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Anatomical Record (Hoboken, N.J. : 2007) Jan 2020This special issue of The Anatomical Record explores extravagant adaptions that vertebrates have evolved from their base groups to survive in the most challenging...
This special issue of The Anatomical Record explores extravagant adaptions that vertebrates have evolved from their base groups to survive in the most challenging environments. The special issue stems from a symposium entitled "Extreme Anatomy: Living beyond the edge," which was held April 23, 2017, at the annual meeting of the American Association of Anatomists, (now called the American Association for Anatomy), in Chicago, IL. In part 1 of this issue, we encounter fossorial mammals and cave-dwelling fish and salamanders that have reduced visual systems accompanied by a variety of mechanosensory adaptations. In rivers and seas, teeth may not suffice in the pursuit of prey: aquatic vertebrates are adorned with armor or weaponry or elaborate keratinous sieves. As vertebrates exploit a great diversity of niches, selection has favored a dizzying array of specialized sensory and locomotor adaptions for deep diving, rapid flight, and navigation through dark and complex settings. Each special adaptation, some seemingly quite "extreme" deviations from an original Bauplan, becomes a tool for a pioneer-like diversification of vertebrates. Anat Rec, 2019. © 2019 American Association for Anatomy.
Topics: Adaptation, Physiological; Animals; Biological Evolution; Conservation of Natural Resources; Environment; Introduced Species; Mammals
PubMed: 31714035
DOI: 10.1002/ar.24299 -
European Cells & Materials May 2022The enthesis demonstrates a distinct highly ordered zonal microanatomy at the osteotendinous/osteoligamentous tissue connection that allows for the smooth transmission... (Review)
Review
The enthesis demonstrates a distinct highly ordered zonal microanatomy at the osteotendinous/osteoligamentous tissue connection that allows for the smooth transmission of mechanical forces between tissues. Interfacial tissue engineering (ITE), a subset of the interdisciplinary field of tissue engineering, is directed at replicating this complex transitional anatomy of the enthesis in vitro. Yet, the limited understanding of tissue boundaries, gradients and structural relationships at specific anatomical locations hampers the development of novel therapeutic strategies for bespoke enthesis regeneration, thus reducing their direct clinical applicability. This review provides an overview of ITE approaches for repair of the osteotendinous/osteoligamentous junction and highlights the importance of complementary inclusion of direct anatomical research. The cross-disciplinary collaboration across an array of experts, including anatomists, involved in the design, development and utilisation of bioengineered tissues will enhance the properties of such tissues and improve their clinical relevance. More specifically, a detailed anatomical analysis of the region of interest should drive the in vitro design and enable researchers to develop anatomically and clinically relevant tissue-engineered replacement tissues for human implantation. Finally, the present review discusses the challenges and future directions of the ITE field and highlights the importance of anatomically driven tissue engineering as an emerging tool in clinical translational research.
Topics: Humans; Tissue Engineering
PubMed: 35510558
DOI: 10.22203/eCM.v043a14 -
Anatomy & Cell Biology Mar 2023An accessory submandibular gland is a rare variation. As such, there is limited literature regarding the embryology, anatomy, variations, clinical imaging, and pathology... (Review)
Review
An accessory submandibular gland is a rare variation. As such, there is limited literature regarding the embryology, anatomy, variations, clinical imaging, and pathology of the accessory submandibular gland. In this article, we review the existing literature on the accessory submandibular gland from clinical and anatomical perspectives. The goal of this review is to provide comprehensive knowledge of this variation which can be useful for oral and maxillofacial/head and neck surgeons, radiologists, and anatomists. Within this review, the embryologic origin as well as the anatomy of the accessory submandibular gland is detailed. Several imaging modalities which can be used to visualize the accessory submandibular gland are outlined as well as its variations. Lastly, this review investigates several reported clinical considerations regarding the accessory submandibular gland including sialoliths, Wharton's duct obstruction, and pleomorphic adenoma.
