-
Sensors (Basel, Switzerland) Jul 2022Sensors are devices that output signals for sensing physical phenomena and are widely used in all aspects of our social production activities. The continuous recording... (Review)
Review
Sensors are devices that output signals for sensing physical phenomena and are widely used in all aspects of our social production activities. The continuous recording of physical parameters allows effective analysis of the operational status of the monitored system and prediction of unknown risks. Thanks to the development of deep learning, the ability to analyze temporal signals collected by sensors has been greatly improved. However, models trained in the source domain do not perform well in the target domain due to the presence of domain gaps. In recent years, many researchers have used deep unsupervised domain adaptation techniques to address the domain gap between signals collected by sensors in different scenarios, , using labeled data in the source domain and unlabeled data in the target domain to improve the performance of models in the target domain. This survey first summarizes the background of recent research on unsupervised domain adaptation with time series sensor data, the types of sensors used, the domain gap between the source and target domains, and commonly used datasets. Then, the paper classifies and compares different unsupervised domain adaptation methods according to the way of adaptation and summarizes different adaptation settings based on the number of source and target domains. Finally, this survey discusses the challenges of the current research and provides an outlook on future work. This survey systematically reviews and summarizes recent research on unsupervised domain adaptation for time series sensor data to provide the reader with a systematic understanding of the field.
Topics: Acclimatization; Neural Networks, Computer; Time Factors
PubMed: 35898010
DOI: 10.3390/s22155507 -
PloS One 2023Two well-established numerical representations of the coagulation cascade either initiated by the intrinsic system (Chatterjee et al., PLOS Computational Biology 2010)...
Two well-established numerical representations of the coagulation cascade either initiated by the intrinsic system (Chatterjee et al., PLOS Computational Biology 2010) or the extrinsic system (Butenas et al., Journal of Biological Chemistry, 2004) were compared with thrombin generation assays under realistic pathological conditions. Biochemical modifications such as the omission of reactions not relevant to the case studied, the modification of reactions related to factor XI activation and auto-activation, the adaptation of initial conditions to the thrombin assay system, and the adjustment of some of the model parameters were necessary to align in vitro and in silico data. The modified models are able to reproduce thrombin generation for a range of factor XII, XI, and VIII deficiencies, with the coagulation cascade initiated either extrinsically or intrinsically. The results emphasize that when existing models are extrapolated to experimental parameters for which they have not been calibrated, careful adjustments are required.
Topics: Thrombin; Acclimatization; Biological Assay; Blood Coagulation; Computational Biology
PubMed: 37639392
DOI: 10.1371/journal.pone.0290531 -
Journal of Neurophysiology Mar 2022Saccade adaptation is the gradual adjustment of saccade end point to maintain spatial accuracy. Contextual adaptation refers to a situation in which the...
Saccade adaptation is the gradual adjustment of saccade end point to maintain spatial accuracy. Contextual adaptation refers to a situation in which the adaptation-related change in saccade end point is contingent on the behavioral context in which the saccade is made. For example, in some situations, the same saccade to the same retinotopic location can be simultaneously adapted in opposite directions depending on the context in which it is made. Saccade adaptation has traditionally been studied in isolated movements, but in everyday life, saccades are often planned and executed in sequences. The oculomotor system may therefore have adaptive mechanisms specific to sequential saccades. Here, in five experiments, we investigated contextual saccade adaptation in sequences of saccades. In the first experiment, we demonstrate that saccades to a given retinotopic location can be simultaneously adapted in opposite directions depending on whether they occur in isolation or in a sequence. In the other experiments, we measured the extent to which properties of the previous and following saccades in a sequence can induce contextual saccade adaptation. Overall, we find that the existence, direction, and amplitude of previous and subsequent saccades, as well as the order of the current saccade within a movement sequence, can all induce contextual adaptation. These novel findings demonstrate the surprising flexibility of the system in maintaining end point accuracy, and support the idea that saccades made in a movement sequence are planned concurrently rather than independently. This study reveals a new type of contextual saccade adaptation: sequential saccades are able to induce contextual saccade adaptation when direction, amplitude, or the existence of preceding and following saccades are used as contexts. These novel findings are also consistent with the idea that saccades made in a sequence are planned concurrently rather than independently.
Topics: Acclimatization; Adaptation, Physiological; Photic Stimulation; Saccades
PubMed: 35171695
DOI: 10.1152/jn.00221.2021 -
Experimental Physiology May 2022What is the central question of this study? What are the profiles of acute physiological and psychophysical strain during and in recovery from different modes of...
