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Scientific Reports Feb 2022This observational case-control study evaluated the anterior ocular segment parameters of patients with celiac disease with a Scheimpflug imaging system and compared... (Observational Study)
Observational Study
This observational case-control study evaluated the anterior ocular segment parameters of patients with celiac disease with a Scheimpflug imaging system and compared them with those of a healthy controls group, highlighting potential differences related to the underlying pathogenetic mechanisms of the disease. Seventy celiac patients and 70 healthy subjects were assessed with a comprehensive ophthalmological evaluation, including clinical history, Snellen best-corrected visual acuity, axial length (AL) measurements with IOLMaster, and anterior segment tomographic evaluation with Pentacam HR. The measurements of all keratometry values, astigmatism, steep axis, anterior and posterior Q value (asphericity), pupil diameter, pupil center, corneal apex, the thinnest point, corneal volume, anterior chamber depth from the epithelium, anterior chamber depth from endothelium, anterior chamber volume, and iridocorneal angle were also appraised. The two study groups were comparable and similar for gender, age, and AL, with no statistically significant differences regarding all analyzed tomographic parameters. Thus, ocular anterior segment parameters of celiac patients are not significantly different from those of healthy subjects, suggesting no underlying pathogenetic implications of celiac disease affecting the assessed structures. Nevertheless, a routine ophthalmological examination for all celiac patients should be recommended throughout their lifetimes due to the potential ocular manifestations of the disease.
Topics: Adolescent; Adult; Aged; Anterior Chamber; Anterior Eye Segment; Astigmatism; Case-Control Studies; Celiac Disease; Cornea; Corneal Topography; Diagnostic Techniques, Ophthalmological; Female; Humans; Male; Middle Aged; Pupil; Tomography; Visual Acuity; Young Adult
PubMed: 35140276
DOI: 10.1038/s41598-022-06058-1 -
Acta Ophthalmologica Dec 2022To determine the utility of Split-Window optical coherence tomography OCT (SW-OCT) biometry in measuring ocular axial dimensions as well as imaging the intraocular lens...
PURPOSE
To determine the utility of Split-Window optical coherence tomography OCT (SW-OCT) biometry in measuring ocular axial dimensions as well as imaging the intraocular lens (IOL) and posterior capsule in pseudophakic eyes.
METHODS
Sixty-nine pseudophakic eyes of 69 subjects were enrolled in the study. The results of SW-OCT biometry implemented in the SD OCT device for posterior and anterior segment imaging (REVO NX, Optopol Technology) were compared with those obtained with the SS-OCT-based biometer IOLMaster 700 (Carl Zeiss Meditec). Differences in measurement values between the two biometers were determined using the paired t-test. Agreement was assessed through intraclass correlation coefficients (ICC) and Bland-Altman plots.
RESULTS
The correlation between measurements obtained with SW-OCT and SS-OCT was very high (ICC for: axial length (AL) = 1.000; anterior chamber depth (ACD) = 0.997; IOL thickness (IOL LT) = 0.997; central corneal thickness (CCT) = 0.987). The mean AL measurement difference was 0.003 ± 0.021 mm (the 95% LoA ranged from -0.04 to 0.05); the mean ACD difference was -0.009 ± 0.025 mm (95% LoA, -0.06 to 0.04); mean LT difference was 0.001 ± 0.021 mm (95% LoA, -0.04 to 0.04); and mean CCT difference was 1.4 ± 5.4 μm (95% LoA, -9 to 12).
CONCLUSION
The study shows small, non-significant differences between the biometric measurements obtained with REVO NX SW-OCT and IOLMaster 700 SS-OCT in pseudophakic eyes. However, SW-OCT offered significantly lower ACD and LT measurement failure rates. With high-resolution imaging, SW-OCT enables accurate assessment of IOL position relative to the posterior capsule and visualization of capsular fibrosis.
