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JACC. Cardiovascular Interventions Oct 2021
Topics: Aortic Valve Stenosis; Artificial Intelligence; Humans; Precision Medicine; Transcatheter Aortic Valve Replacement; Treatment Outcome
PubMed: 34620392
DOI: 10.1016/j.jcin.2021.08.046 -
The Journal of Invasive Cardiology Mar 2022Nonagenarians represent only a small proportion of patients included in large transcatheter aortic valve replacement (TAVR) trials, but will become a relevant future... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Nonagenarians represent only a small proportion of patients included in large transcatheter aortic valve replacement (TAVR) trials, but will become a relevant future population in need of treatment due to demographic change. Thus, this study sought to evaluate outcomes of TAVR for the treatment of severe aortic stenosis (AS) in nonagenarian patients.
METHODS
We screened Medline/Pubmed for studies that stated specific outcomes for nonagenarians undergoing TAVR. A weighted meta-analysis was conducted, calculating pooled estimate rates using a binary random-effects model for dichotomous variables, and comparing non-dichotomous outcomes with a continuous random-effects model.
RESULTS
Data from 23 studies including 16,094 nonagenarians were merged; 53.4% were women. Despite reasonable rates of comorbidities, Society of Thoracic Surgeons mortality risk score was 10.2 ± 5.4. Pooled estimate rate of procedural success was 94.1% (95% confidence interval [CI], 91.7-96.6), with major vascular complications occurring in 6.3% (95% CI, 2.7-9.8) and at least moderate postprocedural paravalvular leak in 7.5% (95% CI, 4.4-10.6). The rate of periprocedural stroke or transient ischemic attack was 2.6% (95% CI, 2.0-3.2). At 30 days, the pooled estimate of mortality was 6.1% (95% CI, 4.7-7.4) and a permanent pacemaker was implanted in 12.6% (95% CI, 7.6-17.6). After 1 year, the mortality rate was 20.5% (95% CI, 15.9-25.1).
CONCLUSION
TAVR in nonagenarians is an effective and safe procedure, with encouraging outcomes given the general life expectancy of these patients. Currently, only selected nonagenarians are undergoing TAVR, but their number will grow as life expectancy continues to increase in the developed world. Specific research to identify ideal candidates and techniques in this cohort is needed.
Topics: Aged, 80 and over; Aortic Valve; Aortic Valve Stenosis; Female; Humans; Male; Nonagenarians; Risk Factors; Transcatheter Aortic Valve Replacement; Treatment Outcome
PubMed: 35235529
DOI: No ID Found -
JACC. Cardiovascular Interventions Oct 2021
Topics: Aortic Valve Insufficiency; Aortic Valve Stenosis; Humans; Transcatheter Aortic Valve Replacement; Treatment Outcome
PubMed: 34620396
DOI: 10.1016/j.jcin.2021.08.022 -
JACC. Cardiovascular Imaging Mar 2020
Topics: Aortic Valve; Aortic Valve Stenosis; Calcinosis; Fibrosis; Humans; Peptidyl-Dipeptidase A
PubMed: 31864990
DOI: 10.1016/j.jcmg.2019.10.018 -
The Journal of Invasive Cardiology Sep 2023A 78-year-old woman with a background of hypertension and osteoarthritis presented with a history of syncope secondary to severe aortic stenosis. She underwent a...
A 78-year-old woman with a background of hypertension and osteoarthritis presented with a history of syncope secondary to severe aortic stenosis. She underwent a computed tomography (CT) scan that showed a heavily calcific trileaflet aortic valve.
Topics: Female; Humans; Aged; Aortic Valve Stenosis; Aortic Valve; Transcatheter Aortic Valve Replacement; Calcinosis
PubMed: 37983111
DOI: 10.25270/jic/22.00363 -
Polish Archives of Internal Medicine Apr 2021
Topics: Aortic Valve Stenosis; Exercise Test; Humans
PubMed: 33913310
DOI: 10.20452/pamw.15978 -
Journal of the American College of... Jan 2021
Topics: Amyloidosis; Aortic Valve Stenosis; Humans; Transcatheter Aortic Valve Replacement
PubMed: 33181245
DOI: 10.1016/j.jacc.2020.11.007 -
Journal of the American College of... Mar 2022
Topics: Aortic Valve Stenosis; Heart Valve Prosthesis Implantation; Humans; Transcatheter Aortic Valve Replacement
PubMed: 35241223
DOI: 10.1016/j.jacc.2021.12.020 -
JACC. Cardiovascular Interventions Jan 2021
Topics: Aortic Valve Stenosis; Humans; Percutaneous Coronary Intervention; Registries; Transcatheter Aortic Valve Replacement; Treatment Outcome
PubMed: 33478638
DOI: 10.1016/j.jcin.2020.11.021 -
The Journal of Thoracic and... Feb 2021
Topics: Aortic Valve; Aortic Valve Stenosis; Cell Differentiation; Heart Valve Prosthesis Implantation; Humans; Osteogenesis
PubMed: 31818429
DOI: 10.1016/j.jtcvs.2019.10.167