NEW FINDINGS
What is the central question of this study? What are the profiles of acute physiological and psychophysical strain during and in recovery from different modes of heating, and to what extent do these diminish after repeated exposure? What is the main finding and its importance? Mode of heating affects the strain profiles during heat stress and recovery. Exercise in the heat incurred the greatest cardiovascular strain during heating and recovery. Humid heat was poorly tolerated despite heat strain being no greater than in other heating modes, and tolerance did not improve with multiple exposures.
ABSTRACT
Heat stress is common and arises endogenously and exogenously. It can be acutely hazardous while also increasingly advocated to drive health and performance-related adaptations. Yet, the nature of strain (deviation in regulated variables) imposed by different heating modes is not well established, despite the potential for important differences. We, therefore, compared three modes of heat stress for thermal, cardiovascular and perceptual strain profiles during exposure and recovery when experienced as a novel stimulus and an accustomed stimulus. In a crossover design, 13 physically active participants (five females) underwent 5 days of 60-min exposures to hot water immersion (40°C), sauna (55°C, 54% relative humidity) and exercise in the heat (40°C, 52% relative humidity), and a thermoneutral water immersion control (36.5°C), each separated by ≥4 weeks. Physiological (thermal, cardiovascular, haemodynamic) and psychophysical strain responses were assessed on days 1 and 5. Sauna evoked the warmest skin (40°C; P < 0.001) but exercise in the heat caused the largest increase in core temperature, sweat rate, heart rate (post hoc comparisons all P < 0.001) and systolic blood pressure (P ≤ 0.002), and possibly decrease in diastolic blood pressures (P ≤ 0.130), regardless of day. Thermal sensation and feeling state were more favourable on day 5 than on day 1 (P ≤ 0.021), with all modes of heat being equivalently uncomfortable (P ≥ 0.215). Plasma volume expanded the largest extent during immersions (P < 0.001). The current data highlight that exercising in the heat generates a more complex strain profile, while passive heat stress in humid heat has lower tolerance and more cardiovascular strain than hot water immersion.
Topics: Acclimatization; Body Temperature; Body Temperature Regulation; Cross-Over Studies; Female; Heart Rate; Heat Stress Disorders; Heat-Shock Response; Hot Temperature; Humans; Male; Water
PubMed: 35193165
DOI: 10.1113/EP089992 -
Scientific Reports Sep 2023High altitude acclimatization and disease have been the centerpiece of investigations concerning human health at high altitude. Almost all investigations have focused on...
High altitude acclimatization and disease have been the centerpiece of investigations concerning human health at high altitude. Almost all investigations have focused on either understanding and ameliorating high altitude disease or finding better methods of acclimatization/training at high altitude. The aspect of altitude de-induction/de-acclimatization has remained clouded despite the fact that it was documented since the first decade of twentieth century. A few recent studies, particularly in China, have stated unanimously that high altitude de-acclimatization involved multiple observable clinical symptoms ranging from headache to abdominal distention. These symptoms have been collectively referred to as "high altitude de-acclimatization syndrome" (HADAS). However, computational omics and network biology centric investigations concerning HADAS are nascent. In this study, we focus on the quantitative proteo-informatics, especially network biology, of human plasma proteome in individuals who successfully descended from high altitude areas after a stay of 120 days. In brief, the protein list was uploaded into STRING and IPA to compute z-score based cut-offs which were used to analyze the directionality and significance of various identified protein networks as well as the proteins within them. Relevant upstream regulators extracted using computational strategies were also validated. Time-points till the 180th day of de-induction have been investigated to comparatively assess the changes in the plasma proteome and protein pathways of such individuals since the 7th day of arrival at altitude. Our investigation revealed extensive effects of de-induction on lipid metabolism, inflammation and innate immune system as well as coagulation system. This novel study provides a conceptual framework for formulating therapeutic strategies to ease the symptoms of HADAS during de-acclimatization. Such strategies should focus on normalization of lipid metabolism, inflammatory signaling and coagulation systems.
Topics: Humans; Altitude; Proteome; Acclimatization; Blood Coagulation; China
PubMed: 37679378
DOI: 10.1038/s41598-023-40576-w -
International Journal of Molecular... Sep 2021Drought has become a major threat to food security, because it affects crop growth and development. Drought tolerance is an important quantitative trait, which is... (Review)
Review
Drought has become a major threat to food security, because it affects crop growth and development. Drought tolerance is an important quantitative trait, which is regulated by hundreds of genes in crop plants. In recent decades, scientists have made considerable progress to uncover the genetic and molecular mechanisms of drought tolerance, especially in model plants. This review summarizes the evaluation criteria for drought tolerance, methods for gene mining, characterization of genes related to drought tolerance, and explores the approaches to enhance crop drought tolerance. Collectively, this review illustrates the application prospect of these genes in improving the drought tolerance breeding of crop plants.
