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Annals of Internal Medicine Feb 2023Chagas disease, which is caused by infection with the parasite , is a leading neglected tropical disease in the United States. An estimated 240 000 to 350 000 persons... (Review)
Review
Chagas disease, which is caused by infection with the parasite , is a leading neglected tropical disease in the United States. An estimated 240 000 to 350 000 persons in the United States are infected, primarily immigrants from Mexico, Central America, and South America, where the disease is endemic. The parasite is transmitted by the triatomine bug but can also be passed through blood transfusion, via organ transplant, or congenitally. Approximately 30% of infected persons later develop cardiac and/or gastrointestinal complications. Health care providers should consider screening at-risk patients with serologic testing. Early diagnosis and treatment with benznidazole or nifurtimox can help prevent complications.
Topics: Humans; United States; Chagas Disease; Trypanosoma cruzi; Nifurtimox; Emigrants and Immigrants; Organ Transplantation
PubMed: 36780647
DOI: 10.7326/AITC202302210 -
Biochimica Et Biophysica Acta.... May 2020This review is a perspective on the history of Chagas disease, and it adopts a novel approach from literary studies, historical documents and the science and... (Review)
Review
This review is a perspective on the history of Chagas disease, and it adopts a novel approach from literary studies, historical documents and the science and epidemiology of the nature of the disease. From this analysis, comes the review's working definition of the Contact Zone (CZ): "the space in which geographically and historically separated people come into contact with each other and establish long-lasting relationships, which usually involve coercive conditions, radical inequality and intolerable conflict." In the Patient-Physician CZ, we verified the triple transition phenomena: the American trypanosomiasis shifted from a rural, acute, and vectorial transmitted disease to an urban, chronic and non-vectorial disease. In the Academic CZ, we describe the original disagreements which denied the existence of the disease and the current controversies about pathogenic mechanisms and etiological treatment. From the News from Latin America, and in the Original CZ, we will review the evolution of different forms of transmission. As in any good story, research across broad disciplines is necessary to reveal historical perspectives, scientific approaches, and the epidemiology of the disease, which has a prequel of 9000 years and an open ending: thus, we explore across the Global CZ, with its multiple and unexpected actors.
Topics: Animals; Body Remains; Chagas Disease; DNA, Protozoan; Disease Eradication; Disease Vectors; Endemic Diseases; Forensic Anthropology; Global Burden of Disease; History, 19th Century; History, 20th Century; History, 21st Century; History, Ancient; Humans; Neglected Diseases; Triatoma; Trypanosoma cruzi
PubMed: 32001300
DOI: 10.1016/j.bbadis.2020.165689 -
Clinical Microbiology Reviews Dec 2019is the etiological agent of Chagas disease, usually transmitted by triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal cardiac... (Review)
Review
is the etiological agent of Chagas disease, usually transmitted by triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal cardiac or gastrointestinal disease. Sylvatic transmission cycles exist in the southern United States, involving 11 triatomine vector species and infected mammals such as rodents, opossums, and dogs. Nevertheless, imported chronic infections in migrants from Latin America vastly outnumber locally acquired human cases. Benznidazole is now FDA approved, and clinical and public health efforts are under way by researchers and health departments in a number of states. Making progress will require efforts to improve awareness among providers and patients, data on diagnostic test performance and expanded availability of confirmatory testing, and evidence-based strategies to improve access to appropriate management of Chagas disease in the United States.
Topics: Chagas Disease; Disease Management; Disease Susceptibility; Humans; Molecular Diagnostic Techniques; Molecular Epidemiology; Phenotype; Public Health Surveillance; Trypanosoma cruzi; United States
PubMed: 31776135
DOI: 10.1128/CMR.00023-19 -
The American Journal of the Medical... Nov 2022Chagas disease, caused by infection with the protozoan Trypanosoma cruzi, is one of the leading public health problems in the Western Hemisphere. The parasite is mainly... (Review)
Review
Chagas disease, caused by infection with the protozoan Trypanosoma cruzi, is one of the leading public health problems in the Western Hemisphere. The parasite is mainly transmitted by contact with infected insect vectors but other forms of transmission are important in endemic areas. In the United States, while the disease is largely restricted to immigrants from endemic countries in Latin America, there is some risk of local acquisition. T. cruzi circulates in a sylvatic cycle between mammals and local triatomine insects in the southern half of the country, where human residents may be at risk for incidental infection. There are several reported cases of locally-acquired Chagas disease in the United States, but there is a paucity of information in Oklahoma. We present a brief summary of the available data of Chagas disease in Oklahoma to raise awareness and serve as a foundation for future research.
Topics: Humans; Animals; United States; Oklahoma; Chagas Disease; Trypanosoma cruzi; Insect Vectors; Mammals
PubMed: 35623395
DOI: 10.1016/j.amjms.2022.03.018 -
Biochimica Et Biophysica Acta.... Dec 2020
Topics: Chagas Disease; Humans; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi
PubMed: 32927344
DOI: 10.1016/j.bbadis.2020.165953 -
Pediatrics in Review Apr 2023
Topics: Humans; Chagas Disease; Infectious Disease Transmission, Vertical
PubMed: 37002357
DOI: 10.1542/pir.2022-005857 -
Arquivos Brasileiros de Cardiologia Jun 2023
Topics: Humans; Chagas Disease; Cardiomyopathies; Chagas Cardiomyopathy
PubMed: 37377258
DOI: 10.36660/abc.20230269 -
Frontiers in Cellular and Infection... 2023
Topics: Humans; Chagas Disease; Trypanosoma cruzi
PubMed: 37197201
DOI: 10.3389/fcimb.2023.1209531 -
Infectious Diseases of Poverty Apr 2020Chagas disease remains a serious problem for public health due to the high disease burden together with its global spreading patterns. However, current treatment and...
Chagas disease remains a serious problem for public health due to the high disease burden together with its global spreading patterns. However, current treatment and vector control are highly challenged by drug and insecticide resistance. Chemotherapy and vector control have been proved to be effective attempts to minimize the disease burden. Continued efforts are necessary to keep adapting the surveillance-response systems to the dynamic health systems. More attention and investments are needed to improve appropriate strategy and technology in different settings. This may be accomplished by creating effective risk early warning, addressing vulnerability and building resilience systems, implementing a vector surveillance system, as well as innovating research and technology.
Topics: Animals; Chagas Disease; Disease Vectors; Global Health; Humans
PubMed: 32336294
DOI: 10.1186/s40249-020-00658-7 -
Arquivos Brasileiros de Cardiologia Jul 2022
Topics: Chagas Cardiomyopathy; Chagas Disease; Heart; Heart Diseases; Humans
PubMed: 35830097
DOI: 10.36660/abc.20220418