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Medicina Oral, Patologia Oral Y Cirugia... May 2023Adverse reactions, caused during the inflammation and healing process, or even later, can be induced by the injection of dermal filler and can present a variety of...
BACKGROUND
Adverse reactions, caused during the inflammation and healing process, or even later, can be induced by the injection of dermal filler and can present a variety of clinical and histological characteristics. In this study we aimed to review the adverse reactions associated with the injection of aesthetic filling materials in the face and neck.
MATERIAL AND METHODS
The review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Studies published that mentioned adverse reactions in patients with aesthetic filling materials in the face or neck were included. Risk of bias was assessed using the Joanna Briggs Institute appraisal tool. After a 2-step selection process, 74 studies were included: 51 case reports, 18 serial cases, and five cohorts.
RESULTS
A total of 303 patients from 20 countries were assessed. Lesions were more prevalent in the lip (18%), nasolabial folds (13%), cheeks (13%), chin (10%), submental (8%), glabella (7%), and forehead (6%). Histopathological analysis revealed a foreign body granuloma in 87.1% of the patients, 3% inflammatory granuloma, 3% lipogranuloma, 2.3% xanthelasma-like reaction, 1% fibrotic reaction, 0.7% amorphous tissues, 0.7% xanthelasma, 0.3% sclerosing lipogranuloma, 0.3% siliconoma, and 0.3% foreign body granuloma with scleromyxedema. In addition, two patients displayed keratoacanthoma and two others displayed sarcoidosis after cutaneous filling. The most commonly used materials were silicone fillers (19.7%), hyaluronic acid (15.5%), and hydroxyethyl methacrylate/ethyl methacrylate suspended in hyaluronic acid acrylic hydrogel (5.6%). All patients were treated, and only 12 had prolonged complications.
CONCLUSIONS
There is evidence that adverse reaction can be caused by different fillers in specific sites on the face. Although foreign body granuloma was the most common, other adverse lesions were diagnosed, exacerbating systemic diseases. In this way, we reinforce the importance of previous systemic evaluations and histopathological analyses for the correct diagnosis of lesions.
Topics: Humans; Granuloma, Foreign-Body; Cosmetic Techniques; Hyaluronic Acid; Esthetics, Dental; Polymethyl Methacrylate
PubMed: 36565218
DOI: 10.4317/medoral.25713 -
Journal of International Society of... 2022The aim of this article is to review the factors that attract to denture base resin (DBR) and to verify the influence of different surface treatments, chemical... (Review)
Review
OBJECTIVES
The aim of this article is to review the factors that attract to denture base resin (DBR) and to verify the influence of different surface treatments, chemical modification, or structural reinforcements on the properties of DBR.
MATERIALS AND METHODS
Searches were carried out in PubMed, Scopus, WOS, Google Scholar, EMBASE, and J-stage databases. The search included articles between 1999 and 2020. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The keywords used during the search were "," "Denture base," "PMMA," "Acrylic resin," "Surface properties," "hydrophobicity/hydrophilicity," "contact angle," and "surface free energy." English full-text articles involving studies with different acrylic resin modifications were included, whereas abstracts, dissertations, reviews, and articles in languages other than English were excluded. A meta-analysis was performed where appropriate.
RESULTS
Out of the 287 articles, 21 articles conformed to inclusion criteria. Sixteen articles were subjected to meta-analysis using random-effects model at 95% confidence interval. Results showed that DBR coatings/plasma coatings were effective methods to modify surface properties with estimated contact angle (CA) of 59.37° [95% confidence interval (CI): 53.69, 65.04]/55.87° (95% CI: 50.68, 61.06) and surface roughness ( ) of 0.55 µm (95% CI: 0.52, 0.58)/0.549 µm (95% CI: 0.5, 0.59), respectively. Antifungal particle incorporation into poly(methylmethacrylate) DBR also produced similar effects with an estimated of 0.16 µm (95% CI: 0.134, 0.187).
CONCLUSION
The three properties responsible for adhesion to DBR were , CA, and surface free energy in terms of hydrophobicity. Therefore, the correlations between the hydrophobicity of DBR and adhesion should be considered during future investigations for -related denture stomatitis.
PubMed: 35462737
DOI: 10.4103/jispcd.JISPCD_213_21 -
Arthroplasty (London, England) Feb 2021Methyl methacrylate (MMA) is commonly used in the fields of dentistry and orthopaedic surgery. However, there remain concerns for the occupational hazards of MMA,... (Review)
Review
INTRODUCTION
Methyl methacrylate (MMA) is commonly used in the fields of dentistry and orthopaedic surgery. However, there remain concerns for the occupational hazards of MMA, particularly during pregnancy and breastfeeding.