Topics: Acclimatization; Crops, Agricultural; Droughts; Genes, Plant; Phenotype; Plant Breeding; Plants, Genetically Modified; Quantitative Trait Loci
PubMed: 34638606
DOI: 10.3390/ijms221910265 -
Journal of Human Evolution Aug 2022Marine Isotope Stages (MIS) 13-11 saw a major transformation in the hominin occupation of Europe, with an expansion in the scale and geographical distribution of sites...
Marine Isotope Stages (MIS) 13-11 saw a major transformation in the hominin occupation of Europe, with an expansion in the scale and geographical distribution of sites and artifact assemblages. That expansion is explored here in the context of paleoenvironmental variability, focusing on geographical and chronological trends in climatic and habitat conditions at and between key Lower Paleolithic sites in Western Europe. Climatic conditions at British sites are compared across MIS 13-11, and used to test predicted values from the Oscillayers data set. Conditions at hominin and nonhominin sites are compared to explore possible limitations in hominin tolerances during MIS 13-11. Trends in conditions are explored with reference to long-term global patterns, short-term substage events, and seasonal variations. The apparent increase in the scale of hominin activity in north-western Europe during MIS 13 is surprising in light of the relatively harsh conditions of late MIS 13, and is likely to reflect significant physiological and/or behavioral adaptations, a mild south-north temperature gradient in western Europe during MIS 13, and the relatively mild, sustained conditions spanning MIS 15-13. The expanded occupation of north-western Europe during MIS 11 probably reflects the extended mild conditions of MIS 11c, since marked seasonal temperature differences and substantial behavioral changes between hominin sites in MIS 13 and 11 are not clearly evident. Site-specific conditions in south-western Europe during MIS 11 suggest milder winters, warmer summers, and reduced seasonal variability compared to north-western Europe. Some or all of these conditions may have supported larger, core populations, as may the relatively mild conditions associated with south-western European sites during MIS 12. Finally, comparisons between north-western and north-central European sites indicate relatively small differences in seasonal temperatures, suggesting that climate may only be a partial factor behind the smaller-scale occupations of north-central Europe during MIS 13-11.
Topics: Acclimatization; Animals; Europe; Hominidae; Isotopes
PubMed: 35704957
DOI: 10.1016/j.jhevol.2022.103213 -
Cell Stress & Chaperones Jan 2020Heat acclimation (HA) in humans promotes thermoregulatory adaptations that support management of core temperature in hot environments and reduces the likelihood of heat... (Meta-Analysis)
Meta-Analysis Review
Heat acclimation (HA) in humans promotes thermoregulatory adaptations that support management of core temperature in hot environments and reduces the likelihood of heat related illness. Another adaptation to HA is thermotolerance through induction of the heat shock protein (HSP) stress system, which provides protection against thermal insult. However, whether or not HA leads to upregulation of the intracellular HSP system, namely intracellular HSP70 (HSP70), is unclear in humans. Therefore, the purposes of this meta-analysis were to determine if HA leads to HSP70 induction among humans and to evaluate how methodological differences among HA studies influence findings regarding HA-induced HSP70 accumulation. Several databases were searched to identify studies that measured HSP70 (protein and mRNA) changes in response to HA among humans. The effect of HA on HSP70 was analyzed. Differences in the effect of HA were assessed between protein and mRNA. The moderating effect of several independent variables (HA frequency, HA duration, core temperature, exercise intensity) on HSP70 was also evaluated. Data were extracted from 12 studies including 118 participants (mean age 24 years, 98% male). There was a significant effect of HA on HSP70 expression, g = 0.97 (95% CI, 0.08-1.89). The effect of HA was different between subgroups (protein vs. mRNA), g = 1.51 (95% CI, 0.71-2.31), and g = - 0.39 (95% CI, - 1.36), respectively. The frequency of HA (in days) moderated HSP70 protein expression. There was a significant effect of heat acclimation on HSP70 induction in humans. The only factor among identified studies that may moderate this response was the frequency (number of days) of heat exposure.
Topics: Acclimatization; Animals; Body Temperature Regulation; Exercise; HSP70 Heat-Shock Proteins; Hot Temperature; Humans; Thermotolerance
PubMed: 31823288
DOI: 10.1007/s12192-019-01059-y -
Anais Da Academia Brasileira de Ciencias 2022We evaluated the influence of a 32-day camping in Antarctica on physical performance and exercise-induced thermoregulatory responses. In Brazil, before and after the...
