list review of included studies. Key authors will be contacted for unpublished or ongoing studies. Two independent reviewers will screen and extract data using piloted forms with discrepancies resolved by discussion with a third reviewer. A matrix map with filters of study characteristics will be generated and presented through software of EPPI-Mapper and NVivo.
DISCUSSION
More informed use of theory can strengthen improvement programmes and facilitate the evaluation of their effectiveness. Findings from the evidence and gap map will present the existing evidence base for researchers, practitioners and policy-makers and inform further research as well as clinical practices aiming at patients' comfort enhancement.
Topics: Adult; Humans; Databases, Factual; Treatment Outcome; Quality Assurance, Health Care
PubMed: 36879339
DOI: 10.1186/s13643-023-02202-8 -
F1000Research 2024The vocational guidance process in educational institutions faces important challenges in managing trials and errors in diagnoses. Technological tools are identified as...
BACKGROUND
The vocational guidance process in educational institutions faces important challenges in managing trials and errors in diagnoses. Technological tools are identified as an effective solution to address these problems. This research seeks to improve career guidance in educational institutions through the implementation of an expert system. The main objective is to reduce test processing time and achieve greater efficiency in students' self-knowledge regarding their interests, based on the personalities of the Holland Test.
METHODS
The development of the expert system followed a six-model approach. First, an organisational model was created to assess the scope and feasibility of the project. Next, a task and agent model was developed to investigate the impact and look for improvements. A knowledge model was then developed to analyse the relevant knowledge bases. A communication model was also developed to evaluate the communication interface of the system. Next, a design model was created to provide guidelines for the implementation of the system. Finally, the implementation of the knowledge system was carried out to ensure its correct functioning.
RESULTS
The implementation of the expert system has shown significant improvements in the vocational guidance process. It was possible to reduce the time needed to apply the test, thus optimising the psychologist's time and allowing a greater capacity for analysis. In addition, an improvement in the effectiveness of the students' self-knowledge in relation to their vocational interests based on the personalities of the Holland Test was observed.
CONCLUSIONS
This study contributes to career guidance in educational institutions by introducing an innovative expert system. This technological solution optimizes the career guidance process, benefiting psychologists administering tests and students seeking self-knowledge about their career interests.
Topics: Humans; Students; Vocational Guidance; Awareness
PubMed: 38904071
DOI: 10.12688/f1000research.145109.1 -
European Journal of Medicinal Chemistry Nov 2023The tyrosinase enzyme, which is widely found in microorganisms, animals and plants, has a significant position in melanogenesis, plays an important role in undesirable... (Review)
Review
The tyrosinase enzyme, which is widely found in microorganisms, animals and plants, has a significant position in melanogenesis, plays an important role in undesirable browning of fruits and vegetables, antibiotic resistance, skin pigment formation, sclerotization of cuticle, neurodegeneration, etc. Therefore, with the wide potential application fields of tyrosinase in food, agriculture, cosmetics and pharmaceutical industries, which has become the target enzyme for the development of therapeutic agents such as antibrowning, anticancer, antibacterial, skin whitening, insecticides, etc., a large number of synthetic tyrosinase inhibitors have been widely reported in recent years. The triazole ring, which has a broad spectrum of biological action, is of increasing interest in the synthesis of new tyrosinase inhibitors. In this review, tyrosinase inhibition effects, structure-activity relationships, enzyme inhibition kinetics and mechanisms of action of 1,2,3- or 1,2,4-triazole derivatives were investigated. The data gathered is anticipated to supply rational guidance and an influential strategy for the development of novel, potent and safe tyrosinase inhibitors for better practical application in the future.
Topics: Animals; Enzyme Inhibitors; Monophenol Monooxygenase; Plants; Structure-Activity Relationship; Triazoles
PubMed: 37482020
DOI: 10.1016/j.ejmech.2023.115655 -
International Journal of Environmental... Apr 2022The authors reviewed the research literature evaluating the effectiveness of vocational counseling interventions focused on employment for consumers with substance use... (Review)
Review
The authors reviewed the research literature evaluating the effectiveness of vocational counseling interventions focused on employment for consumers with substance use disorders. This review included 11 articles related to vocational counseling interventions, which are either incorporated with substance use treatment or not. The results of this review revealed that vocational counseling services have been highly efficacious in resulting in part-time and full-time jobs. The study designs had some limitations, and few studies employed randomized control trials (RCT).