PubMed: 36384887
DOI: 10.5115/acb.22.118 -
Journal of Orthopaedic Research :... Aug 2021The majority of fracture research has been conducted using long bone fracture models, with significantly less research into the mechanisms driving craniofacial repair....
The majority of fracture research has been conducted using long bone fracture models, with significantly less research into the mechanisms driving craniofacial repair. However, craniofacial bones differ from long bones in both their developmental mechanism and embryonic origin. Thus, it is possible that their healing mechanisms could differ. In this study we utilize stabilized and unstabilized mandible fracture models to investigate the pathways regulating repair. Whereas fully stable trephine defects in the ramus form bone directly, mechanical motion within a transverse fracture across the same anatomical location promoted robust cartilage formation before boney remodeling. Literature investigating long bone fractures show chondrocytes are a direct precursor of osteoblasts during endochondral repair. Lineage tracing with Aggrecan-Cre ::Ai9 tdTomato mice demonstrated that mandibular callus chondrocytes also directly contribute to the formation of new bone. Furthermore, immunohistochemistry revealed that chondrocytes located at the chondro-osseous junction expressed Sox2, suggesting that plasticity of these chondrocytes may facilitate this chondrocyte-to-osteoblast transformation. Based on the direct role chondrocytes play in bone repair, we tested the efficacy of cartilage grafts in healing critical-sized mandibular defects. Whereas empty defects remained unbridged and filled with fibrous tissue, cartilage engraftment produced bony-bridging and robust marrow cavity formation, indicating healthy vascularization of the newly formed bone. Engrafted cartilage directly contributed to new bone formation since a significant portion of the newly formed bone was graft/donor-derived. Taken together these data demonstrate the important role of chondrocyte-to-osteoblast transformation during mandibular endochondral repair and the therapeutic promise of using cartilage as a tissue graft to heal craniofacial defects.
Topics: Animals; Bony Callus; Chondrocytes; Fracture Healing; Mandibular Fractures; Mice; Osteoblasts; Osteogenesis
PubMed: 33140859
DOI: 10.1002/jor.24904 -
International Journal of Surgery Case... Dec 2021Sternalis/rectus sterni is a rare muscle found in the anterior chest wall, it occurs in 35% of humans. The early detection of its presence is critical in regular...
INTRODUCTION AND IMPORTANCE
Sternalis/rectus sterni is a rare muscle found in the anterior chest wall, it occurs in 35% of humans. The early detection of its presence is critical in regular mammogram screening in order to avoid possible differential diagnostic dilemma.
CASE PRESENTATION
We report here a case of the sternalis muscle observed bilaterally, it was found during routine dissection session of an elderly male cadaver in the dissection room, Faculty of Medicine, University of Khartoum.
CLINICAL DISCUSSION AND CONCLUSION
Sternalis muscle is a familiar entity to anatomists, but can pose a diagnostic and surgical dilemma to some clinicians. Presence of the muscle can be confusing in regular mammogram screening and CT and MRI should be utilized to clear the dilemma, and further evidence needs to be explored and studied.
PubMed: 34808444
DOI: 10.1016/j.ijscr.2021.106511 -
Turkish Neurosurgery 2022To present the quantitative development of the geniculate ganglion (GG) in foetal cadavers.
AIM
To present the quantitative development of the geniculate ganglion (GG) in foetal cadavers.
MATERIAL AND METHODS
This study focused on 60 temporal bones of 30 (15 female and 15 male) foetuses aged 18?30 weeks of gestation (mean age, 22.83 ± 3.49 weeks) to measure the length, width and area of the GG.
RESULTS
According to gestational weeks and months, the ganglion length (1.21 ± 0.41 mm), width (1.03 ± 0.28 mm) and area (1.24 ± 0.61 mm < sup > 2 < /sup > ) did not change. In terms of sexes or sides, ganglion dimensions were not significantly different. Positive correlation was found between the length and width (p=0.033, r=0.276), between the length and area (p < 0.001, r=0.762) and between the width and area (p < 0.001, r=0.622). Linear functions were calculated for the ganglion area (y=0.355 + 0.039 × weeks), length (y=0.636 + 0.025 × weeks) and width (y=0.634 + 0.017 × weeks).