We evaluated the influence of a 32-day camping in Antarctica on physical performance and exercise-induced thermoregulatory responses. In Brazil, before and after the Antarctic camping, the volunteers performed an incremental exercise at temperate conditions and, two days later, an exercise heat stress protocol (45-min running at 60% of maximum aerobic speed, at 31°C and 60% of relative humidity). In Antarctica, core temperature was assessed on a day of fieldwork, and average values higher than 38.5°C were reported. At pre- and post-Antarctica, physiological (whole-body and local sweat rate, number of active sweat glands, sweat gland output, core and skin temperatures) and perceptual (thermal comfort and sensation) variables were measured. The Antarctic camping improved the participants' performance and induced heat-related adaptations, as evidenced by sweat redistribution (lower in the chest but higher in grouped data from the forehead, forearm, and thigh) and reduced skin temperatures in the forehead and chest during the exercise heat stress protocol. Notwithstanding the acclimatization, the participants did not report differences of the thermal sensation and comfort. In conclusion, staying in an Antarctic camp for 32 days improved physical performance and elicited physiological adaptations to heat due to the physical exertion-induced hyperthermia in the field.
Topics: Acclimatization; Antarctic Regions; Body Temperature; Exercise; Hot Temperature; Humans; Thermotolerance
PubMed: 35239799
DOI: 10.1590/0001-3765202220210593 -
Experimental Physiology Jan 2021What is the central question of this study? We assessed the utility of a new metric for quantifying ventilatory acclimatization to high altitude, derived from...
NEW FINDINGS
What is the central question of this study? We assessed the utility of a new metric for quantifying ventilatory acclimatization to high altitude, derived from differential ascent and descent steady-state cardiorespiratory variables (i.e. hysteresis). Furthermore, we aimed to investigate whether the magnitude of cardiorespiratory hysteresis was associated with the development of acute mountain sickness. What is the main finding and its importance? Hysteresis in steady-state cardiorespiratory variables quantifies ventilatory acclimatization to high altitude. The magnitude of cardiorespiratory hysteresis during ascent to and descent from high altitude was significantly related to the development of symptoms of acute mountain sickness. Hysteresis in steady-state chemoreflex drive can provide a simple, non-invasive method of tracking ventilatory acclimatization to high altitude.
ABSTRACT
Maintenance of arterial blood gases is achieved through sophisticated regulation of ventilation, mediated by central and peripheral chemoreflexes. Respiratory chemoreflexes are important during exposure to high altitude owing to the competing influence of hypoxia and hypoxic hyperventilation-mediated hypocapnia on steady-state ventilatory drive. Inter-individual variability exists in ventilatory acclimatization to high altitude, potentially affecting the development of acute mountain sickness (AMS). We aimed to quantify ventilatory acclimatization to high altitude by comparing differential ascent and descent values (i.e. hysteresis) in steady-state cardiorespiratory variables. We hypothesized that: (i) the hysteresis area formed by cardiorespiratory variables during ascent and descent would quantify the magnitude of ventilatory acclimatization; and (ii) larger hysteresis areas would be associated with lower AMS symptom scores during ascent. In 25 healthy, acetazolamide-free trekkers ascending to and descending from 5160 m, cardiorespiratory hysteresis was measured in the partial pressure of end-tidal CO , peripheral oxygen saturation, minute ventilation, chemoreceptor stimulus index (end-tidal CO /peripheral oxygen saturation) and the calculated steady-state chemoreflex drive (SS-CD; minute ventilation/chemoreceptor stimulus index) using portable devices (capnograph, peripheral pulse oximeter and respirometer, respectively). Symptoms of AMS were assessed daily using the Lake Louise questionnaire. We found that: (i) ascent-descent hysteresis was present in all cardiorespiratory variables; (ii) SS-CD is a valid metric for tracking ventilatory acclimatization to high altitude; and (iii) the highest AMS scores during ascent exhibited a significant, moderate and inverse correlation with the magnitude of SS-CD hysteresis (r = -0.408, P = 0.043). We propose that ascent-descent hysteresis is a new and feasible way to quantify ventilatory acclimatization in trekkers during high-altitude exposure.
Topics: Acclimatization; Adult; Altitude; Altitude Sickness; Humans; Hypoxia; Lung; Oxygen; Oxygen Saturation
PubMed: 32421248
DOI: 10.1113/EP088488