Topics: Adult; Counseling; Employment; Humans; Rehabilitation, Vocational; Substance-Related Disorders; Vocational Guidance
PubMed: 35457542
DOI: 10.3390/ijerph19084674 -
Journal of Physiology and Pharmacology... Aug 2023Parkinson's disease (PD) often presents with autonomic dysregulation, leading to blood pressure irregularities such as neurogenic orthostatic hypotension (nOH),... (Review)
Review
Parkinson's disease (PD) often presents with autonomic dysregulation, leading to blood pressure irregularities such as neurogenic orthostatic hypotension (nOH), neurogenic supine hypertension (nSH), and postprandial hypotension (PPH). Unfortunately, these conditions remain prevalent and receive insufficient attention in scientific discourse. They not only cause complications like syncope, falls, and fractures but also result in long-term damage to vital organs, diminishing patients' quality of life. Early implementation of appropriate non-pharmacologic management is crucial to prevent severe adverse events later on. This review focuses on the types, clinical characteristics, mechanisms, and common non-pharmacologic management measures for PD complicated by abnormal blood pressure. By promoting early diagnosis, recognizing symptoms of abnormal blood pressure, and employing non-pharmacologic interventions such as health education, dietary adjustments, exercise, and Chinese medicine techniques, we aim to improve patients' symptoms and quality of life while providing practical guidance for managing PD-related blood pressure abnormalities.
Topics: Humans; Parkinson Disease; Blood Pressure; Quality of Life; Hypotension, Orthostatic; Hypertension
PubMed: 37865954
DOI: 10.26402/jpp.2023.4.01 -
Current Opinion in Pediatrics Jun 2020The steady rise in number of youth diagnosed with autism spectrum disorder (ASD) has led to the need to examine transition of care considerations specific to ASD.... (Review)
Review
PURPOSE OF REVIEW
The steady rise in number of youth diagnosed with autism spectrum disorder (ASD) has led to the need to examine transition of care considerations specific to ASD. Improved understanding and guidance addressing these needs will allow pediatric and adult providers to work together to optimize social, medical, and occupational outcomes for these patients.
RECENT FINDINGS
Health-care transition is a delicate time when children with ASD outgrow the services of pediatric programs and enter a fragmented healthcare system that is unfamiliar, insufficiently knowledgeable, and underfunded for their needs.
SUMMARY
Increasing autism prevalence and an aging population with autism lend urgency to improve outcomes in children transitioning to adult-care. Research reveals poor consequences in social support, education, vocational training and employment, housing, and healthcare. Specific considerations to address these issues and ensure successful transition from pediatric to adult care are needed.
Topics: Adolescent; Adult; Aged; Autism Spectrum Disorder; Autistic Disorder; Child; Continuity of Patient Care; Delivery of Health Care; Humans; Transition to Adult Care
PubMed: 32068594
DOI: 10.1097/MOP.0000000000000882 -
Human Vaccines & Immunotherapeutics Dec 2023Since March 2020, the pandemic caused by SARS-CoV-2 has affected nearly all aspects of daily life. In this study, we investigated the age-stratified prevalence and...
Since March 2020, the pandemic caused by SARS-CoV-2 has affected nearly all aspects of daily life. In this study, we investigated the age-stratified prevalence and genotype distribution of human papillomavirus (HPV) among females in Shandong province (eastern China) and aimed to provide guidance on HPV-based cervical cancer screening and vaccination. The distribution of HPV genotypes was analyzed using PCR-Reverse Dot Hybridization. The overall infection rate of HPV was 16.4%, which was dominated by high-risk genotypes. The most prevalent genotype was HPV16 (2.9%), followed by HPV52 (2.3%), HPV53 (1.8%), HPV58 (1.5%), and HPV51 (1.3%). Among the positive cases with HPV infection, single-genotype infection was significantly higher than that of multi-genotype infection. In subgroup analyses by age (≤25, 26-35, 36-45, 46-55, >55), HPV16, 52, and 53 were consistently the three most common hrHPV genotypes in all age groups. The infection rate of multi-genotypes in the ≤25 and >55 age groups was significantly higher than that in other age groups. A bimodal distribution of HPV infection rate was observed in different age groups. Among lrHPV genotypes, HPV6, HPV11, and HPV81 were the three most common types in the ≤25 age group, while in other age groups, HPV81, HPV42, and HPV43 are the three most common lrHPV genotypes. This study provides basic information on the distribution and genotypes of HPV in the female population in eastern China, which could improve the application of HPV diagnostic probes and vaccines.