Topics: Humans; Axial Length, Eye; Tomography, Optical Coherence; Reproducibility of Results; Biometry; Lenses, Intraocular; Anterior Chamber; Interferometry; Cornea
PubMed: 35670319
DOI: 10.1111/aos.15198 -
Indian Journal of Ophthalmology Dec 2022
Topics: Child; Humans; Anterior Chamber; Lenses, Intraocular
PubMed: 36453376
DOI: 10.4103/ijo.IJO_1644_22 -
Medicine Dec 2022To determine the distribution of the anterior chamber parameters and associated factors in cataractous adults from middle China. In this cross-sectional study, axial...
To determine the distribution of the anterior chamber parameters and associated factors in cataractous adults from middle China. In this cross-sectional study, axial length, anterior chamber depth (ACD) and lens thickness (LT) were measured with IOLMaster 700. The Pentacam HR was designed to measure the anterior chamber volume (ACV) and anterior chamber angle (ACA). Patients' data were collected and analyzed between 2020 and 2022. A total of 157 eyes of 157 Chinese adults (mean age: 64.43 ± 12.16 years) with a cataract were enrolled in this study. The mean values measured were as follows: axial length, 24.10 ± 2.44mm; ACD, 2.99 ± 0.52 mm; LT, 4.51 ± 0.48 mm; ACV, 113.98 ± 45.12 mm3; ACA, 32.33 ± 7.66 degrees. The ACD and ACV were statistically significantly greater in men than in women and had a decrease trend as age and LT increased. In the simulated linear equation of age with ACD and LT the absolute slope coefficients of equations were the same; however, the directions were opposite. The mean ACV was <100 mm3 when the patients were over 60 years. In the multivariate regression analysis of ACD, ACV and ACA there was a reasonable prediction with adjusted R2 = 0.878, 0.847 and 0.564, respectively. This study may provide normative data for cataract patients. The profile of anterior chamber can help improve the knowledge of the risk of angle closure in cataract candidates.
Topics: Male; Adult; Humans; Female; Middle Aged; Aged; Cross-Sectional Studies; Cataract Extraction; Anterior Chamber; Cataract; China
PubMed: 36626461
DOI: 10.1097/MD.0000000000032211 -
Eye (London, England) Jun 2022To describe anterior chamber angle (ACA) structures and parameters in primary congenital glaucoma (PCG) and normal infant eyes, using Hand-held anterior segment optical...
PURPOSE
To describe anterior chamber angle (ACA) structures and parameters in primary congenital glaucoma (PCG) and normal infant eyes, using Hand-held anterior segment optical coherence tomography (HH AS-OCT), as an in-office, non-contact technique.
METHODS
Normal and PCG-infants <24 months were examined, using HH AS-OCT (RTVue RT- 100, Optovue Inc., Fremont, CA). Sedation was not required. Corneal pachymetry map, ACA width and iris thickness (IT) were measured. Trabecular meshwork (TM), Schlemm's canal (SC), and scleral spur (SS) identification were assessed in both groups.
RESULTS
Forty-eight infants; (26 PCG-eyes and 22 normal-eyes) aged 9.12 ± 6.7 months, were included. Nasal and temporal ACA width in PCG infants was found significantly larger (39.3 ± 6.6° vs. 30.4 ± 5.6, and 40.1 ± 5.3° vs. 32.5 ± 6.2 respectively) (p < 0.001). IT was significantly reduced (121.7 ± 43.9 μm in PCG-infants, vs. 160.3 ± 38.6 μm in normal-eyes) (p < 0.01). TM was identified in all normal eyes (100%) and nine (34.6%) PCG- eyes. SC was identified in 16 (72.7%) normal eyes versus four (15.4%) PCG. In PCG-eyes, an abnormal structure occluding the angle was seen in seven (26.9%), and a hyper-reflective membrane in five (19.2%), the iris was anteriorly inserted in all PCG-eyes, and iridotrabeculodysgenesis was clearly identified (with constant iris anterior insertion). The abnormal tissue obscuring the angle was seen in younger PCG-infants and iris thinning appeared to be part of the pathology, not a result of IOP elevation.