METHODS
We performed a systematic review of studies on effects that MMA may have in pregnancy in the context of exposure during orthopaedic surgery and dentistry. Review articles, studies lacking statistical data, single case reports and other evidence level V studies were excluded.
RESULTS
Nine studies were included. One basic science study demonstrated an increase in neuronal cell lysis and shrunken cell bodies when neocortical neurons were exposed to MMA monomer. Three animal studies exposed pregnant rodents to MMA via intraperitoneal injection or inhalation. Exposed fetuses in two studies had an increase in gross abnormalities such as hemangiomas, while there was no increase in teratologic effects in the third study. In dental workers exposed to MMA, two retrospective cohort studies did not find a statistically significant increase in birth defects or miscarriage. After exposure to MMA during total joint arthroplasty, two studies found that MMA levels were undetectable in the mothers' serum or breast milk. One study measuring the airborne levels of MMA during simulated joint arthroplasty found that concentrations never exceeded 1% of the recommended limit set forth by the Occupational Safety and Health Administration (OSHA).
CONCLUSIONS
Potential teratologic effects of MMA cannot be excluded by existing evidence. However, the typical MMA exposure levels for dental and orthopaedic personnel appear to be substantially less than currently proposed exposure limits.
PubMed: 35236460
DOI: 10.1186/s42836-020-00059-z -
The Japanese Dental Science Review Dec 2023The use of graphecs excellent mechanical properties. However, it is necessary to evaluate the biological effects of this material. This systematic review aimed to... (Review)
Review
The use of graphecs excellent mechanical properties. However, it is necessary to evaluate the biological effects of this material. This systematic review aimed to observe and understand through studies the current state of the art regarding osseointegration, antimicrobial capacity, and the cytotoxicity of graphene coating applied to the surface of dental implant materials. Searches in PubMed, Embase, Science Direct, Web of Science, and Google Scholar databases were conducted between June and July 2021 and updated in May 2022 using the keywords: graphene, graphene oxide, dental implants, zirconium, titanium, peek, aluminum, disilicate, methyl-methacrylate, cytotoxicity, osseointegration, and bone regeneration. The criteria included in vivo and in vitro studies that evaluated antimicrobial capacity and/or osseointegration and/or cytotoxicity of dental implant materials coated with graphene compounds. The risk of bias for in vitro studies was assessed by the JBI tool, and for in vivo studies, Syrcle's risk of bias tool for animal studies was used. The database search resulted in 176 articles. Of the 18 articles selected for full reading, 16 remained in this systematic review. The use of graphene compounds as coatings on the surface of implant materials is promising because it promotes osseointegration and has antimicrobial capacity. However, further studies are needed to ensure its cytotoxic potential.
PubMed: 37680613
DOI: 10.1016/j.jdsr.2023.08.005 -
International Journal of Molecular... May 2022Amidst growing technological advancements, newer denture base materials and polymerization methods have been introduced. During fabrication, certain mechanical... (Review)
Review
Amidst growing technological advancements, newer denture base materials and polymerization methods have been introduced. During fabrication, certain mechanical properties are vital for the clinical longevity of the denture base. This systematic review aimed to explore the effect of newer denture base materials and/or polymerization methods on the mechanical properties of the denture base. An electronic database search of English peer-reviewed published papers was conducted using related keywords from 1 January 2011, up until 31 December 2021. This systematic review was based on guidelines proposed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The search identified 579 papers. However, the inclusion criteria recognized 22 papers for eligibility. The risk of bias was moderate in all studies except in two where it was observed as low. Heat cure polymethyl methacrylate (PMMA) and compression moulding using a water bath is still a widely used base material and polymerization technique, respectively. However, chemically modified PMMA using monomers, oligomers, copolymers and cross-linking agents may have a promising result. Although chemically modified PMMA resin might enhance the mechanical properties of denture base material, no clear inferences can be drawn about the superiority of any polymerization method other than the conventional compression moulding technique.
Topics: Denture Bases; Materials Testing; Polymerization; Polymers; Polymethyl Methacrylate
PubMed: 35628546
DOI: 10.3390/ijms23105737 -
International Journal of Nanomedicine 2023The main objective of this systematic review was to evaluate the effect of coating with titanium dioxide nanoparticles (TiO nanoparticle) on the surface condition of... (Review)
Review
BACKGROUND
The main objective of this systematic review was to evaluate the effect of coating with titanium dioxide nanoparticles (TiO nanoparticle) on the surface condition of removable acrylic resin prosthetic base materials.