Topics: Humans; Female; Uterine Cervical Neoplasms; Papillomavirus Infections; Human Papillomavirus Viruses; Pandemics; Prevalence; Early Detection of Cancer; COVID-19; SARS-CoV-2; Genotype; Papillomaviridae; Human papillomavirus 16; China
PubMed: 37226673
DOI: 10.1080/21645515.2023.2212571 -
American Journal of Cancer Research 2023This study aimed to summarize the current developments and hub genes in the ferroptosis field using bibliometrics and bioinformatics and provide guidance for future...
This study aimed to summarize the current developments and hub genes in the ferroptosis field using bibliometrics and bioinformatics and provide guidance for future developments. The publications on ferroptosis from 2012 to 2021 were extracted from the Web of Science database. VOSviewer software and CiteSpace software were used to visualize and predict the trend of ferroptosis research. The key genes related to ferroptosis were selected from the Web of Genecards, and Kyoto Encyclopedia of Genes and Genomes (KEGG)/Gene Ontology (GO) analysis was performed. Cytoscape software and online survival curve analysis platform were also used to screen hub genes and analyze their roles. Chinese researchers published the highest number of publications in this field, while American publications exhibited higher quality. In terms of institutions, Central South University and Zhejiang University have the highest number of publications. published more studies than other journals. The application of ferroptosis is a major research area, and, importantly, "RCD", "FTH1", and "nomogram" are the keywords. We also found tumor-related pathways of interest in the field of ferroptosis. genes were of significance for the prognosis of tumors. The number of publications on ferroptosis may increase in the future. Cooperation among countries and disciplines is particularly important in this regard. Also, the applications of ferroptosis, especially in chemotherapy and immunotherapy for tumors, will be the focus of future research. Keywords "RCD", "FTH1", and "nomogram" is receiving high attention, and in-depth studies on tumor-related genes , , and may provide new therapeutic targets.
PubMed: 38187041
DOI: No ID Found -
Vocations and Learning 2024Initial vocational training (VT) in high school consists of short-term programs leading to employment in a skilled trade. To better align training with employment...
Initial vocational training (VT) in high school consists of short-term programs leading to employment in a skilled trade. To better align training with employment opportunities and to encourage students to stay in the programs until they graduate, most programs include traineeship. Since traineeships involve acquiring skills directly on the job, they require greater involvement of supervisors to guide the trainees. Given the importance of on-the-job guidance in achieving traineeship objectives, this study examines the potential influence of three dimensions of guidance provided by traineeship supervisors -planning, support, and training- on students' job perception (i.e., occupational image) and traineeship satisfaction. Overall, the results provide mixed results, partially supporting the mediation hypothesis suggested by the results of previous studies. Indeed, the results reveal that the quality of the training offered by the supervisor affects subsequent students' satisfaction with traineeship experience. Training has an indirect effect on satisfaction via the occupational image held by students. However, the expected indirect links between the other two dimensions of supervisor guidance -degree of planning and support perceived by the student- and the students' image of their chosen occupation could not be confirmed. The results support the importance of providing quality on-the-job training to students during their studies.
PubMed: 38799206
DOI: 10.1007/s12186-023-09341-y -
Tidsskrift For Den Norske Laegeforening... Sep 2019
Topics: Humans; Occupational Diseases; Sick Leave; Vocational Guidance
PubMed: 31556517
DOI: 10.4045/tidsskr.19.0428