CONCLUSION
Using HH AS-OCT permits tomographic examination of the ACA in PCG infants and may help in the understanding of disease pathology. Hence, may assist in optimizing treatment.
Topics: Anterior Chamber; Glaucoma; Glaucoma, Angle-Closure; Humans; Infant; Intraocular Pressure; Iris; Tomography, Optical Coherence; Trabecular Meshwork
PubMed: 34117386
DOI: 10.1038/s41433-021-01583-1 -
Clinical & Experimental Ophthalmology Mar 2022The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of the eye. It does this by establishing a tunable outflow resistance, defined by the... (Review)
Review
The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of the eye. It does this by establishing a tunable outflow resistance, defined by the interplay between cells and their extracellular matrix (ECM) milieu, and the molecular interactions between ECM proteins. During normal tissue homeostasis, the ECM is remodelled and trabecular cell behaviour is modified, permitting increased aqueous fluid outflow to maintain intraocular pressure (IOP) within a relatively narrow physiological pressure. Dysfunction in the normal homeostatic process leads to increased outflow resistance and elevated IOP, which is a primary risk factor for glaucoma. This review delineates some of the changes in the ECM that lead to gross as well as some more subtle changes in the structure and function of the ECM, and their impact on trabecular cell behaviour. These changes are discussed in the context of outflow resistance and glaucoma.
Topics: Aqueous Humor; Extracellular Matrix; Glaucoma; Humans; Intraocular Pressure; Trabecular Meshwork
PubMed: 35037377
DOI: 10.1111/ceo.14027 -
Indian Journal of Ophthalmology Feb 2022To compare the quantitative measurements of the anterior chamber angle (ACA) and iris parameters in patients with juvenile open-angle glaucoma (JOAG), pigmentary...
UNLABELLED
To compare the quantitative measurements of the anterior chamber angle (ACA) and iris parameters in patients with juvenile open-angle glaucoma (JOAG), pigmentary glaucoma (PG), and healthy controls using anterior segment optical coherence tomography (AS-OCT).
METHODS
This was a retrospective, cross-sectional study of 25 eyes with JOAG, 25 eyes with PG, and 25 control eyes. Anterior chamber depth, angle-opening distance 500 and 750, trabecular-iris space 500 and 750, scleral spur angle, iris thickness (IT, measured at the thickest part), and iris bowing were obtained using AS-OCT (Visante" OCT 3.0 Model 1000, Carl Zeiss Meditec, Inc).
RESULTS
The quantitative ACA parameters were found to be significantly higher in JOAG and PG patients compared to healthy controls (P < 0.001); there was no significant difference between the eyes with JOAG and PG (P > 0.05). In eyes with JOAG and PG, there was significantly backward bowing of the iris in temporal and nasal angles compared to control subjects (P < 0.001). Median iris bowing was not significantly different between the patients with JOAG and PG (P > 0.05). The temporal and nasal angle iris thickness were significantly thinner in eyes with JOAG than the eyes with PG (P < 0.001) and age-matched control subjects (P < 0.001). The median IT did not differ between the patients with PG and control subjects (P > 0.05). In patients with JOAG, the intraocular pressure (IOP) was inversely correlated with IT (r = -0.43, P < 0.05).
CONCLUSION
AS-OCT provided quantitative data on the ACA and iris parameters in JOAG and PG. The evaluation of the ACA and iris structures using AS-OCT revealed higher ACA measurements and posterior bowing of the iris in patients with JOAG and PG. Furthermore, the patients with JOAG were found to have thinner IT than the ones with PG and healthy controls.