CONCLUSION
The ganglion size did not change in foetal cadavers aged 18?30 weeks of gestation. This finding may be important for anatomists and embryologists in performing morphometric studies and understanding the development of the GG and for neurootologists and neurosurgeons in achieving greater success in skull base surgeries.
Topics: Cadaver; Female; Fetus; Geniculate Ganglion; Gestational Age; Humans; Infant; Male; Neurosurgical Procedures; Temporal Bone
PubMed: 34936075
DOI: 10.5137/1019-5149.JTN.35393-21.2 -
Gynecologic Oncology Reports Nov 2020The resulting characteristics of 20th century radical hysterectomy demonstrated that, in the quest for a radical cure, its surgical procedure became extended. The... (Review)
Review
The resulting characteristics of 20th century radical hysterectomy demonstrated that, in the quest for a radical cure, its surgical procedure became extended. The consequences of this were increased difficulty in the procedure with risk of massive hemorrhage and vesical and anorectal dysfunction. Moreover, the cardinal and transverse cervical ligaments, which were individually recognized during the 19th century, became regarded as synonymous during the middle of the 20th century. Because of this, traditional surgical procedures such as Wertheim and Latzko's were not precisely followed, further delaying the advent of a new idea(s) for radical hysterectomy. The desired goal for 21st radical hysterectomy should be an anatomy and operative procedure that clarify and rectify these aforementioned negative surgical outcomes. In 1998, International Federation of Associations of Anatomists (IFAA) introduced clinical terminology in Terminologia Anatomica. With the IFAA's decision in mind, the author focused, out of the many theories and surgical procedures for cancer of the uterine cervix, on three noteworthy proposals. From these proposals, the possibility for a new idea(s) on theories and surgical procedures was explored through the fusion of anatomy and clinical practice. The idea for a new procedure(s) required a morphological distinction between description in textbooks and intraoperative findings, that is: a) a traditional anatomy that was based on gross/systemic anatomy; and b) an anatomy in which part of an artifact resulting from applying an artificial maneuver to a living body could be regarded as surgical anatomy. The author has tentatively called the former descriptive anatomy and the latter practical anatomy. The development of this practical anatomy led to the idea for and practical application of a less-extirpating and nerve-sparing operation, which improved patient's outcome. Radical hysterectomy of the 21st century should be conducted following this new anatomy that is concentrated around practical anatomy and independent from descriptive anatomy.
PubMed: 32984492
DOI: 10.1016/j.gore.2020.100623 -
Journal of Oral Biosciences Sep 2022Tooth identification is important not only for anatomists and anthropologists but also for dental practitioners and dental students studying dental anatomy courses. This... (Review)
Review
BACKGROUND
Tooth identification is important not only for anatomists and anthropologists but also for dental practitioners and dental students studying dental anatomy courses. This review paper provides an overview of the significance of tooth identification focusing on the morphological and developmental background.
HIGHLIGHT
The process of tooth identification comprises five steps of distinction: (1) between deciduous and permanent teeth; (2) between tooth classes; (3) between maxillary and mandibular teeth; (4) within the same tooth class; and (5) between the left and right sides of a tooth. According to Mühlreiter's features, the mesial half is more developed than the distal half, and the curvature feature is associated with the configuration of the dental arch. Each step of tooth identification refers to effective traits and characteristics. The possibility that systemic conditions affect dental morphology should be considered. Tooth identification is occasionally difficult owing to individual variations (size and shape, supernumerary tubercles, root fusion) and sex-based differences. A tooth type error within the same class is the most frequent error in tooth identification, followed by a left or right side error.
CONCLUSION
To understand tooth identification, it is necessary to have comprehensive knowledge of dental morphology. A broad education with regard to tooth evolution and comparative odontology, as well as a thorough understanding of the morphology and function of teeth, which play a crucial role in sustaining life as organs of mastication, is essential.
Topics: Dentition; Humans; Odontogenesis; Tooth
PubMed: 35598838
DOI: 10.1016/j.job.2022.05.004