METHODS
Our review is registered in the PROSPERO database under the identification code CRD42023397170. Electronic database searches of PubMed, Scopus and Science Direct including studies from January 2009 to January 2023 were conducted and supplemented with manual searches. Research questions were generated in accordance with the PICO strategy. The modified Consolidated Standards of Reporting Trials (CONSORT) checklist was used to evaluate the quality of the selected studies.
RESULTS
Since the included studies were variable in design, a meta-analysis was not performed. The electronic searches retrieved 29 references that met the eligibility criteria, among which 5 studies matched the inclusion criteria for this review. Significant differences were detected between the TiO NP-coated and uncoated groups. The available data indicate that TiO NP coating elicits antimicrobial activity and improves the wear resistance of polymethylmethacrylate (PMMA) surfaces. Moreover, the nanoparticles provide high levels of glossiness and decelerate the process of color change of heat-cured acrylic resin, thus increasing the lifespan of dentures.
CONCLUSION
The collective results clearly indicate that TiO nanoparticle coating induces alterations in the surface properties of pure PMMA, enhancing the mechanical, physical and biological characteristics of the denture base material. Further studies are essential to identify the optimal thickness of coating and concentrations of nanoparticles for clinical applications.
Topics: Polymethyl Methacrylate; Denture Bases; Surface Properties; Acrylic Resins; Titanium; Materials Testing
PubMed: 38026530
DOI: 10.2147/IJN.S425702 -
Dental and Medical Problems 2020At present, new acrylic plastic technologies are being developed in dentistry. Although this kind of material has been used for dental prostheses for over 80 years, it... (Review)
Review
At present, new acrylic plastic technologies are being developed in dentistry. Although this kind of material has been used for dental prostheses for over 80 years, it has been produced in the form of disks with the computer-aided design/computer-aided manufacturing (CAD/CAM) technology for over 15 years. The purpose of the article was to collect information from the literature on acrylic materials processed through the milling technology (CAD/CAM). The publicly available databases PubMed, Google Scholar and Scopus were searched using the key word "acrylic resins, CAD/CAM". All articles describing the application and testing of CAD/CAM disks were selected. Duplicate articles were removed. More than 100 articles that described the use of materials machined using the milling equipment were found. These included works comparing the mechanical properties, biocompatibility and clinical use of the materials. After the initial selection, 36 papers on this subject were included in this review. The number of studies on the processing of acrylic materials with the use of the CAD/CAM technology has been increasing worldwide. Since such materials have better mechanical properties, no polymerization shrinkage occurs during processing, the amount of residual monomer material is very low and they have better color stability than self-curing materials.
Topics: Acrylic Resins; Computer-Aided Design; Dental Materials; Humans; Materials Testing; Polymethyl Methacrylate
PubMed: 33444491
DOI: 10.17219/dmp/124697 -
European Journal of Trauma and... Dec 2022High clinical success rates have been reported with the Masquelet technique in the treatment of traumatic bone loss. An increasing number of studies suggest that various... (Review)
Review
PURPOSE
High clinical success rates have been reported with the Masquelet technique in the treatment of traumatic bone loss. An increasing number of studies suggest that various factors can influence the properties of induced membranes. Goal of this systematic review is to answer the following questions: (1) which are the ideal spacer properties (material, surface topography, antibiotic supplementation) to booster the quality and osteogenic potential of induced membranes? (2) what is the ideal time to perform the second-stage operation?
METHODS
A systematic search using the keywords "((Masquelet) OR (Induced Periosteum)) AND ((Spacer) OR (Time))" was performed in PubMed, Embase and Cochrane Library according to PRISMA guidelines. Studies published up to the 23rd of February 2022 were included and assessed independently by two reviewers.
RESULTS
Thirteen animal and 1 clinical studies were identified to address the above questions. Spacer materials used were PMMA, silicone, titanium, polypropylene, PVA, PCL and calcium sulfate. With the exception of PVA sponges, all solid materials could induce membranes. Low union rates have been reported with titanium and rough surfaced spacers. Scraping of the inner surface of the IM also increased bony union rates. In terms of the ideal timing to perform the second-stage evidence suggests that membranes older than 8 weeks continue to have regenerative capacities similar to younger ones.