Topics: Anterior Chamber; Anterior Eye Segment; Cross-Sectional Studies; Glaucoma, Angle-Closure; Glaucoma, Open-Angle; Gonioscopy; Humans; Intraocular Pressure; Iris; Retrospective Studies; Tomography, Optical Coherence
PubMed: 35086237
DOI: 10.4103/ijo.IJO_2012_21 -
JAMA Feb 2021Exfoliation syndrome is a systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates manifesting clinically in the anterior... (Observational Study)
Observational Study
IMPORTANCE
Exfoliation syndrome is a systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates manifesting clinically in the anterior chamber of the eye. This disorder is the most commonly known cause of glaucoma and a major cause of irreversible blindness.
OBJECTIVE
To determine if exfoliation syndrome is associated with rare, protein-changing variants predicted to impair protein function.
DESIGN, SETTING, AND PARTICIPANTS
A 2-stage, case-control, whole-exome sequencing association study with a discovery cohort and 2 independently ascertained validation cohorts. Study participants from 14 countries were enrolled between February 1999 and December 2019. The date of last clinical follow-up was December 2019. Affected individuals had exfoliation material on anterior segment structures of at least 1 eye as visualized by slit lamp examination. Unaffected individuals had no signs of exfoliation syndrome.
EXPOSURES
Rare, coding-sequence genetic variants predicted to be damaging by bioinformatic algorithms trained to recognize alterations that impair protein function.
MAIN OUTCOMES AND MEASURES
The primary outcome was the presence of exfoliation syndrome. Exome-wide significance for detected variants was defined as P < 2.5 × 10-6. The secondary outcomes included biochemical enzymatic assays and gene expression analyses.
RESULTS
The discovery cohort included 4028 participants with exfoliation syndrome (median age, 78 years [interquartile range, 73-83 years]; 2377 [59.0%] women) and 5638 participants without exfoliation syndrome (median age, 72 years [interquartile range, 65-78 years]; 3159 [56.0%] women). In the discovery cohort, persons with exfoliation syndrome, compared with those without exfoliation syndrome, were significantly more likely to carry damaging CYP39A1 variants (1.3% vs 0.30%, respectively; odds ratio, 3.55 [95% CI, 2.07-6.10]; P = 6.1 × 10-7). This outcome was validated in 2 independent cohorts. The first validation cohort included 2337 individuals with exfoliation syndrome (median age, 74 years; 1132 women; n = 1934 with demographic data) and 2813 individuals without exfoliation syndrome (median age, 72 years; 1287 women; n = 2421 with demographic data). The second validation cohort included 1663 individuals with exfoliation syndrome (median age, 75 years; 587 women; n = 1064 with demographic data) and 3962 individuals without exfoliation syndrome (median age, 74 years; 951 women; n = 1555 with demographic data). Of the individuals from both validation cohorts, 5.2% with exfoliation syndrome carried CYP39A1 damaging alleles vs 3.1% without exfoliation syndrome (odds ratio, 1.82 [95% CI, 1.47-2.26]; P < .001). Biochemical assays classified 34 of 42 damaging CYP39A1 alleles as functionally deficient (median reduction in enzymatic activity compared with wild-type CYP39A1, 94.4% [interquartile range, 78.7%-98.2%] for the 34 deficient variants). CYP39A1 transcript expression was 47% lower (95% CI, 30%-64% lower; P < .001) in ciliary body tissues from individuals with exfoliation syndrome compared with individuals without exfoliation syndrome.
CONCLUSIONS AND RELEVANCE
In this whole-exome sequencing case-control study, presence of exfoliation syndrome was significantly associated with carriage of functionally deficient CYP39A1 sequence variants. Further research is needed to understand the clinical implications of these findings.
Topics: Aged; Aged, 80 and over; Anterior Chamber; Case-Control Studies; Cytochrome P-450 Enzyme System; Exfoliation Syndrome; Female; Genetic Variation; Humans; Logistic Models; Male; Meta-Analysis as Topic; Middle Aged; RNA, Messenger; Steroid Hydroxylases; Exome Sequencing
PubMed: 33620406
DOI: 10.1001/jama.2021.0507 -
Arquivos Brasileiros de Oftalmologia 2020The aim of this study was to evaluate the effect of anterior chamber depth and axial length on clinical performance of the Spot Vision Screener in detecting amblyopia...
PURPOSE
The aim of this study was to evaluate the effect of anterior chamber depth and axial length on clinical performance of the Spot Vision Screener in detecting amblyopia risk factors in children aged 3-10 years.
METHODS
A total of 300 eyes from 150 patients aged 3-10 years were prospectively tested with Spot Vision Screener (firmware version 3.0.02.32, software version 3.0.04.06) and a standard autorefractometer (Nidek ARK-1). The anterior chamber depth and axial length were measured with an optical biometer (Nidek AL-Scan). The sensitivity and specificity values for detecting significant refractive errors using the referral criteria of the American Association for Pediatric Ophthalmology and Strabismus were determined. Pearson's correlation analysis was employed to evaluate the relationship between the Spot Vision results and the anterior chamber depth and axial length.
RESULTS
Compared with the standard autorefractometer results, the Spot Vision Screener's sensitivity and specificity was 59% and 94%, respectively. The differences between the cycloplegic autorefractometer and the Spot Vision Screener spherical equivalents were negatively correlated with anterior chamber depth (r=-0.48; p<0.001) and axial length (r=-0.45; p<0.001).
CONCLUSION
The Spot Vision Screener has moderate sensitivity and high specificity, using the criteria of the American Association for Pediatric Ophthalmology and Strabismus. The anterior chamber depth and axial length affect the Spot Vision results.
Topics: Amblyopia; Anterior Chamber; Axial Length, Eye; Child; Child, Preschool; Humans; Prospective Studies; Refractive Errors; Retinoscopy; Risk Factors; Sensitivity and Specificity; Strabismus; Vision Screening
PubMed: 31664336
DOI: 10.5935/0004-2749.20200009 -
Translational Vision Science &... Dec 2021The purpose of this study was to compare three optical coherence tomography (OCT) modalities in the observation of anterior chamber angle structures; trabecular meshwork...
PURPOSE
The purpose of this study was to compare three optical coherence tomography (OCT) modalities in the observation of anterior chamber angle structures; trabecular meshwork (TM), Schlemm's canal (SC), and band of extracanalicular limbal lamina (BELL).
METHODS
Three OCT modalities were used: (1) 2 × 2 Jones-matrix scattering OCT (S-OCT) representing conventional intensity OCT, (2) polarization-diverse S-OCT that was calculated as summation of all elements of the Jones-matrix to eliminate the influence of artifacts caused by sample birefringence, and (3) polarization-sensitive OCT (PS-OCT) to assess depth-resolved phase retardation.
RESULTS
In a total of 97 eyes of 55 subjects, nasal and temporal angles were scanned. The detection rate of TM and BELL was significantly different among modalities; highest with PS-OCT (95.1% and 99.2%), followed by 2 × 2 Jones-matrix S-OCT (71.1% and 88.7%) and polarization-diverse S-OCT (33.2% and 25.0%), indicating the influence of artifacts on 2 × 2 Jones-matrix S-OCT measurements. SC was visible with 2 × 2 Jones-matrix S-OCT, polarization-diverse S-OCT, and PS-OCT in 14.2%, 14.9%, and 0.3% of images, respectively. The intergrader agreement as evaluated with the prevalence-adjusted bias-adjusted κ value was higher with PS-OCT than with other S-OCTs.
CONCLUSIONS
Visibility of anterior chamber angle structures was assessed with three OCT modalities. For TM and BELL that are rich in collagen fibers, PS-OCT provides significantly better visibility than S-OCT without the influence of artifacts arising from polarization or birefringence. Visualization of SC was more difficult with any OCT modalities.
TRANSLATIONAL RELEVANCE
PS-OCT is a useful tool to investigate the anterior chamber angle structures which are difficult to observe with conventional OCT.
Topics: Anterior Chamber; Birefringence; Humans; Sclera; Tomography, Optical Coherence; Trabecular Meshwork
PubMed: 34964836
DOI: 10.1167/tvst.10.14.29