CONCLUSION
Membranes induced by smooth PMMA spacers loaded with low concentrations of antibiotics showed powerful osteogenic properties. Other materials such as Polypropylene or Calcium sulfate can also be used with good results. Despite current recommendation to perform the second stage operation in 4-8 weeks, membranes older than 8 weeks seem to have similar regenerative capacities to younger ones.
Topics: Animals; Polymethyl Methacrylate; Titanium; Calcium Sulfate; Polypropylenes
PubMed: 35726029
DOI: 10.1007/s00068-022-02005-x -
F1000Research 2023Polymethyl Methacrylate (PMMA) denture-base resins have poor surface properties that facilitates microbial adhesion causing denture stomatitis. This systematic review...
Effect of addition of titanium dioxide nanoparticles on the antimicrobial properties, surface roughness and surface hardness of polymethyl methacrylate: A Systematic Review.
Polymethyl Methacrylate (PMMA) denture-base resins have poor surface properties that facilitates microbial adhesion causing denture stomatitis. This systematic review aims to evaluate the effect of different sizes and percentages of titanium dioxide nanoparticles (TiO2NP) on the antimicrobial property, surface roughness and surface hardness of PMMA denture base resin. A systematic search of English peer-reviewed articles, clinical trial registries, grey literature databases and other online sources was performed using the PRISMA-S Guidelines for and studies. Qualitative data synthesis was performed to analyse sample dimensions, acrylic used, treatments of nanoparticles, methods used for testing and effect of size and percentage of nanoparticle. Risk of bias assessment was done using modified Cochrane risk of bias tool. Out of 1376 articles, 15 were included. TiO NP of size less than 30 nm was most frequently used. Both antimicrobial property and surface hardness improved irrespective of the size of the added TiO NP. Three studies reported increase in the surface roughness with less than 50 nm TiO NP. 3% TiO NP was most frequently used. On increasing the percentage, three studies reported an increase in antimicrobial property, while two studies found no change. With TiO NP greater than or equal to 3%, six studies reported an increase in surface hardness, while two reported increase in surface roughness. Large methodological variations were observed across studies. All studies except one were of moderate quality. On addition of TiO NP to heat polymerized PMMA, the antimicrobial property and surface hardness improved irrespective of the size of the TiO NP, however, addition of nanoparticles less than 50 nm increased the surface roughness. Increasing the percentage of TiO NP increased the surface hardness but did not always increase the antimicrobial property. Addition of 3% TiO NP provided optimum results with regards to antimicrobial effect and surface hardness, but increase in the surface roughness.
Topics: Hardness; Polymethyl Methacrylate; Materials Testing; Denture Bases; Surface Properties; Nanoparticles; Anti-Infective Agents
PubMed: 37424742
DOI: 10.12688/f1000research.130028.1 -
Injury Nov 2022The treatment of infected non-unions of the femur and the tibia remains difficult and requires control of the infection and successful bone healing. Antimicrobial...
The treatment of infected non-unions of the femur and the tibia remains difficult and requires control of the infection and successful bone healing. Antimicrobial coating of intramedullary nails promises both infection control and stabilization for subsequent bone healing. Both results for custom-made and commercially available antimicrobial coating for intramedullary nails have been published in the past mainly consisting of retrospective case series. The purpose of this work is to review the published literature on techniques and clinical outcome of antimicrobial coatings for intramedullary nails for the treatment of infected long bone non-unions. A systematic literature research in Medline, PubMed, Embase and Cochrane Library was performed in accordance to the PRISMA guidelines. Articles reporting on antimicrobial-coated intramedullary nails for the treatment of infected long bone non-unions were eligible for inclusion. In total, 22 publications were found reporting on 506 infected non-unions of the tibia and femur treated with an antimicrobial-coated nail. Most of them consisted of retrospective case series (72.7%). 469 and 37 patients were treated with an individual antibiotic-loaded PMMA-coating and commercially available gentamicin-coating for intramedullary nails, respectively. The overall infection eradication rate was 90.0% (range 68.7-100%) and the bone consolidation rate was 85.5% (range 57.9-100%). Coating specific side effects were not reported. In conclusion, the treatment of infected long bone non-unions with antimicrobial-coated nails is associated with a high infection control and bone consolidation rate and seems to be a reasonable treatment options with minimal side effects. However, scientific quality of the publications is low and randomized controlled trials are needed.
Topics: Anti-Bacterial Agents; Bone Nails; Fracture Fixation, Intramedullary; Fracture Healing; Gentamicins; Humans; Polymethyl Methacrylate; Retrospective Studies; Treatment Outcome
PubMed: 35613970
DOI: 10.1016/j.injury.2022.05.008